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List of works by Deborah T Hung

1830. Single-cell Transcriptional Profiling Reveals an Immune Cell State Signature of Bacterial Sepsis

scientific article published on 23 October 2019

A Point of Inflection and Reflection on Systems Chemical Biology

scientific article published on 28 October 2019

A highly multiplexed and sensitive RNA-seq protocol for simultaneous analysis of host and pathogen transcriptomes

scientific article published on 21 July 2016

A perspective on single cell behavior during infection

scientific article

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

article published in 2021

A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.

scientific article published on 3 July 2017

Accelerating global innovation to address antibacterial resistance: introducing CARB-X.

scientific article published on 29 July 2016

Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae

scientific article published on 13 April 2020

An immune-cell signature of bacterial sepsis

scientific article published on 17 February 2020

Author Correction: Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae

scientific article published on 25 June 2020

Bacterial toxins and small molecules elucidate endosomal trafficking

scientific article published on 23 December 2013

Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors

scientific article published on 14 June 2016

Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner

scientific article

Bile acids stimulate biofilm formation in Vibrio cholerae

scientific article published on 01 January 2006

CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells ⬇️

scientific article published on May 28, 2013

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets ⬇️

journal article from 'Nature' published in 2021

Carbapenem Resistance Caused by High-Level Expression of OXA-663 β-Lactamase in an OmpK36-Deficient Klebsiella pneumoniae Clinical Isolate

scientific article published on 24 October 2018

Chemical biology and bacteria: not simply a matter of life or death.

scientific article published on 30 June 2006

Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis

scientific article published on 21 April 2013

Chemical tools for dissecting bacterial physiology and virulence

scientific article published on September 2009

Conservation of the structure and function of bacterial tryptophan synthases

scientific article published on 29 May 2019

Continuous and High-Throughput Electromechanical Lysis of Bacterial Pathogens Using Ion Concentration Polarization.

scientific article published in December 2017

Defining the core essential genome of

scientific article

Definitions and guidelines for research on antibiotic persistence

scientific article published on 01 July 2019

Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing

scientific article published on 16 September 2020

Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32

scientific article

Direct detection and drug-resistance profiling of bacteremias using inertial microfluidics

scientific article published on May 2015

Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors

scientific article published on 29 September 2018

Elucidation of the physiology of non-replicating, drug tolerant Mycobacterium tuberculosis with the aid of the small molecule probe ML338

scholarly article published 22 November 2013

Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals.

scientific article

GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro.

scientific article

Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies

scientific article published on 05 November 2018

Genomic Analysis of the Evolution of Fluoroquinolone Resistance in Mycobacterium tuberculosis Prior to Tuberculosis Diagnosis.

scientific article published on 29 August 2016

Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011.

scientific article published on 6 February 2012

Harnessing CRISPR Effectors for Infectious Disease Diagnostics

scientific article published on 16 August 2018

How antibiotics kill bacteria: new models needed? ⬇️

scientific article published on May 1, 2013

Hybridization-based capture of pathogen mRNA enables paired host-pathogen transcriptional analysis

scientific article published on 17 December 2019

Identification of a chemically validated target in replicating and non-replicating Mycobacterium tuberculosis with the aid of a small molecule probe

scholarly article published 4 April 2015

Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth

scientific article (publication date: February 2014)

Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death

scientific article published on 4 February 2013

Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.

scientific article published on 21 May 2012

Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model

scientific article

Independent large scale duplications in multiple M. tuberculosis lineages overlapping the same genomic region

scientific article

Induction of a regulatory myeloid program in bacterial sepsis and severe COVID-19

scientific article published on 02 September 2020

Large-Scale Chemical-Genetic Strategy Enables the Design of Antimicrobial Combination Chemotherapy in Mycobacteria

scientific article published on 28 November 2019

Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes

scientific article published on 19 June 2019

Loss of a Class A Penicillin-Binding Protein Alters β-Lactam Susceptibilities in Mycobacterium tuberculosis.

scientific article published on 21 December 2015

Massively multiplexed nucleic acid detection using Cas13

scientific article published on 29 April 2020

Mechanisms of β-lactam killing and resistance in the context of Mycobacterium tuberculosis

scientific article

MetaMerge: scaling up genome-scale metabolic reconstructions, with application to Mycobacterium tuberculosis

scientific article (publication date: 31 January 2012)

Metagenomic Sequencing of an Echovirus 30 Genome From Cerebrospinal Fluid of a Patient With Aseptic Meningitis and Orchitis

scientific article published on 28 July 2017

Multi-institute analysis of carbapenem resistance reveals remarkable diversity, unexplained mechanisms, and limited clonal outbreaks

scientific article published on 17 January 2017

Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa

scientific article published on 23 August 2019

Nucleic acid detection with CRISPR-Cas13a/C2c2

scientific article

Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses

scientific article

Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses

article

Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response ⬇️

scientific article published on 05 April 2013

Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches

scientific article

Productive steps toward an antimicrobial targeting virulence

scientific article published on 22 July 2009

Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants

scientific article published on 21 January 2009

Publisher Correction: Definitions and guidelines for research on antibiotic persistence

scientific article published on 01 July 2019

RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities ⬇️

scientific article published on April 2, 2012

Rapid Phenotypic Antibiotic Susceptibility Testing Through RNA Detection.

scientific article published on 4 October 2017

Rapid identification and phylogenetic classification of diverse bacterial pathogens in a multiplexed hybridization assay targeting ribosomal RNA

scientific article published on 14 March 2019

Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany

scientific article

Resuscitation-promoting factors are required for β-lactam tolerance and the permeability barrier in Mycobacterium tuberculosis.

scientific article published on 12 December 2011

Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment

scientific article published on 21 February 2017

SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication

scientific article

Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing

scientific article published on 14 December 2008

Simultaneous detection of genotype and phenotype enables rapid and accurate antibiotic susceptibility determination

scientific article published on 25 November 2019

Simultaneous generation of many RNA-seq libraries in a single reaction

scientific article published on 2 March 2015

Single-Cell RNA Sequencing to Understand Host-Pathogen Interactions

scientific article published on 31 January 2019

Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization

scientific article

Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32.

scientific article published on 19 September 2013

Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence

scientific article

Systematics-guided bioprospecting for bioactive microbial natural products.

scientific article

Targeting multiple biofilm pathways

scientific article

Targeting virulence: a new paradigm for antimicrobial therapy

scientific article published on September 2007

The First Synthesis of an Epidiselenodiketopiperazine ⬇️

scientific article published on August 22, 2012

The Sensor Kinase KinB Regulates Virulence in Acute Pseudomonas aeruginosa Infection ⬇️

scientific article published on April 22, 2011

The expanding diversity of Mycobacterium tuberculosis drug targets.

scientific article published on 7 February 2018

The fast track to multidrug resistance

scientific article

The two-component sensor KinB acts as a phosphatase to regulate Pseudomonas aeruginosa Virulence

scientific journal article

The two-component sensor kinase KinB acts as a non-canonical switch between acute and chronic infection ⬇️

scientific article published on November 1, 2011

Toward a systems-level analysis of infection biology: a new method for conducting genetic screens in human cells

scientific article published on December 2009

Virstatin inhibits dimerization of the transcriptional activator ToxT

scholarly article

Whole-organism phenotypic screening for anti-infectives promoting host health

scientific article published on 19 March 2018

scDual-Seq: mapping the gene regulatory program of Salmonella infection by host and pathogen single-cell RNA-sequencing

scientific article published on 27 October 2017

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