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List of works by Zeruesenay Desta

A mixture model approach in gene-gene and gene-environmental interactions for binary phenotypes

scientific article published on January 2008

A penalized mixture model approach in genotype/phenotype association analysis for quantitative phenotypes

scientific article

A two-week regimen of high-dose integrase inhibitors does not cause nephrotoxicity in mice

scientific article

Abacavir, didanosine and tenofovir do not induce inflammatory, apoptotic or oxidative stress genes in coronary endothelial cells

scientific article published in January 2011

Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine

scientific article

Anti-inflammatory treatment with pentoxifylline improves HIV-related endothelial dysfunction: a pilot study.

scientific article

Antiestrogen pathway (aromatase inhibitor)

scientific article published on July 2009

Assessment of vascular effects of tamoxifen and its metabolites on the rat perfused hindquarter vascular bed.

scientific article published in May 2009

Association of Variants in Candidate Genes with Lipid Profiles in Women with Early Breast Cancer on Adjuvant Aromatase Inhibitor Therapy

scientific article published on 13 October 2015

Associations between genetic variants and the effect of letrozole and exemestane on bone mass and bone turnover

scientific article published on 4 November 2015

CYP2B6 pharmacogenetics-based in vitro-in vivo extrapolation of efavirenz clearance by physiologically based pharmacokinetic modeling

scientific article published on 11 July 2013

CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment

scientific article

Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro

scientific article

Chiral Plasma Pharmacokinetics and Urinary Excretion of Bupropion and Metabolites in Healthy Volunteers

scientific article published on 2 June 2016

Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations

scientific article

Clinical and educational impact of pharmacogenomics testing: a case series from the INGENIOUS trial

scientific article published on 8 June 2017

Clinical significance of the cytochrome P450 2C19 genetic polymorphism

scientific article (publication date: 2002)

Comparison of changes in the lipid profile of postmenopausal women with early stage breast cancer treated with exemestane or letrozole.

scientific article published on 15 December 2011

Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients

scientific article published on 15 January 2010

Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment

scientific article published on 4 September 2017

Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6.

scientific article

Comprehensive in vitro analysis of voriconazole inhibition of eight cytochrome P450 (CYP) enzymes: major effect on CYPs 2B6, 2C9, 2C19, and 3A

scientific article

Contribution of N-glucuronidation to efavirenz elimination in vivo in the basal and rifampin-induced metabolism of efavirenz.

scientific article

Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance

scientific article published on September 2008

Cytochrome P450 3A4*22, PPAR-α, and ARNT polymorphisms and clopidogrel response

scientific article published on 09 December 2013

Cytochrome P450 pharmacogenetics as a predictor of toxicity and clinical response to pulse cyclophosphamide in lupus nephritis

scientific article published in July 2004

Efavirenz Inhibits the Human Ether-A-Go-Go Related Current (hERG) and Induces QT Interval Prolongation in CYP2B6*6*6 Allele Carriers

scientific article published on 23 June 2016

Efavirenz primary and secondary metabolism in vitro and in vivo: identification of novel metabolic pathways and cytochrome P450 2A6 as the principal catalyst of efavirenz 7-hydroxylation

scientific article

Effects of clopidogrel and itraconazole on the disposition of efavirenz and its hydroxyl metabolites: exploration of a novel CYP2B6 phenotyping index ⬇️

scientific article published on January 1, 2013

Effects of theCYP2B6*6Allele on Catalytic Properties and Inhibition of CYP2B6 In Vitro: Implication for the Mechanism of Reduced Efavirenz Metabolism and Other CYP2B6 Substrates In Vivo ⬇️

scientific article published on January 9, 2012

Endothelial nitric oxide synthase gene haplotypes associated with circulating concentrations of nitric oxide products in healthy men.

scientific article published in August 2005

Endothelial nitric oxide synthase haplotypes are related to blood pressure elevation, but not to resistance to antihypertensive drug therapy

scientific article

Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen.

scientific article published on February 2005

Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells

scientific article published on 11 May 2006

Estimating a positive false discovery rate for variable selection in pharmacogenetic studies

scientific article published on January 2007

Estrogens and their precursors in postmenopausal women with early breast cancer receiving anastrozole

scientific article

Factor XIII Val34Leu polymorphism and recurrent myocardial infarction in patients with coronary artery disease

scientific article

Genetic associations with toxicity-related discontinuation of aromatase inhibitor therapy for breast cancer

scientific article published on 2 April 2013

Genome-wide discovery of drug-dependent human liver regulatory elements

scientific article (publication date: October 2014)

Genotype-guided tamoxifen dosing increases active metabolite exposure in women with reduced CYP2D6 metabolism: a multicenter study

scientific article

Germline pharmacogenetics of tamoxifen response: have we learned enough?

scientific article published on November 2007

Histoplasma capsulatumpreferentially induces IDO in the lung ⬇️

scientific article published on November 27, 2012

Identification of genetic variants in the human indoleamine 2,3-dioxygenase (IDO1) gene, which have altered enzyme activity

scientific article published in June 2009

Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro.

scientific article

Impact of proton pump inhibitors on the effectiveness of clopidogrel after coronary stent placement: the clopidogrel Medco outcomes study

scientific article published on August 2010

In Vitro Analysis and Quantitative Prediction of Efavirenz Inhibition of Eight Cytochrome P450 (CYP) Enzymes: Major Effects on CYPs 2B6, 2C8, 2C9 and 2C19 ⬇️

scientific article published on February 5, 2013

In Vitro Cytochrome P450-Mediated Metabolism of Exemestane ⬇️

scientific article published on September 28, 2010

In Vitro Metabolism of Montelukast by Cytochrome P450s and UDP-Glucuronosyltransferases

scientific article

In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole ⬇️

scientific article published on December 1, 2010

In vitro inhibition of pimozide N-dealkylation by selective serotonin reuptake inhibitors and azithromycin

scientific article published in April 2002

In vivo assessment of the metabolic activity of CYP2D6 diplotypes and alleles

scientific article

Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response ⬇️

scientific article published on February 20, 2012

Inhibition of Cytochrome P450 2B6 Activity by Voriconazole Profiled Using Efavirenz Disposition in Healthy Volunteers

scientific article published on 06 September 2016

Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro

scientific article published on 07 February 2009

Inhibition of platelet aggregation by prostaglandin E1 (PGE1) in diabetic patients during therapy with clopidogrel and aspirin ⬇️

scientific article published on March 2, 2012

Is (+)-[ 13 C]-pantoprazole better than (±)-[ 13 C]-pantoprazole for the breath test to evaluate CYP2C19 enzyme activity? ⬇️

scientific article published on December 21, 2012

Methadone: a substrate and mechanism-based inhibitor of CYP19 (aromatase).

scientific article

Obituary: David Alastair Flockhart , MD, PhD.

scientific article

Pentoxifylline, inflammation, and endothelial function in HIV-infected persons: a randomized, placebo-controlled trial

scientific article

PharmGKB summary: ifosfamide pathways, pharmacokinetics and pharmacodynamics

scientific article

PharmGKB summary: tamoxifen pathway, pharmacokinetics

scientific article published in November 2013

Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes

scientific article

Platelet factor XIIIa release during platelet aggregation and plasma clot strength measured by thrombelastography in patients with coronary artery disease treated with clopidogrel

scientific article published on 15 May 2014

Population Pharmacokinetic Modeling To Estimate the Contributions of Genetic and Nongenetic Factors to Efavirenz Disposition

scientific article published on 31 October 2016

QT analysis: a complex answer to a 'simple' problem

scientific article published on 01 September 2004

Quantification of tamoxifen and three metabolites in plasma by high-performance liquid chromatography with fluorescence detection: application to a clinical trial

scientific article

Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment

scientific article published on 01 July 2006

Rapid identification of the hepatic cytochrome P450 2C19 activity using a novel and noninvasive [13C]pantoprazole breath test

scientific article published on 09 January 2009

Regulation of microRNA expression by rifampin in human hepatocytes

scientific article published on 09 August 2013

Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes

scientific article published on 26 April 2016

Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers

scientific article published on 29 July 2015

Sequence diversity and functional characterization of the 5'-regulatory region of human CYP2C19.

scientific article

Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients

scientific article published on February 2010

Stereoselective Glucuronidation of Bupropion Metabolites In Vitro and In Vivo

scientific article published on 22 January 2016

Stereoselective and regiospecific hydroxylation of ketamine and norketamine ⬇️

scientific article published on May 21, 2012

Stereoselective method to quantify bupropion and its three major metabolites, hydroxybupropion, erythro-dihydrobupropion, and threo-dihydrobupropion using HPLC-MS/MS

scientific article published on 18 February 2016

Stereoselective pharmacokinetics of stable isotope (+/−)‐[13C]‐pantoprazole: Implications for a rapid screening phenotype test of CYP2C19 activity ⬇️

scientific article published on September 20, 2011

Substantial effect of efavirenz monotherapy on bilirubin levels in healthy volunteers

scientific article

Tamoxifen Dose Escalation in Patients With Diminished CYP2D6 Activity Normalizes Endoxifen Concentrations Without Increasing Toxicity

scientific article published on 25 May 2016

Tamoxifen and its metabolites cause acute vasorelaxation of aortic rings by inducing vasodilator prostanoid synthesis

scientific article published on 01 December 2011

Tamoxifen metabolites as active inhibitors of aromatase in the treatment of breast cancer ⬇️

scientific article published on March 9, 2011

The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity

scientific article published on 3 April 2003

The dual role of pharmacogenetics in HIV treatment: mutations and polymorphisms regulating antiretroviral drug resistance and disposition.

scientific article published on July 2012

The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6.

scientific article published in March 2002

The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen

scientific article

Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism

scientific article

Variability of heart rate correction methods for the QT interval

scientific article published in June 2003

Variable aromatase inhibitor plasma concentrations do not correlate with circulating estrogen concentrations in post-menopausal breast cancer patients

article published in 2017

Variants in the CYP2B6 3'UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs

scientific article published on 27 September 2017

Variation in anastrozole metabolism and pharmacodynamics in women with early breast cancer

scientific article

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