Search filters

List of works by Klaus Theodor Wanner

(S)- and (R)-fluoxetine as native markers in mass spectrometry (MS) binding assays addressing the serotonin transporter

scientific article

2-Substituted 4-hydroxybutanamides as potential inhibitors of γ-aminobutyric acid transporters mGAT1-mGAT4: synthesis and biological evaluation

scientific article published on 26 June 2013

A Library Screening Strategy Combining the Concepts of MS Binding Assays and Affinity Selection Mass Spectrometry

scientific article published on 04 October 2019

A rat brain bicistronic gene with an internal ribosome entry site codes for a phencyclidine-binding protein with cytotoxic activity

scientific article

Affinity of 1-aryl-1,2,3,4-tetrahydroisoquinoline derivatives to the ion channel binding site of the NMDA receptor complex.

scientific article

Aminomethyltetrazoles as potential inhibitors of the γ-aminobutyric acid transporters mGAT1-mGAT4: synthesis and biological evaluation

scientific article published on 26 August 2011

Application of MS Transport Assays to the Four Human γ-Aminobutyric Acid Transporters

scientific article published on 27 July 2015

Application of the concept of oxime library screening by mass spectrometry (MS) binding assays to pyrrolidine-3-carboxylic acid derivatives as potential inhibitors of γ-aminobutyric acid transporter 1 (GAT1)

scientific article published on 02 May 2019

Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship.

scientific article published on 14 February 2010

Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores

scientific article published on 10 February 2016

Combination of MS Binding Assays and affinity selection mass spectrometry for screening of structurally homogenous libraries as exemplified for a focused oxime library addressing the neuronal GABA transporter 1

scientific article published on 30 July 2020

Competitive Binding Assays Made Easy with a Native Marker and Mass Spectrometric Quantification ⬇️

scientific article published on November 3, 2003

Competitive MS binding assays for dopamine D2 receptors employing spiperone as a native marker

scientific article

Corrigendum: Simultaneous Multiple MS Binding Assays Addressing D1 and D2 Dopamine Receptors

scientific article published on 4 October 2017

Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning

scientific article

Deamination, oxidation, and C-C bond cleavage reactivity of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine

scientific article published on 17 September 2013

Design, synthesis and SAR studies of GABA uptake inhibitors derived from 2-substituted pyrrolidine-2-yl-acetic acids

scientific article published on 03 February 2015

Determination of enantiomeric excess of nipecotic acid as 1-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl) derivatives

scientific article published on 26 December 2016

Determination of the enantiomeric purity of the selective dopamine transporter inhibitor (+)-R,R-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol

scientific article published on 24 April 2017

Development and validation of a rapid LC-ESI-MS/MS method for quantification of fluoxetine and its application to MS binding assays

scientific article published on 24 April 2011

Development and validation of an LC-ESI-MS/MS method for the quantification of D-84, reboxetine and citalopram for their use in MS Binding Assays addressing the monoamine transporters hDAT, hSERT and hNET

article

Development and validation of an LC-ESI-MS/MS method for the triple reuptake inhibitor indatraline enabling its quantification in MS Binding Assays

scientific article published on 02 December 2014

Development and validation of an LC-ESI-MS/MS quantification method for a potential γ-aminobutyric acid transporter 3 (GAT3) marker and its application in preliminary MS binding assays

scientific article

Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives by Suzuki-Miyaura Cross-Coupling Reactions

scientific article published on 18 December 2015

Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives with N-Arylalkynyl Substituents

scientific article published on 26 January 2017

Development of New Photoswitchable Azobenzene Based γ-Aminobutyric Acid (GABA) Uptake Inhibitors with Distinctly Enhanced Potency upon Photoactivation

scientific article published on 06 July 2018

Development of an (S)-1-{2-[Tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic acid [(S)-SNAP-5114] Carba Analogue Inhibitor for Murine γ-Aminobutyric Acid Transporter Type 4

article

Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors.

scientific article published on 3 February 2011

Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity

scientific article published in October 2021

Development, validation and application of a 96-well enzymatic assay based on LC-ESI-MS/MS quantification for the screening of selective inhibitors against Mycobacterium tuberculosis purine nucleoside phosphorylase.

scientific article published on 20 September 2016

Different Binding Modes of Small and Large Binders of GAT1.

scientific article

Discovery of multifunctional anti-Alzheimer’s agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters

scientific article published in June 2021

Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis

scientific article published on 27 November 2017

Enantiopurity determination of the enantiomers of the triple reuptake inhibitor indatraline

scientific article published on 7 October 2013

Expanding the scope of MS binding assays to low-affinity markers as exemplified for mGAT1.

scientific article

First photoswitchable neurotransmitter transporter inhibitor: light-induced control of γ-aminobutyric acid transporter 1 (GAT1) activity in mouse brain

scientific article published on 25 July 2014

Focused pseudostatic hydrazone libraries screened by mass spectrometry binding assay: optimizing affinities toward γ-aminobutyric acid transporter 1.

scientific article

Generation and screening of oxime libraries addressing the neuronal GABA transporter GAT1.

scientific article

Generation and screening of pseudostatic hydrazone libraries derived from 5-substituted nipecotic acid derivatives at the GABA transporter mGAT4

scientific article published on 22 November 2018

Generation of a 3D model for human GABA transporter hGAT-1 using molecular modeling and investigation of the binding of GABA.

scientific article

Identification of Pyrrolidine-3-acetic Acid Derived Oximes as Potent Inhibitors of γ-Aminobutyric Acid Transporter 1 through Library Screening with MS Binding Assays

scientific article published on 28 November 2018

In vitro and initial in vivo evaluation of (68)Ga-labeled transferrin receptor (TfR) binding peptides as potential carriers for enhanced drug transport into TfR expressing cells

scientific article

Library screening by means of mass spectrometry (MS) binding assays-exemplarily demonstrated for a pseudostatic library addressing γ-aminobutyric acid (GABA) transporter 1 (GAT1).

scientific article

Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2.

scientific article published on 7 November 2014

MS Binding Assays for D1 and D5 Dopamine Receptors

scientific article published on 01 September 2015

MS Binding Assays for Glycine Transporter 2 (GlyT2) Employing Org25543 as Reporter Ligand

scientific article published on 30 July 2020

MS Binding Assays for the Three Monoamine Transporters Using the Triple Reuptake Inhibitor (1R,3S)-Indatraline as Native Marker.

scientific article published on 20 April 2015

MS binding assays for GlyT1 based on Org24598 as nonlabelled reporter ligand

scientific article published on 06 March 2019

MS binding assays-with MALDI toward high throughput

scientific article

MS transport assays for γ-aminobutyric acid transporters--an efficient alternative for radiometric assays

scientific article published on 16 July 2014

MS-Based Screening of 5-Substituted Nipecotic Acid Derived Hydrazone Libraries as Ligands of the GABA Transporter 1

scientific article published on 05 February 2019

MS-based screening of small amino acid derived oxime libraries for hGAT3 inhibitors

scientific article published on 01 November 2020

MS-binding assays: kinetic, saturation, and competitive experiments based on quantitation of bound marker as exemplified by the GABA transporter mGAT1

scientific article published on 01 February 2006

N-Substituted Nipecotic Acids as (S)-SNAP-5114 Analogues with Modified Lipophilic Domains

scientific article published on 18 March 2020

NMDA-NR2B subtype selectivity of stereoisomeric 2-(1,2,3,4-tetrahydro-1-isoquinolyl)ethanol derivatives

scientific article

New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling

scientific article published on 01 January 2019

New highly potent GABA uptake inhibitors selective for GAT-1 and GAT-3 derived from (R)- and (S)-proline and homologous pyrrolidine-2-alkanoic acids

scientific article published on 01 July 2006

Novel Functionalized Amino Acids as Inhibitors of GABA Transporters with Analgesic Activity

scientific article published on 4 August 2021

Novel allosteric ligands of γ-aminobutyric acid transporter 1 (GAT1) by MS based screening of pseudostatic hydrazone libraries

scientific article published on 08 November 2018

Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice

scientific article published on 29 December 2019

Novel parent structures for inhibitors of the murine GABA transporters mGAT3 and mGAT4.

scientific article published on September 2005

Novel, highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties

scientific article published on 19 October 2016

Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors γ-aminobutyric acid transporter 1

scientific article published on 08 February 2019

Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor

scientific article published on 30 October 2017

Shuttle-cargo fusion molecules of transport peptides and the hD2/3 receptor antagonist fallypride: a feasible approach to preserve ligand-receptor binding?

Simultaneous Multiple MS Binding Assays Addressing D1 and D2 Dopamine Receptors.

scientific article published on 4 August 2017

Simultaneous Multiple MS Binding Assays for the Dopamine, Norepinephrine, and Serotonin Transporters.

scientific article published on 16 February 2018

Syntheses of Novel Pyridazinomorphinans by Inverse Electron Demand Cycloaddition and their Binding to μ and κ Receptors ⬇️

scientific article published on June 1, 1997

Synthesis and Biological Evaluation of Nipecotic Acid and Guvacine Derived 1,3-Disubstituted Allenes as Inhibitors of Murine GABA Transporter mGAT1

scientific article published on 08 May 2019

Synthesis and biological evaluation of 4-hydroxy-4-(4-methoxyphenyl)-substituted proline and pyrrolidin-2-ylacetic acid derivatives as GABA uptake inhibitors

scientific article published on 27 November 2012

Synthesis and biological evaluation of a series of N-alkylated imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors

scientific article published on 7 September 2016

Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4.

scientific article

Synthesis and biological evaluation of new GABA-uptake inhibitors derived from proline and from pyrrolidine-2-acetic acid

scientific article

Synthesis and biological evaluation of new derivatives of 2-substituted 4-hydroxybutanamides as GABA uptake inhibitors

scientific article published on 04 November 2010

Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a cis-alkene spacer as GABA uptake inhibitors

scientific article published on 24 January 2019

Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a trans-alkene spacer as potent GABA uptake inhibitors

scientific article published on 03 November 2018

Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with an alkyne spacer as GABA uptake inhibitors

scientific article published on 01 June 2018

Synthesis and evaluation of N-substituted nipecotic acid derivatives with an unsymmetrical bis-aromatic residue attached to a vinyl ether spacer as potential GABA uptake inhibitors

scientific article published on 2 April 2013

Synthesis and pharmacological evaluation of new 4,4-diphenylbut-3-enyl derivatives of 4-hydroxybutanamides as GABA uptake inhibitors

scientific article published on 01 January 2012

Synthesis and pharmacological properties of new GABA uptake inhibitors.

scientific article published in January 2012

Synthesis of 4-substituted nipecotic acid derivatives and their evaluation as potential GABA uptake inhibitors

scientific article published on 22 March 2016

Synthesis of Allene Substituted Nipecotic Acids by Allenylation of Terminal Alkynes.

scientific article

Synthesis of N-substituted acyclic β-amino acids and their investigation as GABA uptake inhibitors

scientific article published on 8 May 2013

Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor

scientific article published on 27 November 2018

Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor

scientific article published on 01 August 2018

Synthesis of a series of γ-amino alcohols comprising an N-methyl isoindoline moiety and their evaluation as NMDA receptor antagonists

scientific article published on 06 August 2011

Synthesis of beta-amino acids based on oxidative cleavage of dihydropyridone derivatives

scientific article published on 01 September 2004

Synthesis, biological evaluation and structure-activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides.

scientific article published on 12 June 2014

The Environment Shapes the Inner Vestibule of LeuT.

scientific article

The glutamic acid-rich protein is a gating inhibitor of cyclic nucleotide-gated channels.

scientific article published on January 2011

Using short columns to speed up LC-MS quantification in MS binding assays

scientific article published on 25 December 2009

t-Bu2SiF-derivatized D2-receptor ligands: the first SiFA-containing small molecule radiotracers for target-specific PET-imaging.

scientific article published on 2 September 2011

Paulina is supported by:

About Paulina

Help