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List of works by Peter T Northcote

13C NMR analysis of 3,6-dihydro-2H-pyrans: assignment of remote stereochemistry using axial shielding effects.

scientific article published on 10 June 2014

Acquired Resistance to Peloruside A and Laulimalide is Associated with Downregulation of Vimentin in Human Ovarian Carcinoma Cells ⬇️

scientific article published on May 15, 2012

Aquaculture trials for the production of biologically active metabolites in the New Zealand sponge Mycale hentscheli (Demospongiae: Poecilosclerida)

article

Az—a colourful azulene-derived protecting group

Characterizing the laulimalide-peloruside binding site using site-directed mutagenesis of TUB2 in S. cerevisiae

scientific article published on January 2014

ChemInform Abstract: Az - A Colorful Azulene-Derived Protecting Group

ChemInform Abstract: Peloruside B, a Potent Antitumor Macrolide from the New Zealand Marine Sponge Mycale hentscheli: Isolation, Structure, Total Synthesis, and Bioactivity.

scientific article published in April 2010

Chemical genetic profiling of the microtubule-targeting agent peloruside A in budding yeast Saccharomyces cerevisiae

article

Clathriol, a novel polyoxygenated 14beta steroid isolated from the New Zealand marine sponge Clathria lissosclera.

scientific article published in April 2002

Delaying the onset of experimental autoimmune encephalomyelitis with the microtubule-stabilizing compounds, paclitaxel and Peloruside A

scientific article published on 04 August 2009

Determination of brevetoxins in shellfish by the neuroblastoma assay

scientific article published on 01 September 2002

Effects of the microtubule stabilizing agent peloruside A on the proteome of HL-60 cells

scientific article

Halogenated Meroditerpenoids from a South Pacific Collection of the Red Alga Callophycus serratus

scientific article published on 08 November 2018

Hamigerans R and S: Nitrogenous Diterpenoids from the New Zealand Marine Sponge Hamigera tarangaensis

scientific article

Heptanosides from galactose-derived oxepenes via stereoselective addition reactions

scientific article published in October 2009

Induction of accelerated senescence by the microtubule-stabilizing agent peloruside A.

scientific article

Inhibition of human vascular endothelial cell migration and capillary-like tube formation by the microtubule-stabilizing agent peloruside A.

scientific article published on 31 March 2015

Lehualides E−K, Cytotoxic Metabolites from the Tongan Marine Sponge Plakortis sp ⬇️

scientific article published on February 25, 2011

Lipophilic toxicity from the marine dinoflagellate Karenia brevisulcata: use of the brevetoxin neuroblastoma assay to assess toxin presence and concentration.

scientific article

Marine Invertebrate Natural Products that Target Microtubules.

scientific article published on 12 February 2018

Marine natural products

scientific article published on 01 February 2003

Marine natural products

scientific article published on 11 January 2007

Marine natural products

scientific article published on 14 January 2004

Marine natural products

scientific article published on 03 January 2008

Marine natural products

scientific article published on 19 January 2005

Marine natural products

scientific article published on 09 January 2006

Marine natural products

scientific article published on 07 January 2010

Marine natural products

scientific article published on 13 December 2010

Marine natural products

scientific article published on 06 January 2009

Metagenomic Exploration of the Marine Sponge Mycale hentscheli Uncovers Multiple Polyketide-Producing Bacterial Symbionts

scientific article published on 24 March 2020

Methods for studying microtubule binding site interactions: zampanolide as a covalent binding agent

scientific article

Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis

scientific article published on 01 November 2009

Microtubule-stabilizing agents delay the onset of EAE through inhibition of migration

scientific article published on 24 September 2013

Microtubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolide

scientific article

Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole.

scientific article

Molecular Recognition of Peloruside A by Microtubules. The C24 Primary Alcohol is Essential for Biological Activity ⬇️

scientific article published on August 16, 2010

Molecular basis for fungicidal action of neothyonidioside, a triterpene glycoside from the sea cucumber, Australostichopus mollis

scientific article published on 25 January 2012

NMR determination of the bioactive conformation of peloruside A bound to microtubules.

scientific article

Peloruside A Inhibits Growth of Human Lung and Breast Tumor Xenografts in an Athymic nu/nu Mouse Model

scientific article published on 8 June 2015

Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines

scientific article published on August 2004

Peloruside A inhibits microtubule dynamics in a breast cancer cell line MCF7.

scientific article

Peloruside A synergizes with other microtubule stabilizing agents in cultured cancer cell lines

scientific article published on March 2007

Peloruside A, a microtubule-stabilizing agent, induces aneuploidy in ovarian cancer cells.

scientific article published on 7 May 2016

Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity

scientific article published on 01 June 2002

Peloruside A: a lead non-taxoid-site microtubule-stabilizing agent with potential activity against cancer, neurodegeneration, and autoimmune disease

scientific article published on 12 February 2016

Peloruside B, a potent antitumor macrolide from the New Zealand marine sponge Mycale hentscheli: isolation, structure, total synthesis, and bioactivity ⬇️

scientific article

Peloruside E (22-Norpeloruside A), a Pelorusane Macrolide from the New Zealand Marine Sponge Mycale hentscheli, Retains Microtubule-Stabilizing Properties

scientific article published on 06 September 2018

Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes.

scientific article

Polyhalogenated Indoles from the Red Alga Rhodophyllis membranacea: The First Isolation of Bromo-Chloro-Iodo Secondary Metabolites.

scientific article published on 12 January 2016

Pyrroloquinoline derivatives from a Tongan specimen of the marine sponge Strongylodesma tongaensis

scholarly article

Resistance to peloruside A and laulimalide: functional significance of acquired βI-tubulin mutations at sites important for drug-tubulin binding

scientific article published on January 2014

Spongian diterpenoids from marine sponges.

scientific article

Structural basis of microtubule stabilization by laulimalide and peloruside A

scientific article

Structurally diverse hamigerans from the New Zealand marine sponge Hamigera tarangaensis: NMR-directed isolation, structure elucidation and antifungal activity.

scientific article published on December 2013

Structure–activity studies of the pelorusides: new congeners and semi-synthetic analogues

scientific article published on 21 April 2011

Successes and pitfalls of the aquaculture of the sponge Mycale hentscheli

Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly

scientific article published on 3 August 2006

Synergistic interactions between peloruside A and other microtubule-stabilizing and destabilizing agents in cultured human ovarian carcinoma cells and murine T cells

scientific article published on 17 September 2010

The Nitrogenous Hamigerans: Unusual Amino Acid-Derivatized Aromatic Diterpenoid Metabolites from the New Zealand Marine Sponge Hamigera tarangaensis.

scientific article

The algal metabolite yessotoxin affects heterogeneous nuclear ribonucleoproteins in HepG2 cells

scientific article published on May 2009

The cellular target specificity of pateamine A.

scientific article published on September 2013

The protein synthesis inhibitors mycalamides A and E have limited susceptibility toward the drug efflux network

scientific article

Triterpenoid glycosides from the Northeastern Pacific marine sponge Xestospongia vanilla ⬇️

Two new 4-methylidene containing steroids, craterol A and B, from the New Zealand two sponge association between Stelletta crater and Desmacella dendyi

article

Unusual sulfamate indoles and a novel indolo[3,2-a]carbazole from Ancorina sp.

scientific article published in September 2002

Xestenone, a new bycyclic C19 terpenoid from the marine sponge xestospongia vanilla

scientific article published on 25 July 2002

Xestolide and secoxestenone, degraded triterpenoids from the sponge Xestospongiavanilla

scientific article published on 8 May 2006

Xestovanin A and secoxestovanin A, triterpenoid glycosides with new carbon skeletons from the sponge Xestospongia vanilla

scientific article published in 1989

Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration

scientific article

Zampanolide, a Potent New Microtubule-Stabilizing Agent, Covalently Reacts with the Taxane Luminal Site in Tubulin α,β-Heterodimers and Microtubules ⬇️

scientific article published on June 22, 2012

Zampanolides B-E from the Marine Sponge Cacospongia mycofijiensis: Potent Cytotoxic Macrolides with Microtubule-Stabilizing Activity

scientific article published on 29 October 2018

βI-tubulin mutations in the laulimalide/peloruside binding site mediate drug sensitivity by altering drug-tubulin interactions and microtubule stability

scientific article published on 4 June 2015

βII-Tubulin and βIII-Tubulin Mediate Sensitivity to Peloruside A and Laulimalide, but not Paclitaxel or Vinblastine, in Human Ovarian Carcinoma Cells ⬇️

scientific article published on December 16, 2011

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