List of works - Daniela Pende

2B4 dysfunction in XLP1 NK cells: More than inability to control EBV infection

scientific article published on 02 November 2018

A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes

scientific article published on 31 January 2012

A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin

scientific article published on 01 March 2005

An Historical Overview: The Discovery of How NK Cells Can Kill Enemies, Recruit Defense Troops, and More

scientific article published on 19 June 2019

Analysis of NK cell/DC interaction in NK-type lymphoproliferative disease of granular lymphocytes (LDGL): role of DNAM-1 and NKp30

scientific article published on 04 July 2009

Analysis of memory-like natural killer cells in human cytomegalovirus-infected children undergoing αβ+T and B cell-depleted hematopoietic stem cell transplantation for hematological malignancies

scientific article published on 11 December 2015

Analysis of natural killer-cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease

scientific article (publication date: October 2006)

Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112)

scientific article

Analysis ofKIR3DP1Polymorphism Provides Relevant Information on CentromericKIRGene Content

scientific article published in August 2018

Anti-leukemia activity of alloreactive NK cells in KIR ligand-mismatched haploidentical HSCT for pediatric patients: evaluation of the functional role of activating KIR and redefinition of inhibitory KIR specificity

scientific article

CD56 Homodimerization and Participation in Anti-Tumor Immune Effector Cell Functioning: A Role for Interleukin-15

scientific article published on 22 July 2019

Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies

scientific article published on 09 August 2019

Cellular and molecular basis of haploidentical hematopoietic stem cell transplantation in the successful treatment of high-risk leukemias: role of alloreactive NK cells ⬇️

scientific article published on January 1, 2013

Cellular and molecular basis of natural killer and natural killer-like activity.

scientific article

Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems

scientific article

Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection

scientific article

Combined genotypic and phenotypic killer cell Ig-like receptor analyses reveal KIR2DL3 alleles displaying unexpected monoclonal antibody reactivity: identification of the amino acid residues critical for staining.

scientific article

Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia

scientific article

Dendritic cell recognition by group 3 innate lymphoid cells through DNAX accessory molecule 1 triggers proinflammatory reciprocal cell activation

scientific article published on 24 June 2019

Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis

scientific article published on 27 June 2014

Different checkpoints in human NK-cell activation

scientific article

Direct involvement of CD56 in cytokine-induced killer-mediated lysis of CD56+ hematopoietic target cells.

scientific article published on 6 September 2014

Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value.

scientific article published on 19 March 2007

Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma

scientific article

Dual-functional capability of CD3+CD56+ CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity.

scientific article

ERAP1 regulates natural killer cell function by controlling the engagement of inhibitory receptors

scientific article

Effect of human natural killer and gammadelta T cells on the growth of human autologous melanoma xenografts in SCID mice

scientific article published in January 2004

Effector and regulatory events during natural killer-dendritic cell interactions

scientific article published on December 2006

Expression and function of NKG2D in CD4+ T cells specific for human cytomegalovirus.

scientific article published on December 2006

Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction

scientific article

Familial hemophagocytic lymphohistiocytosis may present during adulthood: clinical and genetic features of a small series.

scientific article

Familial hemophagocytic lymphohistiocytosis: a model for understanding the human machinery of cellular cytotoxicity

scientific article published on 12 October 2011

Familial hemophagocytic lymphohistiocytosis: when rare diseases shed light on immune system functioning

scientific article published on 16 April 2014

Functional evaluation of natural killer cell cytotoxic activity in NFKB2-mutated patients

scientific article published on 23 December 2017

Genetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry

scientific article

Genotype-phenotype study of familial haemophagocytic lymphohistiocytosis type 3

scientific article

HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells

scientific article

HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders

scientific article published on 28 May 2014

Haemophagocytic lymphohistiocytosis: proposal of a diagnostic algorithm based on perforin expression

scientific article

Haploidentical hemopoietic stem cell transplantation for the treatment of high-risk leukemias: how NK cells make the difference

scientific article published on 29 May 2009

Hematopoietic stem cell transplantation: Improving alloreactive Bw4 donor selection by genotyping codon 86 of KIR3DL1/S1.

scientific article published on 18 March 2016

Histone deacetylase inhibitors sensitize tumour cells for cytotoxic effects of natural killer cells

scientific article

Human NK Cells Lyse Th2-Polarizing Dendritic Cells via NKp30 and DNAM-1

scientific article published on 17 August 2018

Human NK cells and their receptors.

scientific article

Human NK cells: From surface receptors to clinical applications

scientific article published on 13 May 2016

Human NK cells: from surface receptors to the therapy of leukemias and solid tumors

scientific article published on 07 March 2014

Human NK receptors: from the molecules to the therapy of high risk leukemias.

scientific article published on 07 May 2011

Human natural killer cells: Molecular mechanisms controlling NK cell activation and tumor cell lysis

scientific article

Human natural killer cells: news in the therapy of solid tumors and high-risk leukemias.

scientific article published on 20 August 2015

Human natural killer cells: their origin, receptors and function

scientific article (publication date: May 2002)

Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule

scientific article

Inhibition of NKG2D expression in NK cells by cytokines secreted in response to human cytomegalovirus infection

article

Inhibitory 2B4 contributes to NK cell education and immunological derangements in XLP1 patients.

scientific article published on 6 April 2017

Inhibitory Receptor Signals Suppress Ligation-Induced Recruitment of NKG2D to GM1-Rich Membrane Domains at the Human NK Cell Immune Synapse

scientific article published on 01 May 2007

Inhibitory Receptors and Checkpoints in Human NK Cells, Implications for the Immunotherapy of Cancer

scientific article published on 03 September 2020

Isolation of a novel KIR2DL3-specific mAb: comparative analysis of the surface distribution and function of KIR2DL2, KIR2DL3 and KIR2DS2.

scientific article

Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation.

scientific article published on 28 May 2019

Killer Ig–like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation ⬇️

scientific article published on January 20, 2011

Learning how to discriminate between friends and enemies, a lesson from Natural Killer cells.

scientific article published in July 2004

Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals

scientific article

Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity

scientific article published on 01 November 2002

Markers and function of human NK cells in normal and pathological conditions

scientific article published on 5 January 2017

Modulation of CD112 by the alphaherpesvirus gD protein suppresses DNAM-1-dependent NK cell-mediated lysis of infected cells

scientific article

Molecular basis of familial hemophagocytic lymphohistiocytosis

scientific article published on April 2010

Mutations affecting mRNA splicing are the most common molecular defect in patients with familial hemophagocytic lymphohistiocytosis type 3

scientific article

Myeloma cells induce the accumulation of activated CD94low NK cells by cell-to-cell contacts involving CD56 molecules

scientific article published on 01 May 2020

NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo.

scientific article published on 06 April 2009

NK Cell-Based Immunotherapy for Hematological Malignancies

scientific article published on 16 October 2019

NK Cells Mediate a Crucial Graft-versus-Leukemia Effect in Haploidentical-HSCT to Cure High-Risk Acute Leukemia

scientific article published on 21 May 2018

NK cells and ILCs in tumor immunotherapy

scientific article published on 13 August 2020

NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor

scientific article (publication date: 15 July 2005)

NKG2D engagement of colorectal cancer-specific T cells strengthens TCR-mediated antigen stimulation and elicits TCR independent anti-tumor activity

scientific article published on July 2003

NKG2D-mediated antitumor activity by tumor-infiltrating lymphocytes and antigen-specific T-cell clones isolated from melanoma patients

scientific article published on December 2007

NKp46 and DNAM-1 NK-cell receptors drive the response to human cytomegalovirus-infected myeloid dendritic cells overcoming viral immune evasion strategies

article

NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells

scientific article published in May 1999

Natural Killer (NK)/melanoma cell interaction induces NK-mediated release of chemotactic High Mobility Group Box-1 (HMGB1) capable of amplifying NK cell recruitment.

scientific article published on 29 May 2015

Natural Killer Cells Efficiently Reject Lymphoma Silenced for the Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing

scientific article published on 20 January 2011

Natural Killer andNK-LikeT-Cell Activation in Colorectal Carcinoma Patients Treated with Autologous Tumor-Derived Heat Shock Protein 96

scientific article published on 01 May 2005

Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction.

scientific article

Natural killer cells in lymph nodes of healthy calves express CD16 and show both cytotoxic and cytokine-producing properties

scientific article published on 18 December 2007

Natural killer cells: From surface receptors to the cure of high-risk leukemia (Ceppellini Lecture)

scientific article published on 01 April 2019

Neuroradiologic findings and follow‐up with magnetic resonance imaging of the genetic forms of haemophagocytic lymphohistiocytosis with CNS involvement ⬇️

scientific article published on November 21, 2011

Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion

scientific article published on 06 June 2017

Ovine CD16+/CD14- blood lymphocytes present all the major characteristics of natural killer cells

scientific article published on 16 September 2009

PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis

scientific article

Patients with Griscelli syndrome and normal pigmentation identify RAB27A mutations that selectively disrupt MUNC13-4 binding

scientific article published on 11 October 2014

Phenotypic and Functional Characterization of NK Cells in αβT-Cell and B-Cell Depleted Haplo-HSCT to Cure Pediatric Patients with Acute Leukemia

scientific article published on 05 August 2020

Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses

scientific article published on 11 January 2007

Report from the Eleventh Killer Immunoglobulin-like Receptor (KIR) Workshop: Novel insights on KIR polymorphism, ligand recognition, expression and function

scientific article published on 01 August 2019

STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5

scientific article

Surface NK receptors and their ligands on tumor cells

scientific article

Susceptibility of human melanoma cells to autologous natural killer (NK) cell killing: HLA-related effector mechanisms and role of unlicensed NK cells

scientific article

The Activating Human NK Cell Receptor KIR2DS2 Recognizes a β2-Microglobulin-Independent Ligand on Cancer Cells

scientific article published on 15 February 2017

Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction

scientific article published on 11 September 2009

Variations of the UNC13D gene in patients with autoimmune lymphoproliferative syndrome

scientific article

XLP1 inhibitory effect by 2B4 does not affect DNAM-1 and NKG2D activating pathways in NK cells.

scientific article published on 27 February 2014

γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ+/CD19+ lymphocytes

scientific article published on 22 January 2015

List of works by Daniela Pende

2B4 dysfunction in XLP1 NK cells: More than inability to control EBV infection

A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes

A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin

An Historical Overview: The Discovery of How NK Cells Can Kill Enemies, Recruit Defense Troops, and More

Analysis of NK cell/DC interaction in NK-type lymphoproliferative disease of granular lymphocytes (LDGL): role of DNAM-1 and NKp30

Analysis of memory-like natural killer cells in human cytomegalovirus-infected children undergoing αβ+T and B cell-depleted hematopoietic stem cell transplantation for hematological malignancies

Analysis of natural killer-cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease

Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112)

Analysis ofKIR3DP1Polymorphism Provides Relevant Information on CentromericKIRGene Content

Anti-leukemia activity of alloreactive NK cells in KIR ligand-mismatched haploidentical HSCT for pediatric patients: evaluation of the functional role of activating KIR and redefinition of inhibitory KIR specificity

CD56 Homodimerization and Participation in Anti-Tumor Immune Effector Cell Functioning: A Role for Interleukin-15

Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies

Cellular and molecular basis of haploidentical hematopoietic stem cell transplantation in the successful treatment of high-risk leukemias: role of alloreactive NK cells ⬇️

Cellular and molecular basis of natural killer and natural killer-like activity.

Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems

Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection

Combined genotypic and phenotypic killer cell Ig-like receptor analyses reveal KIR2DL3 alleles displaying unexpected monoclonal antibody reactivity: identification of the amino acid residues critical for staining.

Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia

Dendritic cell recognition by group 3 innate lymphoid cells through DNAX accessory molecule 1 triggers proinflammatory reciprocal cell activation

Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis

Different checkpoints in human NK-cell activation

Direct involvement of CD56 in cytokine-induced killer-mediated lysis of CD56+ hematopoietic target cells.

Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value.

Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma

Dual-functional capability of CD3+CD56+ CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity.

ERAP1 regulates natural killer cell function by controlling the engagement of inhibitory receptors

Effect of human natural killer and gammadelta T cells on the growth of human autologous melanoma xenografts in SCID mice

Effector and regulatory events during natural killer-dendritic cell interactions

Expression and function of NKG2D in CD4+ T cells specific for human cytomegalovirus.

Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction

Familial hemophagocytic lymphohistiocytosis may present during adulthood: clinical and genetic features of a small series.

Familial hemophagocytic lymphohistiocytosis: a model for understanding the human machinery of cellular cytotoxicity

Familial hemophagocytic lymphohistiocytosis: when rare diseases shed light on immune system functioning

Functional evaluation of natural killer cell cytotoxic activity in NFKB2-mutated patients

Genetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry

Genotype-phenotype study of familial haemophagocytic lymphohistiocytosis type 3

HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells

HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders

Haemophagocytic lymphohistiocytosis: proposal of a diagnostic algorithm based on perforin expression

Haploidentical hemopoietic stem cell transplantation for the treatment of high-risk leukemias: how NK cells make the difference

Hematopoietic stem cell transplantation: Improving alloreactive Bw4 donor selection by genotyping codon 86 of KIR3DL1/S1.

Histone deacetylase inhibitors sensitize tumour cells for cytotoxic effects of natural killer cells

Human NK Cells Lyse Th2-Polarizing Dendritic Cells via NKp30 and DNAM-1

Human NK cells and their receptors.

Human NK cells: From surface receptors to clinical applications

Human NK cells: from surface receptors to the therapy of leukemias and solid tumors

Human NK receptors: from the molecules to the therapy of high risk leukemias.

Human natural killer cells: Molecular mechanisms controlling NK cell activation and tumor cell lysis

Human natural killer cells: news in the therapy of solid tumors and high-risk leukemias.

Human natural killer cells: their origin, receptors and function

Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule

Inhibition of NKG2D expression in NK cells by cytokines secreted in response to human cytomegalovirus infection

Inhibitory 2B4 contributes to NK cell education and immunological derangements in XLP1 patients.

Inhibitory Receptor Signals Suppress Ligation-Induced Recruitment of NKG2D to GM1-Rich Membrane Domains at the Human NK Cell Immune Synapse

Inhibitory Receptors and Checkpoints in Human NK Cells, Implications for the Immunotherapy of Cancer

Isolation of a novel KIR2DL3-specific mAb: comparative analysis of the surface distribution and function of KIR2DL2, KIR2DL3 and KIR2DS2.

Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation.

Killer Ig–like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation ⬇️

Learning how to discriminate between friends and enemies, a lesson from Natural Killer cells.

Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals

Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity

Markers and function of human NK cells in normal and pathological conditions

Modulation of CD112 by the alphaherpesvirus gD protein suppresses DNAM-1-dependent NK cell-mediated lysis of infected cells

Molecular basis of familial hemophagocytic lymphohistiocytosis

Mutations affecting mRNA splicing are the most common molecular defect in patients with familial hemophagocytic lymphohistiocytosis type 3

Myeloma cells induce the accumulation of activated CD94low NK cells by cell-to-cell contacts involving CD56 molecules

NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo.

NK Cell-Based Immunotherapy for Hematological Malignancies

NK Cells Mediate a Crucial Graft-versus-Leukemia Effect in Haploidentical-HSCT to Cure High-Risk Acute Leukemia

NK cells and ILCs in tumor immunotherapy

NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor

NKG2D engagement of colorectal cancer-specific T cells strengthens TCR-mediated antigen stimulation and elicits TCR independent anti-tumor activity

NKG2D-mediated antitumor activity by tumor-infiltrating lymphocytes and antigen-specific T-cell clones isolated from melanoma patients

NKp46 and DNAM-1 NK-cell receptors drive the response to human cytomegalovirus-infected myeloid dendritic cells overcoming viral immune evasion strategies

NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells

Natural Killer (NK)/melanoma cell interaction induces NK-mediated release of chemotactic High Mobility Group Box-1 (HMGB1) capable of amplifying NK cell recruitment.

Natural Killer Cells Efficiently Reject Lymphoma Silenced for the Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing

Natural Killer andNK-LikeT-Cell Activation in Colorectal Carcinoma Patients Treated with Autologous Tumor-Derived Heat Shock Protein 96

Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction.