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List of works by C Nelson Hayes

A case with life-threatening secondary sclerosing cholangitis caused by nivolumab

scientific article published on 16 November 2020

A nonsynonymous polymorphism in semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation

scientific article

A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections.

scientific article published on 16 October 2013

A single nucleotide polymorphism in activated Cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients.

scientific article published on 18 November 2010

A translational study of resistance emergence using sequential direct-acting antiviral agents for hepatitis C using ultra-deep sequencing.

scientific article published on 30 July 2013

Abatacept treatment for patients with severe acute hepatitis caused by hepatitis B virus infection - Pilot study

scientific article published on 16 November 2020

Accumulation of refractory factors for pegylated interferon plus ribavirin therapy in older female patients with chronic hepatitis C.

scientific article published on 7 October 2010

Advanced liver fibrosis effects on the response to sofosbuvir-based antiviral therapies for chronic hepatitis C

scientific article published on 13 August 2018

Amino acid substitutions in core and NS5A regions of the HCV genome can predict virological decrease with pegylated interferon plus ribavirin therapy

scientific article published in January 2010

Animal model for study of human hepatitis viruses

scientific article published on January 2011

Antiviral effects of anti-HBs immunoglobulin and vaccine on HBs antigen seroclearance for chronic hepatitis B infection

scientific article

Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A.

scientific article published on 4 April 2015

CTL-associated and NK cell-associated immune responses induce different HBV DNA reduction patterns in chronic hepatitis B patients

article

Chromosomal Abnormalities in Human Lymphocytes after Computed Tomography Scan Procedure

scientific article published on 24 July 2018

Circulating Tumor DNA Analysis for Liver Cancers and Its Usefulness as a Liquid Biopsy

scientific article published on 17 June 2015

Circulating cytokines and angiogenic factors based signature associated with the relative dose intensity during treatment in patients with advanced hepatocellular carcinoma receiving lenvatinib

scientific article published on 20 May 2020

Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B.

scientific article published in May 2013

Clinical Usefulness of Serum Autotaxin for Early Prediction of Relapse in Male Patients with Type 1 Autoimmune Pancreatitis

scientific article published on 20 May 2020

Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice

scientific article published on 15 January 2013

Combination therapies with daclatasvir and asunaprevir on NS3-D168 mutated HCV in human hepatocyte chimeric mice.

scientific article

Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy.

scientific article published in June 2011

Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients.

scientific article published on 31 May 2010

Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice

scientific article published on 21 February 2019

Correction to: Genomic landscape of epithelium with low-grade atypia on gastric cancer after Helicobacter pylori eradication therapy

scientific article published on 19 April 2020

Correction: Reduction of hepatitis B surface antigen in sequential versus add-on pegylated interferon to nucleoside/nucleotide analogue therapy in HBe-antigen-negative chronic hepatitis B patients: a pilot study

scientific article published on 01 January 2019

Daclatasvir and asunaprevir treatment improves liver function parameters and reduces liver fibrosis markers in chronic hepatitis C patients

scientific article published on 17 November 2015

Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice

scientific article published on 11 January 2013

Development of a Novel Site-Specific Pegylated Interferon Beta for Antiviral Therapy of Chronic Hepatitis B Virus

scientific article published on 3 April 2017

Differences in serum microRNA profiles in hepatitis B and C virus infection.

scientific article published on 5 November 2014

Early events in hepatitis B virus infection: From the cell surface to the nucleus

scientific article published on 28 September 2015

Effect of prolonged administration of pegylated interferon/ribavirin therapy in genotypes 2a and 2b: propensity score-matched analysis

scientific article published on February 2015

Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones

scientific article published on 26 October 2015

Effect of vitamin D supplementation on pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b: a randomized controlled trial

scientific article published on 30 July 2013

Effects of ITPA polymorphism on decrease of hemoglobin during simeprevir, peg-interferon, and ribavirin combination treatment for chronic hepatitis C.

scientific article published on 25 February 2016

Effects of hepatitis B virus infection on the interferon response in immunodeficient human hepatocyte chimeric mice

scientific article published in July 2011

Efficacy and safety of daclatasvir plus asunaprevir therapy for chronic hepatitis C patients with renal dysfunction.

scientific article

Efficacy and safety of ledipasvir/sofosbuvir with ribavirin in chronic hepatitis C patients who failed daclatasvir/asunaprevir therapy: pilot study

scientific article published on 16 August 2017

Efficacy of Lusutrombopag for Thrombocytopenia in Patients with Chronic Liver Disease Scheduled to Undergo Invasive Procedures

scientific article published on 21 October 2020

Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice

scientific article published on 14 June 2019

Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir and BMS-788329 combination therapy in human hepatocyte chimeric mice

scientific article published on 10 November 2015

Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice

scientific article

Emergence of drug resistance-associated variants and changes in serum lipid profiles in sofosbuvir plus ledipasvir-treated chronic hepatitis C patients.

scientific article published on 28 June 2017

Emergence of resistant variants detected by ultra-deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1.

scientific article published on 19 June 2014

Emerging treatments for chronic hepatitis C.

scientific article

Endoplasmic reticulum-mediated induction of interleukin-8 occurs by hepatitis B virus infection and contributes to suppression of interferon responsiveness in human hepatocytes

scientific article published on 18 September 2018

Erratum to: Serum HMGB1 concentrations at 4 weeks is a useful predictor of extreme poor prognosis for advanced hepatocellular carcinoma treated with sorafenib and hepatic arterial infusion chemotherapy

scientific article published in January 2018

Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C.

scientific article published on 19 January 2011

Genetics of IL28B and HCV--response to infection and treatment

scientific article published on 29 May 2012

Genomic Characterization of Non-Invasive Differentiated-Type Gastric Cancer in the Japanese Population

scientific article published on 22 February 2020

Genomic characterization of early-stage esophageal squamous cell carcinoma in a Japanese population

scientific article published on 25 June 2019

Genomic landscape of epithelium with low-grade atypia on gastric cancer after Helicobacter pylori eradiation therapy

scientific article published on 13 June 2019

HBV culture and infectious systems

scientific article published on 2 March 2016

HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice.

scientific article published on 10 March 2010

HCV Drug Resistance Challenges in Japan: The Role of Pre-Existing Variants and Emerging Resistant Strains in Direct Acting Antiviral Therapy

scientific article

HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy

scientific article published on 10 November 2010

HLA-DQB1*03 confers susceptibility to chronic hepatitis C in Japanese: a genome-wide association study

scientific article

Hepatitis B virus-specific miRNAs and Argonaute2 play a role in the viral life cycle

scientific article

Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy

scientific article published on 8 June 2016

Hepatitis C virus infection suppresses the interferon response in the liver of the human hepatocyte chimeric mouse

scientific article

Hepatitis C virus: How genetic variability affects pathobiology of disease

scientific article published on January 2011

Hepatocellular carcinoma: towards personalized medicine.

scientific article published on 15 March 2012

Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG Mice

scientific article

Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA.

scientific article published on 16 May 2014

IFNL4 polymorphism effects on outcome of simeprevir, peginterferon, and ribavirin therapy for older patients with genotype 1 chronic hepatitis C.

scientific article

IFNL4/IL-28B haplotype structure and its impact on susceptibility to hepatitis C virus and treatment response in the Japanese population

scientific article published on 19 March 2014

IL-28B predicts response to chronic hepatitis C therapy--fine-mapping and replication study in Asian populations.

scientific article published on 12 January 2011

IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy.

scientific article published on 4 February 2011

IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C

scientific article published in July 2011

IL28B polymorphism is associated with fatty change in the liver of chronic hepatitis C patients.

scientific article

ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients.

scientific article published on 14 July 2010

ITPA polymorphism effects on decrease of hemoglobin during sofosbuvir and ribavirin combination treatment for chronic hepatitis C.

scientific article published on 7 November 2016

Identification of novel HCV deletion mutants in chronic hepatitis C patients

scientific article published on 25 July 2012

Impact of interleukin-28B genotype on in vitro and in vivo systems of hepatitis C virus replication

scientific article published on 23 April 2012

Impact of viral amino acid substitutions and host interleukin-28b polymorphism on replication and susceptibility to interferon of hepatitis C virus

scientific article published on 2 August 2011

Impact of viral eradication by DAAs on the risk of HCC development, prognosis and portal hypertension in HCV-related compensated cirrhosis patients

scientific article published on 06 August 2020

Importance of serum concentration of adefovir for Lamivudine-adefovir combination therapy in patients with lamivudine-resistant chronic hepatitis B.

scientific article

Improvement of renal dysfunction in a patient with hepatitis C virus-related liver cirrhosis by daclatasvir and asunaprevir combination therapy: A case report.

scientific article

Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus

scientific article

Interferon lambda 4 polymorphism affects on outcome of telaprevir, pegylated interferon and ribavirin combination therapy for chronic hepatitis C.

scientific article published on 6 May 2014

Interferon stimulated genes and innate immune activation following infection with hepatitis B and C viruses

scientific article

Interleukin-28B polymorphisms and hepatitis C virus clearance.

scientific article published on 29 January 2013

Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state.

scientific article published in September 2011

Involvement of Porphyromonas gingivalis in the progression of non-alcoholic fatty liver disease.

scientific article

Limitations of daclatasvir/asunaprevir plus beclabuvir treatment in cases of NS5A inhibitor treatment failure

scientific article published on 19 June 2018

Liver fibrosis assessments using FibroScan, virtual-touch tissue quantification, the FIB-4 index, and mac-2 binding protein glycosylation isomer levels compared with pathological findings of liver resection specimens in patients with hepatitis C inf

scientific article published on 25 September 2020

Long term persistence of NS5A inhibitor-resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy

scientific article

ME3738 enhances the effect of interferon and inhibits hepatitis C virus replication both in vitro and in vivo.

scientific article published on 29 November 2010

Management of HCV patients in cases of direct-acting antiviral failure

scientific article published on 08 August 2019

MicroRNAs as Biomarkers for Liver Disease and Hepatocellular Carcinoma

scientific article

Molecular Mechanisms of Hepatocarcinogenesis Following Sustained Virological Response in Patients with Chronic Hepatitis C Virus Infection

scientific article published in 2018

New insight into the enhanced effect of pegylated interferon-α.

scientific article

Novel robust in vitro hepatitis B virus infection model using fresh human hepatocytes isolated from humanized mice

scientific article published on 17 March 2015

Optimizing triple therapy and IFN/RBV-free regimens for hepatitis C virus infection

scientific article published on 14 September 2014

PNPLA3 and HLA-DQB1 polymorphisms are associated with hepatocellular carcinoma after hepatitis C virus eradication

scientific article published on 15 October 2020

Pan-genotypic cell culture system for propagation of hepatitis C virus clinical isolates

scientific article published on 2 August 2016

Persistent Loss of Hepatitis B Virus Markers in Serum without Cellular Immunity by Combination of Peginterferon and Entecavir Therapy in Humanized Mice

scientific article published on 10 July 2017

Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b.

scientific article published in June 2011

Predictive value of the IFNL4 polymorphism on outcome of telaprevir, peginterferon, and ribavirin therapy for older patients with genotype 1b chronic hepatitis C.

scientific article published on 21 December 2013

Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b.

scientific article published on 19 September 2010

Prevalence of NS5A resistance associated variants in NS5A inhibitor treatment failures and an effective treatment for NS5A-P32 deleted hepatitis C virus in humanized mice

scientific article published on 2 April 2018

Protease Inhibitor Resistance Remains Even After Mutant Strains Become Undetectable by Deep Sequencing

scientific article published on 20 September 2016

Pruritus in patients with chronic liver disease and serum autotaxin levels in patients with primary biliary cholangitis

scientific article published on 24 October 2019

Publisher Correction: Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP

scientific article published on 05 February 2020

Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo

scientific article published on 2 August 2011

Rapid, Sensitive, and Accurate Evaluation of Drug Resistant Mutant (NS5A-Y93H) Strain Frequency in Genotype 1b HCV by Invader Assay

scientific article

Real-word efficacy of sofosbuvir, velpatasvir plus ribavirin therapy for chronic hepatitis patients who failed to prior DAA therapy with NS5A-P32 deletion mutated HCV infection

scientific article published on 12 July 2020

Real-world efficacy and safety of daclatasvir and asunaprevir therapy for hepatitis C virus-infected cirrhosis patients

scientific article published on 11 August 2016

Real-world efficacy of glecaprevir plus pibrentasvir for chronic hepatitis C patient with previous direct-acting antiviral therapy failures

scientific article published on 17 October 2018

Real-world efficacy of sofosbuvir plus velpatasvir therapy for patients with hepatitis C virus-related decompensated cirrhosis

scientific article published on 11 September 2020

Reduction of hepatitis B surface antigen in sequential versus add-on pegylated interferon to nucleoside/nucleotide analogue therapy in HBe-antigen-negative chronic hepatitis B patients: a pilot study

scientific article published on 01 January 2018

Regression of Idiopathic Thrombocytopenic Purpura in a Patient With Eradication of Hepatitis C Virus by Direct-Acting Antivirals

scientific article published on 11 October 2019

Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP

scientific article published on 11 June 2019

Response to "treatment guidelines for HCV genotype 1: mono for low, triple for high, and dual for 'middle'?"

scientific article published on 13 February 2013

Retrospective Identification of Herpes Simplex 2 Virus-Associated Acute Liver Failure in an Immunocompetent Patient Detected Using Whole Transcriptome Shotgun Sequencing.

scientific article published on 26 December 2017

Ribavirin dose reduction during telaprevir/ribavirin/peg-interferon therapy overcomes the effect of the ITPA gene polymorphism.

scientific article published on 16 June 2014

Ribavirin induces hepatitis C virus genome mutations in chronic hepatitis patients who failed to respond to prior daclatasvir plus asunaprevir therapy

scientific article published on 16 October 2019

Risk factors for histological progression of non-alcoholic steatohepatitis analyzed from repeated biopsy cases

scientific article published on 02 January 2020

Safety and efficacy of dual therapy with daclatasvir and asunaprevir for older patients with chronic hepatitis C.

scientific article published on 8 September 2016

Serum HBV RNA and HBeAg are useful markers for the safe discontinuation of nucleotide analogue treatments in chronic hepatitis B patients.

scientific article

Serum HMGB1 concentrations at 4 weeks is a useful predictor of extreme poor prognosis for advanced hepatocellular carcinoma treated with sorafenib and hepatic arterial infusion chemotherapy.

scientific article

Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse.

scientific article published on 10 July 2012

Signal activation of hepatitis B virus-related hepatocarcinogenesis by upregulation of SUV39h1

scientific article published on 09 June 2020

Successful retreatment with 12 weeks of glecaprevir and pibrentasvir for a genotype 2a HCV-infected hemodialysis patient who failed to respond to 8 weeks of prior glecaprevir and pibrentasvir therapy

scientific article published on 28 August 2019

The Role of Lipids in Hepatocellular Carcinoma

scientific article published on 31 October 2019

The association between serum cytokine and chemokine levels and antiviral response by entecavir treatment in chronic hepatitis B patients

scientific article

The practical management of chronic hepatitis C infection in Japan - dual therapy of daclatasvir + asunaprevir

scientific article published on 12 December 2016

The relationship between HBcrAg and HBV reinfection in HBV related post-liver transplantation patients

scientific article published on 15 July 2016

The risks of hepatocellular carcinoma development after HCV eradication are similar between patients treated with peg-interferon plus ribavirin and direct-acting antiviral therapy.

scientific article published on 10 August 2017

Three patients treated with daclatasvir and asunaprevir for recurrent hepatitis C after liver transplantation: Case report

scientific article published on 6 October 2015

Three patients treated with sofosbuvir plus ledipasvir for recurrent hepatitis C after liver transplantation

scientific article published on 21 February 2017

Toward the establishment of a prediction system for the personalized treatment of chronic hepatitis C.

scientific article published on 28 November 2011

Treatment of HCV patients on hemodialysis with daclatasvir and asunaprevir

scientific article published on 19 August 2016

Treatment of chronic hepatitis C virus infection in Japan: update on therapy and guidelines

scientific article published on 28 November 2012

Tumor Fibroblast Growth Factor Receptor 4 Level Predicts the Efficacy of Lenvatinib in Patients With Advanced Hepatocellular Carcinoma

scientific article published on 01 May 2020

Two patients treated with simeprevir plus pegylated-interferon and ribavirin triple therapy for recurrent hepatitis C after living donor liver transplantation: case report

scientific article published on April 2015

Ultradeep sequencing study of chronic hepatitis C virus genotype 1 infection in patients treated with daclatasvir, peginterferon, and ribavirin.

scientific article

Usefulness of humanized cDNA-uPA/SCID mice for the study of hepatitis B virus and hepatitis C virus virology

scientific article published on 28 January 2017

Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers

scientific journal article

Wisteria floribunda agglutinin positive Mac-2-binding protein level increases in patients with acute liver injury

scientific article

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