List of works - Paul Timpson

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth

scientific article

Acute compressive stress activates RHO/ROCK-mediated cellular processes.

scientific article published on 17 February 2018

Annexin A6 improves anti-migratory and anti-invasive properties of tyrosine kinase inhibitors in EGFR overexpressing human squamous epithelial cells

scientific article published on 23 December 2019

Automated annotation and visualisation of high-resolution spatial proteomic mass spectrometry imaging data using HIT-MAP

scientific article published on 28 May 2021

Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition

Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity ⬇️

scientific article published on November 27, 2001

Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma

scientific article published on 17 March 2010

Ex vivo culture of intact human patient derived pancreatic tumour tissue

scientific article published on 21 January 2021

FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion

scientific article

Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer

scientific article published on 7 June 2013

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue

scientific article published on 22 December 2015

Live cell in vitro and in vivo imaging applications: accelerating drug discovery

scientific article published on 4 April 2011

MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma

scientific article published on 18 November 2019

Molecular mobility and activity in an intravital imaging setting - implications for cancer progression and targeting

scientific article published on 6 March 2018

Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation

scientific article published on 07 August 2019

Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells ⬇️

scientific article published on September 19, 2011

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

scientific article

Myeloid cell leukemia 1 (MCL-1), an unexpected modulator of protein kinase signaling during invasion.

scientific article published on 23 November 2017

N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods

scientific article

Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis

scientific article published on 24 June 2021

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

scientific article published on 25 February 2021

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

scientific article

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors for cancer treatment

scientific article published on 18 December 2021

Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics

scientific article

Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo

scientific article published on 07 October 2009

Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression.

scientific article

Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development

scientific article published on 24 March 2009

Recent advances in understanding the complexities of metastasis

scientific article published on 01 August 2018

Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities

scientific article

Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse.

scientific article published on 18 February 2018

Single cell transcriptome atlas of mouse mammary epithelial cells across development

scientific article published on 29 June 2021

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

scientific article

Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer

scientific article published on 28 October 2017

Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy.

scientific article published on 3 October 2017

Targeting genetically-tuned CAFs in pancreatic cancer via perlecan manipulation

scientific article published on 13 February 2020

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.

scientific article published on 15 June 2015

The Evolving Understanding of the Molecular and Therapeutic Landscape of Pancreatic Ductal Adenocarcinoma

article published in 2018

The Mini-Organo: A rapid high-throughput 3D coculture organotypic assay for oncology screening and drug development

scientific article published on 01 August 2019

The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues

scientific article published on 13 March 2014

The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2

scientific article published on 21 March 2016

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.

scientific article published in April 2017

List of works by Paul Timpson

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth

Acute compressive stress activates RHO/ROCK-mediated cellular processes.

Annexin A6 improves anti-migratory and anti-invasive properties of tyrosine kinase inhibitors in EGFR overexpressing human squamous epithelial cells

Automated annotation and visualisation of high-resolution spatial proteomic mass spectrometry imaging data using HIT-MAP

Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition

Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity ⬇️

Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma

Ex vivo culture of intact human patient derived pancreatic tumour tissue

FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion

Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue

Live cell in vitro and in vivo imaging applications: accelerating drug discovery

MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma

Molecular mobility and activity in an intravital imaging setting - implications for cancer progression and targeting

Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation

Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells ⬇️

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

Myeloid cell leukemia 1 (MCL-1), an unexpected modulator of protein kinase signaling during invasion.

N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods

Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors for cancer treatment

Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics

Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo

Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression.

Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development

Recent advances in understanding the complexities of metastasis

Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities

Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse.

Single cell transcriptome atlas of mouse mammary epithelial cells across development

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer

Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy.

Targeting genetically-tuned CAFs in pancreatic cancer via perlecan manipulation

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.

The Evolving Understanding of the Molecular and Therapeutic Landscape of Pancreatic Ductal Adenocarcinoma

The Mini-Organo: A rapid high-throughput 3D coculture organotypic assay for oncology screening and drug development

The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues

The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.