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List of works by Mark von Zastrow

A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action.

scientific article

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

scientific article published on 30 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing ⬇️

journal article from 'bioRxiv' published in 2020

A cell biologist's perspective on physiological adaptation to opiate drugs

scientific article published in January 2004

A chemical screen identifies class a g-protein coupled receptors as regulators of cilia

scientific article

A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling

scientific article published on 14 October 2020

A novel anterograde trafficking signal present in the N-terminal extracellular domain of ionotropic glutamate receptors

scientific article published on 3 October 2002

A novel endocytic recycling signal that distinguishes the membrane trafficking of naturally occurring opioid receptors

scientific article

A novel sorting sequence in the beta2-adrenergic receptor switches recycling from default to the Hrs-dependent mechanism.

scientific article

A simple cell-based assay reveals that diverse neuropsychiatric risk genes converge on primary cilia

scientific article

Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

scientific article published on 25 February 2020

Alternative splicing determines the post-endocytic sorting fate of G-protein-coupled receptors

scientific article published on 20 October 2008

An expanded palette of dopamine sensors for multiplex imaging in vivo

scientific article published on 07 September 2020

Analysis of GPCR Localization and Trafficking ⬇️

scientific article published on January 1, 2011

Aripiprazole has functionally selective actions at dopamine D2 receptor-mediated signaling pathways.

scientific article

Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder

scientific article

Cargo regulates clathrin-coated pit dynamics

scientific article published on October 2006

Cargo-mediated regulation of a rapid Rab4-dependent recycling pathway

scientific article

Chemical genetic engineering of G protein-coupled receptor kinase 2.

scientific article published on 4 August 2005

Conformational biosensors reveal GPCR signalling from endosomes.

scientific article

Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor

scientific article published on December 2002

DISC1 regulates primary cilia that display specific dopamine receptors

scientific article

Differential activation and trafficking of micro-opioid receptors in brain slices

scientific article

Differentiation of opioid drug effects by hierarchical multi-site phosphorylation

scientific article published on 13 December 2012

Distinct modes of regulated receptor insertion to the somatodendritic plasma membrane

scientific article published on 9 April 2006

Dysbindin promotes the post-endocytic sorting of G protein-coupled receptors to lysosomes

scientific article

Editorial overview: Cell regulation: The ins and outs of G protein-coupled receptors.

scientific article published on 12 February 2014

Effects of endocytosis on receptor-mediated signaling

scientific article

Endocytosis Promotes Rapid Dopaminergic Signaling ⬇️

scientific article published on July 28, 2011

Endocytosis of neurotransmitter receptors: location matters

scientific article

Endocytosis, signaling, and beyond

scientific article

Endosomal Phosphatidylinositol 3-Kinase Is Essential for Canonical GPCR Signaling

scientific article published on 7 November 2016

Engineered protein connectivity to actin mimics PDZ-dependent recycling of G protein-coupled receptors but not its regulation by Hrs

scientific article (publication date: 23 January 2009)

Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signaling.

scientific article

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

scientific article

Functional characterization of vasopressin type 2 receptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis: implications for treatments

scientific article

Functional selectivity of GPCR-directed drug action through location bias

scientific article published on 29 May 2017

G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands

scientific article

G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes

scientific article

G protein-regulated endocytic trafficking of adenylyl cyclase type 9

scientific article published on 09 June 2020

GIV/Girdin activates Gαi and inhibits Gαs via the same motif

scientific article published on 12 September 2016

GPCR signaling along the endocytic pathway

scientific article published on 28 December 2013

GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talk

scientific article

Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK.

scientific article published on 20 June 2017

Identification of protein interactions by yeast two-hybrid screening and coimmunoprecipitation

scientific article published in January 2004

Investigating G protein-coupled receptor endocytosis and trafficking by TIR-FM.

scientific article

Investigating signaling consequences of GPCR trafficking in the endocytic pathway

scientific article

Mass spectrometric analysis of agonist effects on posttranslational modifications of the beta-2 adrenoceptor in mammalian cells

scientific article published in April 2005

Mechanisms regulating membrane trafficking of G protein-coupled receptors in the endocytic pathway

scientific article published on December 2003

Membrane traffic in the post-genomic era.

scientific article published on 25 May 2010

Microtubule Plus-End-Tracking Proteins Target Gap Junctions Directly from the Cell Interior to Adherens Junctions

Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions

scientific article

Modulating neuromodulation by receptor membrane traffic in the endocytic pathway

scientific article

Molecular Pharmacology of δ-Opioid Receptors

scientific article published on July 2016

Morphine acutely regulates opioid receptor trafficking selectively in dendrites of nucleus accumbens neurons.

scientific article

Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons

scientific journal article

Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons

scientific article

Neurotrophin-regulated sorting of opioid receptors in the biosynthetic pathway of neurosecretory cells.

scientific article published on March 2003

Opioid receptor regulation

scientific article published on January 2004

Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras.

scientific article

Quantitative encoding of the effect of a partial agonist on individual opioid receptors by multisite phosphorylation and threshold detection

scientific article published on August 2011

Rapid delivery of internalized signaling receptors to the somatodendritic surface by sequence-specific local insertion

scientific article

Real-time imaging of discrete exocytic events mediating surface delivery of AMPA receptors.

scientific article published on October 2007

Recovery from μ-Opioid Receptor Desensitization after Chronic Treatment with Morphine and Methadone ⬇️

scientific article published on March 23, 2011

Regulated endocytosis of opioid receptors: cellular mechanisms and proposed roles in physiological adaptation to opiate drugs

scientific article

Regulation of GPCRs by endocytic membrane trafficking and its potential implications

scientific article published on January 2008

Regulation of endocytic clathrin dynamics by cargo ubiquitination

scientific article

Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization

scientific article

Regulation of opioid receptors by endocytic membrane traffic: mechanisms and translational implications

scientific article published on 24 March 2010

Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.

scientific article published on 15 January 2013

Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs

scientific article

Retromer mediates a discrete route of local membrane delivery to dendrites

scientific article

Role of PDZ Proteins in Regulating Trafficking, Signaling, and Function of GPCRs: Means, Motif, and Opportunity ⬇️

scientific article published on January 1, 2011

Role of Ubiquitination in Endocytic Trafficking of G‐Protein‐Coupled Receptors ⬇️

scientific article published on October 15, 2010

SH3 binding domains in the dopamine D4 receptor

scientific article

SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane

scientific article

SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors ⬇️

scientific article published on May 22, 2011

Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains.

scientific article

Signaling on the endocytic pathway

Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis

scientific article

Structure of an Arrestin2-Clathrin Complex Reveals a Novel Clathrin Binding Domain That Modulates Receptor Trafficking

scientific article

The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders

article by A Jeremy Willsey et al published 26 July 2018 in Cell

The composition of the beta-2 adrenergic receptor oligomer affects its membrane trafficking after ligand-induced endocytosis

scientific article

The golgi-associated PDZ domain protein PIST/GOPC stabilizes the β1-adrenergic receptor in intracellular compartments after internalization

scientific article

The role of ubiquitination in lysosomal trafficking of δ-opioid receptors

scientific article

The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.

scientific article

The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor

scientific article published on 11 May 2016

Time-gated detection of protein-protein interactions with transcriptional readout.

scientific article published on 30 November 2017

Type I PDZ ligands are sufficient to promote rapid recycling of G Protein-coupled receptors independent of binding to N-ethylmaleimide-sensitive factor

scientific article

Ubiquitination in the First Cytoplasmic Loop of μ-Opioid Receptors Reveals a Hierarchical Mechanism of Lysosomal Down-regulation ⬇️

scientific article published on September 27, 2011

Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes

scientific article

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors

scientific article

When trafficking and signaling mix: How subcellular location shapes G protein-coupled receptor activation of heterotrimeric G proteins

scientific article published on 01 February 2019

{Beta}-blocker drugs mediate calcium signaling in native central nervous system neurons by {beta}-arrestin-biased agonism

scientific journal article

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