List of works - Fernanda De Felice

A Key Role of Insulin Receptors in Memory

scientific article published in November 2015

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

scientific article

Activation of D1/D5 dopamine receptors protects neurons from synapse dysfunction induced by amyloid-beta oligomers

scientific article

Activation of GABA(A) receptors by taurine and muscimol blocks the neurotoxicity of beta-amyloid in rat hippocampal and cortical neurons

scientific article

Acute and chronic neurological consequences of early-life Zika virus infection in mice.

scientific article published in June 2018

Alzheimer's disease and insulin resistance: translating basic science into clinical applications

scientific article

Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.

scientific article published in October 2014

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers

scientific article

Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.

scientific article

Amyloid beta oligomers induce impairment of neuronal insulin receptors

scientific article published on 24 August 2007

Amyloid-beta oligomers increase the localization of prion protein at the cell surface

scientific article published on 23 March 2011

Amyloid-β oligomers induce differential gene expression in adult human brain slices

scientific article published on 10 January 2012

Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons

scientific article

Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria

scientific article

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

scientific article published in April 2012

Are Alzheimer's disease and other neurodegenerative disorders caused by impaired signalling of insulin and other hormones?

scientific article published on 18 May 2018

Association between diabetes and mood disorders and the potential use of anti-hyperglycemic agents as antidepressants

scientific article published on 25 July 2019

Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model.

scientific article published on 8 June 2017

Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via CaM kinase II signaling

scientific article published on 10 July 2014

Behavioral Abnormalities in Knockout and Humanized Tau Mice

scientific article published on 12 March 2020

Beta-amyloid production, aggregation, and clearance as targets for therapy in Alzheimer's disease

scientific article

Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson's disease-like symptoms in mice.

scientific article published on 28 June 2017

Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer's disease

scientific article published on 19 May 2015

Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice.

scientific article published on 13 December 2016

Cerebrospinal fluid irisin correlates with amyloid-β, BDNF, and cognition in Alzheimer's disease

scientific article published on 21 June 2020

Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects

scientific article published on 6 February 2018

Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice.

scientific article published on 13 April 2017

Connecting Alzheimer's disease to diabetes: Underlying mechanisms and potential therapeutic targets

scientific article published on 9 November 2017

Connecting type 2 diabetes to Alzheimer's disease.

scientific article

Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-β Oligomers in Mice.

scientific article published on November 2016

Cyclic AMP enhancers and Abeta oligomerization blockers as potential therapeutic agents in Alzheimer's disease.

scientific article published on July 2007

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models

scientific article published on 07 January 2019

Expression of dopamine signaling genes in the post-mortem brain of individuals with mental illnesses is moderated by body mass index and mediated by insulin signaling genes

article

Expression profile of rat hippocampal neurons treated with the neuroprotective compound 2,4-dinitrophenol: up-regulation of cAMP signaling genes.

scientific article published in December 2009

Extracellular vesicles derived from human Wharton's jelly mesenchymal stem cells protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers

scientific article published on 20 November 2019

Formation of amyloid aggregates from human lysozyme and its disease-associated variants using hydrostatic pressure.

scientific article

Formation of soluble oligomers and amyloid fibrils with physical properties of the scrapie isoform of the prion protein from the C-terminal domain of recombinant murine prion protein mPrP-(121-231)

scientific article published on 13 July 2006

Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer's disease-associated Aβ oligomers

scientific article published on 31 May 2018

Getting a "GRiP" on Hypothalamic Endoplasmic Reticulum Stress to Combat Obesity.

scientific article published in January 2017

How does brain insulin resistance develop in Alzheimer's disease?

scientific article published on February 2014

Impaired peripheral glucose homeostasis and Alzheimer's disease

scientific article published on 20 November 2017

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease

scientific article published on February 2014

Inhibition of Alzheimer's disease beta-amyloid aggregation, neurotoxicity, and in vivo deposition by nitrophenols: implications for Alzheimer's therapy

scientific article

Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes

scientific article published on 14 February 2019

Insulin Resistance in Alzheimer's Disease

scholarly article by Laís S S Ferreira et al published 2018 in Frontiers in Neuroscience

Insulin and leptin as potential cognitive enhancers in metabolic disorders and Alzheimer's disease

scientific article published on 25 April 2020

Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice

scientific article published on 10 March 2017

Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence

scientific article

Long-term consequences of the absence of leptin signaling in early life

scientific article published on 29 January 2019

Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.

scientific article published in June 2013

Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers.

scientific article published on 28 December 2017

Metabolic Dysfunction in Alzheimer's Disease: From Basic Neurobiology to Clinical Approaches

scientific article published on 16 March 2018

Metabolic Syndrome and cognitive decline in the elderly: A systematic review.

scientific article

Metastable, partially folded states in the productive folding and in the misfolding and amyloid aggregation of proteins.

scientific article

Mitochondrial bound hexokinase activity as a preventive antioxidant defense: steady-state ADP formation as a regulatory mechanism of membrane potential and reactive oxygen species generation in mitochondria.

scientific article

Mitochondrial creatine kinase activity prevents reactive oxygen species generation: antioxidant role of mitochondrial kinase-dependent ADP re-cycling activity

scientific article published on 6 October 2006

Monoclonal antibodies that target pathological assemblies of Abeta

scientific article published on 20 November 2006

N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers

scientific article published on 11 November 2010

Neonatal infection leads to increased susceptibility to Aβ oligomer-induced brain inflammation, synapse loss and cognitive impairment in mice

scientific article published on 11 April 2019

Neuritogenesis and neuronal differentiation promoted by 2,4-dinitrophenol, a novel anti-amyloidogenic compound

scientific article published on October 2005

Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes

scientific article published on 06 April 2015

Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer's and Parkinson's Diseases

scientific article published on 01 March 2019

Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.

scientific article published on 9 August 2017

Novel neuroprotective, neuritogenic and anti-amyloidogenic properties of 2,4-dinitrophenol: the gentle face of Janus

scientific article

Opportunities and challenges in developing relevant animal models for Alzheimer's disease

scientific article published on 29 January 2016

Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α

scientific article published on 01 February 2020

Potentials and Pitfalls of Cross-Translational Models of Cognitive Impairment

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

scientific article

Protective actions of exercise-related FNDC5/Irisin in memory and Alzheimer's disease

scientific article published on 12 May 2020

Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer's Therapy?

scientific article published on 31 January 2017

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System

scientific article published on 21 April 2020

Small molecule inhibitors of lysozyme amyloid aggregation

scientific article published on 01 January 2006

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease

scientific article published on 26 May 2015

Soluble oligomers from a non-disease related protein mimic Abeta-induced tau hyperphosphorylation and neurodegeneration

scientific article published on 28 August 2007

Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases.

scientific article

TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.

scientific article published in December 2013

Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Abeta oligomerization

scientific article

Tau ablation in mice leads to pancreatic β cell dysfunction and glucose intolerance

scientific article published on 18 January 2018

The Link Between Tau and Insulin Signaling: Implications for Alzheimer's Disease and Other Tauopathies

scholarly article by Rafaella Araujo Gonçalves et al published 2019 in Frontiers in Cellular Neuroscience

The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer's Disease

scientific article published on 01 January 2018

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease.

scientific article published on 12 February 2018

The effect of lumbar puncture on the neurodegeneration biomarker neurofilament light in macaque monkeys

scientific article published on 13 July 2020

Understanding the link between insulin resistance and Alzheimer's disease: Insights from animal models

scientific article published on 28 March 2019

Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice

scientific article published on 05 September 2019

List of works by Fernanda De Felice

A Key Role of Insulin Receptors in Memory

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

Activation of D1/D5 dopamine receptors protects neurons from synapse dysfunction induced by amyloid-beta oligomers

Activation of GABA(A) receptors by taurine and muscimol blocks the neurotoxicity of beta-amyloid in rat hippocampal and cortical neurons

Acute and chronic neurological consequences of early-life Zika virus infection in mice.

Alzheimer's disease and insulin resistance: translating basic science into clinical applications

Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers

Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.

Amyloid beta oligomers induce impairment of neuronal insulin receptors

Amyloid-beta oligomers increase the localization of prion protein at the cell surface

Amyloid-β oligomers induce differential gene expression in adult human brain slices

Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons

Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

Are Alzheimer's disease and other neurodegenerative disorders caused by impaired signalling of insulin and other hormones?

Association between diabetes and mood disorders and the potential use of anti-hyperglycemic agents as antidepressants

Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model.

Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via CaM kinase II signaling

Behavioral Abnormalities in Knockout and Humanized Tau Mice

Beta-amyloid production, aggregation, and clearance as targets for therapy in Alzheimer's disease

Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson's disease-like symptoms in mice.

Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer's disease

Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice.

Cerebrospinal fluid irisin correlates with amyloid-β, BDNF, and cognition in Alzheimer's disease

Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects

Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice.

Connecting Alzheimer's disease to diabetes: Underlying mechanisms and potential therapeutic targets

Connecting type 2 diabetes to Alzheimer's disease.

Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-β Oligomers in Mice.

Cyclic AMP enhancers and Abeta oligomerization blockers as potential therapeutic agents in Alzheimer's disease.

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models

Expression of dopamine signaling genes in the post-mortem brain of individuals with mental illnesses is moderated by body mass index and mediated by insulin signaling genes

Expression profile of rat hippocampal neurons treated with the neuroprotective compound 2,4-dinitrophenol: up-regulation of cAMP signaling genes.

Extracellular vesicles derived from human Wharton's jelly mesenchymal stem cells protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers

Formation of amyloid aggregates from human lysozyme and its disease-associated variants using hydrostatic pressure.

Formation of soluble oligomers and amyloid fibrils with physical properties of the scrapie isoform of the prion protein from the C-terminal domain of recombinant murine prion protein mPrP-(121-231)

Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer's disease-associated Aβ oligomers

Getting a "GRiP" on Hypothalamic Endoplasmic Reticulum Stress to Combat Obesity.

How does brain insulin resistance develop in Alzheimer's disease?

Impaired peripheral glucose homeostasis and Alzheimer's disease

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease

Inhibition of Alzheimer's disease beta-amyloid aggregation, neurotoxicity, and in vivo deposition by nitrophenols: implications for Alzheimer's therapy

Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes

Insulin Resistance in Alzheimer's Disease

Insulin and leptin as potential cognitive enhancers in metabolic disorders and Alzheimer's disease

Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice

Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence

Long-term consequences of the absence of leptin signaling in early life

Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.

Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers.

Metabolic Dysfunction in Alzheimer's Disease: From Basic Neurobiology to Clinical Approaches

Metabolic Syndrome and cognitive decline in the elderly: A systematic review.

Metastable, partially folded states in the productive folding and in the misfolding and amyloid aggregation of proteins.

Mitochondrial bound hexokinase activity as a preventive antioxidant defense: steady-state ADP formation as a regulatory mechanism of membrane potential and reactive oxygen species generation in mitochondria.

Mitochondrial creatine kinase activity prevents reactive oxygen species generation: antioxidant role of mitochondrial kinase-dependent ADP re-cycling activity

Monoclonal antibodies that target pathological assemblies of Abeta

N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers

Neonatal infection leads to increased susceptibility to Aβ oligomer-induced brain inflammation, synapse loss and cognitive impairment in mice

Neuritogenesis and neuronal differentiation promoted by 2,4-dinitrophenol, a novel anti-amyloidogenic compound

Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes

Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer's and Parkinson's Diseases

Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.

Novel neuroprotective, neuritogenic and anti-amyloidogenic properties of 2,4-dinitrophenol: the gentle face of Janus

Opportunities and challenges in developing relevant animal models for Alzheimer's disease

Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α

Potentials and Pitfalls of Cross-Translational Models of Cognitive Impairment

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

Protective actions of exercise-related FNDC5/Irisin in memory and Alzheimer's disease

Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer's Therapy?

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System

Small molecule inhibitors of lysozyme amyloid aggregation

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease

Soluble oligomers from a non-disease related protein mimic Abeta-induced tau hyperphosphorylation and neurodegeneration

Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases.

TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.

Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Abeta oligomerization

Tau ablation in mice leads to pancreatic β cell dysfunction and glucose intolerance

The Link Between Tau and Insulin Signaling: Implications for Alzheimer's Disease and Other Tauopathies