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List of works by John A. Porco

1,2-dihydroisoquinolines as templates for cascade reactions to access isoquinoline alkaloid frameworks

scientific article

A Cycloisomerization/Friedel–Crafts Alkylation Strategy for the Synthesis of Pyrano[3,4-b]indoles ⬇️

scientific article published on July 8, 2011

A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway

scientific article published on 14 September 2015

A photochemical flow reactor for large scale syntheses of aglain and rocaglate natural product analogues

scientific article published on 11 June 2017

A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization

scientific article

Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors

scientific article published on 10 September 2019

An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris

scientific article published on 22 December 2020

Angiogenesis inhibitor epoxyquinol a: total synthesis and inhibition of transcription factor NF-kappaB.

scientific article published in September 2002

Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes

scientific article published on October 2016

Asymmetric Syntheses of the Flavonoid Diels-Alder Natural Products Sanggenons C and O.

scientific article published on 6 January 2016

Asymmetric Synthesis of Gonytolide A: Strategic Use of an Aryl Halide Blocking Group for Oxidative Coupling

scientific article published on 16 April 2018

Asymmetric Synthesis of Griffipavixanthone Employing a Chiral Phosphoric Acid-Catalyzed Cycloaddition

scientific article published on 26 December 2018

Asymmetric Synthesis of Nidulalin A and Nidulaxanthone A: Selective Carbonyl Desaturation Using an Oxoammonium Salt

scholarly article

Asymmetric Total Synthesis of the Epoxykinamycin FL‐120 B′ ⬇️

scientific article published on August 30, 2011

Atropselective syntheses of (-) and (+) rugulotrosin A utilizing point-to-axial chirality transfer

scientific article

Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosis ⬇️

scientific article published on December 6, 2011

Biomimetic Photocycloaddition of 3‐Hydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation ⬇️

scientific article published on September 3, 2010

Biomimetic Synthesis of Meroterpenoids by Dearomatization-Driven Polycyclization

scientific article published on 25 September 2019

Biomimetic Total Synthesis of (±)-Griffipavixanthone via a Cationic Cycloaddition-Cyclization Cascade

scientific article

Biomimetic dehydrogenative Diels-Alder cycloadditions: total syntheses of brosimones A and B.

scientific article

Catalytic ester-amide exchange using group (IV) metal alkoxide-activator complexes

scientific article published in July 2005

Channeling macrophage polarization by rocaglates increases macrophage resistance to <i>Mycobacterium tuberculosis</i>

scientific article published on 10 July 2021

Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for Hepatitis C Viral Infection

scientific article published on 11 January 2019

Convergent synthesis of a complex oxime library using chemical domain shuffling

scientific article published in June 2005

Convergent synthesis of complex diketopiperazines derived from pipecolic acid scaffolds and parallel screening against GPCR targets

scientific article

Copper-mediated synthesis of N-acyl vinylogous carbamic acids and derivatives: synthesis of the antibiotic CJ-15,801.

scientific article

Development of a Potent and Selective HDAC8 Inhibitor

scientific article published on September 2016

Diastereodivergent Synthesis of Chiral Tetrahydropyrrolodiazepinediones via a One-Pot Intramolecular aza-Michael/Lactamization Sequence

scientific article published on 05 December 2018

Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1

scientific article published on 06 February 2019

Discovery of chemical reactions through multidimensional screening

scientific article

Discovery of new antimalarial chemotypes through chemical methodology and library development

scientific article published on 15 April 2011

Drug-induced Stress Granule Formation Protects Sensory Hair Cells in Mouse Cochlear Explants During Ototoxicity

scientific article published on 29 August 2019

Electron transfer-initiated Diels-Alder cycloadditions of 2'-hydroxychalcones

scientific article

Enantioselective Total Synthesis and Biological Evaluation of (+)-Kibdelone A and a Tetrahydroxanthone Analogue ⬇️

scientific article published on July 23, 2013

Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor

scientific article

Enantioselective synthesis of 3,4-chromanediones via asymmetric rearrangement of 3-allyloxyflavones

scientific article

Enantioselective synthesis of bicyclo[2.2.2]octenones using a copper-mediated oxidative dearomatization/[4 + 2] dimerization cascade

scientific article

Enantioselective synthesis of linear polypropionate arrays using anthracene-tagged organosilanes

scientific article published in September 2005

Eucalyptusdimers A-C, Dimeric Phloroglucinol-Phellandrene Meroterpenoids from Eucalyptus robusta

scientific article published on 08 August 2018

Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma

scientific article published on 2 February 2021

Exploring skeletal diversity via ring contraction of glycal-derived scaffolds

scientific article published in October 2006

Gold Catalyzed Cyclization of Alkyne-Tethered Dihydropyrimidones ⬇️

scientific article published on July 13, 2011

Gold(I)-Mediated Cycloisomerization/Cycloaddition Enables Bioinspired Syntheses of Neonectrolides B-E and Analogues

scientific article published on 12 September 2019

Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer

scientific article published on 07 December 2020

High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics

scientific article published on 01 September 2018

Inhibiting Translation as a Novel Strategy to Target Multiple Myeloma ⬇️

scholarly article

Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma.

scientific article

Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.

scientific article

Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors

scientific article published on 30 July 2019

Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate.

scientific article

Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor kappaB by inhibiting the inhibitor of kappaB kinase.

scientific article published on July 2003

Lobatamide C: total synthesis, stereochemical assignment, preparation of simplified analogues, and V-ATPase inhibition studies

scientific article

Metal-Catalyzed Cascade Rearrangements of 3-Alkynyl Flavone Ethers ⬇️

scientific article published on April 10, 2013

Microwave-based reaction screening: tandem retro-Diels-Alder/Diels-Alder cycloadditions of o-quinol dimers

scientific article

Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones

scientific article

Multidimensional reaction screening for photochemical transformations as a tool for discovering new chemotypes

scientific article

Nucleophilic addition to N-phosphinylimines by rare-earth-metal triflate/trifluoroacetic anhydride activation

scientific article

Polycyclic xanthone natural products: structure, biological activity and chemical synthesis

scientific article

Polymer-assisted solution-phase (PASP) Suzuki couplings employing an anthracene-tagged palladium catalyst

scientific article published in December 2003

Reaction discovery employing macrocycles: transannular cyclizations of macrocyclic bis-lactams

scientific article

Regiodivergent Photocyclization of Dearomatized Acylphloroglucinols: Asymmetric Syntheses of (-)-Nemorosone and (-)-6-epi-Garcimultiflorone A

scientific article published on 02 July 2019

Remodeling of fumagillol: discovery of an oxygen-directed oxidative Mannich reaction

scientific article published on 10 January 2014

Remodelling of the natural product fumagillol employing a reaction discovery approach ⬇️

scientific article published on December 1, 2011

Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

scientific article published on 01 February 2020

Rocaglates as dual-targeting agents for experimental cerebral malaria

scientific article published on 20 February 2018

Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs

scientific article published in Scientific Reports

Sequential transformations to access polycyclic chemotypes: asymmetric crotylation and metal carbenoid reactions

scientific article

Silver nanoparticle-catalyzed Diels-Alder cycloadditions of 2'-hydroxychalcones.

scientific article published on June 2010

Skeletal diversity through radical cyclization of tetrahydropyridine scaffolds

scientific article

Skeletal diversity via cationic rearrangements of substituted dihydropyrans ⬇️

scientific article

Stereochemical and skeletal diversity employing pipecolate ester scaffolds

scientific article published on 17 March 2007

Stereochemical diversity through cyclodimerization: synthesis of polyketide-like macrodiolides

scientific article

Studies toward the Synthesis of the Epoxykinamycin FL-120B′: Discovery of a Decarbonylative Photocyclization ⬇️

scientific article published on May 9, 2012

Syntheses of (+)-30-epi-, (-)-6-epi-, (±)-6,30-epi-13,14-Didehydroxyisogarcinol and (±)-6,30-epi-Garcimultiflorone A Utilizing Highly Diastereoselective, Lewis Acid-Controlled Cyclizations

scientific article published on 16 October 2016

Syntheses of Dimeric Tetrahydroxanthones with Varied Linkages: Investigation of "Shapeshifting" Properties

scientific article

Synthesis and Biological Evaluation of ABCD Ring Fragments of the Kibdelones ⬇️

scientific article published on February 18, 2011

Synthesis and Multiplexed Activity Profiling of Synthetic Acylphloroglucinol Scaffolds

scientific article published on 23 September 2020

Synthesis and V-ATPase inhibition of simplified lobatamide analogues

scientific article published in September 2002

Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridines and related heterocycles by cobalt-catalyzed [2 + 2 + 2] cyclizations

scientific article

Synthesis of a library of complex macrodiolides employing cyclodimerization of hydroxy esters

scientific article

Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations

scientific article

Synthesis of a polymer-supported anthracene and its application as a dienophile scavenger

scientific article published in March 2004

Synthesis of carbamates and ureas using Zr(IV)-catalyzed exchange processes

scientific article

Synthesis of chamaecypanone C analogues from in situ-generated cyclopentadienones and their biological evaluation.

scientific article

Synthesis of epoxyquinol A and related molecules: probing chemical reactivity of epoxyquinol dimers and 2H-pyran precursors

scientific article published in July 2005

Synthesis of photoactivatable acyclic analogues of the lobatamides

scientific article published in April 2005

Synthesis of pyrrolo-isoquinolines related to the lamellarins using silver-catalyzed cycloisomerization/dipolar cycloaddition

scientific article

Synthesis of the Azaphilones (+)-Sclerotiorin and (+)-8-O-Methylsclerotiorinamine Utilizing (+)-Sparteine Surrogates in Copper-Mediated Oxidative Dearomatization ⬇️

scientific article published on March 14, 2011

Synthesis of the epoxyquinol dimer RKB-3564 D: utilization of an alkoxysilanol to promote [4 + 4] dimerization

scientific article

Synthetic cyclohexenyl chalcone natural products possess cytotoxic activities against prostate cancer cells and inhibit cysteine cathepsins in vitro

scientific article

Tandem processes identified from reaction screening: nucleophilic addition to aryl N-phosphinylimines employing La(III)-TFAA activation

scientific article

The synthetic epoxyquinoids jesterone dimer and epoxyquinone A monomer induce apoptosis and inhibit REL (human c-Rel) DNA binding in an IkappaBalpha-deficient diffuse large B-cell lymphoma cell line

scientific article

Total Syntheses of the Isomeric Aglain Natural Products Foveoglin A and Perviridisin B: Selective Excited-State Intramolecular Proton-Transfer Photocycloaddition

scientific article published on 26 September 2017

Total Synthesis and Absolute Stereochemical Assignment of Kibdelone C ⬇️

scientific article published on June 15, 2011

Total Synthesis of Aurofusarin: Studies on the Atropisomeric Stability of Bis-Naphthoquinones

scientific article published on 9 January 2018

Total Synthesis of Plukenetione A ⬇️

scientific article published on October 13, 2010

Total Synthesis of the Quinone Epoxide Dimer (+)-Torreyanic Acid: Application of a Biomimetic Oxidation/Electrocyclization/Diels−Alder Dimerization Cascade1 ⬇️

scientific article published on April 30, 2003

Total syntheses of secalonic acids A and D.

scientific article

Total synthesis and stereochemical assignment of (±)-sorbiterrin A

scientific article

Total synthesis and stereochemical assignment of the salicylate antitumor macrolide lobatamide C(1).

scientific article

Total synthesis and stereochemical assignment of the spiroisoxazoline natural product (+)-calafianin

scientific article published on 01 March 2006

Total synthesis and structure assignment of (+)-hexacyclinol.

scientific article

Total synthesis of (±)-sorocenol B employing nanoparticle catalysis

scientific article

Total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C1.

scientific article

Total synthesis of the interleukin-1beta converting enzyme inhibitor EI-1941-2 using tandem oxa-electrocyclization/oxidation1

scientific article published on 01 June 2006

Total synthesis of the salicylate enamide macrolide oximidine III: application of relay ring-closing metathesis

scientific article published in July 2004

Total synthesis of the ubiquitin-activating enzyme inhibitor (+)-panepophenanthrin

scientific article

Tracing MYC Expression for Small Molecule Discovery

scientific article published on 14 March 2019

Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris

scientific article published on 10 March 2020

Vinylogous addition of siloxyfurans to benzopyryliums: a concise approach to the tetrahydroxanthone natural products

scientific article

eIF4A Inhibitors Suppress Cell-Cycle Feedback Response and Acquired Resistance to CDK4/6 Inhibition in Cancer

scientific article published on 08 August 2019

eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

scientific article published on 13 November 2019

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