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List of works by Erik C Böttger

A mutation associated with clofazimine and bedaquiline cross-resistance in MDR-TB following bedaquiline treatment

scientific article published on 30 October 2014

A mycobacterial smc null mutant is proficient in DNA repair and long-term survival

scientific article

A recA deletion mutant of Mycobacterium bovis BCG confers protection equivalent to that of wild-type BCG but shows increased genetic stability.

scientific article published on October 2003

A statistical approach for determination of disk diffusion-based cutoff values for systematic characterization of wild-type and non-wild-type bacterial populations in antimicrobial susceptibility testing

scientific article published on 11 March 2015

Acquisition of clarithromycin resistance mutations in the 23S rRNA gene of Mycobacterium abscessus in the presence of inducible erm(41).

scientific article published on 24 July 2012

Analysis of the contribution of individual substituents in 4,6-aminoglycoside-ribosome interaction

scientific article

Automated quantitative drug susceptibility testing of non-tuberculous mycobacteria using MGIT 960/EpiCenter TB eXiST

scientific article published on 29 September 2011

Binding of neomycin-class aminoglycoside antibiotics to mutant ribosomes with alterations in the A site of 16S rRNA.

scientific article

Broad-range 16S rRNA gene polymerase chain reaction for diagnosis of culture-negative bacterial infections.

scientific article

Characterization of the mycobacterial NER system reveals novel functions of the uvrD1 helicase

scientific article

DNA alkylation damage as a sensor of nitrosative stress in Mycobacterium tuberculosis

scientific journal article

DNA damage induction of recA in Mycobacterium tuberculosis independently of RecA and LexA.

scientific article published in November 2002

Deletion of zmp1 improves Mycobacterium bovis BCG-mediated protection in a guinea pig model of tuberculosis

scientific article

Determination of MIC distribution and epidemiological cutoff values for bedaquiline and delamanid in Mycobacterium tuberculosis using the MGIT 960 system equipped with TB eXiST.

scientific article published on 4 May 2015

Directed mutagenesis of Mycobacterium smegmatis 16S rRNA to reconstruct the in vivo evolution of aminoglycoside resistance in Mycobacterium tuberculosis

scientific article published on 01 June 2010

Drug susceptibility distributions in slowly growing non-tuberculous mycobacteria using MGIT 960 TB eXiST.

scientific article published on 26 April 2013

Effects of clinical breakpoint changes in CLSI guidelines 2010/2011 and EUCAST guidelines 2011 on antibiotic susceptibility test reporting of Gram-negative bacilli ⬇️

scientific article published on December 13, 2011

Engineering the rRNA decoding site of eukaryotic cytosolic ribosomes in bacteria

scientific article

Evaluation of Cobas TaqMan MTB for direct detection of the Mycobacterium tuberculosis complex in comparison with Cobas Amplicor MTB.

scientific article published on 24 April 2013

Evaluation of the AID ESBL line probe assay for rapid detection of extended-spectrum β-lactamase (ESBL) and KPC carbapenemase genes in Enterobacteriaceae

scientific article published on 04 September 2013

Evaluation of the Bruker MALDI Biotyper for Identification of Fastidious Gram-Negative Rods

scientific article published on 9 December 2015

Evaluation of the Bruker MALDI Biotyper for identification of Gram-positive rods: development of a diagnostic algorithm for the clinical laboratory

scientific article published on 22 January 2014

Fitness cost of chromosomal drug resistance-conferring mutations

scientific article

Fully automated disc diffusion for rapid antibiotic susceptibility test results: a proof-of-principle study

scientific article published on 17 February 2017

Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity

scientific article

Genetic reconstruction of protozoan rRNA decoding sites provides a rationale for paromomycin activity against Leishmania and Trypanosoma

scientific article

Identification of Gram-positive cocci by use of matrix-assisted laser desorption ionization-time of flight mass spectrometry: comparison of different preparation methods and implementation of a practical algorithm for routine diagnostics

scientific article

Important role for Mycobacterium tuberculosis UvrD1 in pathogenesis and persistence apart from its function in nucleotide excision repair.

scientific article

Influence of clinical breakpoint changes from CLSI 2009 to EUCAST 2011 antimicrobial susceptibility testing guidelines on multidrug resistance rates of Gram-negative rods

scientific article published on 17 April 2013

Integrating forecast probabilities in antibiograms: a way to guide antimicrobial prescriptions more reliably?

scientific article published on 6 August 2014

Integrating the Xpert MTB/RIF assay into a diagnostic workflow for rapid detection of Mycobacterium tuberculosis in a low-prevalence area

scientific article published on 24 April 2013

Intrinsic rifamycin resistance of Mycobacterium abscessus is mediated by ADP-ribosyltransferase MAB_0591.

scientific article published on 20 December 2016

Lack of antimicrobial bactericidal activity in Mycobacterium abscessus.

scientific article

Lack of mismatch correction facilitates genome evolution in mycobacteria

scientific article published in September 2004

LspA inactivation in Mycobacterium tuberculosis results in attenuation without affecting phagosome maturation arrest

scientific journal article

MASTER: a model to improve and standardize clinical breakpoints for antimicrobial susceptibility testing using forecast probabilities

scientific article published on September 2017

Mitochondrial deafness alleles confer misreading of the genetic code

scholarly article

Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin.

scientific article

Mutation K42R in ribosomal protein S12 does not affect susceptibility of Mycobacterium smegmatis 16S rRNA A-site mutants to 2-deoxystreptamines

scientific article

Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance

scientific article

Nonmutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase

scientific article published on 3 October 2016

Performance of Copan WASP for Routine Urine Microbiology

scientific article published on 16 December 2015

Phenylethyl Butyrate Enhances the Potency of Second-Line Drugs against Clinical Isolates of Mycobacterium tuberculosis ⬇️

scientific article published on November 21, 2011

Phylogenetic Sequence Variations in Bacterial rRNA Affect Species-Specific Susceptibility to Drugs Targeting Protein Synthesis ⬇️

scientific article published on July 5, 2011

Practical Approach for Reliable Detection of AmpC Beta-Lactamase-Producing Enterobacteriaceae ⬇️

scientific article published on June 1, 2011

Quantitative drug susceptibility testing of Mycobacterium tuberculosis by use of MGIT 960 and EpiCenter instrumentation

scientific article

Rapid detection of ESBL, carbapenemases, MRSA and other important resistance phenotypes within 6-8 h by automated disc diffusion antibiotic susceptibility testing

scientific article

Rapid disc diffusion antibiotic susceptibility testing for Pseudomonas aeruginosa, Acinetobacter baumannii and Enterococcus spp.

scientific article published on 23 November 2017

Recognition of potentially novel human disease-associated pathogens by implementation of systematic 16S rRNA gene sequencing in the diagnostic laboratory.

scientific article

Relief from Zmp1-mediated arrest of phagosome maturation is associated with facilitated presentation and enhanced immunogenicity of mycobacterial antigens.

scientific article

Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket

scientific article published on 16 January 2009

Stabilization of the genome of the mismatch repair deficient Mycobacterium tuberculosis by context-dependent codon choice

scientific article

Structure-Activity Relationships among the Kanamycin Aminoglycosides: Role of Ring I Hydroxyl and Amino Groups ⬇️

scientific article published on September 4, 2012

Systematic internal transcribed spacer sequence analysis for identification of clinical mold isolates in diagnostic mycology: a 5-year study

scientific article published on 23 June 2010

The biological and structural characterization of Mycobacterium tuberculosis UvrA provides novel insights into its mechanism of action ⬇️

scientific article published on May 27, 2011

The functions of OmpATb, a pore-forming protein of Mycobacterium tuberculosis

scientific journal article

The uracil DNA glycosylase UdgB of Mycobacterium smegmatis protects the organism from the mutagenic effects of cytosine and adenine deamination

scientific article published on 14 August 2009

Tuberculosis drug resistance in an area of low endemicity in 2004 to 2006: semiquantitative drug susceptibility testing and genotyping

scientific article published on 15 October 2008

Tuberculosis vaccine strain Mycobacterium bovis BCG Russia is a natural recA mutant

scientific article

Tuberculosis: drug resistance, fitness, and strategies for global control

scientific article published on 7 November 2007

Use of the Bruker MALDI Biotyper for identification of molds in the clinical mycology laboratory

scientific article

UvrD2 Is Essential in Mycobacterium tuberculosis, but Its Helicase Activity Is Not Required ⬇️

scientific article published on July 1, 2011

Validation of antibiotic susceptibility testing guidelines in a routine clinical microbiology laboratory exemplifies general key challenges in setting clinical breakpoints

scientific article published on 28 April 2014

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