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List of works by Jörn Piel

A Close Look at a Ketosynthase from a Trans-Acyltransferase Modular Polyketide Synthase

scientific article

A Lanthipeptide-like N-Terminal Leader Region Guides Peptide Epimerization by Radical SAM Epimerases: Implications for RiPP Evolution

scientific article

A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones

scientific article published on 31 July 2018

A community resource for paired genomic and metabolomic data mining

scientific article published in 2021

A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A ⬇️

scientific article published on 01 September 2002

A monodomain class II terpene cyclase assembles complex isoprenoid scaffolds

scientific article published on 10 August 2020

A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli

scientific article published on 14 April 2020

A novel Dps-type protein from insect gut bacteria catalyses hydrolysis and synthesis of N-acyl amino acids

scientific article published in June 2007

A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles

scientific article

A roadmap for metagenomic enzyme discovery

publication published on 17 November 2021

Acyl hydrolases from trans-AT polyketide synthases target acetyl units on acyl carrier proteins.

scientific article

Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases

scientific article published on 21 December 2014

An Orthogonal D2 O-Based Induction System that Provides Insights into d-Amino Acid Pattern Formation by Radical S-Adenosylmethionine Peptide Epimerases.

scientific article

An Unusual Flavin-Dependent Halogenase from the Metagenome of the Marine Sponge Theonella swinhoei WA.

scientific article published on 15 February 2017

An environmental bacterial taxon with a large and distinct metabolic repertoire

scientific article

An enzymatic domain for the formation of cyclic ethers in complex polyketides

scientific article published in December 2013

Analysis of the sorangicin gene cluster reinforces the utility of a combined phylogenetic/retrobiosynthetic analysis for deciphering natural product assembly by trans-AT PKS.

scientific article published in September 2010

Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei

scholarly article

Anwendungen von Einzelzellmethoden in der mikrobiellen Naturstoffforschung

scholarly article

Approaches to Capturing and Designing Biologically Active Small Molecules Produced by Uncultured Microbes ⬇️

scientific article published on January 1, 2011

Aquimarins, Peptide Antibiotics with Amino‐Modified C‐Termini from a Sponge‐Derived Aquimarina sp. Bacterium

Aranazoles: Extensively Chlorinated Nonribosomal Peptide–Polyketide Hybrids from the Cyanobacterium Fischerella sp. PCC 9339

scientific article published on 24 August 2018

Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products

scientific article

Automated structure prediction of trans-acyltransferase polyketide synthase products ⬇️

scientific article published on 15 July 2019

Bacteria-induced production of the antibacterial sesquiterpene lagopodin B in Coprinopsis cinerea

scientific article published on 29 May 2019

Biosynthesis of furanocoumarins: mevalonate-independent prenylation of umbelliferone in Apium graveolens (Apiaceae)

Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways

scientific article

Biosynthesis of phenylnannolone A, a multidrug resistance reversal agent from the halotolerant myxobacterium Nannocystis pusilla B150. ⬇️

scientific article published in March 2014

Biosynthesis of polyketides by trans-AT polyketide synthases

scientific article published on 12 May 2010

Biosynthesis of polyketides by trans-AT polyketide synthases

scientific article published on 22 December 2015

Biosynthesis of the antibiotic bacillaene, the product of a giant polyketide synthase complex of the trans-AT family

scientific article published on 01 January 2007

Biosynthesis of the myxobacterial antibiotic corallopyronin A.

scientific article published in June 2010

Biosynthetic Insights of Calyculin- and Misakinolide-Type Compounds in "Candidatus Entotheonella sp."

scientific article published on 07 May 2018

Biosynthetic origin of the antibiotic cyclocarbamate brabantamide A (SB-253514) in plant-associated Pseudomonas

scientific article published on 01 January 2014

Biosynthetic potential of the global ocean microbiome

scientific article published in July 2022

Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome

scientific article published on 23 July 2018

Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont

scientific article published on 29 June 2014

Characterization of an Orphan Type III Polyketide Synthase Conserved in Uncultivated "Entotheonella" Sponge Symbionts

scientific article published on 22 October 2019

Cleavage of four carbon-carbon bonds during biosynthesis of the griseorhodin a spiroketal pharmacophore.

scientific article published in February 2009

Combinatorial biosynthesis in symbiotic bacteria

scientific article published on 01 December 2006

Comparative Genomics Underlines Multiple Roles of Profftella, an Obligate Symbiont of Psyllids: Providing Toxins, Vitamins, and Carotenoids

scientific article published on 14 August 2020

Corrigendum: An environmental bacterial taxon with a large and distinct metabolic repertoire

scientific article published in Nature

Corrigendum: Genome Mining of Oxidation Modules in trans-Acyltransferase Polyketide Synthases Reveals a Culturable Source for Lobatamides

scientific article published on 01 July 2020

Cyanobacterial ent-Sterol-Like Natural Products from a Deviated Ubiquinone Pathway.

scientific article published on 30 March 2017

Defense in the aeolidoidean genus Phyllodesmium (Gastropoda).

scientific article published on 23 September 2014

Defensive bacteriome symbiont with a drastically reduced genome.

scientific article published on 11 July 2013

Distribution and diversity of ‘Tectomicrobia’, a deep-branching uncultivated bacterial lineage harboring rich producers of bioactive metabolites

scientific article published in 2023

Effect of tolytoxin on tunneling nanotube formation and function

scientific article published on 05 April 2019

Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins

scientific article published on 26 January 2022

Entotheonella Bacteria as Source of Sponge-Derived Natural Products: Opportunities for Biotechnological Production

scientific article published on January 2017

Enzyme from an Uncultivated Sponge Bacterium Catalyzes S-Methylation in a Ribosomal Peptide.

scientific article

Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice

scientific article published on 07 October 2019

Evidence for a symbiosis island involved in horizontal acquisition of pederin biosynthetic capabilities by the bacterial symbiont of Paederus fuscipes beetles ⬇️

scientific article

Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria ⬇️

scientific article published on 03 March 2021

Evolution-guided engineering of <i>trans</i> -acyltransferase polyketide synthases

scientific article published on 21 March 2024

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

scientific article published on 27 January 2008

Exploring the chemistry of uncultivated bacterial symbionts: antitumor polyketides of the pederin family

scientific article

Expression of the Lantibiotic Mersacidin in Bacillus amyloliquefaciens FZB42 ⬇️

scientific article published on July 21, 2011

Fe2+ chelator proferrorosamine A: a gene cluster of Erwinia rhapontici P45 involved in its synthesis and its impact on growth of Erwinia amylovora CFBP1430.

scientific article published on 5 January 2016

Feeding of [5,5-2H(2)]-1-desoxy-D-xylulose and [4,4,6,6,6-2H(5)]-mevalolactone to a geosmin-producing Streptomyces sp. and Fossombronia pusilla

scientific article published in December 2002

Genome Mining Reveals trans‐AT Polyketide Synthase Directed Antibiotic Biosynthesis in the Bacterial Phylum Bacteroidetes ⬇️

scientific article published on December 10, 2010

Genome Mining of Oxidation Modules in trans-Acyltransferase Polyketide Synthases Reveals a Culturable Source for Lobatamides ⬇️

scientific article published on 10 February 2020

Genome Mining-guided and MALDI Imaging-assisted Discovery of New Antibiotics

Genome mining- and synthetic biology-enabled production of hypermodified peptides ⬇️

scientific article published on 09 September 2019

Genome-Based Identification of a Plant-Associated Marine Bacterium as a Rich Natural Product Source

article

Genome-Based Identification of a Plant-Associated Marine Bacterium as a Rich Natural Product Source

scientific article published on 19 July 2018

Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium

Genomic insights into the marine sponge microbiome

scientific article

Habitat-specific type I polyketide synthases in soils and street sediments

scientific article published on 16 November 2013

Heterologe Expression, Biosynthese und ökologische Funktion des selektiven Gq‐Signaltransduktionsinhibitors FR900359

scientific article published in 2017

Heterologous Expression, Biosynthetic Studies, and Ecological Function of the Selective Gq-Signaling Inhibitor FR900359.

scientific article published in December 2017

High iron supply inhibits the synthesis of the genotoxin colibactin by pathogenic Escherichia coli through a non-canonical Fur/RyhB-mediated pathway.

scientific article

Identification of trans ‐AT polyketide clusters in two marine bacteria reveals cryptic similarities between distinct symbiosis factors ⬇️

scientific article published on 18 March 2021

In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids

scientific article published on 04 February 2019

Insights into the biosynthesis of hormaomycin, an exceptionally complex bacterial signaling metabolite.

scientific article

Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges.

scientific article published on 03 January 2017

Introduction of d-Amino Acids in Minimalistic Peptide Substrates by an S-Adenosyl-l-Methionine Radical Epimerase

scientific article published on 25 January 2019

Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis

scientific article published on 09 January 2019

Landornamides, antiviral ornithine-containing ribosomal peptides discovered by proteusin mining

scientific article published on 12 March 2020

Linking chemical and microbial diversity in marine sponges: possible role for poribacteria as producers of methyl-branched fatty acids

scientific article published in December 2010

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

scientific article published on 9 December 2024

Manipulation of regulatory genes reveals complexity and fidelity in hormaomycin biosynthesis.

scientific article published in June 2013

Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms

scientific article published on 3 August 2015

Metabolic footprint of epiphytic bacteria on Arabidopsis thaliana leaves

scientific article published on 25 August 2015

Metabolites from symbiotic bacteria

scientific article

Metabolites from symbiotic bacteria

scientific article published on 05 December 2008

Metagenome mining reveals polytheonamides as posttranslationally modified ribosomal peptides

scientific article

Metagenomic Approaches to Identify and Isolate Bioactive Natural Products from Microbiota of Marine Sponges ⬇️

scientific article published on January 1, 2010

Metagenomic approaches for exploiting uncultivated bacteria as a resource for novel biosynthetic enzymology.

scientific article

Metagenomic natural product discovery in lichen provides evidence for a family of biosynthetic pathways in diverse symbioses. ⬇️

scientific article published on 29 July 2013

Mevalonate-Independent Biosynthesis of Terpenoid Volatiles in Plants: Induced and Constitutive Emission of Volatiles

scientific article published on 01 October 1998

Minimum Information about a Biosynthetic Gene cluster.

scientific article published on August 2015

Modular Halogenation, α‐Hydroxylation, and Acylation by a Remarkably Versatile Polyketide Synthase

scientific article published in 2022

Natural Metabolic Diversity Encoded by the Enterocin Biosynthesis Gene Cluster

scientific article published on 26 July 2002

Natural noncanonical protein splicing yields products with diverse β-amino acid residues

scientific article published in February 2018

Natural products via enzymatic reactions. Preface.

scientific article

New developments in RiPP discovery, enzymology and engineering

scientific article published on 16 September 2020

Opening up the Single-Cell Toolbox for Microbial Natural Products Research

scientific article published on 12 February 2019

Oxidative dearomatisation: the key step of sorbicillinoid biosynthesis†Electronic supplementary information (ESI) available: Containing all experimental details. See DOI: 10.1039/c3sc52911hClick here for additional data file

scientific article

Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis

scientific article published on 06 July 2018

Pederin-type pathways of uncultivated bacterial symbionts: analysis of o-methyltransferases and generation of a biosynthetic hybrid.

scientific article published in March 2009

Phenalenones: insight into the biosynthesis of polyketides from the marine alga-derived fungus Coniothyrium cereale

scientific article published on 2 July 2015

Phylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria.

scientific article

Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone

scientific article

Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting

scientific article

Polyketide genes in the marine sponge Plakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts.

scientific article published on 25 July 2013

Polyketide proofreading by an acyltransferase-like enzyme

scientific article

Polyketide synthases of bacterial symbionts in sponges--evolution-based applications in natural products research

scientific article published on 13 May 2009

Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated 'Entotheonella' bacteria

scientific article

Posttranslational arginases provide a ribosomal route to non-proteinogenic ornithine residues in diverse peptide sequences

scientific article published on 11 August 2020

Promiscuous Installation of d-Amino Acids in Gene-Encoded Peptides

scientific article published on 07 January 2021

Radical S-Adenosylmethionine Peptide Epimerases: Detection of Activity and Characterization of d-Amino Acid Products

scientific article

Radical S-adenosyl methionine epimerases: regioselective introduction of diverse D-amino acid patterns into peptide natural products

scientific article published on 18 June 2014

Rapid isolation of rare clones from highly complex DNA libraries by PCR analysis of liquid gel pools.

scientific article published on 19 October 2006

Recent advances in genome-based polyketide discovery.

scientific article published on 22 April 2014

Reciprocal cross talk between fatty acid and antibiotic biosynthesis in a nematode symbiont

scientific article published on 24 October 2012

Regio- and Stereoselective Oxidative Phenol Coupling in Aspergillus niger

scientific article published on 03 September 2012

Ribosomally derived lipopeptides containing distinct fatty acyl moieties

scientific article published in 2022

Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium

scientific article published on 28 November 2016

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

scientific article (publication date: 9 August 2016)

Single-bacterial genomics validates rich and varied specialized metabolism of uncultivated Entotheonella sponge symbionts ⬇️

scientific article published on 8 February 2018

Single-cell genomics reveals the lifestyle of Poribacteria, a candidate phylum symbiotically associated with marine sponges

scientific article (publication date: 2011)

Single-cell metabolite detection and genomics reveals uncultivated talented producer

Snf2 controls pulcherriminic acid biosynthesis and antifungal activity of the biocontrol yeast Metschnikowia pulcherrima

scientific article published on 20 May 2019

Soaking it up: the complex lives of marine sponges and their microbial associates

scientific article

Strategies to access biosynthetic novelty in bacterial genomes for drug discovery

scientific article published in 2022

Structural and Functional Studies of a Pyran Synthase Domain from a trans-Acyltransferase Assembly Line

scientific article published on 01 March 2018

Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42. ⬇️

scientific article published in June 2006

Substrate specificity in ketosynthase domains from trans-AT polyketide synthases

scientific article published on 04 December 2012

Supramolecular templating in kirromycin biosynthesis: the acyltransferase KirCII loads ethylmalonyl-CoA extender onto a specific ACP of the trans-AT PKS

scientific article published on 01 April 2011

Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A

scientific article published on 10 June 2020

Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes of uncultured bacterial consortia

scientific article published in September 2004

The ABC exporter IrtAB imports and reduces mycobacterial siderophores

scientific article published on 25 March 2020

The Bacterial Stress-Responsive Hsp90 Chaperone (HtpG) Is Required for the Production of the Genotoxin Colibactin and the Siderophore Yersiniabactin in Escherichia coli

scientific article published on 13 July 2016

The Catalytic Diversity of Multimodular Polyketide Synthases: Natural Product Biosynthesis Beyond Textbook Assembly Rules

scientific article published on March 2011

The Final Steps of Bacillaene Biosynthesis in Bacillus amyloliquefaciens FZB42: Direct Evidence for β,γ Dehydration by a trans-Acyltransferase Polyketide Synthase

scientific article published on 19 January 2010

The New Metabolite (S)-Cinnamoylphosphoramide fromStreptomycessp. and Its Total Synthesis

scientific article published on 09 September 2008

The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin

scientific article published on 02 October 2019

The genus Pseudovibrio contains metabolically versatile bacteria adapted for symbiosis

scientific article published on 18 April 2013

The hidden enzymology of bacterial natural product biosynthesis

scientific article published on 12 June 2019

Toblerols: Cyclopropanol-Containing Polyketide Modulators of Antibiosis in Methylobacteria. ⬇️

scientific article published on 7 November 2017

Tundrenone: An Atypical Secondary Metabolite from Bacteria with Highly Restricted Primary Metabolism. ⬇️

scientific article published on 23 January 2018

Unprecedented diversity of catalytic domains in the first four modules of the putative pederin polyketide synthase

scientific article

Use of a halogenase of hormaomycin biosynthesis for formation of new clorobiocin analogues with 5-chloropyrrole moieties

scientific article published in August 2008

Widespread Microbial Utilization of Ribosomal β-Amino Acid-Containing Peptides and Proteins

scientific article published in 2022

Widespread microbial utilization of ribosomal β-amino acid-containing peptides and proteins

scientific article published in 2022

Widespread occurrence and genomic context of unusually small polyketide synthase genes in microbial consortia associated with marine sponges

scientific article (publication date: April 2007)

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