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List of works by Bastiaan T. Heijmans

A characterization of cis- and trans-heritability of RNA-Seq-based gene expression

scientific article published on 26 September 2019

A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer

scientific article published in March 2003

A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention

scientific article published on 30 August 2011

A metabolomic profile is associated with the risk of incident coronary heart disease

scientific article published on 4 April 2014

Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception.

scientific article

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

scientific article published on 22 September 2016

Alternative Routes to Induce Naïve Pluripotency in Human Embryonic Stem Cells

scientific article published on 24 June 2015

An alternative approach to multiple testing for methylation QTL mapping reduces the proportion of falsely identified CpGs

scientific article published on 04 October 2014

Angiotensin I-converting enzyme and plasminogen activator inhibitor-1 gene variants: risk of mortality and fatal cardiovascular disease in an elderly population-based cohort

scientific article published on 01 October 1999

Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals

scientific article

Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age.

scientific article published in January 2002

Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals

scientific article published on 01 August 2019

Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults

Association of the tumour necrosis factor alpha -308G/A polymorphism with the risk of diabetes in an elderly population-based cohort

scientific article published on 01 June 2002

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

scientific article published in Nature Communications

Blood lipids influence DNA methylation in circulating cells

scientific article published on 27 June 2016

Chromatin remodeling of human subtelomeres and TERRA promoters upon cellular senescence: commonalities and differences between chromosomes

scientific article published on 17 April 2013

Combined association and linkage analysis applied to the APOE locus

scientific article published in May 2004

Commentary: The seven plagues of epigenetic epidemiology ⬇️

scientific article published on January 23, 2012

Common gene variants, mortality and extreme longevity in humans.

scientific article

Common paraoxonase gene variants, mortality risk and fatal cardiovascular events in elderly subjects

scientific article published on 01 March 2000

Comprehensive evaluation of smoking exposures and their interactions on DNA methylation

scientific article published in 2024

Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution

scientific article published on 27 January 2017

Corrigendum: DNA methylation signatures link prenatal famine exposure to growth and metabolism

scientific article published on 7 July 2015

DNA Methylation Landscapes of Human Fetal Development

scientific article published on 22 October 2015

DNA methylation aging clocks: challenges and recommendations

scientific article published on 25 November 2019

DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells.

scientific article published on 13 October 2017

DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood.

scientific article published on 31 January 2018

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

scientific article published in November 2009

DNA methylation differences at birth after conception through ART

scientific article published on 23 November 2020

DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age.

scientific article published on February 2011

DNA methylation of IGF2DMR and H19 is associated with fetal and infant growth: the generation R study

scientific article

DNA methylation profiles at birth and child ADHD symptoms

scientific article published on 7 November 2013

DNA methylation signatures link prenatal famine exposure to growth and metabolism

scientific article

DNA methylation signatures of educational attainment

scientific article published on 23 March 2018

Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES).

scientific article published on 19 May 2015

Design, measurement and processing of region-specific DNA methylation assays: the mass spectrometry-based method EpiTYPER.

scientific article

Differential methylation within the major histocompatibility complex region in rheumatoid arthritis: a replication study

scientific article published on 30 September 2014

Disease variants alter transcription factor levels and methylation of their binding sites

scientific article published on 5 December 2016

Duration of breastfeeding and gender are associated with methylation of the LEPTIN gene in very young children.

scientific article

Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome.

scientific article

Environmentally induced DNA methylation is inherited across generations in an aquatic keystone species

scientific article published on 25 April 2022

Epigenetic drift in the aging genome: a ten-year follow-up in an elderly twin cohort.

scientific article published on 6 August 2016

Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease.

scientific article published on 15 January 2009

Epigenetic signature of birth weight discordance in adult twins

scientific article

Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs

scientific article

Epigenetic variation in monozygotic twins: a genome-wide analysis of DNA methylation in buccal cells

scientific article

Epigenome-Wide Association Study of Aggressive Behavior

scientific article published on 28 October 2015

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

scientific article published on 21 December 2016

Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population.

scientific article published in November 2003

Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study

scientific article published in March 2010

From promises to practical strategies in epigenetic epidemiology ⬇️

scientific article published on July 2, 2013

Further Evidence for a QTL Influencing Body Mass Index on Chromosome 7p from a Genome-wide Scan in Dutch Families

article

Gender-specific association of the factor V Leiden mutation with fertility and fecundity in a historic cohort. The Leiden 85-Plus Study

scientific article published on 26 January 2006

Genetic and environmental influences interact with age and sex in shaping the human methylome.

scientific article published on 7 April 2016

Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies

article

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

scientific article published on 30 October 2017

Genetics of human aging. The search for genes contributing to human longevity and diseases of the old.

scientific article

Genome-wide analysis of DNA methylation in buccal cells: a study of monozygotic twins and mQTLs

scholarly article by Jenny van Dongen published in September 2018

Genome-wide analysis of constitutional DNA methylation in familial melanoma

scientific article published on 06 March 2020

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

scientific article

Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity

scientific article

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

scientific article

Genome-wide identification of directed gene networks using large-scale population genomics data

scientific article published in Nature Communications

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference

scientific article published on 28 August 2020

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

scientific article

Genomic studies in ageing research: the need to integrate genetic and gene expression approaches

article

Genomics of human longevity.

scientific article

Handling blood cell composition in epigenetic studies on ageing.

scientific article published on 3 June 2017

Heritabilities of apolipoprotein and lipid levels in three countries

scientific article

Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus

scientific article published on 05 March 2007

Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis

scientific article published on 9 October 2017

Human insulin/IGF-1 and familial longevity at middle age.

scientific article

Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites

scientific article published on 06 June 2019

Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction

scientific article published on 17 November 2011

Identical twins carry a persistent epigenetic signature of early genome programming

scientific article

Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array

scientific article published on 06 August 2013

Identification of context-dependent expression quantitative trait loci in whole blood

scientific article published on 5 December 2016

IgG glycosylation and DNA methylation are interconnected with smoking

scientific article

Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study

scientific article published on 01 September 2004

Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming

scientific article

Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses

scientific article published on 18 March 2021

LDL cholesterol still a problem in old age? A Mendelian randomization study

Lipid metabolism in long-lived families: the Leiden Longevity Study

scientific article

Lipoprotein particle profiles mark familial and sporadic human longevity

scientific article

Literature-based genetic risk scores for coronary heart disease: the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study

scientific article published on 28 February 2012

Longitudinal weight differences, gene expression and blood biomarkers in BMI-discordant identical twins.

scientific article published on 13 March 2015

Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study

scientific article published on 16 December 2009

Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study

scientific article

Maternal Prenatal Nutrition and Health in Grandchildren and Subsequent Generations

article

Maternal and child cytokine relationship in early life is not altered by cytokine gene polymorphisms. ⬇️

scientific article

Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions

scientific article published in October 2005

MethylAid: visual and interactive quality control of large Illumina 450k datasets.

scientific article published on 21 August 2014

Molecular epidemiology, candidate genes versus genome-wide scans

scientific article published on October 2007

Mortality risk in men is associated with a common mutation in the methylene-tetrahydrofolate reductase gene (MTHFR)

scientific article published on 01 February 1999

Neo-cartilage engineered from primary chondrocytes is epigenetically similar to autologous cartilage, in contrast to using mesenchymal stem cells

scientific article

No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85-plus study

scientific article published on 01 October 2002

Non-homologous end-joining pathway associated with occurrence of myocardial infarction: gene set analysis of genome-wide association study data

scientific article

Non-response to (statin) therapy: the importance of distinguishing non-responders from non-adherers in pharmacogenetic studies

scientific article published on 19 December 2015

Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study.

scientific article published on 17 July 2009

Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene

scientific article

Periconception maternal smoking and low education are associated with methylation of INSIGF in children at the age of 17 months.

scientific article published in October 2012

Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child

scientific article

Persistent epigenetic differences associated with prenatal exposure to famine in humans

scientific article published on 4 November 2008

Prenatal famine and genetic variation are independently and additively associated with DNA methylation at regulatory loci within IGF2/H19.

scientific article

Prenatal parental tobacco smoking, gene specific DNA methylation, and newborns size: the Generation R study

scientific article

Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice

scientific article published on 03 March 2017

RNA-Seq in 296 phased trios provides a high-resolution map of genomic imprinting.

scientific article

Reduced insulin/IGF-1 signalling and human longevity.

scientific article

Relationship between genome and epigenome--challenges and requirements for future research

scientific article published on 18 June 2014

Repeat UVA exposure of human skin fibroblasts induces both a transitionary and recovery DNA methylation response

scientific article published on 09 June 2020

Reply to 'Chinese famine and the diabetes mellitus epidemic'

scientific article published on 01 February 2020

Reply to 'Early-life exposure to the Chinese Famine and subsequent T2DM'

scientific article published on 01 February 2020

Selective Survival of Embryos Can Explain DNA Methylation Signatures of Adverse Prenatal Environments

scientific article published on 01 December 2018

Sex-limited genome-wide linkage scan for body mass index in an unselected sample of 933 Australian twin families

scientific article published in December 2005

Skewed X-inactivation is common in the general female population

scientific article published on 14 December 2018

Systematic testing of literature reported genetic variation associated with coronary restenosis: results of the GENDER Study

scientific article

Tea and coffee consumption in relation to DNA methylation in four European cohorts

scientific article published in August 2017

The effect of the Chinese Famine on type 2 diabetes mellitus epidemics

scientific article published on 01 June 2019

The epigenome: archive of the prenatal environment.

scientific article

The multifaceted interplay between lipids and epigenetics.

scientific article published on 30 March 2016

The risk of mortality and the factor V Leiden mutation in a population-based cohort.

scientific article

The tissue-specific aspect of genome-wide DNA methylation in newborn and placental tissues: implications for epigenetic epidemiologic studies

scientific article published on 24 April 2020

Thermolabile methylenetetrahydrofolate reductase gene and the risk of cognitive impairment in those over 85

scientific article

Transcription of the IL10 gene reveals allele-specific regulation at the mRNA level

scientific article published on 15 June 2004

TwinLIFE: The Twin Longitudinal Investigation of FEtal Discordance

scientific article published on 25 July 2019

Two-locus Linkage Analysis Applied to Putative Quantitative Trait Loci for Lipoprotein(a) Levels

article

Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis

scientific article published on 2 April 2014

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

scholarly article published 19 October 2018

Value of platelet pharmacogenetics in common clinical practice of patients with ST-segment elevation myocardial infarction

scientific article published on 29 August 2012

Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology

scientific article published on 12 April 2010

Visit-to-visit lipid variability: Clinical significance, effects of lipid-lowering treatment, and (pharmaco)genetics

scientific article published on 11 January 2018

omicsPrint: DETECTION OF DATA LINKAGE ERRORS IN MULTIPLE OMICS STUDIES.

scientific article published on 6 February 2018

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