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List of works by Tom H M Ottenhoff

A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts

scientific article published on 13 April 2018

A Systematic Review on Novel Antigens and Their Discriminatory Potential for the Diagnosis of Latent and Active Tuberculosis

article

A Trial of M72/AS01E Vaccine to Prevent Tuberculosis

scientific article published on 01 April 2020

A blood RNA signature for tuberculosis disease risk: a prospective cohort study

scientific article

A dose-dependent plasma signature of the safety and immunogenicity of the rVSV-Ebola vaccine in Europe and Africa.

scientific article published on April 2017

A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians

scientific article

A helicopter perspective on TB biomarkers: pathway and process based analysis of gene expression data provides new insight into TB pathogenesis

scientific article

A high-throughput screen for tuberculosis progression

scientific article (publication date: 2011)

A multistage-polyepitope vaccine protects against Mycobacterium tuberculosis infection in HLA-DR3 transgenic mice

scientific article published on 24 October 2012

A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human

scientific article published on 30 October 2014

A novel view on the pathogenesis of complications after intravesical BCG for bladder cancer

scientific article published on 17 May 2018

A user-friendly, highly sensitive assay to detect the IFN-gamma secretion by T cells.

scientific article published on 3 January 2008

Abnormalities suggestive of latent tuberculosis infection on chest radiography; how specific are they?

scientific article published on 25 January 2019

Acquired immunodeficiencies and tuberculosis: focus on HIV/AIDS and diabetes mellitus

scientific article

Africa-wide evaluation of host biomarkers in QuantiFERON supernatants for the diagnosis of pulmonary tuberculosis.

scientific article published on 8 February 2018

Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers

scientific article published on 11 March 2010

Ag85B-ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection

scientific article

An Internet-Based Psychological Intervention With a Serious Game to Improve Vitality, Psychological and Physical Condition, and Immune Function in Healthy Male Adults: Randomized Controlled Trial

scientific article published on 24 July 2020

An imaging mass cytometry immunophenotyping panel for non-human primate tissues

scientific article published in 2022

An unbiased genome-wide Mycobacterium tuberculosis gene expression approach to discover antigens targeted by human T cells expressed during pulmonary infection

scientific article published on 14 January 2013

Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations

scientific article

Analysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa

scientific article

Analysis of immune responses against a wide range of Mycobacterium tuberculosis antigens in patients with active pulmonary tuberculosis

scientific article published on 26 September 2012

Analyzing the impact of Mycobacterium tuberculosis infection on primary human macrophages by combined exploratory and targeted metabolomics

scientific article published on 27 April 2020

Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors.

scientific article published in August 2010

Antibody Subclass and Glycosylation Shift Following Effective TB Treatment

scientific article published on 05 July 2021

Antibody glycosylation in inflammation, disease and vaccination

scientific article published on 11 June 2018

Antigen presentation by MHC-E: a putative target for vaccination?

scientific article published in 2022

Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum

scientific article

Assessment of cross-reactivity between Mycobacterium bovis and M. kansasii ESAT-6 and CFP-10 at the T-cell epitope level

scientific article published on August 2007

Association of polymorphisms in IL-12/IFN-gamma pathway genes with susceptibility to pulmonary tuberculosis in Indonesia

scientific article

Atypical Human Effector/Memory CD4 T Cells With a Naive-Like Phenotype

BLR1 and FCGR1A transcripts in peripheral blood associate with the extent of intrathoracic tuberculosis in children and predict treatment outcome

scientific article published on 12 December 2016

Big Data in Vaccinology: Introduction and section summaries

scientific article published in May 2015

Biomarkers Can Identify Pulmonary Tuberculosis in HIV-infected Drug Users Months Prior to Clinical Diagnosis

scientific article published on 2 December 2014

Bioorthogonal Correlative Light-Electron Microscopy of <i>Mycobacterium tuberculosis</i> in Macrophages Reveals the Effect of Antituberculosis Drugs on Subcellular Bacterial Distribution

scientific article published on 16 October 2020

Borderline QuantiFERON results and the distinction between specific responses and test variability

scientific article published on 07 June 2018

CD39 is involved in mediating suppression by Mycobacterium bovis BCG-activated human CD8(+) CD39(+) regulatory T cells.

scientific article published on 29 May 2013

CD8+ regulatory T cells, and not CD4+ T cells, dominate suppressive phenotype and function after in vitro live Mycobacterium bovis-BCG activation of human cells

scientific article

CXCR6 is a marker for protective antigen-specific cells in the lungs after intranasal immunization against Mycobacterium tuberculosis

scientific article

Cationic submicron emulsions for pulmonary DNA immunization

scientific article

Cell-Mediated Immune Responses to in vivo-Expressed and Stage-Specific Mycobacterium tuberculosis Antigens in Latent and Active Tuberculosis Across Different Age Groups

scientific article published on 11 February 2020

Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy

scientific article published on 22 September 2016

Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases

scientific article

Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin Hlp.

scientific article

Circulating Mycobacterium tuberculosis DosR latency antigen-specific, polyfunctional, regulatory IL10+ Th17 CD4 T-cells differentiate latent from active tuberculosis

scientific article published on 20 September 2017

Clinical immunology and multiplex biomarkers of human tuberculosis

scientific article

Clonal analysis of the T-cell response to in vivo expressed Mycobacterium tuberculosis protein Rv2034, using a CD154 expression based T-cell cloning method

scientific article

Co-infection with Schistosoma haematobium modulates the gene expression profile of malaria infection in schoolchildren in Gabon

scientific article published on 22 September 2014

Combination of gene expression patterns in whole blood discriminate between tuberculosis infection states

scientific article

Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials

scientific article

Combining host-derived biomarkers with patient characteristics improves signature performance in predicting tuberculosis treatment outcomes

scientific article published on 09 July 2020

Comment on "CCR5 dictates the equilibrium of proinflammatory IL-17+ and regulatory Foxp3+ T cells in fungal infections"

scientific article published on 01 August 2010

Common variants at 11p13 are associated with susceptibility to tuberculosis

scientific article

Complement Component C1q as Serum Biomarker to Detect Active Tuberculosis

scientific article published on 23 October 2018

Composition of the type VII secretion system membrane complex.

scientific article published on 27 August 2012

Control of human host immunity to mycobacteria.

scientific article

Correction: MVA.85A Boosting of BCG and an Attenuated, Deficient Vaccine Both Show Protective Efficacy Against Tuberculosis in Rhesus Macaques

Correction: Potential of Host Markers Produced by Infection Phase-Dependent Antigen-Stimulated Cells for the Diagnosis of Tuberculosis in a Highly Endemic Area.

scientific article published on 31 August 2012

Correlates of vaccine adjuvanticity, vaccine activity, protective immunity and disease in human infectious disease and cancer

scientific article published on 11 October 2018

Cross-laboratory evaluation of multiplex bead assays including independent common reference standards for immunological monitoring of observational and interventional human studies

scientific article published in PLoS ONE

Cross-reactive immunity to Mycobacterium tuberculosis DosR regulon-encoded antigens in individuals infected with environmental, nontuberculous mycobacteria

scientific article published on 08 September 2009

Detailed characterization of human Mycobacterium tuberculosis specific HLA-E restricted CD8+ T cells

scientific article published on 9 November 2017

Detection of IgG1 antibodies against Mycobacterium tuberculosis DosR and Rpf antigens in tuberculosis patients before and after chemotherapy.

scientific article published on 30 November 2015

Detection of Mycobacterium leprae infection employing a combinatorial approach of anti-45 kDa and modified anti-PGL-I antibody detection assays

scientific article published on 01 August 2007

Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study

scientific article (publication date: October 2013)

Diagnosis and treatment of lung infection with nontuberculous mycobacteria

scientific article published on May 2009

Diagnosis of childhood tuberculosis and host RNA expression in Africa

scientific article published in May 2014

Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB.

scientific article published on 4 May 2016

Differences in IgG responses against infection phase related Mycobacterium tuberculosis (Mtb) specific antigens in individuals exposed or not to Mtb correlate with control of TB infection and progression

scientific article published on 8 June 2017

Discrepancy between Mycobacterium tuberculosis-specific gamma interferon release assays using short and prolonged in vitro incubation

scientific article published on 16 May 2007

Discriminative expression of whole blood genes in HIV patients with latent and active TB in Ethiopia

scientific article published on 13 June 2016

Disparate Tuberculosis Disease Development in Macaque Species Is Associated With Innate Immunity

scientific article published on 01 November 2019

Disseminated Mycobacterium peregrinum infection in a child with complete interferon-gamma receptor-1 deficiency

scientific article published in April 2003

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

scientific article

Divergent role for TNF-alpha in IFN-gamma-induced killing of Toxoplasma gondii and Salmonella typhimurium contributes to selective susceptibility of patients with partial IFN-gamma receptor 1 deficiency

scientific article published in October 2002

Double- and monofunctional CD4⁺ and CD8⁺ T-cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long-term latently infected individuals

scientific article published on 30 August 2011

Dynamic changes in pro- and anti-inflammatory cytokine profiles and gamma interferon receptor signaling integrity correlate with tuberculosis disease activity and response to curative treatment

scientific article

Dynamics of the T cell response to Mycobacterium tuberculosis DosR and Rpf antigens in a Colombian population of household contacts of recently diagnosed pulmonary tuberculosis patients

scientific article published on 21 January 2016

Dysregulation of Apoptosis Is a Risk Factor for Tuberculosis Disease Progression

scientific article published on 20 April 2015

ESAT-6/CFP-10 fusion protein and peptides for optimal diagnosis of mycobacterium tuberculosis infection by ex vivo enzyme-linked immunospot assay in the Gambia

scientific article

Ebola vaccine R&D: Filling the knowledge gaps.

scientific article

Effect of vesicle size on tissue localization and immunogenicity of liposomal DNA vaccines

scientific article published on 10 May 2011

Effectiveness of Stress-Reducing Interventions on the Response to Challenges to the Immune System: A Meta-Analytic Review

scientific article published on 06 August 2019

Enhancing sensitivity of detection of immune responses to Mycobacterium leprae peptides in whole-blood assays

scientific article published on 28 April 2010

Epitope mapping of the immunodominant antigen TB10.4 and the two homologous proteins TB10.3 and TB12.9, which constitute a subfamily of the esat-6 gene family

scientific article

Epstein-Barr virus gp42 is posttranslationally modified to produce soluble gp42 that mediates HLA class II immune evasion.

scientific article

Erratum: Author Correction: Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination

scientific article published on 06 October 2020

Evaluation of cytokine responses against novel Mtb antigens as diagnostic markers for TB disease

scientific article published on 13 June 2016

Evaluation of the high-pressure extrusion technique as a method for sizing plasmid DNA-containing cationic liposomes.

scientific article published on 18 March 2011

Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis

scientific article published on 20 January 2005

Evidence for Highly Variable, Region-Specific Patterns of T-Cell Epitope Mutations Accumulating in Strains

Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults

scientific article published in 2022

Expression and production of the SERPING1-encoded endogenous complement regulator C1-inhibitor in multiple cohorts of tuberculosis patients

scientific article published on 13 March 2020

Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans.

scientific article

Extensive flow cytometric immunophenotyping of human <scp>PBMC</scp> incorporating detection of chemokine receptors, cytokines and tetramers

scientific article published in 2023

Field-evaluation of a new lateral flow assay for detection of cellular and humoral immunity against Mycobacterium leprae. ⬇️

scientific article

First in humans: a new molecularly defined vaccine shows excellent safety and strong induction of long-lived Mycobacterium tuberculosis-specific Th1-cell like responses

scientific article published on December 2010

Focused human gene expression profiling using dual-color reverse transcriptase multiplex ligation-dependent probe amplification

scientific article published on 24 April 2015

Four-gene Pan-African Blood Signature Predicts Progression to Tuberculosis

scientific article published on 6 April 2018

Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances in vitro and in vivo Anti-mycobacterial Activity in Human Macrophages and in Zebrafish

scientific article published on 03 February 2020

Gene expression profiles classifying clinical stages of tuberculosis and monitoring treatment responses in Ethiopian HIV-negative and HIV-positive cohorts

scientific article published on 10 December 2019

Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis

scientific article published in October 2008

Genetic deficiencies of innate immune signalling in human infectious disease

scientific article

Genetic variations in the interleukin-12/interleukin-23 receptor (beta1) chain, and implications for IL-12 and IL-23 receptor structure and function

scientific article (publication date: March 2003)

Genetics, cytokines and human infectious disease: lessons from weakly pathogenic mycobacteria and salmonellae

scientific article

Genome wide approaches discover novel Mycobacterium tuberculosis antigens as correlates of infection, disease, immunity and targets for vaccination

scientific article published on 07 July 2018

Genome-based in silico identification of new Mycobacterium tuberculosis antigens activating polyfunctional CD8+ T cells in human tuberculosis

scientific article published on 17 December 2010

Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis

scientific article

Guidance for Studies Evaluating the Accuracy of Tuberculosis Triage Tests

scientific article published on 01 October 2019

HIV Skews a Balanced Mtb-Specific Th17 Response in Latent Tuberculosis Subjects to a Pro-inflammatory Profile Independent of Viral Load

scientific article published on 01 December 2020

HLA and leprosy in the pre and postgenomic eras

scientific article

Harnessing donor unrestricted T-cells for new vaccines against tuberculosis

scientific article published on 27 April 2019

High prevalence of subclinical tuberculosis in HIV-1-infected persons without advanced immunodeficiency: implications for TB screening

scientific article

Higher frequency of T-cell response to M. tuberculosis latency antigen Rv2628 at the site of active tuberculosis disease than in peripheral blood

scientific article (publication date: 2011)

Host Blood RNA Transcript and Protein Signatures for Sputum-Independent Diagnostics of Tuberculosis in Adults

scientific article published on 04 February 2021

Host Gene Expression Kinetics During Treatment of Tuberculosis in HIV-Coinfected Individuals Is Independent of Highly Active Antiretroviral Therapy

article

Host Immune Responses Differ between M. africanum- and M. tuberculosis-Infected Patients following Standard Anti-tuberculosis Treatment

scientific article

Host cytokine responses induced after overnight stimulation with novel M. tuberculosis infection phase-dependent antigens show promise as diagnostic candidates for TB disease

scientific article

Host-pathogen interactions

scientific article published in August 2004

Host-pathogen interactions in latent Mycobacterium tuberculosis infection: identification of new targets for tuberculosis intervention

scientific article published on March 2008

Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During Mycobacterium Tuberculosis Infection and Correlate With Active Disease.

scientific article

Human CD4 and CD8 regulatory T cells in infectious diseases and vaccination

scientific article published on 07 October 2008

Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis and express type 2 cytokines

scientific article

Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human T-cell subset.

scientific article

Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria

scientific article

Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis

scientific article published on 13 June 2006

Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1.

scientific article published in August 2008

Human deficiencies in type-1 cytokine receptors reveal the essential role of type-1 cytokines in immunity to intracellular bacteria.

scientific article

Human genetics of intracellular infectious diseases: molecular and cellular immunity against mycobacteria and salmonellae

scientific article

Human host defense and cytokines in mycobacterial infectious diseases: interleukin-18 cannot compensate for genetic defects in the interleukin-12 system

scientific article published on 01 July 2002

Human host genetic factors in mycobacterial and Salmonella infection: lessons from single gene disorders in IL-12/IL-23-dependent signaling that affect innate and adaptive immunity

scientific article

Humoral Responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR Regulon-Encoded Proteins of Mycobacterium tuberculosis in Individuals with Latent Tuberculosis Infection.

scientific article published on February 2017

IFN-γ and IgA against non-methylated heparin-binding hemagglutinin as markers of protective immunity and latent tuberculosis: Results of a longitudinal study from an endemic setting

scientific article published on 27 October 2015

IL-12 receptor deficiency revisited: IL-23-mediated signaling is also impaired in human genetic IL-12 receptor beta1 deficiency

scientific article

Identification and characterization of the ESAT-6 homologue of Mycobacterium leprae and T-cell cross-reactivity with Mycobacterium tuberculosis

scientific article published on May 2002

Identification of HLA-E Binding -Derived Epitopes through Improved Prediction Models

scholarly article

Identification of T-cell antigens specific for latent mycobacterium tuberculosis infection

scientific article published on 18 May 2009

Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4.

scholarly article

Identification of a systemic interferon-γ inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction

scientific article published on 10 October 2019

Identification of human T-cell responses to Mycobacterium tuberculosis resuscitation-promoting factors in long-term latently infected individuals

scientific article

Identification of major factors influencing ELISpot-based monitoring of cellular responses to antigens from Mycobacterium tuberculosis

scientific article

Identification of probable early-onset biomarkers for tuberculosis disease progression

scientific article

IgA and IgG against Mycobacterium tuberculosis Rv2031 discriminate between pulmonary tuberculosis patients, Mycobacterium tuberculosis-infected and non-infected individuals

scientific article published on 26 January 2018

Immunogenicity of 60 novel latency-related antigens of Mycobacterium tuberculosis

scientific article

Immunogenicity of Mycobacterium leprae unique antigens in leprosy endemic populations in Asia and Africa

scientific article published in December 2011

Immunogenicity of eight dormancy regulon-encoded proteins of Mycobacterium tuberculosis in DNA-vaccinated and tuberculosis-infected mice

scientific article

Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa

scientific article published on 24 June 2009

Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19

scientific article published on 22 March 2022

Immunological characterization of latent tuberculosis infection in a low endemic country

scientific article published on 4 July 2017

Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations

scientific article

Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease Outcome

scientific article published on 22 March 2019

Impaired Immune Response to Primary but Not to Booster Vaccination Against Hepatitis B in Older Adults.

scientific article published on 15 May 2018

Improved long-term protection against Mycobacterium tuberculosis Beijing/W in mice after intra-dermal inoculation of recombinant BCG expressing latency associated antigens

scientific article published on 24 August 2011

Increased IgG1, IFN-gamma, TNF-alpha and IL-6 responses to Mycobacterium tuberculosis antigens in patients with tuberculosis are lower after chemotherapy

scientific article

Induction of in vivo functional Db-restricted cytolytic T cell activity against a putative phosphate transport receptor of Mycobacterium tuberculosis

scientific article published in June 2004

Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species.

scientific article

Infection withMycobacterium tuberculosisBeijing Genotype Strains Is Associated with Polymorphisms inSLC11A1/NRAMP1in Indonesian Patients with Tuberculosis

scholarly article by Reinout van Crevel et al published December 2009 in Journal of Infectious Diseases

Influenza virus vaccination induces interleukin-12/23 receptor beta 1 (IL-12/23R beta 1)-independent production of gamma interferon (IFN-gamma) and humoral immunity in patients with genetic deficiencies in IL-12/23R beta 1 or IFN-gamma receptor I.

scientific article published on 18 June 2008

Inherited defects in the interferon-gamma receptor or interleukin-12 signalling pathways are not sufficient to cause allergic disease in children

scientific article published on 23 August 2005

Innate immunity to Mycobacterium tuberculosis

scientific article

Innate immunity to Mycobacterium tuberculosis

scientific article published on 01 January 2003

Innovative Strategies to Identify M. tuberculosis Antigens and Epitopes Using Genome-Wide Analyses

scientific article

Interactions between Type 1 Interferons and the Th17 Response in Tuberculosis: Lessons Learned from Autoimmune Diseases

scientific article published on 05 April 2017

Interference with T cell receptor–HLA-DR interactions by Epstein–Barr virus gp42 results in reduced T helper cell recognition ⬇️

scientific article published on September 22, 2003

Interferon-gamma production in response to M. tuberculosis antigens in TB patients in Indonesia

scientific article

Interferon-γ responses to Mycobacterium tuberculosis Rpf proteins in contact investigation.

scientific article published on 17 August 2013

Interleukin (IL)-12 and IL-23 are key cytokines for immunity against Salmonella in humans

scientific article published on 7 October 2004

Interleukin-10 promoter haplotypes are differently distributed in the Brazilian versus the Dutch population

scientific article

Interleukin-6 and Mycobacterium tuberculosis dormancy antigens improve diagnosis of tuberculosis

scientific article published on 02 December 2020

Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines

scientific article published on 14 September 2015

Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1.

scientific article published on November 2007

Introduction: new susceptibility genes in mycobacterial infectious diseases

scientific article published on 19 January 2006

Iron deficiency and NRAMP1 polymorphisms (INT4, D543N and 3'UTR) do not contribute to severity of anaemia in tuberculosis in the Indonesian population

scientific article

Janus-faced liposomes enhance antimicrobial innate immune response in Mycobacterium tuberculosis infection

scientific article

KLRG1 and PD-1 expression are increased on T-cells following tuberculosis-treatment and identify cells with different proliferative capacities in BCG-vaccinated adults

scientific article

Kinetics of T cell-activation molecules in response to Mycobacterium tuberculosis antigens

scientific article published on 01 December 2002

LL-37 directs macrophage differentiation toward macrophages with a proinflammatory signature

scientific article published on 07 July 2010

Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination

scientific article published on 14 May 2007

Lateral flow assay for simultaneous detection of cellular- and humoral immune responses.

scientific article

Leprosy bacillus triggers the wrong cells

scientific article published on 01 September 2005

Longitudinal immune responses and gene expression profiles in type 1 leprosy reactions

scientific article published on 27 December 2013

Low induction of proinflammatory cytokines parallels evolutionary success of modern strains within the Mycobacterium tuberculosis Beijing genotype

scientific article

MHC Ib molecule Qa-1 presents Mycobacterium tuberculosis peptide antigens to CD8+ T cells and contributes to protection against infection.

scientific article

ML1419c peptide immunization induces Mycobacterium leprae-specific HLA-A*0201-restricted CTL in vivo with potential to kill live mycobacteria

scientific article published on 24 June 2011

MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques

scientific article

Mapping immune reactivity toward Rv2653 and Rv2654: two novel low-molecular-mass antigens found specifically in the Mycobacterium tuberculosis complex

scientific article published on 13 February 2004

Mechanisms behind TB, HBV, and HIV chronic infections.

scientific article published on 12 September 2017

Metabolite changes in blood predict the onset of tuberculosis

scientific article published in Nature Communications

Mobilizing unconventional T cells

scientific article published on 01 October 2019

Molecular Signatures of Immunity and Immunogenicity in Infection and Vaccination

scientific article published on 15 November 2017

Molecular complementation of IL-12Rbeta1 deficiency reveals functional differences between IL-12Rbeta1 alleles including partial IL-12Rbeta1 deficiency

scientific article published on 17 November 2005

Monokine induced by interferon gamma and IFN-gamma response to a fusion protein of Mycobacterium tuberculosis ESAT-6 and CFP-10 in Brazilian tuberculosis patients

scientific article published on 22 July 2005

Multi-center evaluation of a user-friendly lateral flow assay to determine IP-10 and CCL4 levels in blood of TB and non-TB cases in Africa

scientific article

Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection

scientific article published in August 2010

Multifunctional T Cell Response to DosR and Rpf Antigens Is Associated with Protection in Long-Term Mycobacterium tuberculosis-Infected Individuals in Colombia

scientific article published on 03 August 2016

Mycobacterial secretion systems ESX-1 and ESX-5 play distinct roles in host cell death and inflammasome activation

scientific article published on 28 September 2011

Mycobacterium bovis BCG Vaccination Induces Divergent Proinflammatory or Regulatory T Cell Responses in Adults

scientific article published on 6 May 2015

Mycobacterium leprae and demyelination

scientific article published on 01 August 2002

Mycobacterium leprae virulence-associated peptides are indicators of exposure to M. leprae in Brazil, Ethiopia and Nepal

scientific article published on December 2012

Mycobacterium paratuberculosis is recognized by Toll-like receptors and NOD2.

scientific article published on 25 July 2007

Mycobacterium tuberculosis clinical isolates of the Beijing and East-African Indian lineage induce fundamentally different host responses in mice compared to H37Rv

scientific article published on 27 December 2019

Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism

scientific article

Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity

scientific article

Mycobacterium tuberculosis-specific CD4+ T-cell response is increased, and Treg cells decreased, in anthelmintic-treated patients with latent TB.

scientific article published on 7 December 2015

NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification.

scientific article published on 15 November 2018

NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis

scientific article

New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles

scientific article

New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy

scientific article

New insights and tools to combat leprosy nerve damage

scientific article published on 01 December 2011

New pathways of protective and pathological host defense to mycobacteria ⬇️

scientific article published on July 10, 2012

Not to wake a sleeping giant: new insights into host-pathogen interactions identify new targets for vaccination against latent Mycobacterium tuberculosis infection

scientific article published on May 2008

Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children.

scientific article

Optimisation, harmonisation and standardisation of the direct mycobacterial growth inhibition assay using cryopreserved human peripheral blood mononuclear cells

scientific article published on 31 January 2019

Overcoming the global crisis: "yes, we can", but also for TB ... ?

scientific article published in August 2009

Oxidized low-density lipoprotein (oxLDL) supports Mycobacterium tuberculosis survival in macrophages by inducing lysosomal dysfunction

scientific article published on 18 April 2019

PPE protein (Rv3873) from DNA segment RD1 of Mycobacterium tuberculosis: strong recognition of both specific T-cell epitopes and epitopes conserved within the PPE family

scientific article

Patients with Concurrent Tuberculosis and Diabetes Have a Pro-Atherogenic Plasma Lipid Profile.

scientific article

Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment

scientific article

Peptide Binding to HLA-E Molecules in Humans, Nonhuman Primates, and Mice Reveals Unique Binding Peptides but Remarkably Conserved Anchor Residues

scientific article published on 05 October 2020

Peptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls

scientific article published on 29 January 2012

Pharmacological Poly (ADP-Ribose) Polymerase Inhibitors Decrease <i>Mycobacterium tuberculosis</i> Survival in Human Macrophages

scientific article published on 26 November 2021

Phenotypic and functional characterization of CD4 T cells expressing killer Ig-like receptors

scientific article published on 01 December 2004

Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-gamma- and CD40L-mediated costimulation

scientific article published on 05 December 2005

Plasma metabolomics in tuberculosis patients with and without concurrent type 2 diabetes at diagnosis and during antibiotic treatment

scientific article published on 10 December 2019

Polymorphisms in SP110 are not associated with pulmonary tuberculosis in Indonesians

scientific article

Polymorphisms in autophagy genes and susceptibility to tuberculosis

scientific article

Postgenomic approach to identify novel Mycobacterium leprae antigens with potential to improve immunodiagnosis of infection

scientific article

Potential of DosR and Rpf antigens from Mycobacterium tuberculosis to discriminate between latent and active tuberculosis in a tuberculosis endemic population of Medellin Colombia

scientific article published on 8 January 2018

Potential of host markers produced by infection phase-dependent antigen-stimulated cells for the diagnosis of tuberculosis in a highly endemic area

scientific article

Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting

scientific article

Presentation of interleukin-12/-23 receptor beta1 deficiency with various clinical symptoms of Salmonella infections

scientific article published in January 2006

Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques

scientific article published on 21 January 2019

Pro- and anti-inflammatory cytokines against Rv2031 are elevated during latent tuberculosis: a study in cohorts of tuberculosis patients, household contacts and community controls in an endemic setting

scientific article published on 21 April 2015

Proof of concept that most borderline Quantiferon results are true antigen-specific responses.

scientific article published on 16 November 2017

Pulmonary DNA vaccination: concepts, possibilities and perspectives

scientific article

Pulmonary delivery of DNA encoding Mycobacterium tuberculosis latency antigen Rv1733c associated to PLGA-PEI nanoparticles enhances T cell responses in a DNA prime/protein boost vaccination regimen in mice.

scientific article published on 3 May 2009

Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis

scientific article

Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate Improves Host Control of <i>Salmonella enterica</i> Serovar Typhimurium Infection in Human Macrophages

scientific article published on 06 September 2021

Radiological Signs of Latent Tuberculosis on Chest Radiography: A Systematic Review and Meta-Analysis

scientific article published on 01 July 2019

Random forest and live single‐cell metabolomics reveal metabolic profiles of human macrophages upon polarization

scientific article published in 2023

Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination

scientific article published on 14 April 2020

Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infection

scientific article published on 16 January 2008

Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis

scientific article

Recombinant ESAT-6-CFP10 Fusion Protein Induction of Th1/Th2 Cytokines and FoxP3 Expressing Treg Cells in Pulmonary TB

scientific article

Regulatory T-Cells at the Interface between Human Host and Pathogens in Infectious Diseases and Vaccination

scientific article

Repurposing diphenylbutylpiperidine-class antipsychotic drugs for host-directed therapy of Mycobacterium tuberculosis and Salmonella enterica infections

scientific article published on 04 October 2021

Retinal Pigment Epithelial Cells Control Early Mycobacterium tuberculosis Infection via Interferon Signaling.

scientific article

Retracted: Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection

retracted article

Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells

scientific article published on 14 September 2016

Risk factors associated with indeterminate gamma interferon responses in the assessment of latent tuberculosis infection in a high-incidence environment

scientific article

Role of Tumor Necrosis Factor–α and Interleukin‐10 Promoter Gene Polymorphisms in Leprosy

article

Safety and immunogenicity of the novel H4:IC31 tuberculosis vaccine candidate in BCG-vaccinated adults: Two phase I dose escalation trials

scientific article

Selection of a Single Domain Antibody, Specific for an HLA-Bound Epitope of the Mycobacterial Ag85B Antigen

scientific article published on 02 October 2020

Serological heterogeneity against various Mycobacterium leprae antigens and its use in serodiagnosis of leprosy patients

scientific article published on 01 September 2007

Serum Biomarker Profile Including CCL1, CXCL10, VEGF, and Adenosine Deaminase Activity Distinguishes Active From Remotely Acquired Latent Tuberculosis

scientific article published in 2021

Severe Mycobacterium bovis BCG infections in a large series of novel IL-12 receptor beta1 deficient patients and evidence for the existence of partial IL-12 receptor beta1 deficiency

scientific article published on 01 January 2003

Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects.

scientific article published on January 2015

Significance of antigen and epitope specificity in tuberculosis

scientific article published on 23 October 2014

Simultaneous immunization against tuberculosis

scientific article (publication date: 2011)

Single nucleotide polymorphisms (SNPs) at -238 and -308 positions in the TNFalpha promoter: clinical and bacteriological evaluation in leprosy

scientific article

Smoking, BCG and employment and the risk of tuberculosis infection in HIV-infected persons in South Africa

scientific article

South Asian men have lower expression of IFN signalling genes in white adipose tissue and skeletal muscle compared with white men.

scientific article published on 8 September 2017

Stratification of COVID-19 patients based on quantitative immune-related gene expression in whole blood

publication published on 04 March 2022

Study of the antibody response against Mycobacterium tuberculosis antigens in Warao Amerindian children in Venezuela.

scientific article published in August 2004

Synthetic Long Peptide Derived from Mycobacterium tuberculosis Latency Antigen Rv1733c Protects against Tuberculosis

scientific article published on 22 July 2015

Systemic and pulmonary C1q as biomarker of progressive disease in experimental non-human primate tuberculosis

scientific article published on 14 April 2020

T cell responses to DosR and Rpf proteins in actively and latently infected individuals from Colombia

scientific article published on 5 January 2012

T-cell and serological responses to Erp, an exported Mycobacterium tuberculosis protein, in tuberculosis patients and healthy individuals

scientific article

T-cell recognition of the HspX protein of Mycobacterium tuberculosis correlates with latent M. tuberculosis infection but not with M. bovis BCG vaccination

scientific article published on 26 March 2007

T-cell regulation in lepromatous leprosy

scientific article

T-cell responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 in Brazilian tuberculosis patients

scientific article

TB biomarkers, TB correlates and human challenge models: New tools for improving assessment of new TB vaccines

scientific article published on 16 June 2016

TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development

scientific article published on 4 October 2017

TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'how can big data help?'.

scientific article

Ten challenges for TB biomarkers

scientific article published on 01 March 2012

The <i>In Vivo</i> Transcriptomic Blueprint of <i>Mycobacterium tuberculosis</i> in the Lung

scientific article published on 22 December 2021

The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity

scientific article published on February 2015

The DNA damage-regulated autophagy modulator DRAM1 links mycobacterial recognition via TLR-MYD88 to autophagic defense [corrected].

scientific article published on June 2014

The ESX-5 secretion system of Mycobacterium marinum modulates the macrophage response

scientific article published in November 2008

The SysteMHC Atlas project

scientific article published on 29 July 2017

The antimicrobial peptide hLF1-11 drives monocyte-dendritic cell differentiation toward dendritic cells that promote antifungal responses and enhance Th17 polarization

scientific article published on 19 January 2012

The effect of HIV coinfection, HAART and TB treatment on cytokine/chemokine responses to Mycobacterium tuberculosis (Mtb) antigens in active TB patients and latently Mtb infected individuals.

scientific article

The effect of type 2 diabetes mellitus on the presentation and treatment response of pulmonary tuberculosis

scientific article

The effects of a psychological intervention directed at optimizing immune function: study protocol for a randomized controlled trial

scientific article published on 26 May 2017

The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4⁺ T-cells that protect against pulmonary infection in HLA-DR transgenic mice and guinea pigs

scientific article published on 14 May 2014

The influence of influenza virus infections on the development of tuberculosis

scientific article

The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress

scientific article published on 27 July 2010

The role of donor‐unrestricted T‐cells, innate lymphoid cells, and NK cells in anti‐mycobacterial immunity

scientific article published in 2021

The search for a tuberculosis vaccine: an elusive quest?

scientific article

Transcriptional and inflammasome-mediated pathways for the induction of IL-1beta production by Mycobacterium tuberculosis.

scientific article

Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria

scientific article published on 10 August 2016

Transcriptomic signatures induced by the Ebola virus vaccine rVSVΔG-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular biomarker study

scientific article published in February 2022

Trends in diagnostic methods and treatment of latent tuberculosis infection in a tertiary care center from 2000 to 2017

scientific article published on 20 February 2020

Tuberculin skin testing and in vitro T cell responses to ESAT-6 and culture filtrate protein 10 after infection with Mycobacterium marinum or M. kansasii

scientific article published on 19 November 2002

Tuberculosis Biomarkers: From Diagnosis to Protection

scientific article

Tuberculosis causes highly conserved metabolic changes in human patients, mycobacteria-infected mice and zebrafish larvae

scientific article published on 15 July 2020

Tuberculosis vaccines: Opportunities and challenges

scientific article published on 17 January 2018

Two patients with complete defects in interferon gamma receptor-dependent signaling

scientific article published on 21 May 2007

Two-Hit in vitro T-Cell Stimulation Detects Mycobacterium tuberculosis Infection in QuantiFERON Negative Tuberculosis Patients and Healthy Contacts From Ghana

scientific article published on 03 July 2019

Update on tuberculosis biomarkers: From correlates of risk, to correlates of active disease and of cure from disease.

scientific article published on 18 February 2018

Use of enzyme-linked immunospot assay with Mycobacterium tuberculosis-specific peptides for diagnosis of recent infection with M. tuberculosis after accidental laboratory exposure

scientific article published on March 2006

Use of lateral flow assays to determine IP-10 and CCL4 levels in pleural effusions and whole blood for TB diagnosis

scientific article

Use of resuscitation-promoting factor proteins improves the sensitivity of culture-based tuberculosis testing in special samples

scientific article published on 01 March 2014

Vaccination with a Hybrid 1 (H1) fusion protein combined with a liposomal adjuvant (CAF01) induced antigen specific T-cells 3 years post vaccination in a human clinical trial. (VAC7P.971)

scientific article published in 2014

Vaccines against tuberculosis: where are we and where do we need to go?

scientific article

Vaccines for Leprosy and Tuberculosis: Opportunities for Shared Research, Development, and Application

scientific article published on 26 February 2018

Variable BCG efficacy in rhesus populations: Pulmonary BCG provides protection where standard intra-dermal vaccination fails.

scientific article

Whole blood RNA signatures in leprosy patients identify reversal reactions before clinical onset: a prospective, multicenter study

scientific article published on 29 November 2019

Whole-blood transcriptomic signatures induced during immunization by chloroquine prophylaxis and Plasmodium falciparum sporozoites

scientific article published on 10 June 2019

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