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List of works by Hendrik Luesch

A Complementary Chemical and Genomic Screening Approach for Druggable Targets in the Nrf2 Pathway and Small Molecule Inhibitors to Overcome Cancer Cell Drug Resistance.

scientific article published on 22 March 2018

A Highly Potent Class of Halogenated Phenazine Antibacterial and Biofilm-Eradicating Agents Accessed Through a Modular Wohl-Aue Synthesis

scientific article published on 17 May 2017

A Natural Products Approach to Drug Discovery: Probing Modes of Action of Antitumor Agents by Genome-Scale cDNA Library Screening ⬇️

scientific article published on January 1, 2009

A Tryptoline Ring-Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine

scientific article

A dive into membrane dynamics with sponge peptides

scientific article published on 01 May 2015

A functional genomics approach to the mode of action of apratoxin A.

scientific article published on 12 February 2006

A genome-wide overexpression screen in yeast for small-molecule target identification

scientific article

A genomic screen for activators of the antioxidant response element

scientific article

A small-molecule inducer of the antioxidant response element

scientific article published on May 2010

Activation of the antioxidant response element by specific oxidized metabolites of linoleic acid

scientific article published on 29 May 2009

Advances in exploring the therapeutic potential of marine natural products

scientific article published on 25 July 2019

Ahp-Cyclodepsipeptide Inhibitors of Elastase: Lyngbyastatin 7 Stability, Scalable Synthesis, and Focused Library Analysis

scientific article published on 04 March 2020

Ahp-Cyclodepsipeptides as tunable inhibitors of human neutrophil elastase and kallikrein 7: Total synthesis of tutuilamide A, serine protease selectivity profile and comparison with lyngbyastatin 7

scientific article published on 09 September 2020

Amantelides A and B, Polyhydroxylated Macrolides with Differential Broad-Spectrum Cytotoxicity from a Guamanian Marine Cyanobacterium. ⬇️

scientific article

An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration.

scientific article

Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor.

scientific article

Apratoxin E, a cytotoxic peptolide from a guamanian collection of the marine cyanobacterium Lyngbya bouillonii.

scientific article published on 8 May 2008

Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors

scientific article published on 18 September 2017

Apratoxin S4 Inspired by a Marine Natural Product, a New Treatment Option for Ocular Angiogenic Diseases

scientific article published on 01 July 2019

Apratoxin a reversibly inhibits the secretory pathway by preventing cotranslational translocation

scientific article published on 29 April 2009

Apratyramide, a Marine-Derived Peptidic Stimulator of VEGF-A and Other Growth Factors with Potential Application in Wound Healing ⬇️

scientific article published on 5 December 2017

Bifunctional Doscadenamides Activate Quorum Sensing in Gram-Negative Bacteria and Synergize with TRAIL to Induce Apoptosis in Cancer Cells

scientific article published on 22 January 2021

Bioassay-guided isolation and identification of desacetylmicrocolin B from Lyngbya cf. polychroa ⬇️

scientific article published on 08 May 2009

Biological effects of Byrsocarpus coccineus in vitro

scientific article published on 26 November 2010

Biological targets and mechanisms of action of natural products from marine cyanobacteria

scientific article

Biosynthesis of 4-methylproline in cyanobacteria: cloning of nosE and nosF genes and biochemical characterization of the encoded dehydrogenase and reductase activities

scientific article

CUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment.

scientific article published on 05 August 2016

Caldora penicillata gen. nov., comb. nov. (cyanobacteria), a pantropical marine species with biomedical relevance

scientific article

Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata ⬇️

scientific article published on 05 July 2016

Can we develop effective combination antiangiogenic therapy for patients with hepatocellular carcinoma?

scientific article

Caylobolide B, a Macrolactone from Symplostatin 1-Producing Marine Cyanobacteria Phormidium spp. from Florida ⬇️

scientific article published on September 24, 2010

ChemInform Abstract: New Apratoxins of Marine Cyanobacterial Origin from Guam and Palau

scientific article published on 22 May 2010

Chemical and Metagenomic Studies of the Lethal Black Band Disease of Corals Reveal Two Broadly Distributed, Redox-Sensitive Mixed Polyketide/Peptide Macrocycles ⬇️

scientific article published on 13 January 2019

Combination therapy for renal cell cancer: what are possible options?

scientific article

Combination therapy targeting cancer metabolism ⬇️

scientific article published on October 13, 2010

Combinatorial strategies by marine cyanobacteria: symplostatin 4, an antimitotic natural dolastatin 10/15 hybrid that synergizes with the coproduced HDAC inhibitor largazole

scientific article

Construction and characterization of melanocortin-2 and -4 receptor chimeras

scientific article published in January 2009

Continuing studies on the cyanobacterium Lyngbya sp.: isolation and structure determination of 15-norlyngbyapeptin A and lyngbyabellin D.

scientific article published on May 2003

Correction to "Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors".

scientific article published on 7 December 2017

Correction to Apratoxin E, a Cytotoxic Peptolide from a Guamanian Collection of the Marine Cyanobacterium Lyngbya bouillonii.

scientific article published on 19 December 2017

Correction to Caylobolide B, a Macrolactone from Symplostatin 1-Producing Marine Cyanobacteria Phormidium spp. from Florida

scientific article published on 17 February 2016

Cover Feature: Structural Diversity and Anticancer Activity of Marine-Derived Elastase Inhibitors: Key Features and Mechanisms Mediating the Antimetastatic Effects in Invasive Breast Cancer (ChemBioChem 8/2018)

scientific article published in 2018

Cultivated sea lettuce is a multiorgan protector from oxidative and inflammatory stress by enhancing the endogenous antioxidant defense system

scientific article published on September 2013

Cyanobacterial Sfp-type phosphopantetheinyl transferases functionalize carrier proteins of diverse biosynthetic pathways.

scientific article published on 19 September 2017

Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases

scientific article

Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam ⬇️

scientific article

Development of apratoxin S10 (Apra S10) as an anti-pancreatic cancer agent and its preliminary evaluation in an orthotopic patient-derived xenograft (PDX) model

scientific article published on 03 August 2018

Discovery and Total Synthesis of Doscadenamide A: A Quorum Sensing Signaling Molecule from a Marine Cyanobacterium

scientific article published on 15 August 2019

Discovery and mechanism of natural products as modulators of histone acetylation

scientific article published on July 2012

Discovery of Amantamide, a Selective CXCR7 Agonist from Marine Cyanobacteria ⬇️

scientific article published on 19 February 2019

Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes.

scientific article published on 6 May 2015

Discovery of new A- and B-type laxaphycins with synergistic anticancer activity. ⬇️

scientific article published on 14 March 2018

Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFRWT and EGFRT790M

scientific article published on 22 September 2020

Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A-E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium

scientific article published on 17 July 2018

Discovery, Total Synthesis and Key Structural Elements for the Immunosuppressive Activity of Cocosolide, a Symmetrical Glycosylated Macrolide Dimer from Marine Cyanobacteria ⬇️

scientific article published on 3 May 2016

Discovery, Total Synthesis, and SAR of Anaenamides A and B: Anticancer Cyanobacterial Depsipeptides with a Chlorinated Pharmacophore

scientific article published on 16 May 2020

Dolastatin 15 from a Marine Cyanobacterium Suppresses HIF-1α Mediated Cancer Cell Viability and Vascularization

scientific article published on 01 April 2020

Dragonamides C and D, linear lipopeptides from the marine cyanobacterium brown Lyngbya polychroa.

scientific article published on 5 April 2008

Evaluation of class I HDAC isoform selectivity of largazole analogues

scientific article

Fungal epithiodiketopiperazines carrying α,β-polysulfide bridges from Penecillium steckii YE, and their chemical interconversion

scientific article published on 20 August 2020

Genome-wide overexpression screen for activators of antioxidant gene transcription

scientific article

Grassypeptolides A−C, Cytotoxic Bis-thiazoline Containing Marine Cyclodepsipeptides ⬇️

scientific article published on November 4, 2010

Grassypeptolides as natural inhibitors of dipeptidyl peptidase 8 and T-cell activation

scientific article

Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation ⬇️

scientific article

Grassystatins D-F, Potent Aspartic Protease Inhibitors from Marine Cyanobacteria as Potential Antimetastatic Agents Targeting Invasive Breast Cancer. ⬇️

scientific article published on 31 October 2017

Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non-Biofilm Cultures, and Mycobacterium tuberculosis

scientific article published on 20 October 2015

Heterologous production of cyanobacterial compounds

scientific article published in 2021

High-Yield Production of Herbicidal Thaxtomins and Thaxtomin Analogs in a Nonpathogenic Streptomyces Strain ⬇️

scientific article published on 17 May 2018

High-throughput gene screen reveals modulators of nuclear shape

scientific article published on 22 April 2020

Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with differential stability and further enhanced activity

scientific article

In Vitro and In Vivo Osteogenic Activity of Largazole.

scientific article

In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway

scientific article published on 17 June 2013

Intramolecular modulation of serine protease inhibitor activity in a marine cyanobacterium with antifeedant properties. ⬇️

scientific article

Isolation and Characterization of Anaephenes A-C, Alkylphenols from a Filamentous Cyanobacterium ( Hormoscilla sp., Oscillatoriales) ⬇️

scientific article published on 29 November 2018

Isolation and Characterization of the Cyanobacterial Macrolide Glycoside Moorenaside, an Anti-Inflammatory Analogue of Aurisides Targeting the Keap1/Nrf2 Pathway

scientific article published in 2024

Isolation and biological evaluation of 8-epi-malyngamide C from the Floridian marine cyanobacterium Lyngbya majuscula. ⬇️

scientific article

Isolation, Structure Elucidation and Biological Evaluation of Lagunamide D: A New Cytotoxic Macrocyclic Depsipeptide from Marine Cyanobacteria ⬇️

scientific article published on 01 February 2019

Kempopeptin C, a Novel Marine-Derived Serine Protease Inhibitor Targeting Invasive Breast Cancer ⬇️

scientific article published on 16 September 2017

Kempopeptins A and B, serine protease inhibitors with different selectivity profiles from a marine cyanobacterium, Lyngbya sp.

scientific article published on 12 August 2008

Largamides A-C, tiglic acid-containing cyclodepsipeptides with elastase-inhibitory activity from the marine cyanobacterium Lyngbya confervoides

scientific article published on 12 February 2009

Largazole is a Brain-Penetrant Class I HDAC Inhibitor with Extended Applicability to Glioblastoma and CNS Diseases

scientific article published on 19 June 2020

Largazole pharmacokinetics in rats by LC-MS/MS.

scientific article published on 20 March 2014

Largazole: from discovery to broad-spectrum therapy

scientific article published on 14 February 2012

Lyngbyaloside B, a new glycoside macrolide from a Palauan marine cyanobacterium, Lyngbya sp

scientific article published on 01 December 2002

Lyngbyastatin 4, a dolastatin 13 analogue with elastase and chymotrypsin inhibitory activity from the marine cyanobacterium Lyngbya confervoides.

scientific article published in January 2007

Lyngbyastatins 5-7, potent elastase inhibitors from Floridian marine cyanobacteria, Lyngbya spp.

scientific article published on 3 October 2007

Lyngbyastatins 8-10, elastase inhibitors with cyclic depsipeptide scaffolds isolated from the marine cyanobacterium Lyngbya semiplena ⬇️

scientific article

Lyngbyoic acid, a "tagged" fatty acid from a marine cyanobacterium, disrupts quorum sensing in Pseudomonas aeruginosa ⬇️

scientific article published on 24 January 2011

Malyngamide 3 and cocosamides A and B from the marine cyanobacterium Lyngbya majuscula from Cocos Lagoon, Guam ⬇️

scientific article

Marine cyanobacterial fatty acid amides acting on cannabinoid receptors.

scientific article

Marine natural products: a new wave of drugs?

scientific article

Modular strategies for structure and function employed by marine cyanobacteria: characterization and synthesis of pitinoic acids

scientific article published on 05 August 2013

Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties

scientific article

Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis

scientific article published in March 2010

Multidimensional Screening Platform for Simultaneously Targeting Oncogenic KRAS and Hypoxia-Inducible Factors Pathways in Colorectal Cancer

scientific article

Natural products as modulators of eukaryotic protein secretion

scientific article published on 18 February 2020

New apratoxins of marine cyanobacterial origin from Guam and Palau

scientific article published on 01 June 2002

New methods for isolation and structure determination of natural products

scientific article published on 28 June 2019

Photosynthetic Production of Sunscreen Shinorine Using an Engineered Cyanobacterium

scientific article

Phylogenetic and chemical diversity of three chemotypes of bloom-forming lyngbya species (Cyanobacteria: Oscillatoriales) from reefs of southeastern Florida

scientific article

Pitiamides A and B, Multifunctional Fatty Acid Amides from Marine Cyanobacteria ⬇️

scientific article published on 02 May 2016

Pitipeptolides C-F, antimycobacterial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula from Guam. ⬇️

scientific article

Pitiprolamide, a proline-rich dolastatin 16 analogue from the marine cyanobacterium Lyngbya majuscula from Guam ⬇️

scientific article

Poly(N-(2-Hydroxypropyl) Methacrylamide)-Valproic Acid Conjugates as Block Copolymer Nanocarriers

scientific article

Pompanopeptins A and B, new cyclic peptides from the marine cyanobacterium Lyngbya confervoides

scientific article published on 19 February 2008

Porpoisamides A and B, two novel epimeric cyclic depsipeptides from a Florida Keys collection of Lyngbya sp ⬇️

scientific article

Potent Elastase Inhibitors from Cyanobacteria: Structural Basis and Mechanisms Mediating Cytoprotective and Anti-Inflammatory Effects in Bronchial Epithelial Cells

scientific article

Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine's Biological Activity

scientific article published on 23 March 2020

Protection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defenses.

scientific article

Rational engineering of Streptomyces albus J1074 for the overexpression of secondary metabolite gene clusters. ⬇️

scientific article published on 17 February 2018

Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway

scientific article

Seaweed natural products modify the host inflammatory response via Nrf2 signaling and alter colon microbiota composition and gene expression

scientific article published on 16 September 2019

Structural Diversity and Anticancer Activity of Marine-Derived Elastase Inhibitors: Key Features and Mechanisms Mediating the Antimetastatic Effects in Invasive Breast Cancer. ⬇️

scientific article published on 5 February 2018

Structurally diverse new alkaloids from Palauan collections of the apratoxin-producing marine cyanobacterium Lyngbya sp.

scientific article published on 25 March 2003

Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp.

scientific article published on 19 January 2008

Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis

scientific article published on 28 March 2016

Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452

scientific article published on 26 July 2002

Synthesis and activity of largazole analogues with linker and macrocycle modification

scientific article

Synthesis and biological evaluation of largazole zinc-binding group analogs

scientific article

Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity

scientific article published on 31 August 2011

Targeted natural products discovery from marine cyanobacteria using combined phylogenetic and mass spectrometric evaluation

scientific article

Targeting and extending the eukaryotic druggable genome with natural products

scientific article published on 11 June 2020

Targeting eukaryotic proteases for natural products-based drug development

scientific article published on 10 June 2020

Tasiamide F, a potent inhibitor of cathepsins D and E from a marine cyanobacterium ⬇️

scientific article published on 30 April 2016

Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression

scientific journal article

The adaptive regulation of thiamine pyrophosphokinase-1 facilitates malignant growth during supplemental thiamine conditions

The molecular pharmacology of symplostatin 1: a new antimitotic dolastatin 10 analog

scientific article published on 01 April 2003

The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non-cancer cells.

scientific article published on 25 May 2017

Tiglicamides A-C, cyclodepsipeptides from the marine cyanobacterium Lyngbya confervoides ⬇️

scientific article published on 6 October 2009

Total Synthesis and Biological Evaluation of Apratoxin E and Its C30 Epimer: Configurational Reassignment of the Natural Product.

scientific article published on 10 October 2016

Total Synthesis of Asperphenins A and B

scientific article published on 20 September 2018

Total Synthesis of the Potent Marine-Derived Elastase Inhibitor Lyngbyastatin 7 and in Vitro Biological Evaluation in Model Systems for Pulmonary Diseases ⬇️

scientific article published on 28 December 2015

Total structure determination of grassypeptolide, a new marine cyanobacterial cytotoxin.

scientific article published on 26 January 2008

Total synthesis and biological evaluation of grassypeptolide A.

scientific article published on 27 March 2013

Total synthesis and molecular target of largazole, a histone deacetylase inhibitor

scientific article published on 29 May 2008

Total synthesis of grassystatin A, a probe for cathepsin E function

scientific article published on 07 June 2012

Towards high-throughput characterization of small molecule mechanisms of action

scientific article published on 27 October 2006

Tutuilamides A-C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties ⬇️

scientific article published on 28 January 2020

Ulongamides A-F, new beta-amino acid-containing cyclodepsipeptides from Palauan collections of the marine cyanobacterium Lyngbya sp.

scientific article

Veraguamides A-G, cyclic hexadepsipeptides from a dolastatin 16-producing cyanobacterium Symploca cf. hydnoides from Guam ⬇️

scientific article

Vicinal difluorination as a C=C surrogate: an analog of piperine with enhanced solubility, photostability, and acetylcholinesterase inhibitory activity

scientific article published on 28 October 2020

Weapons in disguise--activating mechanisms and protecting group chemistry in nature.

scientific article

Yohimbine as a Starting Point to Access Diverse Natural Product-Like Agents with Re-programmed Activities against Cancer-Relevant GPCR Targets

scientific article published on 07 May 2020

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