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List of works by Paul A Lyons

A CD8+ T cell transcription signature predicts prognosis in autoimmune disease

scientific article

A blood-based prognostic biomarker in IBD

scientific article published on 27 April 2019

A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus

scientific article

A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes.

scientific article

ANCA-associated vasculitis

scientific article published on 27 August 2020

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity

An open-access long oligonucleotide microarray resource for analysis of the human and mouse transcriptomes.

scientific article

Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity.

scientific article

Association Between Genetic Variation in FOXO3 and Reductions in Inflammation and Disease Activity in Inflammatory Polyarthritis

scientific article published on 23 May 2016

Association of a TNFSF13B (BAFF) regulatory region single nucleotide polymorphism with response to rituximab in antineutrophil cytoplasmic antibody-associated vasculitis.

scientific article

Belimumab in kidney transplantation: an experimental medicine, randomised, placebo-controlled phase 2 trial

scientific article published on 14 June 2018

CD8 T Cells Mediate Direct Biliary Ductule Damage in Nonobese Diabetic Autoimmune Biliary Disease ⬇️

scientific article published on December 17, 2010

Combined Influence of B-Cell Receptor Rearrangement and Somatic Hypermutation on B-Cell Class-Switch Fate in Health and in Chronic Lymphocytic Leukemia

article

Combined point of care nucleic acid and antibody testing for SARS-CoV-2 following emergence of D614G Spike Variant

scientific article published on 01 September 2020

Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: the NOD model of type 1 diabetes

scientific article published on February 2002

Comment on "The inhibiting Fc receptor for IgG, FcγRIIB, is a modifier of autoimmune susceptibility"

scientific article published on 01 December 2011

Comparison of gene expression microarray data with count-based RNA measurements informs microarray interpretation

scientific article

Complement abnormalities in acquired lipodystrophy revisited

scientific article published on 14 October 2008

Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis

scientific article

Continued discovery of transcriptional units expressed in cells of the mouse mononuclear phagocyte lineage

scientific article published in June 2003

Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis

scientific article

Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake

scientific article published on 16 June 2008

Copy number, linkage disequilibrium and disease association in the FCGR locus

scientific article

Correction: Lipid Anti-Lipid Antibody Responses Correlate with Disease Activity in Systemic Lupus Erythematosus.

scientific article published on 16 October 2013

Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis. ⬇️

scientific article

Discovery of imprinted transcripts in the mouse transcriptome using large-scale expression profiling

scientific article

Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb

scientific article published on 24 March 2008

Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development

scientific article published on 31 August 2020

Efficient inhibition of miR-155 function in vivo by peptide nucleic acids

scientific article

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity

scientific article published on 28 March 2017

Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity.

scientific article published on 11 August 2013

Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.

scientific article

Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis

scientific article

Genetic control of autoimmunity: protection from diabetes, but spontaneous autoimmune biliary disease in a nonobese diabetic congenic strain

scientific article published on 01 August 2004

Genetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases

scientific article published on 25 November 2020

Genetically distinct subsets within ANCA-associated vasculitis

scientific journal article

Genetics of ANCA-associated vasculitides: HLA and beyond

scientific article published on 15 May 2014

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease.

scientific article published on 9 January 2017

Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status.

scientific article

Genome-wide end-sequenced BAC resources for the NOD/MrkTac() and NOD/ShiLtJ() mouse genomes

scientific article

Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type-specific hypomethylated regions.

scientific article published on 24 October 2013

High prevalence of autoantibodies to hLAMP-2 in anti-neutrophil cytoplasmic antibody-associated vasculitis

scientific article published on 9 February 2012

Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway

scientific article published on 12 September 2013

Idd9.1 locus controls the suppressive activity of FoxP3+CD4+CD25+ regulatory T-cells

scientific article

Identification of a Structurally Distinct CD101 Molecule Encoded in the 950-kb Idd10 Region of NOD Mice

scientific article published on 01 June 2003

Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease

scientific article

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

scientific article

L31. A GWAS in ANCA-associated vasculitis: Will genetics help re-define clinical classification? ⬇️

scientific article published on March 11, 2013

Leucocyte subset-specific type 1 interferon signatures in SLE and other immune-mediated diseases

scientific article

Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis.

scientific article published on 20 February 2013

Lipid Anti-Lipid Antibody Responses Correlate with Disease Activity in Systemic Lupus Erythematosus ⬇️

scientific article published on February 7, 2013

MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production

scientific article published on 19 August 2013

Microarray analysis of human leucocyte subsets: the advantages of positive selection and rapid purification

scientific article

NBEAL2 is required for neutrophil and NK cell function and pathogen defense

scientific article published on 7 August 2017

Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse

scientific article published on 01 January 2005

Novel expression signatures identified by transcriptional analysis of separated leucocyte subsets in systemic lupus erythematosus and vasculitis

scientific article

PRedicting Outcomes For Crohn's dIsease using a moLecular biomarkEr (PROFILE): protocol for a multicentre, randomised, biomarker-stratified trial

scientific article published on 05 December 2018

Peripheral Immune Cell Populations Associated with Cognitive Deficits and Negative Symptoms of Treatment-Resistant Schizophrenia

scientific article published on 31 May 2016

Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes

scientific article

Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

scientific article published on 17 July 2020

Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease

scientific article published on 10 September 2018

Signalling lymphocyte activation molecule family member 9 is found on select subsets of antigen-presenting cells and promotes resistance to Salmonella infection

scientific article published on 28 January 2020

Single-cell multi-omics analysis of the immune response in COVID-19

scientific article published on 20 April 2021

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection.

scientific article

Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network

scientific article published on 19 July 2016

Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia

scientific article

The Contribution of Transcriptomics to Biomarker Development in Systemic Vasculitis and SLE.

scientific article published on January 2015

The cellular immune response to COVID-19 deciphered by single cell multi-omics across three UK centres

scientific article published on 15 January 2021

The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis

scientific article

The derivation of highly germline-competent embryonic stem cells containing NOD-derived genome

scientific article published on January 2003

The nervous spleen: The nervous spleen.

scientific article published in January 2008

The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro

scientific article

The role of a functional variant of TYK2 in vasculitides and infections

scientific article published on 10 March 2020

Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report

scientific article published on 14 December 2020

Type I interferon as a biomarker in autoimmunity and viral infection: a leukocyte subset-specific analysis unveils hidden diagnostic options

scientific article published on 29 March 2017

Whole Genome Sequencing of Primary Immunodeficiency reveals a role for common and rare variants in coding and non-coding sequences

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

scientific article published on 06 May 2020

miR-374a-5p regulates inflammatory genes and monocyte function in patients with inflammatory bowel disease

scientific article published on 01 April 2022

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