List of works - Thomas E Smithgall

A single β-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding.

scientific article published on 7 February 2018

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases

scientific article

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases

scientific article published in Journal of Biological Chemistry

Cell-based Fluorescence Complementation Reveals a Role for HIV-1 Nef Protein Dimerization in AP-2 Adaptor Recruitment and CD4 Co-receptor Down-regulation

scientific article published on 28 December 2016

Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds

scientific article

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

scientific article

Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD+ AML cell growth

scientific article

Dynamics of the Tec-family tyrosine kinase SH3 domains

scientific article published on 25 January 2016

Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance

scientific article published on 02 December 2019

Hydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants

scientific article published on 31 March 2016

Inhibition of histone deacetylase expands the renal progenitor cell population

scientific article

Nef Homodimers Downregulate SERINC5 by AP-2-Mediated Endocytosis to Promote HIV-1 Infectivity

scientific article published on 01 September 2020

Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation.

scholarly article

Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding.

scientific article published on 16 December 2017

Selective inhibition of the myeloid Src-family kinase Fgr potently suppresses AML cell growth in vitro and in vivo.

scientific article

Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action

scientific article

Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes

scientific article published on 29 August 2020

Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor

scientific article published on 6 October 2015

Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists

scientific article published on 21 January 2016

The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation

scientific article published on 23 October 2018

Tight-Binding Hydroxypyrazole HIV-1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC-I Downregulation

scientific article published on 16 December 2019

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

scientific article

c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution

scientific article published on 11 May 2016

List of works by Thomas E Smithgall

A single β-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding.

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases

Cell-based Fluorescence Complementation Reveals a Role for HIV-1 Nef Protein Dimerization in AP-2 Adaptor Recruitment and CD4 Co-receptor Down-regulation

Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD+ AML cell growth

Dynamics of the Tec-family tyrosine kinase SH3 domains

Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance

Hydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants

Inhibition of histone deacetylase expands the renal progenitor cell population

Nef Homodimers Downregulate SERINC5 by AP-2-Mediated Endocytosis to Promote HIV-1 Infectivity

Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation.

Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding.

Selective inhibition of the myeloid Src-family kinase Fgr potently suppresses AML cell growth in vitro and in vivo.

Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action

Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes

Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor

Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists

The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation

Tight-Binding Hydroxypyrazole HIV-1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC-I Downregulation

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution