Search filters

List of works by Cobi J Heijnen

A dual role of the NF-kappaB pathway in neonatal hypoxic-ischemic brain damage

scientific article

Acetylsalicylic acid as an adjuvant therapy for schizophrenia

scientific article (publication date: 23 October 2006)

Adjuvant aspirin therapy reduces symptoms of schizophrenia spectrum disorders: results from a randomized, double-blind, placebo-controlled trial

scientific article

Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappaB inhibition in neonatal cerebral hypoxia-ischemia

scientific article

Angiopoietin-1 treatment reduces inflammation but does not prevent ventilator-induced lung injury

scientific article

Assessment of long-term safety and efficacy of intranasal mesenchymal stem cell treatment for neonatal brain injury in the mouse

scientific article

Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage

scientific article published on 8 January 2013

Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer

scientific article published on 20 March 2020

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

scientific article

Bexarotene normalizes chemotherapy-induced myelin decompaction and reverses cognitive and sensorimotor deficits in mice

scientific article published on 12 November 2020

Beyond symptomatic relief for chemotherapy-induced peripheral neuropathy: Targeting the source.

scientific article published on 20 February 2018

Bilateral molecular changes in a neonatal rat model of unilateral hypoxic-ischemic brain damage

scientific article published in March 2006

CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain.

scientific article published on October 2016

CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines.

scientific article

Cell-specific roles of GRK2 in onset and severity of hypoxic-ischemic brain damage in neonatal mice

scientific article

Cisplatin treatment induces attention deficits and impairs synaptic integrity in the prefrontal cortex in mice

scientific article published in Scientific Reports

Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test

scientific article

Combined fetal inflammation and postnatal hypoxia causes myelin deficits and autism-like behavior in a rat model of diffuse white matter injury

scientific article published on 19 September 2017

Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.

scientific article published on 29 February 2016

Cytokine production by leukocytes of military personnel with depressive symptoms after deployment to a combat-zone: a prospective, longitudinal study

scientific article

Delayed administration of neural stem cells after hypoxia-ischemia reduces sensorimotor deficits, cerebral lesion size, and neuroinflammation in neonatal mice

scientific article published on 15 September 2016

Development of cerebral gray and white matter injury and cerebral inflammation over time after inflammatory perinatal asphyxia

scientific article published on 23 January 2015

Dexamethasone attenuates VEGF expression and inflammation but not barrier dysfunction in a murine model of ventilator-induced lung injury

scientific article

Dorsal Root Ganglion Infiltration by Macrophages Contributes to Paclitaxel Chemotherapy-Induced Peripheral Neuropathy

scientific article published on 12 March 2016

Effects of murine and human bone marrow-derived mesenchymal stem cells on cuprizone induced demyelination

scientific article published on 26 July 2013

Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos

scientific article (publication date: 2012)

Expression of nitric oxide synthase isoforms and nitrotyrosine formation after hypoxia-ischemia in the neonatal rat brain

scientific article

FOXP1 Promotes Embryonic Neural Stem Cell Differentiation by Repressing Jagged1 Expression

scientific article published in November 2017

G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration

scientific article published on 14 March 2013

G protein-coupled receptor kinase 2 positively regulates epithelial cell migration

scientific article

G protein-coupled receptor kinase 6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting phosphatidylinositol 3-kinase and inhibiting p38 signaling.

scientific article

GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain

scientific article

GRKs and arrestins: regulators of migration and inflammation

scientific article published on 30 August 2006

Gender-dependent pathways of hypoxia-ischemia-induced cell death and neuroprotection in the immature P3 rat.

scientific article published in January 2007

Gender-specific neuroprotection by 2-iminobiotin after hypoxia-ischemia in the neonatal rat via a nitric oxide independent pathway

scientific article

Hematopoietic G-protein-coupled receptor kinase 2 deficiency decreases atherosclerotic lesion formation in LDL receptor-knockout mice

scientific article

IL-1β reactivity and the development of severe fatigue after military deployment: a longitudinal study

scientific article

IL4-10 Fusion Protein Is a Novel Drug to Treat Persistent Inflammatory Pain.

scientific article published on July 2016

Impaired neuroendocrine and immune response to acute stress in medication-naive patients with a first episode of psychosis

scientific article published on 17 June 2010

Impaired oligodendrocyte maturation in preterm infants: Potential therapeutic targets

scientific article

Inhibition of Mitochondrial p53 Accumulation by PFT-μ Prevents Cisplatin-Induced Peripheral Neuropathy

scientific article

Inhibition of the JNK/AP-1 pathway reduces neuronal death and improves behavioral outcome after neonatal hypoxic-ischemic brain injury

scientific article published on 17 September 2009

Intranasal administration of human MSC for ischemic brain injury in the mouse: in vitro and in vivo neuroregenerative functions

scientific article

Intranasal mesenchymal stem cell treatment for neonatal brain damage: long-term cognitive and sensorimotor improvement

scientific article

Intranasal stem cell treatment as a novel therapy for subarachnoid hemorrhage

scientific article

Intranasally administered mesenchymal stem cells promote a regenerative niche for repair of neonatal ischemic brain injury

scientific article published on 16 June 2014

Long-term functional consequences and ongoing cerebral inflammation after subarachnoid hemorrhage in the rat.

scientific article

Long-term neuroprotection with 2-iminobiotin, an inhibitor of neuronal and inducible nitric oxide synthase, after cerebral hypoxia-ischemia in neonatal rats

scientific article

Low endogenous G-protein-coupled receptor kinase 2 sensitizes the immature brain to hypoxia-ischemia-induced gray and white matter damage.

scientific article published in March 2008

Mechanisms of chemotherapy-induced behavioral toxicities

scientific article

Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice

scientific article

MicroRNA-124 as a novel treatment for persistent hyperalgesia ⬇️

scientific article published on June 25, 2012

Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling.

scientific article

Mitochondrial JNK phosphorylation as a novel therapeutic target to inhibit neuroinflammation and apoptosis after neonatal ischemic brain damage

scientific article

Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin

scientific article published on 12 December 2018

Monocytes/Macrophages control resolution of transient inflammatory pain.

scientific article

NF-kappaB inhibition after neonatal cerebral hypoxia-ischemia improves long-term motor and cognitive outcome in rats

scientific article published on 2 February 2010

Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation

scientific article

Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss

scientific article

Neuroprotective properties and mechanisms of erythropoietin in in vitro and in vivo experimental models for hypoxia/ischemia.

scientific article

Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice.

scientific article published on 28 January 2015

Pharmacological neuroprotection after perinatal hypoxic-ischemic brain injury ⬇️

scientific article

Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ.

scientific article published on November 2015

Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling

scientific article published on 16 July 2018

Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2.

scientific article

Role and modulation of G protein-coupled receptor signaling in inflammatory processes

scientific article

Sickness behavior induced by cisplatin chemotherapy and radiotherapy in a murine head and neck cancer model is associated with altered mitochondrial gene expression

scientific article

Stress, genetics, and immunity

scientific article

Strong neuroprotection by inhibition of NF-kappaB after neonatal hypoxia-ischemia involves apoptotic mechanisms but is independent of cytokines

scientific article

Targeting the A<sub>3</sub> adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice

scientific article published on 29 January 2022

Targeting the p53 pathway to protect the neonatal ischemic brain.

scientific article published on 14 June 2011

The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model

scientific article (publication date: 2014)

The endogenous regenerative capacity of the damaged newborn brain: boosting neurogenesis with mesenchymal stem cell treatment.

scientific article published on 13 February 2013

The neonatal brain is not protected by osteopontin peptide treatment after hypoxia-ischemia

scientific article published on 11 March 2015

The rodent endovascular puncture model of subarachnoid hemorrhage: mechanisms of brain damage and therapeutic strategies.

scientific article published on 03 January 2014

Tumour necrosis factor-alpha stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-kappaB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b

scientific article

Type D personality, temperament, and mental health in military personnel awaiting deployment

scientific article

Paulina is supported by:

About Paulina

Help