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List of works by Shinichi Toyooka

A new human lung adenocarcinoma cell line harboring the EML4-ALK fusion gene

scientific article published on 28 August 2014

Aberrant promoter methylation in pleural fluid DNA for diagnosis of malignant pleural effusion

scientific article published in May 2007

Aberrant promoter methylation of insulin-like growth factor binding protein-3 gene in human cancers.

scientific article published on February 2007

Acquired resistance mechanisms to afatinib in HER2-amplified gastric cancer cells

scientific article published on 24 June 2019

Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.

scientific article published on 29 March 2013

Acquisition of cancer stem cell-like properties in non-small cell lung cancer with acquired resistance to afatinib

scientific article

Activation of AXL as a Preclinical Acquired Resistance Mechanism Against Osimertinib Treatment in EGFR-Mutant Non-Small Cell Lung Cancer Cells

scientific article published on 21 November 2018

Activation of downstream epidermal growth factor receptor (EGFR) signaling provides gefitinib-resistance in cells carrying EGFR mutation

scientific article published on March 2007

Anti-cancer effects of REIC/Dkk-3-encoding adenoviral vector for the treatment of non-small cell lung cancer

scientific article published on 03 February 2014

Antitumor activity of pan-HER inhibitors in HER2-positive gastric cancer.

scientific article published on 21 February 2018

Antitumor effect of afatinib, as a human epidermal growth factor receptor 2-targeted therapy, in lung cancers harboring HER2 oncogene alterations

scientific article

Clinical features and outcomes of patients with stage I multiple primary lung cancers

scientific article published on 25 November 2020

Clinical significance of epidermal growth factor receptor gene mutations on treatment outcome after first-line cytotoxic chemotherapy in Japanese patients with non-small cell lung cancer

scientific article published in July 2007

Combined inhibition of MEK and PI3K pathways overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer

scientific article published on 14 September 2018

Comparative mutational evaluation of multiple lung cancers by multiplex oncogene mutation analysis

scientific article published on 06 October 2018

Comprehensive analysis of EGFR signaling pathways in Japanese patients with non-small cell lung cancer

scientific article published on 31 January 2009

DNA copy number gains in malignant pleural mesothelioma

scientific article

Distant Bystander Effect of REIC/DKK3 Gene Therapy Through Immune System Stimulation in Thoracic Malignancies

scientific article published on January 2017

Downregulation of TBXAS1 in an iron-induced malignant mesothelioma model

scientific article published on 24 July 2015

Drug resistance to EGFR tyrosine kinase inhibitors for non-small cell lung cancer

scientific article

EGFR Mutation, But Not Sex and Smoking, Is Independently Associated with Favorable Prognosis of Gefitinib-treated Patients with Lung Adenocarcinoma

Elacridar, a third-generation ABCB1 inhibitor, overcomes resistance to docetaxel in non-small cell lung cancer.

scientific article published on 26 July 2017

Epidermal Growth Factor Receptor Mutation Status and Adjuvant Chemotherapy With Uracil-Tegafur for Adenocarcinoma of the Lung

Epidermal growth factor receptor mutation, but not sex and smoking, is independently associated with favorable prognosis of gefitinib-treated patients with lung adenocarcinoma

scientific article published in February 2008

Epigenetic silencing of microRNA-34b/c plays an important role in the pathogenesis of malignant pleural mesothelioma.

scientific article published on 14 June 2011

Erratum to "Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer" [Lung Cancer 76 (1) (2012) 32-38]

scientific article published on 27 April 2017

Establishment and molecular characterization of cell lines from Japanese patients with malignant pleural mesothelioma.

scientific article published on 23 November 2015

Estimation of age-related DNA degradation from formalin-fixed and paraffin-embedded tissue according to the extraction methods

scientific article published on 17 July 2017

Genetic alterations in lung adenocarcinoma with a micropapillary component

scientific article published on 2 December 2015

Genetic predictors of MEK dependence in non-small cell lung cancer

scientific article

Hsp90 inhibitor NVP-AUY922 enhances the radiation sensitivity of lung cancer cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors.

scientific article

Impact of GLUT1 and Ki-67 expression on early‑stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification

scientific article published on 17 October 2012

Impact of aberrant methylation of microRNA-9 family members on non-small cell lung cancers.

scientific article published on 03 September 2012

Impact of age on epidermal growth factor receptor mutation in lung cancer.

scientific article

Induction chemoradiotherapy followed by surgical resection for clinical T3 or T4 locally advanced non-small cell lung cancer

scientific article

Induction chemoradiotherapy using docetaxel and cisplatin with definitive-dose radiation followed by surgery for locally advanced non-small cell lung cancer.

scientific article published in September 2017

Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway.

scientific article published on 23 December 2016

Is tumor location an independent prognostic factor in locally advanced non-small cell lung cancer treated with trimodality therapy?

scientific article published on May 2017

Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.

scientific article

Mutations of epidermal growth factor receptor andK-rasgenes in adenosquamous carcinoma of the lung

scientific article published on 01 March 2006

Non-BAC Component but not Epidermal Growth Factor Receptor Gene Mutation is Associated with Poor Outcomes in Small Adenocarcinoma of the Lung

article

Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas.

scientific article published on 07 December 2013

Optimal method for quantitative detection of plasma EGFR T790M mutation using droplet digital PCR system

scientific article

Preclinical evaluation of microRNA-34b/c delivery for malignant pleural mesothelioma.

scientific article published on January 2014

Presence of the minor EGFR T790M mutation is associated with drug-sensitive EGFR mutations in lung adenocarcinoma patients.

scientific article published on 16 May 2014

Prognostic impact of cancer stem cell-related markers in non-small cell lung cancer patients treated with induction chemoradiotherapy

scientific article published on 03 March 2012

Relationship between epidermal growth factor receptor gene mutations and the severity of adverse events by gefitinib in patients with advanced non-small cell lung cancer

scientific article published on 28 February 2006

STAT3 expression in activating EGFR-driven adenocarcinoma of the lung

scientific article published on January 2012

Second primary cancer in survivors of locally advanced non-small cell lung cancer treated with concurrent chemoradiation followed by surgery

scientific article published on 2 February 2018

Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer

scientific article published on 11 October 2011

Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features.

scientific article published on 13 January 2017

The aberrant promoter methylation of BMP3b and BMP6 in malignant pleural mesotheliomas

scientific article

The degree of microRNA-34b/c methylation in serum-circulating DNA is associated with malignant pleural mesothelioma

scientific article published on 10 October 2013

The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer

scientific article published in October 2007

The proliferative effects of asbestos-exposed peripheral blood mononuclear cells on mesothelial cells.

scientific article published on 5 April 2016

The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers

scientific article published in February 2005

Therapeutic potential of targeting S100A11 in malignant pleural mesothelioma.

scientific article

Therapeutic strategies for afatinib-resistant lung cancer harboring HER2 alterations.

scientific article published on 15 April 2018

Triplet chemotherapy with cisplatin, docetaxel, and irinotecan for patients with recurrent or refractory non-small cell lung cancer

scientific article published on February 2010

Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring mutant EGFR.

scientific article published on 13 March 2018

Use of a vessel sealing system versus conventional electrocautery for lung parenchymal resection: a comparison of the clinicopathological outcomes in porcine lungs

scientific article published on 15 March 2013

Usefulness of cumulative smoking dose for identifying the EGFR mutation and patients with non-small-cell lung cancer for gefitinib treatment

scientific article published on 2 July 2009

Validity of using lobe-specific regional lymph node stations to assist navigation during lymph node dissection in early stage non-small cell lung cancer patients

scientific article published on 31 October 2013

YES1 activation induces acquired resistance to neratinib in HER2-amplified breast and lung cancers

scientific article published on 16 January 2020

Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer

scientific article

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