List of works - Philip L. De Jager

Early Elevation of Serum Tumor Necrosis Factor-α is Associated with Poor Outcome in Subarachnoid Hemorrhage

scientific article published on October 1, 2012

Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping

article

Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility

scientific article published on 08 October 2018

Single-Cell Detection of Secreted Aβ and sAPPα from Human IPSC-Derived Neurons and Astrocytes.

scientific article published on February 2016

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

scientific article

A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology

scientific article published on March 2015

GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.

scientific article

Similar risk of depression and anxiety following surgery or hospitalization for Crohn's disease and ulcerative colitis

scientific article published on 22 January 2013

Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease

scientific article published in August 2005

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.

scientific article

Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility

scientific article

The CD6 Multiple Sclerosis Susceptibility Allele Is Associated with Alterations in CD4+ T Cell Proliferation

scientific article published on August 17, 2011

Genetic variation in toll-like receptor 9 and susceptibility to systemic lupus erythematosus

scientific article

Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells

scientific article published on 21 June 2008

Tau Activates Transposable Elements in Alzheimer's Disease

scientific article published on 01 June 2018

An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity

scientific article

Intermediate phenotypes identify divergent pathways to Alzheimer's disease

scientific article (publication date: 21 June 2010)

Polygenic risk of Alzheimer disease is associated with early- and late-life processes

scientific article published on 6 July 2016

An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype

scientific article published on 8 December 2016

Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau

scientific article published on 01 August 2018

Evaluation of an online platform for multiple sclerosis research: patient description, validation of severity scale, and exploration of BMI effects on disease course

scientific article

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis

scientific article

A random change point model for cognitive decline in Alzheimer's disease and mild cognitive impairment

scientific article

Association of APOE with tau-tangle pathology with and without β-amyloid

scientific article published on September 28, 2015

ImmVar project: Insights and design considerations for future studies of "healthy" immune variation

scientific article published on February 2015

Relation of genomic variants for Alzheimer disease dementia to common neuropathologies

scientific article published on July 2016

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome

Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers

scientific article published on 28 February 2017

CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis

scientific article

Genetic risk variants in African Americans with multiple sclerosis

scientific article published on 14 June 2013

APOE and cerebral amyloid angiopathy in community-dwelling older persons

scientific article

A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research

scientific article published on 07 August 2018

Modeling disease severity in multiple sclerosis using electronic health records

scientific article

Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway

scientific article

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data

scientific article (publication date: April 2017)

The association of magnetic resonance imaging measures with cognitive function in a biracial population sample

scientific article

5'RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy.

scientific article published on 10 February 2014

New therapeutic approaches for multiple sclerosis

scientific article published on January 2007

Allelic variant in CTLA4 alters T cell phosphorylation patterns

scholarly article

Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex

scientific article

PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis

scientific article

Evidence for a common pathway linking neurodegenerative diseases

scientific article

Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies

scientific article

Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis

scientific article published in March 2006

A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.

scientific article

Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies

scientific article published on 04 August 2016

Alzheimer's loci: epigenetic associations and interaction with genetic factors

scientific article published on April 24, 2015

Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease

scientific article

A common polymorphism near PER1 and the timing of human behavioral rhythms

scientific article

A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants.

scientific article published in December 2017

List of works by Philip L. De Jager

Early Elevation of Serum Tumor Necrosis Factor-α is Associated with Poor Outcome in Subarachnoid Hemorrhage

Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping

Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility

Single-Cell Detection of Secreted Aβ and sAPPα from Human IPSC-Derived Neurons and Astrocytes.

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology

GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.

Similar risk of depression and anxiety following surgery or hospitalization for Crohn's disease and ulcerative colitis

Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.

Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility

The CD6 Multiple Sclerosis Susceptibility Allele Is Associated with Alterations in CD4+ T Cell Proliferation

Genetic variation in toll-like receptor 9 and susceptibility to systemic lupus erythematosus

Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells

Tau Activates Transposable Elements in Alzheimer's Disease

An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity

Intermediate phenotypes identify divergent pathways to Alzheimer's disease

Polygenic risk of Alzheimer disease is associated with early- and late-life processes

An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype

Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau

Evaluation of an online platform for multiple sclerosis research: patient description, validation of severity scale, and exploration of BMI effects on disease course

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis

A random change point model for cognitive decline in Alzheimer's disease and mild cognitive impairment

Association of APOE with tau-tangle pathology with and without β-amyloid

ImmVar project: Insights and design considerations for future studies of "healthy" immune variation

Relation of genomic variants for Alzheimer disease dementia to common neuropathologies

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome

Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers

CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis

Genetic risk variants in African Americans with multiple sclerosis

APOE and cerebral amyloid angiopathy in community-dwelling older persons

A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research

Modeling disease severity in multiple sclerosis using electronic health records

Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data

The association of magnetic resonance imaging measures with cognitive function in a biracial population sample

5'RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy.

New therapeutic approaches for multiple sclerosis

Allelic variant in CTLA4 alters T cell phosphorylation patterns

Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex

PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis

Evidence for a common pathway linking neurodegenerative diseases

Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies

Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis

A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.

Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies

Alzheimer's loci: epigenetic associations and interaction with genetic factors

Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease

A common polymorphism near PER1 and the timing of human behavioral rhythms

A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants.