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List of works by Bruce S Klein

A C-terminal EGF-like domain governs BAD1 localization to the yeast surface and fungal adherence to phagocytes, but is dispensable in immune modulation and pathogenicity of Blastomyces dermatitidis

scientific article

A TCR transgenic mouse reactive with multiple systemic dimorphic fungi

scientific article published on 24 June 2011

A large community outbreak of blastomycosis in Wisconsin with geographic and ethnic clustering

scientific article published on 3 June 2013

Adaptive immunity to fungi

scientific article

Adaptive immunity to fungi.

scientific article

Agrobacterium tumefaciens integrates transfer DNA into single chromosomal sites of dimorphic fungi and yields homokaryotic progeny from multinucleate yeast

scientific article published on December 2002

An unappreciated role for neutrophil-DC hybrids in immunity to invasive fungal infections.

scientific article

Analysis of non-adhesive pathogenic mechanisms of BAD1 on Blastomyces dermatitidis

scientific article published in February 2006

Antifungal Tc17 cells are durable and stable, persisting as long-lasting vaccine memory without plasticity towards IFNγ cells

scientific article

Antigen discovery unveils resident memory and migratory cell roles in antifungal resistance

scientific article published on 03 January 2020

Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense

scientific article published in May 2017

Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense

scientific article published on 01 June 2017

BAD1, an essential virulence factor of Blastomyces dermatitidis, suppresses host TNF-alpha production through TGF-beta-dependent and -independent mechanisms

scientific article published on 01 June 2002

Blastomyces dermatitidis serine protease dipeptidyl peptidase IVA (DppIVA) cleaves ELR+ CXC chemokines altering their effects on neutrophils.

scientific article published on 27 March 2017

C-type lectin receptors differentially induce th17 cells and vaccine immunity to the endemic mycosis of North America

scientific article published on 03 January 2014

CARD9-Associated Dectin-1 and Dectin-2 Are Required for Protective Immunity of a Multivalent Vaccine against Coccidioides posadasii Infection

scientific article published on 01 May 2020

CBLB Constrains Inactivated Vaccine-Induced CD8+ T Cell Responses and Immunity against Lethal Fungal Pneumonia

scientific article published on 27 July 2018

CD28 is required for optimal induction, but not maintenance, of vaccine-induced immunity to Blastomyces dermatitidis

scientific article

CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis.

scientific article published on 3 April 2018

Calcium binding by the essential virulence factor BAD-1 of Blastomyces dermatitidis

scientific article published on 21 October 2005

Calnexin induces expansion of antigen-specific CD4(+) T cells that confer immunity to fungal ascomycetes via conserved epitopes.

scientific article

Characterization of C-type lectins reveals an unexpectedly limited interaction between Cryptococcus neoformans spores and Dectin-1

scientific article published on 10 March 2017

Chitin elicits CCL2 from airway epithelial cells and induces CCR2-dependent innate allergic inflammation in the lung

scientific article

Clinical Manifestations and Treatment of Blastomycosis

scientific article published on 12 June 2017

Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation

scientific article published on 27 February 2020

Club cell TRPV4 as a damage sensor driving lung allergic inflammation

scientific article

Complement component 3C3 and C3a receptor are required in chitin-dependent allergic sensitization to Aspergillus fumigatus but dispensable in chitin-induced innate allergic inflammation

scientific article published on 2 April 2013

Dectin-2 is a C-Type Lectin Receptor that Recognizes Pneumocystis and Participates in Innate Immune Responses

scientific article published on 8 September 2017

Detection and measurement of two-component systems that control dimorphism and virulence in fungi

scientific article published on 01 January 2007

Development of a highly sensitive and specific blastomycosis antibody enzyme immunoassay using Blastomyces dermatitidis surface protein BAD-1

scientific article published on 27 November 2013

Differential requirements of T cell subsets for CD40 costimulation in immunity to Blastomyces dermatitidis

scientific article published on 01 May 2006

Discordant influence of Blastomyces dermatitidis yeast-phase-specific gene BYS1 on morphogenesis and virulence

scientific article

Dynamic interplay among monocyte-derived, dermal, and resident lymph node dendritic cells during the generation of vaccine immunity to fungi

scientific article

Early immune response against Fonsecaea pedrosoi requires Dectin-2-mediated Th17 activity, whereas Th1 response, aided by Treg cells, is crucial for fungal clearance in later stage of experimental chromoblastomycosis

scientific article published on 15 June 2020

Exploiting type 3 complement receptor for TNF-alpha suppression, immune evasion, and progressive pulmonary fungal infection

scientific article

Fonsecaea pedrosoi-induced Th17-cell differentiation in mice is fostered by Dectin-2 and suppressed by Mincle recognition

scientific article

Fungal Mimicry of a Mammalian Aminopeptidase Disables Innate Immunity and Promotes Pathogenicity

scientific article

Fungi subvert vaccine T cell priming at the respiratory mucosa by preventing chemokine-induced influx of inflammatory monocytes

scientific article

Gene Editing in Dimorphic Fungi Using CRISPR/Cas9

scientific article published on 01 December 2020

Genetic diversity in Blastomyces dermatitidis: implications for PCR detection in clinical and environmental samples

scientific article

Global control of dimorphism and virulence in fungi

scientific article published on April 2006

Helper T-Cell Responses and Pulmonary Fungal Infections.

scientific article

IL-12 is required for induction but not maintenance of protective, memory responses to Blastomyces dermatitidis: implications for vaccine development in immune-deficient hosts

scientific article published in October 2005

Identification of the mating-type (MAT) locus that controls sexual reproduction of Blastomyces dermatitidis

scientific article published on 9 November 2012

Indirect regulation of CD4 T-cell responses by tumor necrosis factor receptors in an acute viral infection.

scientific article published on 4 April 2007

Infectious particle identity determines dissemination and disease outcome for the inhaled human fungal pathogen Cryptococcus

scientific article published on 27 June 2019

Inhaled Cryptococcus neoformans elicits allergic airway inflammation independent of Nuclear Factor Kappa B signalling in lung epithelial cells

scientific article

Interleukin 1 enhances vaccine-induced antifungal T-helper 17 cells and resistance against Blastomyces dermatitidis infection

scientific article published on 20 June 2013

Interleukin-1 receptor but not Toll-like receptor 2 is essential for MyD88-dependent Th17 immunity to Coccidioides infection

scientific article published on 10 March 2014

Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia.

scientific article published on 14 September 2015

Investigation of Genetic Susceptibility to Blastomycosis Reveals Interleukin-6 as a Potential Susceptibility Locus

scientific article published on 18 June 2019

Isolation of Blastomyces dermatitidis yeast from lung tissue during murine infection for in vivo transcriptional profiling

scientific article published on 14 March 2013

Ligation of Dectin-2 with a novel microbial ligand promotes adjuvant activity for vaccination.

scientific article published on 9 August 2017

Limited model antigen expression by transgenic fungi induces disparate fates during differentiation of adoptively transferred T cell receptor transgenic CD4+ T cells: robust activation and proliferation with weak effector function during recall.

scientific article published on 28 November 2011

Linking fungal morphogenesis with virulence

scientific article

Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection

scientific article published on 22 March 2018

Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection

scientific article published on 01 April 2019

Mannose Receptor Is Required for Optimal Induction of Vaccine-Induced T-Helper Type 17 Cells and Resistance to Blastomyces dermatitidis Infection

scientific article published on March 2016

Molecular genetic analysis of Blastomyces dermatitidis reveals new insights about pathogenic mechanisms

scientific article

MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase

scientific article

Non-Rural Point Source Blastomycosis Outbreak Near a Yard Waste Collection Site ⬇️

scientific article published on October 25, 2010

Novel strategies to enhance vaccine immunity against coccidioidomycosis

scientific article

O-Mannosylation of Proteins Enables Histoplasma Yeast Survival at Mammalian Body Temperatures

scientific article published on 2 January 2018

Progress in vaccination for histoplasmosis and blastomycosis: coping with cellular immunity

scientific article

Protective antifungal memory CD8(+) T cells are maintained in the absence of CD4(+) T cell help and cognate antigen in mice

scientific article published on 22 February 2012

Pulmonary neuroendocrine cells amplify allergic asthma responses

scientific article published on 29 March 2018

Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hosts

scientific article published on 01 December 2002

SREB, a GATA transcription factor that directs disparate fates in Blastomyces dermatitidis including morphogenesis and siderophore biosynthesis

scientific article

Safety, tolerability, and immunogenicity of a recombinant, genetically engineered, live-attenuated vaccine against canine blastomycosis

scientific article

Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to Candida Species

scientific article published on 12 May 2020

Structural basis of Blastomyces Endoglucanase-2 adjuvancy in anti-fungal and -viral immunity

scientific article published on 18 March 2021

Structure and function of a fungal adhesin that binds heparin and mimics thrombospondin-1 by blocking T cell activation and effector function.

scientific article

T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity

scientific article

Tc17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells

scientific article

The C-Type Lectin Receptor MCL Mediates Vaccine-Induced Immunity against Infection with Blastomyces dermatitidis.

scientific article published on 14 December 2015

The Dynamic Genome and Transcriptome of the Human Fungal Pathogen Blastomyces and Close Relative Emmonsia

scientific article published on 6 October 2015

The Eng1 β-Glucanase Enhances Histoplasma Virulence by Reducing β-Glucan Exposure

scientific article published on 19 April 2016

The Interaction of Pneumocystis with the C-Type Lectin Receptor Mincle Exerts a Significant Role in Host Defense against Infection

scientific article

The unappreciated intracellular lifestyle of Blastomyces dermatitidis

scientific article

Threats Posed by the Fungal Kingdom to Humans, Wildlife, and Agriculture

scientific article published on 05 May 2020

Through the Scope Darkly: The Gut Mycobiome Comes into Focus

scientific article published in December 2017

Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1α/Jagged2/Notch Axis

scientific article published on 14 June 2016

Turning on Virulence: Mechanisms that underpin the Morphologic Transition and Pathogenicity of Blastomyces.

scientific article published on 13 March 2018

Using new genetic tools to study the pathogenesis of Blastomyces dermatitidis

scientific article

V beta1+ J beta1.1+/V alpha2+ J alpha49+ CD4+ T cells mediate resistance against infection with Blastomyces dermatitidis

scientific article published on 9 October 2006

Vaccine immunity against fungal infections

scientific article

Vaccine immunity to coccidioidomycosis occurs by early activation of three signal pathways of T helper cell response (Th1, Th2, and Th17).

scientific article published on 22 August 2011

Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts

scientific article

Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice

scientific article published on 01 February 2016

Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice.

scientific article

Virally-vectored vaccine candidates against white-nose syndrome induce anti-fungal immune response in little brown bats (Myotis lucifugus)

scientific article published on 01 May 2019

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