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List of works by Nuggehally R Srinivas

A concise review of bioanalytical methods of small molecule immuno-oncology drugs in cancer therapy

scientific article published on 12 October 2020

A concise review of the bioanalytical methods for the quantitation of sitagliptin, an important dipeptidyl peptidase-4 (DPP4) inhibitor, utilized for the characterization of the drug

scientific article published on 13 February 2016

A rapid and highly sensitive method for the determination of glimepiride in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a pre-clinical pharmacokinetic study

scientific article

A review of bioanalytical methods for chronic lymphocytic leukemia drugs and metabolites in biological matrices

scientific article published on 26 December 2019

A review of bioanalytical quantitative methods for selected sphingosine 1-phosphate receptor modulators

scientific article

A sensitive assay for ZYAN1 in human whole blood and urine utilizing positive LC-MS/MS electrospray ionization

scientific article published on 10 May 2017

A sensitive quantitative assay for the determination of propafenone and two metabolites, 5-hydroxypropafenone and N-depropylpropafenone, in human K2EDTA plasma using LC-MS/MS with ESI operated in positive mode

scientific article published on 29 August 2019

A sensitive quantitative assay for the determination of propafenone and two metabolites, 5-hydroxypropafenone and N-depropylpropafenone, in human K2EDTA plasma using LC-MS/MS with ESI operated in positive mode.

scientific article

A strategy for extending the applicability of a validated plasma calibration curve to quantitative measurements in multiple tissue homogenate samples: a case study from a rat tissue distribution study of JI-101, a triple kinase inhibitor

scientific article

Allometric prediction of the human pharmacokinetic parameters for naveglitazar

scientific article

Allometric scaling of a metabolically complex camptothecin analog: differences in scaling of irinotecan and its active metabolite, SN-38.

scientific article

An LC-MS/MS assay for the quantitative determination of 2-pyridyl acetic acid, a major metabolite and key surrogate for betahistine, using low-volume human K2 EDTA plasma

scientific article

An overview of various validated HPLC and LC-MS/MS methods for quantitation of drugs in bile: challenges and considerations

scientific article

Analysis of five HMG-CoA reductase inhibitors-- atorvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin: pharmacological, pharmacokinetic and analytical overview and development of a new method for use in pharmaceutical formulations anal

scientific article published in March 2006

Area under the curve predictions of dalbavancin, a new lipoglycopeptide agent, using the end of intravenous infusion concentration data point by regression analyses such as linear, log-linear and power models

scientific article

Assessing the issue of instability due to Michael adduct formation in novel chemical entities possessing a carbon-carbon double bond during early drug development--applicability of common laboratory analytical protocols

scientific article

Assessment of dose proportionality of muraglitazar after repeated oral dosing in rats via a sparse sampling methodology

scientific article published in January 2007

Assessment of oral bioavailability and preclinical pharmacokinetics of DRF-6196, a novel oxazolidinone analogue, in comparison to linezolid

scientific article

Assessment of the in vitro cytochrome P450 (CYP) inhibition potential of ZYTP1, a novel poly (ADP-ribose) polymerase inhibitor

scientific article published on 08 January 2019

Bioanalytical methods for the determination of itraconazole and hydroxyitraconazole: overview from clinical pharmacology, pharmacokinetic, pharmacodynamic and metabolism perspectives

scientific article

Bioavailability enhancement of poorly water soluble and weakly acidic new chemical entity with 2-hydroxy propyl-beta-cyclodextrin: selection of meglumine, a polyhydroxy base, as a novel ternary component

scientific article published in January 2006

Chiral bioanalysis of torcetrapib enantiomers in hamster plasma by normal-phase liquid chromatography and detection by atmospheric pressure chemical ionization tandem mass spectrometry

scientific article

Chirality and neuropsychiatric drugs: an update on stereoselective disposition and clinical pharmacokinetics of bupropion

scientific article published on 6 September 2017

Clinical Drug-Drug Pharmacokinetic Interaction Potential of Sucralfate with Other Drugs: Review and Perspectives

scientific article published on 16 April 2016

Clopidogrel: review of bioanalytical methods, pharmacokinetics/pharmacodynamics, and update on recent trends in drug-drug interaction studies

scientific article

Comment on: Pharmacokinetics and Safety of Recombinant Human Interleukin-1 Receptor Antagonist GR007 in Healthy Chinese Subjects

scientific article published on 01 October 2019

Comparative Pharmacokinetics of Cholecalciferol in Dogs from 2 Different Oral Formulations Using Corrective Measures to Overcome Interference from Endogenous Cholecalciferol

scientific article

Comparative pharmacokinetics of three SGLT-2 inhibitors sergliflozin, remogliflozin and ertugliflozin: an overview

scientific article

Concurrent determination of ezetimibe and its phase-I and II metabolites by HPLC with UV detection: quantitative application to various in vitro metabolic stability studies and for qualitative estimation in bile

scientific article

Consequences of daily corticosteroid dosing with or without pre-treatment with quinidine on the in vivo cytochrome P450 2D (CYP2D) enzyme in rats: effect on O-demethylation activity of dextromethorphan and expression levels of CYP2D1 mRNA.

scientific article published on 23 December 2016

Critical Assessment of Pharmacokinetic Drug-Drug Interaction Potential of Tofacitinib, Baricitinib and Upadacitinib, the Three Approved Janus Kinase Inhibitors for Rheumatoid Arthritis Treatment

scientific article published on 04 May 2020

Determination of a neuroprotective agent (S)-(+)-BMS-204352 in human, rat and dog plasma by enantioselective liquid chromatography-tandem mass spectrometry

scientific article published in November 2004

Determination of lipoic acid in rat plasma by LC-MS/MS with electrospray ionization: assay development, validation and application to a pharamcokinetic study

scientific article

Determination of rosuvastatin in rat plasma by HPLC: Validation and its application to pharmacokinetic studies

scientific article published in September 2006

Development and validation of a chiral liquid chromatographic method, based on Chiralpak to quantify enantiomers of (+/-)-DRF 2725 in rat plasma: lack of inversion of ragaglitazar (S(-)-DRF 2725) to its antipode in plasma

scientific article published on 01 September 2004

Development and validation of a highly sensitive and robust LC-MS/MS with electrospray ionization method for quantification of rosuvastatin in small volume human plasma samples and its application to a clinical study

scientific article

Development and validation of a sensitive ELISA for quantitation of Grastim (rhG-CSF) in rat plasma: Application to a pharmacokinetic study

scientific article published in September 2006

Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of rhein in human plasma: application to a pharmacokinetic study

scientific article

Development and validation of a sensitive LC-MS/MS method with electrospray ionization using multiple ions for quantitation of torcetrapib in hamster and dog plasma

scientific article

Development and validation of an enantioselective HPLC-UV method using Chiralpak AD-H to quantify (+)- and (-)-torcetrapib enantiomers in hamster plasma--application to a pharmacokinetic study

scientific article published on 6 August 2007

Differential outcomes from metabolic ratios in the identification of CYP2D6 phenotypes--focus on venlafaxine and O-desmethylvenlafaxine

scientific article published on 6 May 2010

Differential pharmacokinetic drug-drug interaction potential of eletriptan between oral and subcutaneous routes

scientific article published on 27 December 2018

Digoxin – a Therapeutic Agent and Mechanistic Probe: Review of Liquid Chromatographic Mass Spectrometric Methods and Recent Nuances in the Clinical Pharmacology Attributes of Digoxin ⬇️

scientific article published on April 1, 2009

Disposition of radiolabeled BMS-204352 in rats and dogs

scientific article published on 01 January 2002

Effect of Food on the Pharmacokinetics of Saroglitazar Magnesium, a Novel Dual PPARαγ Agonist, in Healthy Adult Subjects

scientific article published on 11 October 2017

Effect of dose and input rate on the brain penetration of BMS-204352 following intravenous administration to rats

scientific article published in September 2002

Enantioselective LC-ESI-MS/MS method for quantitation of (-)-lumefantrine and (+)-lumefantrine in mice plasma and application to a pharmacokinetic study

scientific article published on 09 May 2020

Enantioselective in vitro ADME, absolute oral bioavailability and pharmacokinetics of (-)-lumefantrine and (+)-lumefantrine in mice

scientific article published on 15 September 2020

Evaluation of In Vitro Cytochrome P450 Inhibition and In Vitro Fate of Structurally Diverse N-Oxide Metabolites: Case Studies with Clozapine, Levofloxacin, Roflumilast, Voriconazole and Zopiclone

scientific article published on 01 August 2017

Glucuronidation of DRF-6574, hydroxy metabolite of DRF-4367 (a novel COX-2 inhibitor) by pooled human liver, intestinal microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT1A1, 1A3 and 1A8

scientific article published on 01 October 2006

HPLC method for determination of DRF-4367 in rat plasma: validation and its application to pharmacokinetics in Wistar rats

scientific article

High performance liquid chromatographic-mass spectrometric assay for the quantitation of BMS-204352 in dog K(3)EDTA plasma.

scientific article

High-performance liquid chromatography method development and validation for simultaneous determination of five model compounds, antipyrine, metoprolol, ketoprofen, furosemide and phenol red, as a tool for the standardization of rat in situ intestin

scientific article published in April 2006

Highly sensitive method for the determination of JI‐101, a multi‐kinase inhibitor in human plasma and urine by LC‐MS/MS‐ESI: method validation and application to a clinical pharmacokinetic study ⬇️

scientific article published on May 19, 2011

Highly sensitive method for the determination of a novel triple kinase inhibitor with anti‐cancer activity, JI‐101, in rat plasma by liquid chromatography–electrospray ionization tandem mass spectrometry: application to a pharmacokinetic study ⬇️

scientific article published on September 27, 2010

Identification and preclinical characterization of a novel and potent poly (ADP-ribose) polymerase (PARP) inhibitor ZYTP1

scientific article published on 25 July 2018

Impact of collagen-induced arthritis on the pharmacokinetic disposition of voriconazole, a widely used antifungal agent: in vitro and in vivo investigations in DBA/1J mice

scientific article published on 30 July 2018

In Vitro Drug-Drug Interaction Potential of Sulfoxide and/or Sulfone Metabolites of Albendazole, Triclabendazole , Aldicarb, Methiocarb, Montelukast and Ziprasidone.

scientific article published in January 2018

Incurred sample reanalysis (ISR) in drug discovery bioanalysis

scientific article published on 06 December 2018

Incurred sample reanalysis of cefuroxime in rabbit ocular tissues-A case study

scientific article published on 17 January 2020

Influence of acute and chronic kidney failure in rats on the disposition and pharmacokinetics of ZYAN1, a novel prolyl hydroxylase inhibitor, for the treatment of chronic kidney disease-induced anemia

scientific article published on 31 December 2016

Influence of number of calibration standards within a defined range on pharmacokinetic disposition-case studies with omeprazole and clopidogrel carboxylic acid

scientific article

Interspecies scaling of urinary excretory amounts of nine drugs belonging to different therapeutic areas with diverse chemical structures - accurate prediction of the human urinary excretory amounts

scientific article published on 19 April 2016

Intravenous pharmacokinetics, oral bioavailability and dose proportionality of ragaglitazar, a novel PPAR-dual activator in rats

scientific article published in October 2004

Intravenous prediction of human pharmacokinetic parameters for ketorolac, a non-steroidal anti-inflammatory agent, using allometry approach ⬇️

scientific article published on March 5, 2011

Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives

scientific article

Is the Inhibition of Dipeptidyl Peptidase-4 (DDP-4) Enzyme Route Dependent and/or Driven by High Peak Concentration?- Seeking Answers with ZYDPLA1, a Novel Long Acting DPP-4 Inhibitor, in a Rodent Model

scientific article published on 3 February 2017

Key Pharmacokinetic Essentials of Fixed-Dosed Combination Products: Case Studies and Perspectives

scientific article published on 8 August 2017

LC-ESI-MS/MS determination of 4-methylpyrazole in dog plasma and its application to a pharmacokinetic study in dogs

scientific article published on 15 August 2017

Lack of effect of sucralfate on the absorption and pharmacokinetics of rosiglitazone

scientific article published in June 2002

Lack of inhibition of CYP2C8 by saroglitazar magnesium: In vivo assessment using montelukast, rosiglitazone, pioglitazone, repaglinide and paclitaxel as victim drugs in Wistar rats

scientific article published on 08 January 2019

Letter: CYP2C19 polymorphisms and exacerbation of rabeprazole's effects on celecoxib-induced small bowel injury.

scientific article

Letter: clinical response to pioglitazone in nonalcoholic steatohepatitis [NASH] treatment-use of pharmacokinetic surrogate

scientific article published in August 2017

Letter: high oral dose of taurine for portal hypertension in cirrhotic patients-some clinical pharmacology considerations.

scientific article published in March 2018

Letter: sublingual dosing of tacrolimus in transplant patients-interesting concept to overcome first pass effects

scientific article published in July 2017

Liquid chromatography/mass spectrometry for the quantitation of muraglitazar in monkey plasma

scientific article published in October 2006

Measurement of xenobiotics in saliva: is saliva an attractive alternative matrix? Case studies and analytical perspectives

scientific article

Metabolism, pharmacokinetics, and protein covalent binding of radiolabeled MaxiPost (BMS-204352) in humans

scientific article published on 22 October 2004

Niacin and its metabolites: role of LC‐MS/MS bioanalytical methods and update on clinical pharmacology. An overview ⬇️

scientific article published on November 5, 2010

Non-alcoholic Steatohepatitis (NASH) Drug Discovery - Building a Consensus on ADME Screening Tools and Clinical Pharmacology Strategies to Aid Candidate Development

scientific article published on 01 January 2018

Novel methodology to perform incurred sample reanalysis (ISR) on dried blood spot (DBS) cards - Experimental data using darolutamide and filgotinib

scientific article published on 02 July 2020

One should avoid retro-orbital pharmacokinetic sample collections for intranasal dosing in rats: Illustration of spurious pharmacokinetics generated for anti-migraine drugs zolmitriptan and eletriptan

scientific article published on 23 May 2017

Oral bioavailability and pharmacokinetics of DRF-4367, a new COX-2 inhibitor in rats

scientific article published in April 2003

Pharmacokinetic evaluation of differential drug release formulations of rabeprazole in dogs

scientific article published on 20 June 2019

Pharmacokinetics and dose proportionality of BMS-204352 after intraarterial administration to rats

scientific article published on 01 September 2002

Pharmacokinetics and dose proportionality of BMS-204352 after intravenous administration to dogs.

scientific article published in March 2002

Pharmacokinetics of Darolutamide in Mouse - Assessment of the Disposition of the Diastereomers, Key Active Metabolite and Interconversion Phenomenon: Implications to Cancer Patients

scientific article published on 20 May 2020

Pharmacokinetics of etoposide in rats with uranyl nitrate (UN)-induced acute renal failure (ARF): optimization of the duration of UN dosing

scientific article

Pharmacological and pharmacokinetic evaluation of celecoxib prodrugs in rats

scientific article published in October 2002

Phase I Clinical Study of ZYAN1, A Novel Prolyl-Hydroxylase (PHD) Inhibitor to Evaluate the Safety, Tolerability, and Pharmacokinetics Following Oral Administration in Healthy Volunteers

scientific article published on 16 May 2017

Phase I and beyond - the importance of switching to patient's plasma: considerations and perspectives on bioanalytical procedures

scientific article published on 01 September 2013

Ponesimod, a selective sphingosine 1-phosphate (S1P1) receptor modulator for autoimmune diseases: review of clinical pharmacokinetics and drug disposition

scientific article published on 10 May 2017

Preclinical evaluation of saroglitazar magnesium, a dual PPAR-α/γ agonist for treatment of dyslipidemia and metabolic disorders

scientific article published on 9 December 2017

Preclinical pharmacokinetics and interspecies scaling of ragaglitazar, a novel biliary excreted PPAR dual activator

scientific article

Preclinical pharmacokinetics of novel trioxane antimalarial drug (99/411) - several unanswered questions and development perspectives

scientific article published on 16 February 2017

Prediction of Human Pharmacokinetics of Bendamustine from Preclinical Species Pharmacokinetics Based on Normalizing Time Course Profiles

scientific article published on 11 July 2018

Prediction of Human Pharmacokinetics of Fomepizole from Preclinical Species Pharmacokinetics Based on Normalizing Time Course Profiles

scientific article published on 18 June 2019

Prediction of human pharmacokinetic parameters using animal data and principles of allometry. A case using bicifadine, a non-narcotic analgesic, as an example

scientific article

Pronounced influence of presystemic metabolism on the metabolic disposition of imrecoxib in renally impaired patients

scientific article published on 03 January 2020

Protein Binding and Stability of Drug Candidates: The Achilles' Heel in In Vitro Potency Assays

scientific article published on 08 April 2020

Quantification of fexofenadine in biological matrices: a review of bioanalytical methods

scientific article

Quantitative determination of DRF-1042 in human plasma by HPLC: validation and application in clinical pharmacokinetics

scientific article

Quantitative determination of saroglitazar, a predominantly PPAR alpha agonist, in human plasma by a LC-MS/MS method utilizing electrospray ionization in a positive mode

scientific article

Rats and rabbits as pharmacokinetic screening tools for long acting intramuscular depots: case study with paliperidone palmitate suspension

scientific article published on 08 May 2018

Reappraisal and perspectives of clinical drug-drug interaction potential of α-glucosidase inhibitors such as acarbose, voglibose and miglitol in the treatment of type 2 diabetes mellitus

scientific article published on 23 December 2016

Relevance of preclinical rodent pharmacokinetics in the selection of a companion antibiotic for combining with beta-lactamase inhibitor

scientific article published on 02 December 2019

Resolution of enantiomers of ketoprofen by HPLC: a review ⬇️

scientific article published on October 1, 2003

Retrospective and Prospective Human Intravenous and Oral Pharmacokinetic Projection of Dipeptidyl peptidase-IV Inhibitors Using Simple Allometric Principles - Case Studies of ABT-279, ABT-341, Alogliptin, Carmegliptin, Sitagliptin and Vildagliptin

scientific article published on July 2015

Review of Clinical Pharmacokinetics of Avibactam, A Newly Approved non-β lactam β-lactamase Inhibitor Drug, In Combination Use With Ceftazidime

article

Review of DBS methods as a quantitative tool for anticancer drugs

scientific article published on 01 January 2019

Review of HPLC and LC-MS/MS assays for the determination of various nonsteroidal anti-androgens used in the treatment of prostate cancer.

scientific article

Review of HPLC methods and HPLC methods with mass spectrometric detection for direct determination of aspirin with its metabolite(s) in various biological matrices ⬇️

scientific article published on February 2, 2012

Review of Pharmacokinetic Data of Different Drug Classes in Goto-Kakizaki Rats, a Non-obese Model for Type 2 Diabetes Mellitus: Case Studies and Perspectives

scientific article

Review of bioanalytical assays for the quantitation of various HDAC inhibitors such as vorinostat, belinostat, panobinostat, romidepsin and chidamine

scientific article

Review of the bioanalytical methods for the determination of methotrexate and its metabolites in in vitro, preclinical and clinical studies: Case studies and perspectives

scientific article

Review of the pharmacokinetics of dalbavancin, a recently approved lipoglycopeptide antibiotic

scientific article published on 6 March 2017

Review of the quantitative analysis of cholesteryl ester transfer protein inhibitors

scientific article

Role of Ceramides in Drug Delivery

scientific article published on 13 August 2019

Safety, tolerability, and pharmacokinetics of a capsule formulation of DRF-1042, a novel camptothecin analog, in refractory cancer patients in a bridging phase I study

scientific article

Safety, tolerability, pharmacokinetics, and pharmacodynamics of an orally active novel camptothecin analog, DRF-1042, in refractory cancer patients in a phase I dose escalation study

scientific article

Sensitive LC-MS/MS Method for the Simultaneous Determination of Bendamustine and its Active Metabolite, γ-Hydroxybendamustine in Small Volume Mice and Dog Plasma and its Application to a Pharmacokinetic Study in Mice and Dogs

scientific article published on 30 May 2017

Sensitive and specific LC-ESI-MS/MS method for determination of ZYDPLA1, a novel long-acting dipeptidyl peptidase 4 inhibitor in rat plasma: An application for toxicokinetic study in rats.

scientific article

Sensitivity enhancement and matrix effect evaluation during summation of multiple transition pairs-case studies of clopidogrel and ramiprilat

scientific article

Severe metabolic impairment with increasing age for CYP3A and CYP2D substrates in rats: Possible consequences for drug development

scientific article

Simple method for the determination of rosiglitazone in human plasma using a commercially available internal standard

scientific article

Simultaneous determination of bendamustine and γ-hydroxybendamustine in mice dried blood spots and its application in a mice pharmacokinetic study

scientific article published on 28 May 2019

Simultaneous determination of colchicine and febuxostat in rat plasma: Application in a rat pharmacokinetic study

scientific article published on 02 July 2020

Simultaneous determination of rosuvastatin and fenofibric acid in human plasma by LC-MS/MS with electrospray ionization: assay development, validation and application to a clinical study

scientific article published in September 2005

Simultaneous estimation of six anti-diabetic drugs--glibenclamide, gliclazide, glipizide, pioglitazone, repaglinide and rosiglitazone: development of a novel HPLC method for use in the analysis of pharmaceutical formulations and its application to h

scientific article published in October 2006

Simultaneous quantitation of etoricoxib, salicylic acid, valdecoxib, ketoprofen, nimesulide and celecoxib in plasma by high-performance liquid chromatography with UV detection

scientific article published in January 2006

Simultaneous quantitation of rosuvastatin and gemfibrozil in human plasma by high-performance liquid chromatography and its application to a pharmacokinetic study

scientific article

Standard curve range for clinical sample analysis of oral bioavailability/bioequivalence studies: dilemma, introspection and strategies

scientific article published on 17 May 2018

Stereoselective Conversion of Ketoprofen in Men Versus Women from Two Different Oral Dosage Formulations: Observations and Introspection of the Pharmacokinetic Data

scientific article published on 01 February 2017

Stereoselective and nonstereoselective pharmacokinetics of rabeprazole - an overview

scientific article published on 15 March 2017

Stereoselective pharmacokinetics and tissue distribution of levodropropizine after administration of pure levodropropizine and the rac-dropropizine to Sprague-Dawley rats

scientific article published on 10 May 2019

Torcetrapib for Animal and Human Pharmacokinetic Studies: Applicability of Chiral and Achiral Methodologies ⬇️

scientific article published on June 1, 2009

Two Decades-Long Journey from Riluzole to Edaravone: Revisiting the Clinical Pharmacokinetics of the Only Two Amyotrophic Lateral Sclerosis Therapeutics

scientific article published on 01 November 2018

Unsuspected poor metabolizer phenotypes of fluoxetine in bioavailability/bioequivalence studies from an indian population perspective. Retrospective pharmacokinetic data evaluation

scientific article

Uptake and pharmacokinetics of cefuroxime in rabbits after intravitreal, intracameral, and topical dosing: relevance to human ocular injection of cefuroxime

scientific article published on 19 June 2019

Use of Cocktail Probe Drugs for Indexing Cytochrome P450 Enzymes in Clinical Pharmacology Studies - Review of Case Studies

scientific article published on 01 January 2019

Use of bile correction factors for allometric prediction of human pharmacokinetic parameters of torcetrapib, a facile cholesteryl ester transfer protein inhibitor

scientific article

Use of sorbitol as pharmaceutical excipient in the present day formulations - issues and challenges for drug absorption and bioavailability

scientific article published on 01 September 2019

Validated HPLC analytical method with programmed wavelength UV detection for simultaneous determination of DRF-4367 and Phenol red in rat in situ intestinal perfusion study

scientific article published on 21 January 2005

Validation of a simple HPLC method for DRF-4848, a novel COX-2 inhibitor suitable for pharmacokinetic application in rats

scientific article

Validation of a simple bioanalytical method for the determination of DRF-6196, a novel oxazolidinone, in mouse plasma: application to a single-dose pharmacokinetic study

scientific article published in January 2005

ZYBT1, a potent, irreversible Bruton's Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer

scientific article published on 01 August 2020

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