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List of works by Nicholas A. Meanwell

1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones - inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation ⬇️

scientific article published on 01 September 1991

2015 Philip S. Portoghese Medicinal Chemistry Lectureship. Curing Hepatitis C Virus Infection with Direct-Acting Antiviral Agents: The Arc of a Medicinal Chemistry Triumph

scientific article

5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors

scientific article published on 18 January 2019

A Novel Small Molecule Inhibitor of Hepatitis C Virus Entry ⬇️

scientific article published on September 2, 2010

Active site-directed thrombin inhibitors-II. Studies related to arginine/guanidine bioisosteres ⬇️

scientific article published on 01 August 1995

Advances toward COVID-19 Therapies Special Issue Call for Papers

scientific article published on 02 December 2020

Allosteric Modulators of Drug Targets Special Issue.

scientific article published on 7 February 2018

Artificial Intelligence in Drug Discovery: Into the Great Wide Open

scientific article published on 08 July 2020

Azetidin-2-one derivatives as inhibitors of thrombin ⬇️

scientific article published on 01 August 1995

Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors.

scientific article published on 28 November 2017

C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors

scientific article published on 2 March 2016

Coupling of an Acyl Migration Prodrug Strategy with Bio-activation To Improve Oral Delivery of the HIV-1 Protease Inhibitor Atazanavir

scientific article

Design strategies in the prodrugs of HIV-1 protease inhibitors to improve the pharmaceutical properties.

scientific article

Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir

scientific article published on 02 April 2019

Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamet

article

Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain.

scientific article

Development of the Large-Scale Synthesis of Tetrahydropyran Glycine, a Precursor to the HCV NS5A Inhibitor BMS-986097.

scientific article published on 6 September 2017

Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors

scientific article published on 21 February 2020

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection

scientific article

Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase

scientific article

Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase

scientific article

Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity

scientific article published on 22 April 2016

Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase

scientific article published on 11 June 2017

Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

scientific article published on 23 November 2020

Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain

scientific article published on 08 January 2019

Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies

scientific article published on 21 April 2017

Discovery of new indole-based acylsulfonamide Nav1.7 inhibitors

scientific article published on 06 December 2018

Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation

scientific article published on 9 August 2017

Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug Fostemsavir

article

Drug-target interactions that involve the replacement or displacement of magnesium ions.

scientific article published on 10 November 2017

Epigenetics 2.0: Special Issue on Epigenetics-Call for Papers

scientific article published on 22 October 2020

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.

scientific article

Functionalized triazines as potent HCV entry inhibitors.

scientific article published on 18 December 2016

HCV NS5A replication complex inhibitors. Part 2: Investigation of stilbene prolinamides ⬇️

scientific article published on August 21, 2012

HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies ⬇️

scientific article published on December 3, 2012

Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons

scientific article published on 17 January 2014

Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.

scientific article

Imidazoquinoline derivatives: Potent inhibitors of platelet cAMP phosphodiesterase which elevate cAMP levels and activate protein kinase in platelets ⬇️

scientific article published on April 1, 1991

Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety ⬇️

scientific article published on July 26, 2011

In VitroAntiviral Characteristics of HIV-1 Attachment Inhibitor BMS-626529, the Active Component of the Prodrug BMS-663068 ⬇️

scientific article published on April 30, 2012

Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers ⬇️

scientific article published on September 6, 2011

Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes

scientific article published on 11 January 2011

Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir

scientific article published on 22 December 2017

Inhibitors of HIV-1 attachment. Part 10. The discovery and structure–activity relationships of 4-azaindole cores ⬇️

scientific article published on November 7, 2012

Inhibitors of HIV-1 attachment. Part 7: Indole-7-carboxamides as potent and orally bioavailable antiviral agents ⬇️

scientific article published on November 6, 2012

Inhibitors of HIV-1 attachment. Part 8: The effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors ⬇️

scientific article published on November 5, 2012

Inhibitors of HIV-1 attachment. Part 9: An assessment of oral prodrug approaches to improve the plasma exposure of a tetrazole-containing derivative ⬇️

scientific article published on November 7, 2012

Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids

scientific article

Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment 13. Synthesis and Profiling of a Novel Amminium Prodrug of the HIV-1 Attachment Inhibitor BMS-585248 ⬇️

scientific article published on February 12, 2013

Inhibitors of blood platelet cAMP phosphodiesterase. 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains

scientific article published on July 10, 1992

Inhibitors of blood platelet cAMP phosphodiesterase. 3. 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives with enhanced aqueous solubility

scientific article published on July 10, 1992

Introduction to hepatitis C virus (HCV) therapies special thematic issue

scientific article published on 31 January 2014

Introduction: Drug Metabolism and Toxicology Special Issue

scientific article published on 02 June 2020

Journal of Medicinal Chemistry, Technological Advances: Highlights 2015-2016.

scientific article

Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors

scientific article

Metabolic and Pharmaceutical Aspects of Fluorinated Compounds

scientific article published on 17 March 2020

New first and second generation inhibitors of human immunodeficiency virus-1 integrase ⬇️

scientific article published on May 20, 2011

Nonprostanoid prostacyclin mimetics. 2. 4,5-Diphenyloxazole derivatives

scientific article published on September 18, 1992

Nonprostanoid prostacyclin mimetics. 3. Structural variations of the diphenyl heterocycle moiety

scientific article published on September 18, 1992

Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity

scientific article published on 24 December 2020

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A.

scientific article published on 4 November 2015

Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors

scientific article published on 05 November 2018

Structure-activity relationships associated with 3,4,5-triphenyl-1H-pyrazole-1-nonanoic acid, a nonprostanoid prostacyclin mimetic

scientific article published on January 24, 1992

Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus.

scientific article published on 9 December 2016

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design ⬇️

scientific article published on March 17, 2011

Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity

scientific article published on 22 January 2020

The 2020 Nobel Prize in Physiology or Medicine

scientific article published on 05 November 2020

The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors ⬇️

scientific article

The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation

scientific article published on 26 March 2018

The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease.

scientific article published on 3 November 2017

The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase

scientific article published on 08 February 2017

The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection

scientific article published on 5 March 2014

Writing Your Next Medicinal Chemistry Article: Journal Bibliometrics and Guiding Principles for Industrial Authors

scientific article published on 26 October 2020

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