List of works - Rajat Rohatgi

Biochemical mechanisms of vertebrate hedgehog signaling

scientific article published on 15 May 2019

Cholesterol access in cellular membranes controls Hedgehog signaling

scientific article published on 16 November 2020

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

scientific article published on 30 October 2019

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.

scientific article published on 05 October 2016

Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling.

scientific article published on 20 December 2016

Discovery of gene regulatory elements through a new bioinformatics analysis of haploid genetic screens

scientific article published in PLoS ONE

G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.

scientific article published on 6 February 2018

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling

scientific article published on 09 December 2021

Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution

scientific article published on 17 March 2021

Lipid droplets can promote drug accumulation and activation

scientific article published on 13 January 2020

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

scientific article published on 26 October 2021

Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain

scientific article published on 03 June 2022

Phase separation-deficient TDP43 remains functional in splicing

scientific article published on 25 October 2019

R-spondins can potentiate WNT signaling without LGRs.

scientific article

R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling

scientific article published on 20 May 2020

Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling.

scientific article published on 30 April 2018

TDP-43 α-helical structure tunes liquid-liquid phase separation and function

scientific article published on 04 March 2020

List of works by Rajat Rohatgi