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List of works by Leo Lit Man Poon

A case for the ancient origin of coronaviruses

scientific article (publication date: June 2013)

A highly conserved neutralizing epitope on group 2 influenza A viruses

scientific article

A novel group of avian astroviruses in wild aquatic birds

scientific article

A novel molecular test for influenza B virus detection and lineage differentiation.

scientific article

A novel small-molecule inhibitor of the avian influenza H5N1 virus determined through computational screening against the neuraminidase.

scientific article

A one step quantitative RT-PCR for detection of SARS coronavirus with an internal control for PCR inhibitors

scientific article published in July 2004

A six-plex droplet digital RT-PCR assay for seasonal influenza virus typing, subtyping, and lineage determination

scientific article published on 10 June 2020

A statistical strategy to identify recombinant viral ribonucleoprotein of avian, human, and swine influenza A viruses with elevated polymerase activity

scientific article

A46 MERS-CoV in Arabian camels in Africa and Central Asia

scientific article

Absence of MERS-Coronavirus in Bactrian Camels, Southern Mongolia, November 2014.

scientific article published on July 2015

Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013-2014.

scientific article published on 25 July 2016

Amino acid substitutions in polymerase basic protein 2 gene contribute to the pathogenicity of the novel A/H7N9 influenza virus in mammalian hosts.

scientific article published on 08 January 2014

Analytical sensitivity of rapid influenza antigen detection tests for swine-origin influenza virus (H1N1).

scientific article

Anti-inflammatory and antiviral effects of indirubin derivatives in influenza A (H5N1) virus infected primary human peripheral blood-derived macrophages and alveolar epithelial cells.

scientific article published on 6 April 2014

Are changes in HLA Ags responsible for leukemia relapse after HLA-matched allogeneic hematopoietic SCT?

scientific article published on 26 January 2015

Assessment of enhanced influenza vaccination finds that FluAd conveys an advantage in mice and older adults

scientific article published on 03 February 2020

Asymptomatic MERS-CoV Infection in Humans Possibly Linked to Infected Dromedaries Imported from Oman to United Arab Emirates, May 2015.

scientific article

Avian coronavirus in wild aquatic birds

scientific article published on 28 September 2011

Avian influenza H5N1 in viverrids: implications for wildlife health and conservation.

scientific article published in July 2006

BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses

scientific article

Biology of influenza a virus.

scientific article

Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia

scientific article

Characterization of H9 subtype influenza viruses from the ducks of southern China: a candidate for the next influenza pandemic in humans?

scientific article

Characterization of a novel gyrovirus in human stool and chicken meat.

scientific article

Characterization of influenza A viruses with polymorphism in PB2 residues 701 and 702.

scientific article published on 12 September 2017

Circulating Fetal RNA in Maternal Plasma ⬇️

scientific article published on September 1, 2001

Circulating fetal DNA in maternal plasma ⬇️

scientific article published on November 1, 2001

Circulation of Influenza A(H5N8) Virus, Saudi Arabia

scientific article published on 17 October 2018

Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study

scientific article published on May 2003

Codon usage bias and the evolution of influenza A viruses. Codon Usage Biases of Influenza Virus

scientific article

Combined use of live-attenuated and inactivated influenza vaccines to enhance heterosubtypic protection

scientific article published on 21 September 2018

Comparison of serological assays in human Middle East respiratory syndrome (MERS)-coronavirus infection

scientific article published on October 2015

Comparison of the NucliSens easyMAG and Qiagen BioRobot 9604 nucleic acid extraction systems for detection of RNA and DNA respiratory viruses in nasopharyngeal aspirate samples

scientific article

Continuing evolution of H9N2 influenza viruses endemic in poultry in southern China

scientific article published in May 2011

Continuing evolution of H9N2 influenza viruses in Southeastern China.

scientific article

Coronavirus as a possible cause of severe acute respiratory syndrome

scientific article (publication date: 19 April 2003)

Coronavirus infections in horses in Saudi Arabia and Oman.

scientific article

Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections

scientific article (preprint)

Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia

scientific article published on 6 October 2017

Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: possible relevance to pathogenesis

scientific article

DNA intercalator stimulates influenza transcription and virus replication

scientific article

Dating the emergence of pandemic influenza viruses

scientific article

Definition of the cellular interactome of the highly pathogenic avian influenza H5N1 virus: identification of human cellular regulators of viral entry, assembly, and egress

scientific article published on June 2016

Detection of Novel Reassortant Influenza A (H3N2) and H1N1 2009 Pandemic Viruses in Swine in Hanoi, Vietnam.

scientific article

Detection of SARS Coronavirus ⬇️

scientific article published on January 1, 2011

Detection of SARS coronavirus in humans and animals by conventional and quantitative (real time) reverse transcription polymerase chain reactions.

scientific article

Detection of SARS coronavirus in patients with severe acute respiratory syndrome by conventional and real-time quantitative reverse transcription-PCR assays.

scientific article published in January 2004

Detection of diverse astroviruses from bats in China

scientific article

Detection of group 1 coronaviruses in bats using universal coronavirus reverse transcription polymerase chain reactions

scientific article published in January 2008

Detection of highly pathogenic influenza and pandemic influenza virus in formalin fixed tissues by immunohistochemical methods

scientific article

Detection of human influenza A viruses by loop-mediated isothermal amplification.

scientific article

Detection of novel astroviruses in urban brown rats and previously known astroviruses in humans

scientific article

Development of a safe neutralization assay for SARS-CoV and characterization of S-glycoprotein

scientific article

Differential DNA methylation between fetus and mother as a strategy for detecting fetal DNA in maternal plasma ⬇️

scientific article published on 01 January 2002

Dissemination, divergence and establishment of H7N9 influenza viruses in China

scientific article

Diversity of Dromedary Camel Coronavirus HKU23 in African Camels Revealed Multiple Recombination Events among Closely Related Betacoronaviruses of the Subgenus Embecovirus

Early diagnosis of SARS coronavirus infection by real time RT-PCR.

scientific article published in December 2003

Emergence and dissemination of a swine H3N2 reassortant influenza virus with 2009 pandemic H1N1 genes in pigs in China

scientific article

Emergence of a novel swine-origin influenza A virus (S-OIV) H1N1 virus in humans

scientific article published on 11 June 2009

Entry of influenza A Virus with a α2,6-linked sialic acid binding preference requires host fibronectin

scientific article

Establishment of influenza A virus (H6N1) in minor poultry species in southern China.

scientific article

Evaluation of novel H1N1-specific primer-probe sets using commercial RT-PCR mixtures and a premixed reaction stored in a lyophilized format.

scientific article

Evaluation of real-time reverse transcriptase PCR and real-time loop-mediated amplification assays for severe acute respiratory syndrome coronavirus detection.

scientific article

Evidence for an Ancestral Association of Human Coronavirus 229E with Bats

scientific article published on 16 September 2015

Full factorial analysis of mammalian and avian influenza polymerase subunits suggests a role of an efficient polymerase for virus adaptation

scientific article

Generation and characterization of influenza A viruses with altered polymerase fidelity

scientific article

Generation of Live Attenuated Influenza Virus by Using Codon Usage Bias.

scientific article

Generic detection of coronaviruses and differentiation at the prototype strain level by reverse transcription-PCR and nonfluorescent low-density microarray

scientific article published on 17 January 2007

Genogroup I and II picobirnaviruses in respiratory tracts of pigs

scientific article published in December 2011

Genomic characterizations of bat coronaviruses (1A, 1B and HKU8) and evidence for co-infections in Miniopterus bats.

scientific article published in May 2008

Genomic epidemiology of SARS-CoV-2 under an elimination strategy in Hong Kong

scientific article published on 08 February 2022

H5N1 influenza: a protean pandemic threat

scientific article

Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets

scientific article

Heterologous influenza vRNA segments with identical non-coding sequences stimulate viral RNA replication in trans

scientific article

Heterosubtypic immune pressure accelerates emergence of influenza A virus escape phenotypes in mice

scientific article published in 2023

Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells

scientific article

Highly Conserved Protective Epitopes on Influenza B Viruses

scientific article

Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection

scientific article

Human annexin A6 interacts with influenza a virus protein M2 and negatively modulates infection.

scientific article

Human coronavirus NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong, China

scientific article

Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants

scientific article (publication date: July 2006)

Hyperinduction of cyclooxygenase-2-mediated proinflammatory cascade: a mechanism for the pathogenesis of avian influenza H5N1 infection.

scientific article published in August 2008

IL-15 adjuvanted multivalent vaccinia-based universal influenza vaccine requires CD4+ T cells for heterosubtypic protection

scientific article

Identification of a novel coronavirus in bats

scientific article

Identification of influenza polymerase inhibitors targeting C-terminal domain of PA through surface plasmon resonance screening

scientific article published on 2 February 2018

Identification of influenza polymerase inhibitors targeting polymerase PB2 cap-binding domain through virtual screening.

scientific article published on 16 June 2017

Immune responses to twice-annual influenza vaccination in older adults in Hong Kong.

scientific article

Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?

scientific article (publication date: 7 December 2002)

Induction of proinflammatory cytokines in primary human macrophages by influenza A virus (H5N1) is selectively regulated by IFN regulatory factor 3 and p38 MAPK.

scientific article

Infection of dogs with SARS-CoV-2

scientific article published on 14 May 2020

Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs.

scientific article

Influenza A virus expresses high levels of an unusual class of small viral leader RNAs in infected cells

scientific article

Influenza A viruses with different amino acid residues at PB2-627 display distinct replication properties in vitro and in vivo: revealing the sequence plasticity of PB2-627 position

scientific article

Influenza: emergence and control

scientific article

Inhalable dry powder formulations of siRNA and pH-responsive peptides with antiviral activity against H1N1 influenza virus

scientific article

Inhibition of SARS-associated coronavirus infection and replication by RNA interference.

scientific article published in November 2003

Initial viral load and the outcomes of SARS.

scientific article

Intraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans

scientific article published on 16 December 2009

Kinetics of Serologic Responses to MERS Coronavirus Infection in Humans, South Korea

scientific article

Lack of middle East respiratory syndrome coronavirus transmission from infected camels

scientific article

Lack of serological evidence of Middle East respiratory syndrome coronavirus infection in virus exposed camel abattoir workers in Nigeria, 2016

Long-term evolution and transmission dynamics of swine influenza A virus

scientific article

Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014-2015.

scientific article published on 21 June 2017

Loop-mediated isothermal amplification for influenza A (H5N1) virus

scientific article published on June 2007

Lung pathology of fatal severe acute respiratory syndrome.

scientific article published in May 2003

MERS coronavirus in dromedary camel herd, Saudi Arabia

scientific article

MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity.

scientific article published on 5 March 2018

MERS coronaviruses in dromedary camels, Egypt.

scientific article

MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015.

scientific article

Mass extinctions, biodiversity and mitochondrial function: are bats 'special' as reservoirs for emerging viruses?

scientific article

Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia, 2010 to 2013.

scientific article published on 12 December 2013

Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria, 2015.

scientific article published on December 2015

Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group

scientific article

Mini viral RNAs act as innate immune agonists during influenza virus infection

article

Molecular detection of a novel human influenza (H1N1) of pandemic potential by conventional and real-time quantitative RT-PCR assays

scientific article

Molecular detection of human H7N9 influenza A virus causing outbreaks in China

scientific article

Molecular diagnosis of a novel coronavirus (2019-nCoV) causing an outbreak of pneumonia

scientific article published on 31 January 2020

Molecular epidemiology of influenza A(H1N1)pdm09 virus among humans and swine, Sri Lanka

scientific article

Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome.

scientific article published in January 2004

Novel astroviruses in insectivorous bats.

scientific article published on 11 June 2008

OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1

scientific article published on 01 February 2020

Occult respiratory viral infections in coronial autopsies: a pilot project

scientific article published in June 2009

One step closer to a universal influenza A vaccine?

scientific article

One step closer to universal influenza epitopes

scientific article

Outcomes of second allogeneic hematopoietic stem cell transplantation for patients with acute lymphoblastic leukemia

scientific article published on 22 October 2012

Potent inhibition of SARS-associated coronavirus (SCOV) infection and replication by type I interferons (IFN-alpha/beta) but not by type II interferon (IFN-gamma).

scientific article published on July 2004

Preexisting Antibody-Dependent Cellular Cytotoxicity-Activating Antibody Responses Are Stable Longitudinally and Cross-reactive Responses Are Not Boosted by Recent Influenza Exposure.

scientific article

Prevalence and genetic diversity of coronaviruses in bats from China

scientific article

Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells

scientific article

Protection by universal influenza vaccine is mediated by memory CD4 T cells

scientific article published on 07 June 2018

Pseudoparticle neutralization assay for detecting ebola- neutralizing antibodies in biosafety level 2 settings

scientific article published on 31 March 2015

Public health. Surveillance of animal influenza for pandemic preparedness.

scientific article

Quantifying influenza virus diversity and transmission in humans

scientific article

Quantitative analysis of four rapid antigen assays for detection of pandemic H1N1 2009 compared with seasonal H1N1 and H3N2 influenza A viruses on nasopharyngeal aspirates from patients with influenza.

scientific article

Rapid detection of reassortment of pandemic H1N1/2009 influenza virus

scientific article

Rapid detection of the severe acute respiratory syndrome (SARS) coronavirus by a loop-mediated isothermal amplification assay.

scientific article published on 30 March 2004

Rapid diagnosis of a coronavirus associated with severe acute respiratory syndrome (SARS).

scientific article published in June 2003

Rapid genotyping of swine influenza viruses

scientific article

Reassortants of H5N1 Influenza Viruses Recently Isolated from Aquatic Poultry in Hong Kong SAR

scientific article published on January 1, 2003

Reassortment of pandemic H1N1/2009 influenza A virus in swine

scientific article published on 18 June 2010

Recombinant influenza virus with a pandemic H2N2 polymerase complex has a higher adaptive potential than one with seasonal H2N2 polymerase complex.

scientific article

Recurrent mutations associated with isolation and passage of SARS coronavirus in cells from non-human primates

scientific article published on August 2005

Reemerging H5N1 influenza viruses in Hong Kong in 2002 are highly pathogenic to ducks

scientific article

Reliable universal RT-PCR assays for studying influenza polymerase subunit gene sequences from all 16 haemagglutinin subtypes

article

Replicative virus shedding in the respiratory tract of the patients with Middle East respiratory syndrome coronavirus infection

scientific article

Risk assessment of the tropism & pathogenesis of the highly pathogenic avian influenza A/H7N9 virus using ex vivo & in vitro cultures of human respiratory tract.

scientific article published on 18 April 2019

Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings. ⬇️

scientific article published on March 2004

SARS and other coronaviruses in humans and animals

scientific article published on January 2006

SARS coronavirus 8b reduces viral replication by down-regulating E via an ubiquitin-independent proteasome pathway.

scientific article published on 28 October 2010

Sensitive and inexpensive molecular test for falciparum malaria: detecting Plasmodium falciparum DNA directly from heat-treated blood by loop-mediated isothermal amplification

scientific article

Serial analysis of the plasma concentration of SARS coronavirus RNA in pediatric patients with severe acute respiratory syndrome

scientific article published in December 2003

Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013.

scientific article published on 5 September 2013

Serological responses in patients with severe acute respiratory syndrome coronavirus infection and cross-reactivity with human coronaviruses 229E, OC43, and NL63.

scientific article

Similar transplantation outcomes for acute myeloid leukemia and myelodysplastic syndrome patients with haploidentical versus 10/10 human leukocyte antigen-matched unrelated and related donors.

scientific article

Stability of SARS-CoV-2 in different environmental conditions

scientific article (preprint)

Stalking influenza by vaccination with pre-fusion headless HA mini-stem

scientific article

Substitution at aspartic acid 1128 in the SARS coronavirus spike glycoprotein mediates escape from a S2 domain-targeting neutralizing monoclonal antibody

scientific article

Swine influenza in Sri Lanka

scientific article published on March 2013

The Effects of Temperature and Relative Humidity on the Viability of the SARS Coronavirus.

scientific article

The Hurdles From Bench to Bedside in the Realization and Implementation of a Universal Influenza Vaccine

scientific article published on 02 July 2018

The Role of Allogeneic Hematopoietic Stem Cell Transplantation in the Therapy of Patients with Acute Lymphoblastic Leukemia ⬇️

scientific article published on June 1, 2012

The aetiology, origins, and diagnosis of severe acute respiratory syndrome.

scientific article

The development and genetic diversity of H5N1 influenza virus in China, 1996-2006.

scientific article published on 06 September 2008

The emergence of human coronavirus EMC: how scared should we be?

scientific article

The evolving threat of influenza viruses of animal origin and the challenges in developing appropriate diagnostics

scientific article

The genesis and source of the H7N9 influenza viruses causing human infections in China

scientific article

The ins and outs of fetal DNA in maternal plasma

scientific article published on 01 January 2003

The nsp9 replicase protein of SARS-coronavirus, structure and functional insights

scientific article

The role of influenza virus gene constellation and viral morphology on cytokine induction, pathogenesis, and viral virulence.

scientific article published in June 2009

The severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase belongs to a distinct class of 5' to 3' viral helicases.

scientific article published on 13 August 2003

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

scientific article published on 2 March 2020

The viruses of wild pigeon droppings

scientific article

Three Indonesian clusters of H5N1 virus infection in 2005

scientific article

Time course and cellular localization of SARS-CoV nucleoprotein and RNA in lungs from fatal cases of SARS.

scientific article

Tissue tropism of swine influenza viruses and reassortants in ex vivo cultures of the human respiratory tract and conjunctiva

scientific article

Transgenic plant-derived siRNAs can suppress propagation of influenza virus in mammalian cells.

scientific article

Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets.

scientific article

Transmission of H7N9 influenza viruses with a polymorphism at PB2 residue 627 in chickens and ferrets

journal article published in 2015

Tropism and innate host responses of a novel avian influenza A H7N9 virus: an analysis of ex-vivo and in-vitro cultures of the human respiratory tract.

scientific article

Tropism and innate host responses of the 2009 pandemic H1N1 influenza virus in ex vivo and in vitro cultures of human conjunctiva and respiratory tract.

scientific article

Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an in-vitro and ex-vivo study.

scientific article

Tropism of and innate immune responses to the novel human betacoronavirus lineage C virus in human ex vivo respiratory organ cultures

scientific article published on 3 April 2013

Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin

scientific article

Use of fractional factorial design to study the compatibility of viral ribonucleoprotein gene segments of human H7N9 virus and circulating human influenza subtypes

scientific article

Vaccine-induced T cell protection from influenza viruses

scientific article published on 01 October 2019

Vaccinia virus-based multivalent H5N1 avian influenza vaccines adjuvanted with IL-15 confer sterile cross-clade protection in mice

scientific article

Viral genetic sequence variations in pandemic H1N1/2009 and seasonal H3N2 influenza viruses within an individual, a household and a community

scientific article published on 29 July 2011

Viral load of SARS-CoV-2 in clinical samples

scientific article published on 24 February 2020

Viral reassortment as an information exchange between viral segments

scientific article

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