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List of works by Marcel Karperien

A High Cell-Bearing Capacity Multibore Hollow Fiber Device for Macroencapsulation of Islets of Langerhans

scientific article published on 22 June 2020

A Protocol to Enhance INS1E and MIN6 Functionality-The Use of Theophylline

scientific article published on 12 September 2016

A Wnt/β-catenin negative feedback loop inhibits interleukin-1-induced matrix metalloproteinase expression in human articular chondrocytes

scientific article

A dual flow bioreactor with controlled mechanical stimulation for cartilage tissue engineering

scientific article published on 15 April 2013

A facile approach for thermal and reduction dual-responsive prodrug nanogels for intracellular doxorubicin delivery

scientific article published in 2016

A fluorogenic monolayer to detect the co-immobilization of peptides that combine cartilage targeting and regeneration

scientific article published on 25 February 2013

A supramolecular host-guest carrier system for growth factors employing V(H)H fragments.

scientific article published on 29 August 2014

APC mutations are associated with increased bone mineral density in patients with familial adenomatous polyposis

scientific article published on 18 June 2010

Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors

scientific article

An ECHO of Cartilage: <i>In Silico</i> Prediction of Combinatorial Treatments to Switch Between Transient and Permanent Cartilage Phenotypes With <i>Ex Vivo</i> Validation

scientific article published on 15 November 2021

An important step towards a prevascularized islet macroencapsulation device-effect of micropatterned membranes on development of endothelial cell network

scientific article published on 25 June 2018

An important step towards a prevascularized islet microencapsulation device: in vivo prevascularization by combination of mesenchymal stem cells on micropatterned membranes

scientific article published on 09 November 2018

An injectable platelet lysate-hyaluronic acid hydrogel supports cellular activities and induces chondrogenesis of encapsulated mesenchymal stem cells

scientific article published on 24 October 2018

An orthotopic mouse model for chondrosarcoma of bone provides an in vivo tool for drug testing

scientific article

Apc bridges Wnt/β-catenin and BMP signaling during osteoblast differentiation of KS483 cells

scientific article published on 22 March 2011

Arthroscopic Airbrush-Assisted Cell Spraying for Cartilage Repair: Design, Development, and Characterization of Custom-Made Arthroscopic Spray Nozzles

scientific article published on 6 July 2017

Autophagy Is Involved in Mesenchymal Stem Cell Death in Coculture with Chondrocytes

scientific article published on 22 July 2020

BNP is a transcriptional target of the short stature homeobox gene SHOX.

scientific article

Biological networks 101: computational modeling for molecular biologists.

scientific article published on 12 October 2013

Boosting angiogenesis and functional vascularization in injectable dextran-hyaluronic acid hydrogels by endothelial-like mesenchymal stromal cells

scientific article published on 12 November 2013

Cartilage Regeneration in the Head and Neck Area: Combination of Ear or Nasal Chondrocytes and Mesenchymal Stem Cells Improves Cartilage Production

scientific article

Cartilage Tissue Engineering

scientific article published on 22 August 2011

Cell sources for articular cartilage repair strategies: shifting from monocultures to cocultures.

scientific article published on 05 September 2012

Cell-based and molecular imaging tools for validating new therapies in the treatment of bone metabolic disorders and metastases

scientific article published on 01 December 2006

Cellular signaling

Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Preventing Cell Escape

scientific article published on 28 April 2017

Changes in Fluorescence Recovery After Photobleaching (FRAP) as an indicator of SOX9 transcription factor activity

scientific article published on 20 November 2018

Chitosan scaffolds containing hyaluronic acid for cartilage tissue engineering

scientific article published on 25 April 2011

Chitosan/Poly(ɛ-caprolactone) blend scaffolds for cartilage repair

scientific article published on 27 October 2010

Chondrocytes Cocultured with Stromal Vascular Fraction of Adipose Tissue Present More Intense Chondrogenic Characteristics Than with Adipose Stem Cells

scientific article published on 6 January 2016

Chondrogenesis in injectable enzymatically crosslinked heparin/dextran hydrogels

scientific article published on 01 February 2011

Clinical and biochemical characteristics of a male patient with a novel homozygous STAT5b mutation.

scientific article published on 20 June 2006

Co-treatment of TGF-β3 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments.

scientific article published on 6 July 2018

Coculturing Human Islets with Proangiogenic Support Cells to Improve Islet Revascularization at the Subcutaneous Transplantation Site.

scientific article published on 27 January 2016

Controlled aggregation of primary human pancreatic islet cells leads to glucose-responsive pseudoislets comparable to native islets

scientific article

Copy number variants in patients with short stature.

scientific article published on 25 September 2013

Correlation between Gene Expression and Osteoarthritis Progression in Human

scientific article published on 14 July 2016

Developing hyaluronic acid microgels for sustained delivery of platelet lysate for tissue engineering applications

scientific article published on 09 November 2019

Different response of human chondrocytes from healthy looking areas and damaged regions to IL1β stimulation under different oxygen tension

scientific article published on 01 October 2018

Differential expression of the calcium sensing receptor and combined loss of chromosomes 1q and 11q in parathyroid carcinoma

scientific article published on 01 January 2004

Differentiation of Mesenchymal Stem Cells under Hypoxia and Normoxia: Lipid Profiles Revealed by Time-of-Flight Secondary Ion Mass Spectrometry and Multivariate Analysis

article

Downregulation of Wnt signaling by increased expression of Dickkopf-1 and -2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells

scientific article published on 26 June 2005

ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in health and disease

scientific article published on 11 December 2019

Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells

scientific article published on 12 October 2016

Engineering cartilage tissue by pellet coculture of chondrocytes and mesenchymal stromal cells.

scientific article published in January 2015

Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice

scientific article published on 13 June 2018

Enzymatic Crosslinking of Polymer Conjugates is Superior over Ionic or UV Crosslinking for the On-Chip Production of Cell-Laden Microgels

scientific article published on 21 July 2016

Enzymatically crosslinked dextran-tyramine hydrogels as injectable scaffolds for cartilage tissue engineering

scientific article published in August 2010

Enzyme-catalyzed crosslinkable hydrogels: emerging strategies for tissue engineering

scientific article

Epiphyseal fusion in the human growth plate does not involve classical apoptosis

scientific article published in December 2009

Estrogen signaling is active in cartilaginous tumors: implications for antiestrogen therapy as treatment option of metastasized or irresectable chondrosarcoma

scientific article published on November 2005

Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo

scientific article

Expression of the Parathyroid Hormone-Related Peptide Gene in Retinoic Acid-Induced Differentiation: Involvement of ETS and Sp1 ⬇️

scientific article published on September 1, 1997

Expression of vascular endothelial growth factor in the growth plate is stimulated by estradiol and increases during pubertal development

scientific article

Extracellular matrix domain formation as an indicator of chondrocyte dedifferentiation and hypertrophy

scientific article published on 23 July 2013

Fetal mesenchymal stromal cells differentiating towards chondrocytes acquire a gene expression profile resembling human growth plate cartilage

scientific article

Fibroblast growth factor-1 is a mesenchymal stromal cell-secreted factor stimulating proliferation of osteoarthritic chondrocytes in co-culture

scientific article published on 29 May 2013

Fibronectin and Collagen IV microcontact printing can improve insulin secretion by INS1E cells

scientific article published on 07 November 2018

Founder Effect in Different European Countries for the Recurrent P392L SQSTM1 Mutation in Paget’s Disease of Bone

scientific article published on 10 June 2008

Functional expression of ZNF467 and PCBP2 supports adipogenic lineage commitment in adipose-derived mesenchymal stem cells

scientific article published on 04 February 2020

GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors.

scientific article published on 19 September 2013

Genetic variation in the TNFRSF11A gene encoding RANK is associated with susceptibility to Paget's disease of bone

scientific article

Genome-wide SNP array analysis in patients with features of sotos syndrome

scientific article

Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation.

scientific article published on 09 February 2011

Genomic and non-genomic actions of sex steroids in the growth plate

scientific article

Genotype-phenotype correlation in patients suspected of having Sotos syndrome

scientific article published on 24 September 2004

Glucocorticoid-induced osteoporosis in growing mice is not prevented by simultaneous intermittent PTH treatment

scientific article published on 21 October 2009

Glucose gradients influence zonal matrix deposition in 3D cartilage constructs

scientific article published on December 2014

Growth hormone secretion and immunological function of a male patient with a homozygous STAT5b mutation.

scientific article published in February 2007

Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells

scientific article published on December 2003

High-Throughput Screening Assay for the Identification of Compounds Enhancing Collagenous Extracellular Matrix Production by ATDC5 Cells.

scientific article published on 8 April 2015

Hybrid Polycaprolactone/Alginate Scaffolds Functionalized with VEGF to Promote de Novo Vessel Formation for the Transplantation of Islets of Langerhans.

scientific article published on 26 April 2016

Hydrogels by supramolecular crosslinking of terpyridine end group functionalized 8-arm poly(ethylene glycol).

scientific article published in October 2014

Hydrolytically Labile Linkers Regulate Release and Activity of Human Bone Morphogenetic Protein-6

scientific article published on 26 July 2018

Hypoxia inhibits hypertrophic differentiation and endochondral ossification in explanted tibiae

scientific article

Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production

scientific article published on 11 August 2016

Identification of novel SHOX target genes in the developing limb using a transgenic mouse model

scientific article (publication date: 2014)

Impaired body weight and tail length gain and altered bone quality after treatment with the aromatase inhibitor exemestane in male rats

scientific article published on 14 April 2010

In Vitro Evaluation of Small Molecule Delivery into Articular Cartilage: Effect of Synovial Clearance and Compressive Load

scientific article published on 01 May 2019

In vitro degradation profiles and in vivo biomaterial-tissue interactions of microwell array delivery devices

scientific article published on 16 July 2020

In vivo screening of extracellular matrix components produced under multiple experimental conditions implanted in one animal

scientific article published on 01 June 2013

In-air microfluidics enables rapid fabrication of emulsions, suspensions, and 3D modular (bio)materials.

scientific article

Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma

scientific article published on 01 January 2010

Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: the role of the retinoic acid receptor

scientific article published on 13 September 2005

Induction of stimulating thyrotropin receptor antibodies after radioiodine therapy for toxic multinodular goitre and Graves' disease measured with a novel bioassay.

scientific article published on February 2007

Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2

scientific article published on 24 April 2020

Injectable Hydrogels by Enzymatic Co-Crosslinking of Dextran and Hyaluronic Acid Tyramine Conjugates

Iodide kinetics and experimental (131)I therapy in a xenotransplanted human sodium-iodide symporter-transfected human follicular thyroid carcinoma cell line

scientific article published on March 2002

Kinetically stable metal ligand charge transfer complexes as crosslinks in nanogels/hydrogels: Physical properties and cytotoxicity

scientific article

Label-free Raman monitoring of extracellular matrix formation in three-dimensional polymeric scaffolds

scientific article published on 03 July 2013

Label-free detection of insulin and glucagon within human islets of Langerhans using Raman spectroscopy

scientific article

Localization and regulation of the growth hormone receptor and growth hormone-binding protein in the rat growth plate

scientific journal article

Locked-in biomimetic surface gradients that are tunable in size, density and functionalization

scientific article published on 12 August 2014

Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development

scientific article published in Journal of Biological Chemistry

Marginal growth increase, altered bone quality and polycystic ovaries in female prepubertal rats after treatment with the aromatase inhibitor exemestane

scientific article published on 15 January 2010

Mechanisms of growth plate maturation and epiphyseal fusion

scientific article published on 04 May 2011

Mesenchymal stromal/stem cell-or chondrocyte-seeded microcarriers as building blocks for cartilage tissue engineering

scientific article published on 28 April 2014

Metabolic programming of mesenchymal stromal cells by oxygen tension directs chondrogenic cell fate

scientific article

Micro-fabricated scaffolds lead to efficient remission of diabetes in mice.

scientific article

MicroRNA Levels as Prognostic Markers for the Differentiation Potential of Human Mesenchymal Stromal Cell Donors

scientific article

Microwell Scaffolds Using Collagen-IV and Laminin-111 Lead to Improved Insulin Secretion of Human Islets

scientific article published on 01 February 2019

Microwell scaffolds for the extrahepatic transplantation of islets of Langerhans

scientific article

Mimicking the Articular Joint with In Vitro Models

scientific article published on 16 April 2019

Modeling biological pathway dynamics with timed automata

scientific article published on May 2014

Modelling biological pathway dynamics with Timed Automata

scientific article published in November 2012

Modelling with ANIMO: between fuzzy logic and differential equations.

scientific article

Molecular Validation of Chondrogenic Differentiation and Hypoxia Responsiveness of Platelet-Lysate Expanded Adipose Tissue-Derived Human Mesenchymal Stromal Cells

scientific article published on 21 July 2016

Molecular characterization of physis tissue by RNA sequencing

article

Morphogenesis, generation of tissue in the embryo

Multiple mechanisms are involved in inhibition of osteoblast differentiation by PTHrP and PTH in KS483 Cells

scientific article published on 29 August 2005

Multivalency Enables Dynamic Supramolecular Host-Guest Hydrogel Formation

scientific article published on 03 April 2020

Nanoemulsion-induced enzymatic crosslinking of tyramine-functionalized polymer droplets

scientific article published on 10 May 2017

Nanomaterials for the Local and Targeted Delivery of Osteoarthritis Drugs

Nanoparticle Enhancement Cascade for Sensitive Multiplex Measurements of Biomarkers in Complex Fluids with Surface Plasmon Resonance Imaging.

scientific article published on 15 May 2018

Nanostructured 3D constructs based on chitosan and chondroitin sulphate multilayers for cartilage tissue engineering

scientific article

Nitric Oxide Mediates Crosstalk between Interleukin 1β and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression

scientific article published on 22 November 2017

No haploinsufficiency but loss of heterozygosity for EXT in multiple osteochondromas

scientific article

Novel early target genes of parathyroid hormone-related peptide in chondrocytes

scientific article published on 23 February 2006

Novel late response genes of PTHrP in chondrocytes

scientific article published on 25 October 2006

O-Phenanthroline as modulator of the hypoxic and catabolic response in cartilage tissue-engineering models

scientific article published on 21 November 2014

On-chip electrophoresis in supported lipid bilayer membranes achieved using low potentials

scientific article published on 19 December 2013

On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials

scientific article published on 24 April 2019

Opening the "White Box" in Tissue Engineering: Visualization of Cell Aggregates in Optically Scattering Scaffolds

scientific article published on 8 April 2016

Optical imaging of cancer metastasis to bone marrow: a mouse model of minimal residual disease

scientific article published on March 2002

Optimizing cell viability in droplet-based cell deposition

scientific article published on 11 June 2015

Outer-membrane PhoE protein of Escherichia coli K-12 as an exposure vector: possibilities and limitations ⬇️

scientific article published on March 30, 1990

Oxygen-Dependent Lipid Profiles of Three-Dimensional Cultured Human Chondrocytes Revealed by MALDI-MSI.

scientific article published on 20 July 2017

Pancreatic islet macroencapsulation using microwell porous membranes.

scientific article published on 23 August 2017

Patterns of amino acid metabolism by proliferating human mesenchymal stem cells

scientific article published on 21 November 2011

Photoresponsive Cucurbit[8]uril-Mediated Adhesion of Bacteria on Supported Lipid Bilayers

scientific article published on 15 October 2015

Poly(amido amine)-based multilayered thin films on 2D and 3D supports for surface-mediated cell transfection.

scientific article published on 28 January 2015

Primary chondrocytes enhance cartilage tissue formation upon co-culture with a range of cell types

article

Promoted Chondrogenesis of Cocultured Chondrocytes and Mesenchymal Stem Cells under Hypoxia Using In-situ Forming Degradable Hydrogel Scaffolds.

scientific article published on 6 December 2017

Raman Microspectroscopy: A Noninvasive Analysis Tool for Monitoring of Collagen-Containing Extracellular Matrix Formation in a Medium-Throughput Culture System

article

Reactive Copolymers Based on N-Vinyl Lactams with Pyridyl Disulfide Side Groups via RAFT Polymerization and Postmodification via Thiol–Disulfide Exchange Reaction

scientific article published on 22 September 2016

Recognizing different tissues in human fetal femur cartilage by label-free Raman microspectroscopy

scientific article published on November 2012

Redox-responsive degradable prodrug nanogels for intracellular drug delivery by crosslinking of amine-functionalized poly(N-vinylpyrrolidone) copolymers

scientific article published on 14 January 2019

Regeneration of articular cartilage by adipose tissue derived mesenchymal stem cells: perspectives from stem cell biology and molecular medicine

scientific article published on May 2013

Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist

scientific article

Self-attaching and cell-attracting in-situ forming dextran-tyramine conjugates hydrogels for arthroscopic cartilage repair

scientific article published on 20 January 2012

Setting Parameters for Biological Models With ANIMO ⬇️

Short Stature Associated with a Novel Heterozygous Mutation in theInsulin-Like Growth Factor 1Gene ⬇️

scientific article published on July 28, 2010

Single Cell Microgel Based Modular Bioinks for Uncoupled Cellular Micro- and Macroenvironments

scientific article published on 14 December 2016

Single-Cell Microgels: Technology, Challenges, and Applications

scientific article published on 12 April 2018

Small molecule inhibitors of WNT/β-catenin signaling block IL-1β- and TNFα-induced cartilage degradation

scientific article published on 21 August 2013

Sotos syndrome is associated with deregulation of the MAPK/ERK-signaling pathway.

scientific article

Spatiotemporal material functionalization via competitive supramolecular complexation of avidin and biotin analogs

scientific article published on 25 September 2019

Spatiotemporal proliferation of human stromal cells adjusts to nutrient availability and leads to stanniocalcin-1 expression in vitro and in vivo

scientific article published on 15 May 2015

Stem cells

Stimuli-responsive poly(N-vinylcaprolactam-co-2-methoxyethyl acrylate) core–shell microgels: facile synthesis, modulation of surface properties and controlled internalisation into cells

scientific article published on 14 July 2016

Structural and functional characteristics of the Val44Met insulin-like growth factor I missense mutation: correlation with effects on growth and development

scientific article published on 2 December 2004

Successful long-term growth hormone therapy in a girl with haploinsufficiency of the insulin-like growth factor-I receptor due to a terminal 15q26.2->qter deletion detected by multiplex ligation probe amplification

scientific article published on 18 March 2008

Supported Lipid Bilayers for the Generation of Dynamic Cell-Material Interfaces

scientific article

Supporting data of spatiotemporal proliferation of human stromal cells adjusts to nutrient availability and leads to stanniocalcin-1 expression in vitro and in vivo

scientific article

T cell factor 4 is a pro-catabolic and apoptotic factor in human articular chondrocytes by potentiating nuclear factor κB signaling

scientific article

The Effects of the WNT-Signaling Modulators BIO and PKF118-310 on the Chondrogenic Differentiation of Human Mesenchymal Stem Cells

scientific article published on 13 February 2018

The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity

scientific article published on 04 April 2019

The Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular Chondrocytes

scientific article (publication date: 2015)

The effect of platelet lysate supplementation of a dextran-based hydrogel on cartilage formation

scientific article published on 18 February 2012

The majority of the genetic risk for Paget’s disease of bone is explained by genetic variants close to the CSF1, OPTN, TM7SF4, and TNFRSF11A genes

article

The role of p27Kip1 in the regulation of growth plate chondrocyte proliferation in mice

scientific article published on 20 July 2006

The short stature homeodomain protein SHOX induces cellular growth arrest and apoptosis and is expressed in human growth plate chondrocytes

scientific article published on 15 May 2004

The synovial microenvironment of osteoarthritic joints alters RNA-seq expression profiles of human primary articular chondrocytes

scientific article published on July 2016

Thyroid hormone, but not parathyroid hormone, partially restores glucocorticoid-induced growth retardation.

scientific article published on 2 February 2005

Tissue assembly and organization: developmental mechanisms in microfabricated tissues

scientific article published on 9 July 2009

Trophic effects of mesenchymal stem cells in chondrocyte co-cultures are independent of culture conditions and cell sources

scientific article published on 26 April 2012

Trophic effects of mesenchymal stem cells in tissue regeneration.

scientific article published on 10 May 2017

Trophic effects of mesenchymal stem cells increase chondrocyte proliferation and matrix formation.

scientific article published on 28 February 2011

Ultrahigh-Throughput Production of Monodisperse and Multifunctional Janus Microparticles Using in-Air Microfluidics

scientific article published on 02 July 2018

WNT signaling and cartilage: of mice and men.

scientific article published on 02 December 2012

Wettability influences cell behavior on superhydrophobic surfaces with different topographies.

scientific article

Whole-body bioluminescent imaging of human uveal melanoma in a new mouse model of local tumor growth and metastasis

scientific article

Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation

scientific article

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