List of works - Stephen Fowler

Application of New Cellular and Microphysiological Systems to Drug Metabolism Optimization and Their Positioning Respective to In Silico Tools

scientific article published on 28 February 2019

Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance Prediction

scientific article published on 01 August 2020

Characterization of the Ontogeny of Hepatic UDP-Glucuronosyltransferase Enzymes Based on Glucuronidation Activity Measured in Human Liver Microsomes

scientific article published on 01 September 2019

Coexpression of Human Hepatic Uridine Diphosphate Glucuronosyltransferase Proteins: Implications for Ontogenetic Mechanisms and Isoform Coregulation

scientific article published on 26 December 2019

Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies

scientific article published on 18 June 2019

In vitro metabolism of alectinib, a novel potent ALK inhibitor, in human: contribution of CYP3A enzymes.

scientific article published on 21 July 2017

Low Potential of Basimglurant to Be Involved in Drug-Drug Interactions: Influence of Non-Michaelis-Menten P450 Kinetics on Fraction Metabolized.

scientific article published on 7 November 2016

Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling

scientific article

Microphysiological systems for ADME-related applications: current status and recommendations for system development and characterization

scientific article published on 14 January 2020

Minimizing DILI risk in drug discovery - A screening tool for drug candidates

scientific article published on 22 September 2015

Model-Based Assessments of CYP-Mediated Drug-Drug Interaction Risk of Alectinib: Physiologically Based Pharmacokinetic Modeling Supported Clinical Development.

scientific article published on 11 December 2017

Optimization of Experimental Conditions of Automated Glucuronidation Assays in Human Liver Microsomes Using a Cocktail Approach and Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry

scientific article published on 26 November 2018

Progress in Prediction and Interpretation of Clinically Relevant Metabolic Drug-Drug Interactions: a Minireview Illustrating Recent Developments and Current Opportunities.

scientific article published on February 2017

Simultaneous Assessment of Clearance, Metabolism, Induction and Drug-Drug Interaction Potential using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor.

scientific article published on 16 February 2018

The In Vitro Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1

scientific article published on 11 March 2019

The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling

scientific article published on 01 February 2019

List of works by Stephen Fowler