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List of works by Nicholas G Brown

A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins

scientific article published in 2024

APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.

scientific article published on 24 September 2012

Analysis of the Functional Contributions of Asn233 in Metallo-β-Lactamase IMP-1 ⬇️

scientific article published on September 6, 2011

Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates

scientific article published on 04 July 2018

Co-Crystal Structures of PKG Iβ (92–227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding ⬇️

scientific article published on April 19, 2011

Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding

scientific article published on 07 July 2020

Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation

scientific article

Deep Sequencing of Systematic Combinatorial Libraries Reveals β-Lactamase Sequence Constraints at High Resolution ⬇️

scientific article published on September 25, 2012

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.

scientific article

Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown

scientific article

Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes

scientific article published on 23 December 2021

Identification of the β-Lactamase Inhibitor Protein-II (BLIP-II) Interface Residues Essential for Binding Affinity and Specificity for Class A β-Lactamases ⬇️

scientific article published on April 27, 2013

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators

scientific article published on 11 December 2020

Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1 Complex

scientific article published in 2022

Mechanism of APC/CCDC20 activation by mitotic phosphorylation

scientific article published on 25 April 2016

Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.

scientific article published on 9 October 2014

Molecular basis for the catalytic specificity of the CTX-M extended-spectrum β-lactamases

scientific article

Multiple Global Suppressors of Protein Stability Defects Facilitate the Evolution of Extended-Spectrum TEM β-Lactamases ⬇️

scientific article published on October 16, 2010

Paradoxical mitotic exit induced by a small molecule inhibitor of APC/CCdc20

scientific article published on 09 March 2020

Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division

scientific article published on 25 October 2018

Probing the sites of interactions of rotaviral proteins involved in replication.

scientific article published on 27 August 2014

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site

scientific article published on 26 July 2019

Quantifying the heterogeneity of macromolecular machines by mass photometry

scientific article published on 14 April 2020

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

scientific article published on 30 March 2015

Role of β-lactamase residues in a common interface for binding the structurally unrelated inhibitory proteins BLIP and BLIP-II.

scientific article published on July 2014

Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae

scientific article published on 20 September 2019

Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome

scientific article published on 6 December 2014

Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-d-Xylulose-5-Phosphate Reductoisomerase ⬇️

scientific article published on May 7, 2012

UBE2S Learns Self-Control

scientific article published on 01 August 2019

USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2

scientific article published on 18 September 2020

Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming

scientific article published on 11 May 2020

Use of periplasmic target protein capture for phage display engineering of tight-binding protein–protein interactions ⬇️

scientific article published on September 6, 2011

biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes

scientific article published on 25 April 2016

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