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List of works by Yukio Nagasaki

A high-performance waveguide-mode biosensor for detection of factor IX using PEG-based blocking agents to suppress non-specific binding and improve sensitivity

scientific article published in May 2013

A novel biointerface that suppresses cell morphological changes by scavenging excess reactive oxygen species

scientific article published on 26 February 2015

A novel nitric oxide-based anticancer therapeutics by macrophage-targeted poly(l-arginine)-based nanoparticles

scientific article published on 16 September 2015

A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.

scientific article published on 21 June 2009

An anti-oxidative cell culture dish inhibits intracellular reactive oxygen species accumulation and modulates pluripotency-associated gene expression in mesenchymal stem cells

scientific article published on 04 March 2020

An orally administered redox nanoparticle that accumulates in the colonic mucosa and reduces colitis in mice

scientific article published on 03 July 2012

Anti-cancer vaccination by transdermal delivery of antigen peptide-loaded nanogels via iontophoresis

scientific article

Antioxidant Nanomedicine Protects against Ionizing Radiation-Induced Life-Shortening in C57BL/6J Mice

scientific article published on 11 March 2019

Antioxidant Nanomedicine with Cytoplasmic Distribution in Neuronal Cells Shows Superior Neurovascular Protection Properties

scientific article published on 03 June 2020

Antioxidative Nanoparticles Significantly Enhance Therapeutic Efficacy of an Antibacterial Therapy against Listeria monocytogenes Infection.

scientific article published on 18 February 2018

Antioxidative biointerface: biocompatible materials scavenging reactive oxygen species

scientific article published on 16 March 2018

Application of surface enhanced Raman spectroscopy as a diagnostic system for hypersialylated metastatic cancers

scientific article

Binding enhancement of antigen-functionalized PEGylated gold nanoparticles onto antibody-immobilized surface by increasing the functionalized antigen using alpha-sulfanyl-omega-amino-PEG.

scientific article published on 16 September 2008

Block ionomer complexes of PEG-block-poly(4-vinylbenzylphosphonate) and cationic surfactants as highly stable, pH responsive drug delivery system.

scientific article

Characterization of aldehyde-PEG tethered surfaces: influence of PEG chain length on the specific biorecognition

scientific article (publication date: 21 December 2004)

Chemical nanotherapy: nitroxyl radical-containing nanoparticle protects neuroblastoma SH-SY5Y cells from Abeta-induced oxidative stress.

scientific article published on May 2011

Chronic treatment with a smart antioxidative nanoparticle for inhibition of amyloid plaque propagation in Tg2576 mouse model of Alzheimer's disease

scientific article

Co-immobilized poly(ethylene glycol)-block-polyamines promote sensitivity and restrict biofouling on gold sensor surface for detecting factor IX in human plasma

scientific article published on August 2014

Coffee component hydroxyl hydroquinone (HHQ) as a putative ligand for PPAR gamma and implications in breast cancer

scientific article

Colloidal Au replacement assay for highly sensitive quantification of low molecular weight analytes by surface plasmon resonance

scientific article published on 19 June 2007

Combination Treatment of Murine Colon Cancer with Doxorubicin and Redox Nanoparticles

scientific article published on 25 November 2015

Completely dispersible PEGylated gold nanoparticles under physiological conditions: modification of gold nanoparticles with precisely controlled PEG-b-polyamine

scientific article published on 04 April 2008

Creation of a blood-compatible surface: a novel strategy for suppressing blood activation and coagulation using a nitroxide radical-containing polymer with reactive oxygen species scavenging activity

scientific article published on 02 December 2011

Creation of a mixed poly(ethylene glycol) tethered-chain surface for preventing the nonspecific adsorption of proteins and peptides

scientific article published in December 2007

Density control of poly(ethylene glycol) layer to regulate cellular attachment

scientific article published on 5 May 2007

Design and Preparation of a Nanoprobe for Imaging Inflammation Sites

scientific article published on 09 February 2012

Design and use of silica-containing redox nanoparticles, siRNPs, for high-performance peritoneal dialysis.

scientific article published in March 2014

Design of amino acid-based self-assembled nano-drugs for therapeutic applications

scientific article published on 17 June 2020

Design of core--shell-type nanoparticles carrying stable radicals in the core

scientific article published in March 2009

Design of poly(ethylene glycol)/streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling

scientific article

Development of a high-performance immunolatex based on "soft landing" antibody immobilization mechanism

scientific article published on 29 September 2011

Development of a long-acting, protein-loaded, redox-active, injectable gel formed by a polyion complex for local protein therapeutics

scientific article published on 19 January 2016

Development of an oral nanotherapeutics using redox nanoparticles for treatment of colitis-associated colon cancer.

scientific article published on 9 April 2015

Development of nitroxide radicals-containing polymer for scavenging reactive oxygen species from cigarette smoke

scientific article published on 27 May 2014

Development of silica-containing redox nanoparticles for medical applications.

scientific article

Different mechanisms of action of poly(ethylene glycol) and arginine on thermal inactivation of lysozyme and ribonuclease A

scientific article published on 11 May 2012

Direct observation of adsorption-induced inactivation of antibody fragments surrounded by mixed-PEG layer on a gold surface

scientific article published on 01 June 2010

Efficient inhibition of interfacial nonspecific interaction to create practically utilizable high ferritin-response immunolatex

scientific article published in December 2009

Efficient short interference RNA delivery to tumor cells using a combination of octaarginine, GALA and tumor-specific, cleavable polyethylene glycol system

scientific article published in May 2009

Efficient siRNA delivery based on PEGylated and partially quaternized polyamine nanogels: enhanced gene silencing activity by the cooperative effect of tertiary and quaternary amino groups in the core

scientific article published on 4 June 2010

Electric stimulus opens intercellular spaces in skin.

scientific article published on 6 December 2013

Elevated atherogenic index following oral administration of quaternized polyamine nanogels

scientific article

Encapsulation of tissue plasminogen activator in pH-sensitive self-assembled antioxidant nanoparticles for ischemic stroke treatment - Synergistic effect of thrombolysis and antioxidant

scientific article published on 13 May 2019

Engineering of poly(ethylene glycol) chain-tethered surfaces to obtain high-performance bionanoparticles

scientific article published on October 2010

Enhanced cytoplasmic delivery of siRNA using a stabilized polyion complex based on PEGylated nanogels with a cross-linked polyamine structure.

scientific article

Enhanced growth inhibition of hepatic multicellular tumor spheroids by lactosylated poly(ethylene glycol)-siRNA conjugate formulated in PEGylated polyplexes.

scientific article published in September 2007

Enhanced immunoresponse of antibody/mixed-PEG co-immobilized surface construction of high-performance immunomagnetic ELISA system

scientific article published on 26 March 2007

Enhanced intracellular drug delivery of pH-sensitive doxorubicin/poly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells

scientific article published on 30 January 2013

Evaluation of the in vivo antioxidative activity of redox nanoparticles by using a developing chicken egg as an alternative animal model

scientific article published on 15 March 2014

Facile and Quantitative Synthesis of a Poly(ethylene glycol)-b-Poly(l-arginine) Block Copolymer and Its Use for the Preparation of Polyion Complex Micelles with Polyanions for Biomedical Applications.

scientific article

Facile construction of sulfanyl-terminated poly(ethylene glycol)-brushed layer on a gold surface for protein immobilization by the combined use of sulfanyl-ended telechelic and semitelechelic poly(ethylene glycol)s

scientific article published on 29 July 2008

Facile solid-phase synthesis of a highly stable poly(ethylene glycol)-oligonucleotide conjugate

scientific article published on 21 November 2012

Fibrinolytic tissue plasminogen activator installed redox-active nanoparticles (t-PA@iRNP) for cancer therapy

scientific article published on 14 August 2020

Fluorescence-based affinity labeling of nucleobase by hydrogen-bond forming metal complex.

scientific article published in January 2007

Gd@C82 metallofullerenes for neutron capture therapy-fullerene solubilization by poly(ethylene glycol)-block-poly(2-(N, N-diethylamino)ethyl methacrylate) and resultant efficacy in vitro

scientific article published on 07 July 2011

Glycolytic enzymes PGK1 and PKM2 as novel transcriptional targets of PPARγ in breast cancer pathophysiology ⬇️

scientific article published on November 6, 2012

High PEGylation efficiency of pentaethylenehexamine-end poly(ethylene glycol) (mPEG-N6) for active-ester surface

scientific article published on 11 November 2011

High-performance immunolatex possessing a mixed-PEG/antibody coimmobilized surface: highly sensitive ferritin immunodiagnostics

scientific article published in February 2009

High-performance surface acoustic wave immunosensing system on a PEG/aptamer hybridized surface.

scientific article

Improved complementary polymer pair system: switching for enzyme activity by PEGylated polymers

scientific article published on 21 February 2012

Improving the heat resistance of ribonuclease A by the addition of poly(N,N-diethylaminoethyl methacrylate)-graft-poly(ethylene glycol) (PEAMA-g-PEG).

scientific article published in August 2010

In vitro and in vivo characteristics of core–shell type nanogel particles: Optimization of core cross-linking density and surface poly(ethylene glycol) density in PEGylated nanogels ⬇️

scientific article published on May 27, 2011

Indomethacin-loaded redox nanoparticles improve oral bioavailability of indomethacin and suppress its small intestinal inflammation.

scientific article published in January 2014

Intra-tumor distribution of metallofullerene using micro-particle induced X-ray emission (PIXE).

scientific article published on 8 January 2014

Intracellular inducible alkylation system that exhibits antisense effects with greater potency and selectivity than the natural oligonucleotide

scientific article published on 01 May 2006

Lactose-installed poly(ethylene glycol)-poly(d,l-lactide) block copolymer micelles exhibit fast-rate binding and high affinity toward a protein bed simulating a cell surface. A surface plasmon resonance study

scientific article

Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells.

scientific article published on February 2005

Large payloads of gold nanoparticles into the polyamine network core of stimuli-responsive PEGylated nanogels for selective and noninvasive cancer photothermal therapy.

scientific article

Ligand density effect on biorecognition by PEGylated gold nanoparticles: regulated interaction of RCA120 lectin with lactose installed to the distal end of tethered PEG strands on gold surface

scientific article

Long-term bioavailability of redox nanoparticles effectively reduces organ dysfunctions and death in whole-body irradiated mice

scientific article published on 14 March 2017

Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array ⬇️

scientific article published on April 21, 2012

Molecular design of a high-performance polymeric carrier for delivery of a variety of boronic acid-containing drugs

scientific article published on 13 December 2020

Near-infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate)

scientific article published on 27 July 2011

Neurovascular Unit Protection From Cerebral Ischemia-Reperfusion Injury by Radical-Containing Nanoparticles in Mice.

scientific article published on 27 June 2017

Newly Designed Silica-Containing Redox Nanoparticles for Oral Delivery of Novel TOP2 Catalytic Inhibitor for Treating Colon Cancer.

scientific article published on 24 July 2017

Newly synthesized radical-containing nanoparticles enhance neuroprotection after cerebral ischemia-reperfusion injury

scientific article published on 01 May 2011

Nitric Oxide Nano-Delivery Systems for Cancer Therapeutics: Advances and Challenges

scientific article published on 26 August 2020

Nitroxide Radicals and Nanoparticles: a Partnership for Nanomedicine Radical Delivery ⬇️

scientific article published on February 1, 2012

Nitroxide radical-containing nanoparticles attenuate tumorigenic potential of triple negative breast cancer

scientific article published on 26 May 2018

Nitroxyl radical-containing nanoparticles for novel nanomedicine against oxidative stress injury.

scientific article published on April 2011

Non-Fouling Character of Poly[2-(methacryloyloxy)ethyl Phosphorylcholine]-Modified Gold Surfaces Fabricated by the 'Grafting to' Method: Comparison of its Protein Resistance with Poly(ethylene glycol)-Modified Gold Surfaces

scientific article published on 16 October 2009

Non-isotope enriched phenylboronic acid-decorated dual-functional nano-assembles for an actively targeting BNCT drug

scientific article published on 24 November 2020

Novel Synthesized Radical-Containing Nanoparticles Limit Infarct Size Following Ischemia and Reperfusion in Canine Hearts

scientific article published on 3 November 2017

Novel angiogenesis therapeutics by redox injectable hydrogel - Regulation of local nitric oxide generation for effective cardiovascular therapy

scientific article published on 13 March 2018

Novel antioxidative nanotherapeutics in a rat periodontitis model: Reactive oxygen species scavenging by redox injectable gel suppresses alveolar bone resorption

scientific article published on 30 October 2015

Novel biocompatible nanoreactor for silica/gold hybrid nanoparticles preparation ⬇️

scientific article published on September 27, 2012

Novel molecular recognition via fluorescent resonance energy transfer using a biotin-PEG/polyamine stabilized CdS quantum dot.

scientific article published in July 2004

Novel neuroprotection using antioxidant nanoparticles in a mouse model of head trauma

scientific article published on 07 February 2020

Novel oligonucleotide carrier as scavenger for reactive oxygen species

article

Novel protein PEGylation chemistry via glutalaldehyde-functionalized PEG.

scientific article published on 4 November 2013

Novel redox nanomedicine improves gene expression of polyion complex vector.

scientific article

On-off regulation of 19F magnetic resonance signals based on pH-sensitive PEGylated nanogels for potential tumor-specific smart 19F MRI probes

scientific article published on 31 August 2007

Oral nanotherapeutics: Redox nanoparticles attenuate ultraviolet B radiation-induced skin inflammatory disorders in Kud:Hr- hairless mice

scientific article

Oral nanotherapeutics: effect of redox nanoparticle on microflora in mice with dextran sodium sulfate-induced colitis

scientific article published on 29 May 2013

PEGylated nanoparticles for biological and pharmaceutical applications

scientific article

Pharmacokinetics of core-polymerized, boron-conjugated micelles designed for boron neutron capture therapy for cancer.

scientific article

Physicochemical characterization of densely packed poly(ethylene glycol) layer for minimizing nonspecific protein adsorption

scientific article published on 01 July 2007

Poly(ornithine)-based self-assembling drug for recovery of hyperammonemia and damage in acute liver injury

scientific article published on 12 August 2019

Preparation of a novel PEG-clay hybrid as a DDS material: dispersion stability and sustained release profiles

scientific article published in October 2005

Preparation of functionally Pegylated gold nanoparticles with narrow distribution through autoreduction of auric cation by alpha-biotinyl-PEG-block-[poly(2- (N,N-dimethylamino)ethyl methacrylate)].

scientific article

Preparation of highly dispersible and tumor-accumulative, iron oxide nanoparticles Multi-point anchoring of PEG-b-poly(4-vinylbenzylphosphonate) improves performance significantly

scientific article published on 22 August 2011

Prevention of UV-Induced Melanin Production by Accumulation of Redox Nanoparticles in the Epidermal Layer via Iontophoresis

scientific article

Protection of Coral Larvae from Thermally Induced Oxidative Stress by Redox Nanoparticles

scientific article published on 28 April 2018

Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles.

scientific article published on 14 February 2014

Reactive oxygen species-scavenging nanomedicines for the treatment of oxidative stress injuries

scientific article published on 30 January 2014

Recovery of Cognitive Dysfunction via Orally Administered Redox-Polymer Nanotherapeutics in SAMP8 Mice

scientific article (publication date: 2015)

Redox Nanoparticle Therapeutics for Acetaminophen-Induced Hepatotoxicity in Mice

scientific article published on 17 March 2016

Redox injectable gel protects osteoblastic function against oxidative stress and suppresses alveolar bone loss in a rat peri-implantitis model

scientific article published on 26 April 2020

Redox nanoparticle increases the chemotherapeutic efficiency of pioglitazone and suppresses its toxic side effects.

scientific article published on 13 May 2016

Redox nanoparticle therapeutics to cancer--increase in therapeutic effect of doxorubicin, suppressing its adverse effect

scientific article published on 17 August 2013

Redox nanoparticle treatment protects against neurological deficit in focused ultrasound-induced intracerebral hemorrhage

scientific article published on 6 March 2012

Redox nanoparticles as a novel treatment approach for inflammation and fibrosis associated with nonalcoholic steatohepatitis.

scientific article published on 28 May 2015

Redox nanoparticles inhibit curcumin oxidative degradation and enhance its therapeutic effect on prostate cancer.

scientific article published on 22 April 2015

Redox-active injectable gel using polyion complex to achieve sustained release of exenatide and enhance therapeutic efficacy for the treatment of type 2 diabetes

scientific article published on 19 March 2019

Redox-active injectable gel using thermo-responsive nanoscale polyion complex flower micelle for noninvasive treatment of local inflammation.

scientific article published on 21 October 2013

Regulation of lysozyme activity based on thermotolerant protein/smart polymer complex formation

scientific article published in May 2009

Self-assembled polydopamine nanoparticles improve treatment in Parkinson's disease model mice and suppress dopamine-induced dyskinesia

scientific article published on 05 April 2020

Silica-installed redox nanoparticles for novel oral nanotherapeutics - improvement in intestinal delivery with anti-inflammatory effects

scientific article published on 23 June 2014

Simple solid-phase synthesis and biological properties of carbohydrate-oligonucleotide conjugates modified at the 3'-terminus

scientific article published on September 2010

Smart polyion complex micelles for targeted intracellular delivery of PEGylated antisense oligonucleotides containing acid-labile linkages.

scientific article

Smart polymeric micelles as nanocarriers for oligonucleotides and siRNA delivery

scientific article published in January 2005

Smart siRNA Delivery Systems Based on Polymeric Nanoassemblies and Nanoparticles ⬇️

scientific article published on September 1, 2010

Specific accumulation of orally administered redox nanotherapeutics in the inflamed colon reducing inflammation with dose-response efficacy

scientific article

Stimuli-responsive smart nanogels for cancer diagnostics and therapy

scientific article published on April 2010

Structure and activity assay of nanozymes prepared by the coimmobilization of practically useful enzymes and hydrophilic block copolymers on gold nanoparticles

scientific article published on 30 May 2008

Studies on the adsorption property and structure of polyamine-ended poly(ethylene glycol) derivatives on a gold surface by surface plasmon resonance and angle-resolved X-ray photoelectron spectroscopy

scientific article published in October 2009

Sulfobetaine-terminated PEG improves the qualities of an immunosensing surface

scientific article published in May 2014

Suppression of NSAID-induced small intestinal inflammation by orally administered redox nanoparticles.

scientific article published on 27 July 2013

Synthesis and evaluation of the functional oligonucleotides-PEG conjugates

scientific article

Synthesis and in vitro and in vivo evaluations of poly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) magnetic nanoparticles containing doxorubicin as a potential targeted drug delivery system

scientific article published on 8 April 2014

Synthesis of heterotelechelic poly(ethylene glycol) derivatives having alpha-benzaldehyde and omega-pyridyl disulfide groups by ring opening polymerization of ethylene oxide using 4-(diethoxymethyl)benzyl alkoxide as a novel initiator

scientific article published in March 2004

Synthesis of poly[N-isopropylacrylamide-g-poly(ethylene glycol)] with a reactive group at the poly(ethylene glycol) end and its thermosensitive self-assembling character

Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid.

scientific article published on 22 March 2011

TEMPOL protects human neuroblastoma SH-SY5Y cells against β-amyloid-induced cell toxicity

scientific article published on 20 October 2010

Targeting and Treatment of Tumor Hypoxia by Newly Designed Prodrug Possessing High Permeability in Solid Tumors

scientific article published on 17 May 2016

The ROS scavenging and renal protective effects of pH-responsive nitroxide radical-containing nanoparticles.

scientific article

The behavior of ROS-scavenging nanoparticles in blood.

scientific article

The use of nitroxide radical-containing nanoparticles coupled with piperine to protect neuroblastoma SH-SY5Y cells from Aβ-induced oxidative stress

scientific article

Thermal characterization of poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles based on pyrene excimer formation

scientific article

Tumor growth suppression by gadolinium-neutron capture therapy using gadolinium-entrapped liposome as gadolinium delivery agent

scientific article published on 26 December 2012

Two-dimensional multiarray formation of hepatocyte spheroids on a microfabricated PEG-brush surface

scientific article published in June 2004

Use of boron cluster-containing redox nanoparticles with ROS scavenging ability in boron neutron capture therapy to achieve high therapeutic efficiency and low adverse effects

scientific article published on 11 July 2016

pH-responsive oligodeoxynucleotide (ODN)-poly(ethylene glycol) conjugate through acid-labile beta-thiopropionate linkage: preparation and polyion complex micelle formation

scientific article

pH-responsive three-layered PEGylated polyplex micelle based on a lactosylated ABC triblock copolymer as a targetable and endosome-disruptive nonviral gene vector

scientific article published on May 2006

pH-sensitive radical-containing-nanoparticle (RNP) for the L-band-EPR imaging of low pH circumstances.

scientific article published in September 2009

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