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List of works by Darren J Moore

A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

scientific article

A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.

scientific article published on December 2003

Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease

scientific article published on September 2009

Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease.

scientific article published on 28 February 2015

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

scientific article

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

scholarly article

Common Pathogenic Effects of Missense Mutations in the P-Type ATPase ATP13A2 (PARK9) Associated with Early-Onset Parkinsonism ⬇️

scientific article published on June 29, 2012

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

scientific article

Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

scientific article published on 24 July 2009

Contribution of GTPase activity to LRRK2-associated Parkinson disease

scientific article published on 10 June 2013

Deciphering the role of VPS35 in Parkinson's disease.

scientific article published on 18 May 2018

Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity

scientific article published on 06 July 2020

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

scientific article published on 6 April 2011

Dynamic and redundant regulation of LRRK2 and LRRK1 expression

scientific article

Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain

scientific article published on 13 November 2006

Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily

scientific article

G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain.

scientific article published on 27 October 2017

GTPase activity plays a key role in the pathobiology of LRRK2.

scientific article

Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease

scientific article published on 29 October 2016

LRRK2 secretion in exosomes is regulated by 14-3-3.

scientific article published on 25 July 2013

Lessons from Drosophila models of DJ-1 deficiency

scientific article

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

scientific article

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

scientific article

Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain

scientific article

Mechanisms of LRRK2-Mediated Neurodegeneration ⬇️

scientific article published on June 1, 2012

Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.

scientific article published on February 2017

Mitochondrial dysfunction in genetic animal models of Parkinson's disease

scientific article published on 4 October 2011

Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

scientific article

Modeling LRRK2 Pathobiology in Parkinson's Disease: From Yeast to Rodents

scientific article

Molecular pathophysiology of Parkinson's disease

scientific article

Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.

scientific article

PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

scientific journal article

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

scientific article

Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons

scientific article published on 4 January 2017

Parkin mediates the degradation-independent ubiquitination of Hsp70

scientific article published on February 2008

Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting

scientific article published on 01 September 2018

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1 ⬇️

scientific article published on June 6, 2011

Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36 ⬇️

scientific article published on August 25, 2011

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

scientific article

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

scientific article

Parkinson's disease-linked knockin mice manifest tau neuropathology and dopaminergic neurodegeneration

scientific article published on 06 March 2019

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

scientific article

Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration

scientific article published on 14 March 2019

Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations

scientific article

Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2

scientific article

Revelations and revolutions in the understanding of Parkinson's disease.

scientific article

Role for the ubiquitin-proteasome system in Parkinson's disease and other neurodegenerative brain amyloidoses

scientific article published on January 2003

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

scientific article

Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils

scientific article published on 02 July 2019

Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1.

scientific article published on 07 June 2016

Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.

scientific article published on January 2017

VPS35, the Retromer Complex and Parkinson's Disease.

scientific article

Value of genetic models in understanding the cause and mechanisms of Parkinson's disease

scientific article

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

scientific article

α-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9).

scientific article

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