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List of works by Ireneusz Majsterek

A comparison of the action of amifostine and melatonin on DNA-damaging effects and apoptosis induced by idarubicin in normal and cancer cells.

scientific article published in May 2005

A/G Polymorphism of the MMP-7 Gene Promoter Region in Colorectal Cancer

scientific article published on November 2011

ABL-fusion oncoproteins activate multi-pathway of DNA repair: role in drug resistance?

scientific article published on January 2004

Advances in antioxidative therapy of multiple sclerosis

scientific article published on January 2013

Altered Expression Levels of MMP1, MMP9, MMP12, TIMP1, and IL-1β as a Risk Factor for the Elevated IOP and Optic Nerve Head Damage in the Primary Open-Angle Glaucoma Patients

scientific article published on 11 May 2015

Altered Expression of miRNAs Is Related to Larynx Cancer TNM Stage and Patients' Smoking Status

scientific article published on 21 April 2017

An association between vascular endothelial growth factor gene promoter polymorphisms and diabetic retinopathy

article

An association of selected ERCC2 and ERCC5 genes polymorphisms, the level of oxidative DNA damage and its repair efficiency with a risk of colorectal cancer in Polish population

scientific article published on 2 April 2015

An association of the MCP-1 and CCR2 single nucleotide polymorphisms with colorectal cancer prevalence

scientific article published in October 2017

An association selected polymorphisms of XRCC1, OGG1 and MUTYH gene and the level of efficiency oxidative DNA damage repair with a risk of colorectal cancer

scientific article published on 23 April 2013

An evaluation of the antioxidant and anticancer properties of complex compounds of copper(II), platinum(II), palladium(II) and ruthenium(III) for use in cancer therapy

scientific article published on 23 April 2018

Analysis of antioxidative factors related to AMD risk development in the polish patients.

scientific article

Analysis of oxidative DNA damage and its repair in Polish patients with diabetes mellitus type 2: Role in pathogenesis of diabetic neuropathy

scientific article published on 13 April 2015

Analysis of the expression and polymorphism of APOE, HSP, BDNF, and GRIN2B genes associated with the neurodegeneration process in the pathogenesis of primary open angle glaucoma

scientific article

Analysis of the polymorphic variants of RAN and GEMIN3 genes and risk of Primary Open-Angle Glaucoma in the Polish population

scientific article

Analysis of the polymorphic variants of genes involved in miRNA pathway and its impact on matrix metalloproteinases (MMPs) in pathogenesis of primary open angle galucoma

article

Angiogenesis markers quantification in breast cancer and their correlation with clinicopathological prognostic variables

scientific article

Antioxidant properties of trans-3,3',5,5'-tetrahydroxy-4'-methoxystilbene against modification of variety of biomolecules in human blood cells treated with platinum compounds

scientific article published on 01 November 2006

Assessment of DNA damage profile and oxidative /antioxidative biomarker level in patients with inflammatory bowel disease

scientific article published on 01 May 2020

Association between SOD1, CAT, GSHPX1 polymorphisms and the risk of inflammatory bowel disease in the Polish population

scientific article published on 27 November 2017

Association between sorbitol dehydrogenase gene polymorphisms and type 2 diabetic retinopathy

scientific article

Association of -1112 c/t promoter region polymorphism of the interleukin 13 gene with occurrence of colorectal cancer

scientific article published on 01 January 2011

Association of IL1β and IL4 gene polymorphisms with nasal polyps in a Polish population.

scientific article

Association of MMP1-1607 1G/2G and TIMP1 372 T/C gene polymorphisms with risk of primary open angle glaucoma in a Polish population

scientific article published on July 2011

Association of Polymorphic Variants of miRNA Processing Genes with Larynx Cancer Risk in a Polish Population

scientific article

Association of Thr241Met polymorphism of XRCC3 gene with risk of colorectal cancer in the Polish population

scientific article published in October 2013

Association of XRCC6 C1310G and LIG4 T9I polymorphisms of NHEJ DNA repair pathway with risk of colorectal cancer in the Polish population

scientific article published on 01 March 2019

Association of apolipoprotein E with a risk of primary open-angle glaucoma

Association of microRNA DGCR8 and XPO5 gene polymorphisms with the risk of primary open angle glaucoma occurrence

article

Association of polymorphic variants of miRNA processing genes DGCR8 and XPO5 with primary open-angle glaucoma risk in a Polish population

article

Association of polymorphism of Lys589Glu Exo1 gene with the risk of colorectal cancer in the Polish population.

scientific article published in August 2014

Association of the -14C/G MET and the -765G/C COX-2 gene polymorphisms with the risk of chronic rhinosinusitis with nasal polyps in a Polish population

scientific article

Association of the -33C/G OSF-2 and the 140A/G LF gene polymorphisms with the risk of chronic rhinosinusitis with nasal polyps in a Polish population.

scientific article published on 16 December 2011

Association of the 399Arg/Gln XRCC1, the 194 Arg/Trp XRCC1, the 326Ser/Cys OGG1, and the 324Gln/His MUTYH gene polymorphisms with clinical parameters and the risk for development of primary open-angle glaucoma

scientific article published on 7 March 2013

Association of the Arg194Trp and the Arg399Gln polymorphisms of the XRCC1 gene with risk occurrence and the response to adjuvant therapy among Polish women with breast cancer

scientific article published on 26 October 2012

Association of the expression level of the neurodegeneration-related proteins with the risk of development and progression of primary open-angle glaucoma

scientific article published on 27 May 2017

Association of the-801G/A Polymorphism of CXCL12 Gene with the Risk of Inflammatory Bowel Diseases Development in a Polish Population ⬇️

scientific article published on 01 June 2011

BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance

scientific article published on 9 March 2006

BDNF and HSP gene polymorphisms and their influence on the progression of primary open-angle glaucoma in a Polish population

scientific article

Biological properties of benzopyran-based platinum (II) complexes

scientific article published in April 2014

Breaking the DNA damage response via serine/threonine kinase inhibitors to improve cancer treatment

scientific article published on 16 January 2018

Carbon nanotubes functionalized with folic acid attached via biomimetic peptide linker

scientific article published on 17 August 2017

Chlorophenols, chlorocatechols and chloroguaiacols induce DNA base oxidation in human lymphocytes (in vitro).

scientific article published on 16 December 2009

Circulating Tumor Cells In Colorectal Cancer.

scientific article published on May 2015

Comparative study of DNA damage and repair in head and neck cancer after radiation treatment

scientific article published on 01 March 2009

Comparative study of DNA damage, cell cycle and apoptosis in human K562 and CCRF-CEM leukemia cells: role of BCR/ABL in therapeutic resistance.

scientific article

Comparison of the effect of three different topoisomerase II inhibitors combined with cisplatin in human glioblastoma cells sensitized with double strand break repair inhibitors

scientific article published on 24 April 2019

Contribution of the -173 G/C polymorphism of macrophage migration inhibitory factor gene to the risk of inflammatory bowel diseases

scientific article published on 01 February 2011

Corrigendum to “Interplay between the pro-oxidant and antioxidant system, and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression” [Free Rad. Bio. Med. 63C (2013) 187–194]

scholarly article published in Free Radical Biology and Medicine

DNA damage and oxidant-antioxidant status in blood of patients with head and neck cancer

scientific article published on 09 December 2014

DNA damage and repair of head and neck cancer cells after radio- and chemotherapy

scientific article published on July 2009

DNA double strand breaks repair and apoptosis induction in peripheral blood lymphocytes of head and neck cancer patients

scientific article published on 01 September 2009

Decreased expression level of BER genes in Alzheimer's disease patients is not derivative of their DNA methylation status.

scientific article published on 11 July 2017

Discovery of New Cyclopentaquinoline Analogues as Multifunctional Agents for the Treatment of Alzheimer's Disease

scientific article published on 24 January 2019

Distribution of C-->T and T-->C polymorphisms of the urokinase-type plasminogen activator gene in children with type 1 diabetes mellitus and insulin resistance.

scientific article

Does the bcr/abl-mediated increase in the efficacy of DNA repair play a role in the drug resistance of cancer cells?

scientific article

Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis

scientific article published on 05 September 2019

Effect of Cu(II) Coordination Compounds on the Activity of Antioxidant Enzymes Catalase and Superoxide Dismutase in Patients with Colorectal Cancer ⬇️

scientific article published on 01 March 2011

Effect of copper(II) the activity of glutathione peroxidase in patients with head and neck cancer

scientific article published on November 2016

Effect of short-term cryostimulation on antioxidative status and its clinical applications in humans

scientific article published on 28 August 2011

Efficiency of Base Excision Repair of Oxidative DNA Damage and Its Impact on the Risk of Colorectal Cancer in the Polish Population

scientific article

Environmental factors increasing the risk of activation and development of inflammatory bowel diseases

scientific article published on 27 June 2020

Ethylene glycol dimethacrylate and diethylene glycol dimethacrylate exhibits cytotoxic and genotoxic effect on human gingival fibroblasts via induction of reactive oxygen species.

scientific article

Evaluation Of Antioxidant Defense In Patients With Colorectal Carcinoma

scientific article published on 01 July 2015

Evaluation of DNA double strand breaks repair efficiency in head and neck cancer

scientific article published on 29 August 2011

Evaluation of Effect CAT -262C/T, SOD + 35A/C, GPx1 Pro197Leu Polymorphisms in Patients with IBD in the Polish Population.

scientific article

Evaluation of MMP-1 gene expression variants as a risk factors of primary open-angle glaucoma

article

Evaluation of enterochromaffin cells and melatonin secretion exponents in ulcerative colitis

scientific article published on June 2013

Evaluation of oxidative DNA damage and antioxidant defense in patients with nasal polyps.

scientific article published on 13 January 2015

Evaluation of oxidative stress markers in pathogenesis of diabetic neuropathy

scientific article

Evaluation of oxidative stress markers in pathogenesis of primary open-angle glaucoma

scientific article published on 15 January 2011

Evaluation of polymorphisms in microRNA biosynthesis genes and risk of laryngeal cancer in the Polish population

scientific article

Evaluation of selected indicators of antioxidant status in patients with head and neck cancer

scientific article

Evaluation of the impact of radical tumor resection in lung cancer patients on the activity of selected antioxidant enzymes

scientific article

Evaluation pro/antioxidant balance in patients with wet form of age-related macular degeneration

scientific article published in January 2016

Expression of POSTN, IL-4, and IL-13 in Chronic Rhinosinusitis with Nasal Polyps.

scientific article

Expression of the PLS3 Gene in Circulating Cells in Patients with Colorectal Cancer.

scientific article published in February 2015

Fusion oncogenic tyrosine kinases alter DNA damage and repair after genotoxic treatment: role in drug resistance?

scientific article published on March 2003

Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis

scientific article

Gene polymorphisms and antigen levels of matrix metalloproteinase-1 in type 2 diabetes mellitus coexisting with coronary heart disease.

scientific article

Gene polymorphisms of the MMP1, MMP9, MMP12, IL-1β and TIMP1 and the risk of primary open-angle glaucoma

scientific article published on 25 June 2013

Genetic polymorphisms (Pro197Leu of Gpx1, +35A/C of SOD1, -262C/T of CAT), the level of antioxidant proteins (GPx1, SOD1, CAT) and the risk of distal symmetric polyneuropathy in Polish patients with type 2 diabetes mellitus

scientific article published on 10 November 2015

Genetic polymorphisms in DNA base excision repair gene XRCC1 and the risk of squamous cell carcinoma of the head and neck

scientific article published on 13 March 2009

Genotoxicity of idarubicin and its modulation by vitamins C and E and amifostine

scientific article published in April 2002

Hyperglycemia Changes Expression of Key Adipogenesis Markers (C/EBPα and PPARᵞ)and Morphology of Differentiating Human Visceral Adipocytes

scientific article published on 08 August 2019

Imatinib (STI571) inhibits DNA repair in human leukemia oncogenic tyrosine kinase-expressing cells

scientific article published on 01 November 2006

Imatinib mesylate (STI571) abrogates the resistance to doxorubicin in human K562 chronic myeloid leukemia cells by inhibition of BCR/ABL kinase-mediated DNA repair.

scientific article published on 4 January 2006

Immunometabolic disorders in the pathogenesis of systemic lupus erythematosus

scientific article published on 01 October 2019

Impact of APEX Ile64val Gene Polymorphisms of DNA Repair Ber System on Modulation of the Risk of Colorectal Cancer in the Polish Population.

scientific article published on March 2015

Impact of the Ser326Cys polymorphism of the OGG1 gene on the level of oxidative DNA damage in patients with colorectal cancer

scientific article published on 01 April 2018

Impaired nucleotide excision repair pathway as a possible factor in pathogenesis of head and neck cancer.

scientific article

Influence of complex deacon-tetra (N1,3-triazole,кN2) copper (II) on the barrier and antioxidant pro people with nasal polyps

scientific article published on 13 February 2013

Inhibition of PERK-dependent pro-adaptive signaling pathway as a promising approach for cancer treatment.

scientific article published in June 2017

Inhibition of the PERK-Dependent Unfolded Protein Response Signaling Pathway Involved in the Pathogenesis of Alzheimer's Disease

scientific article published on 01 January 2019

Interplay between Redox Signaling, Oxidative Stress, and Unfolded Protein Response (UPR) in Pathogenesis of Human Diseases

scientific article published on 07 April 2019

Interplay between the pro-oxidant and antioxidant systems and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression

scientific article published on 23 May 2013

Lack of association between the 135G/C RAD51 gene polymorphism and the risk of colorectal cancer among Polish population

article

MUTYH Tyr165Cys, OGG1 Ser326Cys and XPD Lys751Gln polymorphisms and head neck cancer susceptibility: a case control study

scientific article published on 23 June 2010

Melatonin reduces oxidative stress in the erythrocytes of multiple sclerosis patients with secondary progressive clinical course

scientific article published on 19 March 2013

MicroRNAs in glaucoma and neurodegenerative diseases

scientific article

Modulation of Colorectal Cancer Risk by Polymorphisms in 51Gln/His, 64Ile/Val, and 148Asp/Glu of APEX Gene; 23Gly/Ala of XPA Gene; and 689Ser/Arg of ERCC4 Gene.

scientific article

Molecular basis of human diseases and targeted therapy based on small-molecule inhibitors of ER stress-induced signaling pathways

scientific article published on 6 March 2017

Neurodegenerative Genes Polymorphisms of the -491A/T APOE, the -877T/C APP and the Risk of Primary Open-angle Glaucoma in the Polish Population.

scientific article

New Tetrahydroacridine Hybrids with Dichlorobenzoic Acid Moiety Demonstrating Multifunctional Potential for the Treatment of Alzheimer's Disease

scientific article published on 26 May 2020

New cyclopentaquinoline hybrids with multifunctional capacities for the treatment of Alzheimer's disease

scientific article published in December 2017

New tacrine-acridine hybrids as promising multifunctional drugs for potential treatment of Alzheimer's disease

scientific article published on 05 June 2018

Novel tetrahydroacridine and cyclopentaquinoline derivatives with fluorobenzoic acid moiety induce cell cycle arrest and apoptosis in lung cancer cells by activation of DNA damage signaling.

scientific article

Nucleotide Excision Repair Capacity and XPC and XPD Gene Polymorphism Modulate Colorectal Cancer Risk

scientific article published on 10 January 2017

Oxidative modification of patient's plasma proteins and its role in pathogenesis of multiple sclerosis

scientific article published on 14 October 2011

PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma.

scientific article

Polymorphism of Gly39Glu (c.116G>A) hMSH6 is associated with sporadic colorectal cancer development in the Polish population: Preliminary results

scientific article published in December 2017

Polymorphism of MSH2 Gly322Asp and MLH1 -93G>A in non-familial colon cancer - a case-controlled study

scientific article published on 3 April 2017

Polymorphism within the distal RAD51 gene promoter is associated with colorectal cancer in a Polish population

scientific article

Polymorphisms of the BRCA2 and RAD51 genes in breast cancer.

scientific article

Polymorphisms of the DNA base excision repair gene MUTYH in head and neck cancer.

scientific article published in March 2009

Polymorphisms of the XRCC3 C722T and the RAD51 G135C genes and the risk of head and neck cancer in a Polish population

scientific article published on 8 September 2010

Potential of redox therapies in neurodegenerative disorders.

scientific article published on March 2017

Potential therapeutic application of PERK inhibitors

scientific article published on 06 June 2019

Practical applications of recombinant alpha-1-antitrypsin in medicine

scientific article published on December 1, 2010

Procollagen VII Self-Assembly Depends on Site-Specific Interactions and Is Promoted by Cleavage of the NC2 Domain with Procollagen C-Proteinase ⬇️

scientific article published on October 7, 2003

Prospects and limitations of the rational engineering of fibrillar collagens

scientific article published on September 2003

Reactive oxygen species promote localized DNA damage in glaucoma-iris tissues of elderly patients vulnerable to diabetic injury.

scientific article published on 10 February 2010

Relation between sonic hedgehog pathway gene polymorphisms and basal cell carcinoma development in the Polish population

scientific article published on 21 November 2015

Resveratrol may reduce oxidative stress induced by platinum compounds in human plasma, blood platelets and lymphocytes.

scientific article published in July 2005

Role of base-excision repair in the treatment of childhood acute lymphoblastic leukaemia with 6-mercaptopurine and high doses of methotrexate

scientific article

Role of impaired DNA repair in genotoxic susceptibility of patients with head and neck cancer

scientific article published on 12 September 2008

Role of the -765 G/C polymorphism of COX-2 gene in pathogenesis of chronic rhinosinusitis with nose polyps in a Polish population

scientific article published in May 2012

Significance of CYCLOOXYGENASE-2(COX-2), PERIOSTIN (POSTN) and INTERLEUKIN-4(IL-4) gene expression in the pathogenesis of chronic rhinosinusitis with nasal polyps.

scientific article

Single nucleotide polymorphisms of NR3C1 gene and recurrent depressive disorder in population of Poland

scientific article published on 17 October 2012

Sirt3 regulates the level of mitochondrial DNA repair activity through deacetylation of NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 in colorectal cancer

scientific article published on 01 November 2019

TC2 C776G polymorphism studies in patients with oral cancer in the Polish population

scientific article published on January 2016

TEL-fusion oncogenic tyrosine kinases determine leukemic cells response to idarubicin

scientific article published on September 2003

Tetrahydroacridine derivatives with dichloronicotinic acid moiety as attractive, multipotent agents for Alzheimer's disease treatment

scientific article published on 9 January 2018

Tetrahydroacridine derivatives with fluorobenzoic acid moiety as multifunctional agents for Alzheimer's disease treatment

scientific article published on 5 May 2017

The -1562C/T MMP-9 and the -511C/T IL-1β gene polymorphisms in primary open-angle glaucoma patients

article

The -2518 A/G MCP-1 Polymorphism as a Risk Factor of Inflammatory Bowel Disease ⬇️

scientific article published on May 1, 2012

The -553 T/A polymorphism in the promoter region of the FGF2 gene is associated with increased breast cancer risk in Polish women

scientific article published on 23 January 2014

The 116G > A MSH6 and IVS1-1121C > T PMS2 Genes Polymorphisms Modulate the Risk of the Sporadic Colorectal Cancer Development in Polish Population

scientific article published on 27 April 2017

The Cytotoxicity and Genotoxicity of Three Dental Universal Adhesives-An In Vitro Study

scientific article published on 31 May 2020

The Genetic and Endoplasmic Reticulum-Mediated Molecular Mechanisms of Primary Open-Angle Glaucoma

scientific article published on 11 June 2020

The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases

scientific article published on 19 March 2020

The Role of the ER-Induced UPR Pathway and the Efficacy of Its Inhibitors and Inducers in the Inhibition of Tumor Progression

scientific article published on 03 February 2019

The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress

scientific article

The Role of the XPF Gene Polymorphism (Xrcc4) Ser835ser in the Risk of Malignant Transformation of Cells in the Colorectal Cancer.

scientific article published on February 2015

The Trp64Arg beta3-adrenergic receptor amino-acid variant is not associated with overweight and type 2 diabetes mellitus in Polish population.

scientific article published in December 2005

The analysis of single nucleotide polymorphisms of the DGCR8 and XPO5 genes, and their association with the incidence of primary open angle glaucoma

article published in 2016

The association of polymorphisms in DNA base excision repair genes XRCC1, OGG1 and MUTYH with the risk of childhood acute lymphoblastic leukemia

scientific article published on 04 April 2010

The effects of whole-body cryotherapy and melatonin supplementation on total antioxidative status and some antioxidative enzymes in multiple sclerosis patients

scientific article published on 01 September 2011

The lL-8 and IL-13 gene polymorphisms in inflammatory bowel disease and colorectal cancer

scientific article

The protective role of the -735C/T and the -1306C/T polymorphisms of the MMP-2 gene in the development of primary open-angle glaucoma

scientific article published on 31 May 2013

The relationship between HDAC6, CXCR3, and SIRT1 genes expression levels with progression of primary open-angle glaucoma

scientific article published on 31 January 2018

The relationship of TP53 and GRIN2B gene polymorphisms with risk of occurrence and progression of primary open-angle glaucoma in a Polish population

article

The relationship of TP53 and GRIN2B gene polymorphisms with risk of occurrence and progression of primary open-angle glaucoma in a Polish population.

scientific article published in December 2014

The role of Cat -262C/T, GPX1 Pro198Leu and Sod1+35A/C gene polymorphisms in a development of primary open-angle glaucoma in a Polish population

scientific article published on January 2016

The role of base excision repair in pathogenesis of breast cancer in the Polish population.

scientific article published on 19 November 2015

The role of base excision repair in the development of primary open angle glaucoma in the Polish population

scientific article published on 19 May 2015

The role of oncogenic tyrosine kinases in the cellular response to anticancer therapy

scientific article

The role of polymorphisms of genes CXCL12/CXCR4 and MIF in the risk development IBD the Polish population

scientific article published on 01 April 2014

The role of the 148 Asp/Glu polymorphism of the APE1 gene in the development and progression of primary open angle glaucoma development in the Polish population

scientific article published on December 2013

The role of the endoplasmic reticulum stress in depression

scientific article published on 30 June 2020

Thermostability gradient in the collagen triple helix reveals its multi-domain structure

scientific article published in May 2004

Toxicity of microcystin from cyanobacteria growing in a source of drinking water

scientific article published in October 2004

Tumor progression and the different faces of the PERK kinase

scientific article

Tumour protein 53 is linked with type 2 diabetes mellitus

scientific article published in August 2017

Tyrosine kinase blockers: new hope for successful cancer therapy.

scientific article published on January 2009

Tyrosine kinases. New target of anticancer therapy

scientific article published in January 2005

Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer's Disease

scientific article published on 17 August 2015

Use of Small-molecule Inhibitory Compound of PERK-dependent Signaling Pathway as a Promising Target-based Therapy for Colorectal Cancer

scientific article published on 01 January 2020

VDR polymorphisms effect on bone mineral density in Polish postmenopausal women

scientific article published on 28 September 2021

[Genetic predeterminations of head and neck cancer]

scientific article published on 23 September 2008

[Matrix metalloproteinases (MMPs): modern molecular markers of open-angle glaucoma diagnosis and therapy]

scientific article published on 31 October 2008

[Molecular basis of diabetic retinopathy]

scientific article published on 07 December 2007

[Niskocząsteczkowe inhibitory szlaku adaptacyjnej odpowiedzi na stres zależnego od kinazy PERK jako nowatorska strategia terapeutyczna w leczeniu choroby Alzheimera]

scientific article published on 01 January 2019

[Philadelphia chromosome]

scientific article published on 01 January 2002

[Small molecule inhibitors of PERK-dependent signaling pathway as a novel, therapeutic molecular strategy in Alzheimer's disease treatment].

scientific article published in July 2016

[The role of the adaptive stress response in the pathogenesis of neurodegenerative diseases, cancer and diabetes mellitus type 2].

scientific article published in December 2015

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