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List of works by John Koomen

A chemical and phosphoproteomic characterization of dasatinib action in lung cancer

scientific article

Activity-Based Protein Profiling Shows Heterogeneous Signaling Adaptations to BRAF Inhibition

scientific article

An immunoproteomic approach to characterize the CAR interactome and signalosome

scientific article published on 12 February 2019

Combined BRAF and HSP90 Inhibition in Patients with Unresectable -Mutant Melanoma

Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer.

scientific article published on 22 November 2017

Diagnostic protein discovery using liquid chromatography/mass spectrometry for proteolytic peptide targeting.

scientific article published in January 2005

Diagnostic protein discovery using proteolytic peptide targeting and identification

scientific article

Direct tandem mass spectrometry reveals limitations in protein profiling experiments for plasma biomarker discovery

scientific article published in May 2005

Evaluating melanoma drug response and therapeutic escape with quantitative proteomics

scientific article

Functional Proteomics and Deep Network Interrogation Reveal a Complex Mechanism of Action of Midostaurin in Lung Cancer Cells

scientific article published on 14 September 2018

Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer

scientific article published on 20 April 2021

HDAC Inhibition Enhances the In Vivo Efficacy of MEK Inhibitor Therapy in Uveal Melanoma

scientific article published on 21 June 2019

HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy

scientific article published on 15 April 2019

Inhibition of Wee1, AKT, and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS-mutant melanoma

scientific article published on 28 March 2013

K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling

scientific article published on 23 April 2019

Ligand-independent EPHA2 signaling drives the adoption of a targeted therapy-mediated metastatic melanoma phenotype

scientific article

Lowering Sample Requirements to Study Tyrosine Kinase Signaling using Phosphoproteomics with the TMT Calibrator Approach

scientific article published on 31 August 2020

PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression

scientific article

PTPN11 plays oncogenic roles and is a therapeutic target for BRAF wild-type melanomas

article

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms

scientific article

Plasma protein profiling for diagnosis of pancreatic cancer reveals the presence of host response proteins

scientific article published in February 2005

Proteogenomic landscape of squamous cell lung cancer

scientific article published on 08 August 2019

Proteomic Analysis of CSF from Patients with Leptomeningeal Melanoma Metastases Identifies Signatures Associated with Disease Progression and Therapeutic Resistance

scientific article published on 10 January 2020

Serum amyloid A as a tumor marker in sera of nude mice with orthotopic human pancreatic cancer and in plasma of patients with pancreatic cancer.

scientific article

Single-cell Characterization of the Cellular Landscape of Acral Melanoma Identifies Novel Targets for Immunotherapy

scientific article published in 2022

TAp63-regulated microRNAs suppress cutaneous squamous cell carcinoma through inhibition of a network of cell cycle genes

scientific article published on 10 March 2020

The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms

scientific article

Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial

scientific article published on 12 August 2021

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