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List of works by Stephen Safe

1,1-Bis (3'-indolyl)-1-(p-substitutedphenyl)methane compounds inhibit lung cancer cell and tumor growth in a metastasis model

scientific article published on 23 July 2013

1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice

scientific article

1,1-Bis(3'-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease gamma-radiation-induced survivin in colon and pancreatic cancer cells

scientific article

1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth

scientific article published on December 2008

1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer ⬇️

scientific article published on December 3, 2010

1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPARgamma-dependent and PPARgamma-independent pathways

scientific article published on 01 May 2006

1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase

scientific article published on 05 May 2008

1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit ovarian cancer cell growth through peroxisome proliferator-activated receptor-dependent and independent pathways

scientific article published on September 2006

1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways.

scientific article

1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal ant

scientific article published on 9 September 2005

1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce peroxisome proliferator-activated receptor gamma-mediated growth inhibition, transactivation, and differentiation markers in colon cancer cells

scientific article published on September 2004

1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells

scientific article published on April 2008

1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines ⬇️

scientific article published on July 2008

1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce apoptosis and inhibit renal cell carcinoma growth

scientific article published on November 2007

1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes inhibit growth, induce apoptosis, and decrease the androgen receptor in LNCaP prostate cancer cells through peroxisome proliferator-activated receptor gamma-independent pathways

scientific article published on 8 November 2006

17 beta-Estradiol-mediated growth inhibition of MDA-MB-468 cells stably transfected with the estrogen receptor: cell cycle effects

scientific article published on 01 September 1997

2,2',4,4',5,5'-hexachlorobiphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6J mice

scientific article

2,3,4,4'-Pentachlorobiphenyl: differential effects on C57BL/6J and DBA/2J inbred mice

scientific article published on 01 September 1982

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Compounds as Antioestrogens: Characterization and Mechanism of Action ⬇️

scientific article published on December 1, 1991

2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells.

scientific article published on May 2001

2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor gamma-dependent and -independent pathways

scientific article

2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer

scientific article published on 23 August 2005

2-cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor gamma in colon and pancreatic cancer cells

scientific article published on 27 August 2007

3,3'-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and -independent prostate cancer cells.

scientific article published on May 2015

3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5.

scientific article

3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha

scientific article published on February 2006

5,5'-Dibromo-bis(3'-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cells

scientific article published on July 2008

6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice

scientific article published on 01 February 1989

6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines: evidence for the role of the Ah receptor

scientific article published on April 1, 1992

6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities

scientific article published on 01 February 1988

7-Methyl-7-hexadecenoic acid: Isolation from lipids of the ocean sunfishMola mola (Linnaeus) 1758 ⬇️

scientific article published on January 1, 1973

732 A novel nuclear receptor 4A1 (NR4A1) antagonists attenuates T-cell exhaustion in colorectal cancer

scientific article published in 2021

A Bis-Indole-Derived NR4A1 Antagonist Induces PD-L1 Degradation and Enhances Antitumor Immunity

scientific article published on 07 January 2020

A bioassay to measure energy metabolism in mouse colonic crypts, organoids, and sorted stem cells

scientific article published on 14 May 2015

A comparison of the mouse versus human aryl hydrocarbon (Ah) receptor complex: effects of proteolysis

scientific article published on November 30, 1992

A general method for the preparation of tritiated polychlorobiphenyls of high specific activity: 2,2',5,5'-tetrachlorobiphenyl-(3H) and 2,2',4,4',5,5'-hexachlorobiphenyl-(3H).

scientific article published in June 1972

A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes.

scientific article published on March 2004

A novel diindolylmethane analog, 1,1-bis(3'-indolyl)-1-(p-chlorophenyl) methane, inhibits the tumor necrosis factor-induced inflammatory response in primary murine synovial fibroblasts through a Nurr1-dependent mechanism

scientific article published on 02 June 2018

A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation

scientific article published on 11 May 2012

A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia

scientific article

A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro

scientific article published on 14 September 2015

Absorption and biological activity of phytochemical-rich extracts from açai (Euterpe oleracea Mart.) pulp and oil in vitro

scientific article published on 29 April 2008

Abstract 154: Inhibition of pancreatic cancer Panc-1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK

scholarly article

Abstract 1714: Nuclear receptor Nurr1 facilitates pancreatic ductal adenocarcinoma cell survival under metabolic stress

scholarly article

Activation of COUP-TFI by a Novel Diindolylmethane Derivative

scientific article published on 07 March 2019

Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways

scientific article

Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds

scientific article published on 18 January 2006

Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth

scientific article

Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors

scientific article

Ah receptor ligands and their impacts on gut resilience: structure-activity effects

scientific article published on 29 June 2020

Alteration of oxytocin-induced calcium oscillations in clone 9 cells by toxin exposure

scientific article published on October 1996

Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer

scientific article published on 6 January 2005

Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways.

scientific article published on 23 May 2007

Antiandrogenic and growth inhibitory effects of ring-substituted analogs of 3,3'-diindolylmethane (ring-DIMs) in hormone-responsive LNCaP human prostate cancer cells.

scientific article published on 14 February 2011

Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum

scientific article published on January 1997

Applications of the in vitro aryl hydrocarbon hydroxylase induction assay for determining "2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents": pyrolyzed brominated flame retardants

scientific article published on 01 October 1988

Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: effects on enzyme induction and immunotoxicity

scientific article published on 01 October 1987

Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth

scientific article published on 8 May 2010

Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs)

scientific article published on 11 September 2020

Aryl Hydrocarbon Receptor (AhR) Ligands as Selective AhR Modulators: Genomic Studies

scientific article published on 01 October 2018

Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes

scientific article

Aryl hydrocarbon receptor (AHR)-active pharmaceuticals are selective AHR modulators in MDA-MB-468 and BT474 breast cancer cells

scientific article

Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells.

scientific article published on September 2006

Aryl hydrocarbon receptor agonists induce microRNA-335 expression and inhibit lung metastasis of estrogen receptor negative breast cancer cells.

scientific article published on 27 October 2011

Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells.

scientific article published in June 2003

Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation.

scientific article published on January 2004

Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors

scientific article

Autophagy inhibition improves the chemotherapeutic efficacy of cruciferous vegetable-derived diindolymethane in a murine prostate cancer xenograft model

scientific article published on 02 April 2018

Bardoxolone Methyl and a Related Triterpenoid Downregulate cMyc Expression in Leukemia Cells.

scientific article published on 8 March 2017

Benzyl Isothiocyanate (BITC) Induces Reactive Oxygen Species-dependent Repression of STAT3 Protein by Down-regulation of Specificity Proteins in Pancreatic Cancer

scientific article published on 15 November 2016

Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10

scientific article

Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors

scientific article

Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors

scientific article published on March 2007

Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer

scientific article published on 02 May 2012

Binding of polychlorinated biphenyls classified as either phenobarbitone-, 3-methylcholanthrene- or mixed-type inducers to cytosolic Ah receptor

scientific article published on 01 April 1982

Bis-Indole-Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells

scientific article published on 01 May 2018

Bis-Indole-Derived Nuclear Receptor 4A1 (NR4A1, Nur77) Ligands as Inhibitors of Endometriosis

scientific article published on 01 April 2020

Bis-indole derived nuclear receptor 4A1 (NR4A1) antagonists inhibit TGFβ-induced invasion of embryonal rhabdomyosarcoma cells

scientific article published on 01 August 2020

Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol

scientific article published on July 1998

Bortezomib Targets Sp Transcription Factors in Cancer Cells

scientific article published on 16 August 2018

CDODA-Me decreases specificity protein transcription factors and induces apoptosis in bladder cancer cells through induction of reactive oxygen species

scientific article published on 30 March 2016

Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs

scientific article published on 22 May 2008

Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells ⬇️

scientific article published on February 14, 2012

Characterization and Biological Potency of Mono- to Tetra-Halogenated Carbazoles

scientific article published on 30 July 2015

Characterization of calcium oscillations in normal and benzo[a]pyrene-treated clone 9 cells

scientific article published on August 2002

Characterization of the aryl hydrocarbon receptor in the human C-4II cervical squamous carcinoma cell line ⬇️

scientific article published on April 1, 1992

Chemoprevention of skin cancer with 1,1-Bis (3'-indolyl)-1-(aromatic) methane analog through induction of the orphan nuclear receptor, NR4A2 (Nurr1)

scientific article

Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells

scientific article published on 01 September 2011

Chemopreventive effects of tolfenamic acid against esophageal tumorigenesis in rats.

scientific article published on 4 January 2011

Chlorobiphenylols. Thin-layer chromatography and colour reactions of some hydroxylated chlorobiphenyls

scientific article published on 01 October 1974

Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells

scientific article

Comparative activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and progesterone as antiestrogens in the female rat uterus

scientific article published on 01 March 1988

Comparative estrogenic activity of wine extracts and organochlorine pesticide residues in food

scientific article

Comparative in vitro and in vivo genotoxicities of 7H-benzo[c]fluorene, manufactured gas plant residue (MGP), and MGP fractions

scientific article published in January 2004

Comparative potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in male Wistar rats--assessment of the toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs)

scientific article published on 01 May 1993

Compensatory Expression of Nur77 and Nurr1 Regulates NF-B-Dependent Inflammatory Signaling in Astrocytes

scholarly article by Katriana A Popichak et al published October 2018 in Molecular Pharmacology

Competitive binding of 7-substituted-2,3-dichlorodibenzo-p-dioxins with human placental ah receptor--a QSAR analysis

scientific article published in August 1990

Competitive binding to the cytosolic 2,3,7,8-tetrachlorodibenzo-p-dioxin receptor. Effects of structure on the affinities of substituted halogenated biphenyls--a QSAR analysis

scientific article published in December 1983

Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner

scientific article published on 14 November 2005

Cooperative coactivation of estrogen receptor alpha in ZR-75 human breast cancer cells by SNURF and TATA-binding protein

scientific article

Correction for Hedrick et al., "NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration".

scientific article published on 28 August 2017

Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs

scientific article

Curcumin decreases specificity protein expression in bladder cancer cells

scientific article published on July 2008

Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins

scientific article

Cytochrome P-450-mediated metabolism of biphenyl and the 4-halobiphenyls

scientific article published on 01 May 1982

Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation

scientific article

DNA binding properties of the Ah receptor in wild-type and variant mouse hepatoma cells

scientific article published on November 1991

DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs

scientific article

Development and validation of bioassays for polychlorinated dibenzo-p-dioxins and dibenzofurans

scientific article published on January 1, 1991

Development and validation of in vitro induction assays for toxic halogenated aromatic mixtures: a review

scientific article published on October 1989

Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells

scientific article published on January 2007

Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice.

scientific article published on September 2001

Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta

scientific article

Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells

scientific article

Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK).

scientific article published on 15 September 2017

Domains of estrogen receptor alpha (ERalpha) required for ERalpha/Sp1-mediated activation of GC-rich promoters by estrogens and antiestrogens in breast cancer cells

scientific article

Dopamine is an aryl hydrocarbon receptor agonist

scientific article published on 09 September 2020

Dose-response immunotoxicities of commercial polychlorinated biphenyls (PCBs) and their interaction with 2,3,7,8-tetrachlorodibenzo-p-dioxin

scientific article published on 01 July 1989

Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells

scientific article

Dual targeting of Nur77 and AMPKα by isoalantolactone inhibits adipogenesis in vitro and decreases body fat mass in vivo

scientific article published on 11 December 2018

Editor's Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure-Activity Relationships and Receptor Modeling.

scientific article published on 11 November 2016

Effect of diet and intestinal AhR expression on fecal microbiome and metabolomic profiles

scientific article published on 30 November 2020

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds on the occupied nuclear estrogen receptor in MCF-7 human breast cancer cells

scientific article

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on I-compounds in hepatic DNA of Sprague-Dawley rats: sex-specific effects and structure-activity relationships

scientific article published in April 1990

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic and uterine estrogen receptor levels in rats

scientific article published on 01 February 1987

Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cells.

scientific article published on 29 March 2006

Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins

scientific article

Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis

scientific article published on 06 January 2020

Effects of ligand structure on the in vitro transformation of the rat cytosolic aryl hydrocarbon receptor

scientific article published on August 15, 1992

Effects of structure on binding to the 2,3,7,8-TCDD receptor protein and AHH induction--halogenated biphenyls

scientific article

Effects of substituents on the cytosolic receptor-binding avidities and aryl hydrocarbon hydroxylase induction potencies of 7-substituted 2,3-dichlorodibenzo-p-dioxins. A quantitative structure-activity relationship analysis

scientific article published on June 1985

Electron-donor-acceptor complexing reagents in the analysis of pesticides. V. The analysis of pesticide decomposition products via electron-donor-acceptor complexes; photolysis of methoxychlor

scientific article published on November 1, 1972

Enhanced Percutaneous Delivery of 1,1-bis(3'-indolyl)-1-(p-chlorophenyl) Methane for Skin Cancer Chemoprevention

scientific article published on July 2015

Enhancement of docetaxel anticancer activity by a novel diindolylmethane compound in human non-small cell lung cancer

scientific article

Erratum to: Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target.

scientific article

Erratum: 3,3'-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and-independent prostate cancer cells

scientific article published on January 2016

Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1.

scientific article published on 05 January 2001

Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17beta-estradiol in breast cancer cells

scientific article published in June 2003

Estrogen regulates transcription of the ovine oxytocin receptor gene through GC-rich SP1 promoter elements.

scientific article published on 27 October 2005

Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum response factor in MCF-7 breast cancer cells

scientific article published in June 2002

Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins

scientific article published on February 2004

Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex

scientific article published in August 2002

Estrogen-dependent regulation of ornithine decarboxylase in breast cancer cells through activation of nongenomic cAMP-dependent pathways

scientific article published in July 2004

Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism

scientific article

Evaluation of Spray BIO-Max DIM-P in Dogs for Oral Bioavailability and in Nu/nu Mice Bearing Orthotopic/Metastatic Lung Tumor Models for Anticancer Activity

scientific article

Evaluation of self-emulsified DIM-14 in dogs for oral bioavailability and in Nu/nu mice bearing stem cell lung tumor models for anticancer activity

scientific article published on 12 June 2015

Evidence for the mechanism of action of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decrease of nuclear estrogen receptor levels in wild-type and mutant mouse Hepa 1c1c7 cells

scientific article published on 01 June 1991

Examination of the estrogenicity of 2,4,6,2',6'-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2',6'-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorinated derivative, 2,4,6,2',4',6'-hexachlorobiphenyl (PCB 155) ⬇️

scientific article published on November 1, 1997

Failure of chloro-S-triazine-derived compounds to induce estrogen receptor-mediated responses in vivo and in vitro

scientific article published on March 1996

Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context

scientific article

Further characterization and applications of the 4-chlorobiphenyl hydroxylase assay

scientific article published on 01 January 1981

GT-094, a NO-NSAID, Inhibits Colon Cancer Cell Growth by Activation of a Reactive Oxygen Species-MicroRNA-27a: ZBTB10-Specificity Protein Pathway ⬇️

scientific article published on December 14, 2010

Guggulsterones Induce Apoptosis and Differentiation in AML: Identification of Isomer-Specific Antileukemic Activities of the Pregnanedienedione Structure. ⬇️

scholarly article

Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure

scientific article published in December 2005

HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer.

scientific article

Halogenated biphenyls as AHH inducers: effects of different halogen substituents

scientific article published on August 1982

Halogenated biphenyls: molecular toxicology

scientific article published on 01 July 1982

Hepatic microsomal enzyme induction by 2,2', 3,3', 4,4'- and 2,2', 3', 4,4', 5-hexachlorobiphenyl

scientific article published on 01 December 1980

Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes

scientific article published on March 1983

High passage T47D human breast cancer cells: altered endocrine and 2,3,7,8-tetrachlorodibenzo-p-dioxin responsiveness

scientific article published on January 1994

Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species-Dependent Targeting of Specificity Protein Transcription Factors

scientific article

Hormonal regulation of lactate dehydrogenase-A through activation of protein kinase C pathways in MCF-7 breast cancer cells

scientific article published on July 2004

Hydroxylated Chalcones as Aryl Hydrocarbon Receptor Agonists: Structure-Activity Effects

scientific article published on 02 December 2020

Hydroxylated Polychlorinated Biphenyls (PCBs) as Estrogens and Antiestrogens: Structure–Activity Relationships ⬇️

scientific article published on 01 July 1997

Hypoxia induces proteasome-dependent degradation of estrogen receptor alpha in ZR-75 breast cancer cells

scientific article

Identification of 4-chloro-4'-hydroxybiphenyl and 4,4'-dichloro-3-hydroxybiphenyl as metabolites of 4-chloro- and 4,4'-dichlorobiphenyl fed to rats

scientific article published on 01 July 1974

Identification of a motif within the 5' regulatory region of pS2 which is responsible for AP-1 binding and TCDD-mediated suppression

scientific article published on May 1997

Identification of metabolic dechlorination of highly chlorinated biphenyl in rabbit

scientific article

Identification of toxic impurities in commercial diphenylamine

scientific article published on 01 February 1977

Immunosuppressive and monooxygenase induction activities of highly chlorinated diphenyl ether congeners in C57BL/6 and DBA/2 mice

scientific article published on 01 May 1993

Immunosuppressive and monooxygenase induction activities of polychlorinated diphenyl ether congeners in C57BL/6N mice: quantitative structure-activity relationships

scientific article published on 01 September 1990

Immunosuppressive effects of highly chlorinated biphenyls and diphenyl ethers on T-cell dependent and independent antigens in mice

scientific article published on 01 December 1993

Immunotoxic potencies of polychlorinated biphenyl (PCB), dibenzofuran (PCDF) and dibenzo-p-dioxin (PCDD) congeners in C57BL/6 and DBA/2 mice

scientific article published on 01 June 1993

In vivo profiling of estrogen receptor/specificity protein-dependent transactivation

scientific article published on 17 July 2008

Inactivation of the orphan nuclear receptor NR4A1 contributes to apoptosis induction by fangchinoline in pancreatic cancer cells

scientific article published on 25 July 2017

Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth

scientific article

Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative

scientific article published on August 2009

Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent.

scientific article published on November 2011

Induction of both 3-methylcholanthrene- and phenobarbitone-type microsomal enzyme activity by a single polychlorinated biphenyl isomer

scientific article published on 01 February 1980

Induction of cytochrome P450-dependent monooxygenase activities in rat hepatoma H-4-IIE cells in culture by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds: mechanistic studies using radiolabeled congeners

scientific article published on 01 August 1989

Induction of endoplasmic reticulum-induced stress genes in Panc-1 pancreatic cancer cells is dependent on Sp proteins

scientific article

Induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by a series of 4'-substituted-2,3,4,5-tetrachlorobiphenyls

scientific article published on 01 December 1988

Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters

scientific article published on 29 June 2012

Inhalation Delivery of a Novel Diindolylmethane Derivative for the Treatment of Lung Cancer ⬇️

scientific article published on October 26, 2010

Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation

scientific article

Inhibition of NR4A1 Promotes ROS Accumulation and IL24-Dependent Growth Arrest in Rhabdomyosarcoma

scientific article published on 28 August 2019

Inhibition of bladder tumor growth by 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes: a new class of peroxisome proliferator-activated receptor gamma agonists

scientific article published in January 2006

Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM.

scientific article

Inhibition of pancreatic cancer Panc1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK.

scientific article

Inhibition of pituitary tumor‐transforming gene‐1 in thyroid cancer cells by drugs that decrease specificity proteins ⬇️

scientific article published on January 25, 2011

Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors

scientific article

Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies.

scientific article published in October 2000

Interaction of the aryl hydrocarbon receptor ligand 6-methyl-1,3,8-trichlorodibenzofuran with estrogen receptor alpha

scientific article published on April 2004

Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization

scientific article

Interferon-tau activates multiple signal transducer and activator of transcription proteins and has complex effects on interferon-responsive gene transcription in ovine endometrial epithelial cells

scientific article

Interleukin-24 (IL24) Is Suppressed by PAX3-FOXO1 and Is a Novel Therapy for Rhabdomyosarcoma

scientific article published on 06 September 2018

Investigation of macrophage polarization using bone marrow derived macrophages

scientific article published on 23 June 2013

Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure-Activity Relationships

scientific article published on 29 October 2019

Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens.

scientific article published on 23 February 2008

Ligand structure-dependent differences in activation of estrogen receptor alpha in human HepG2 liver and U2 osteogenic cancer cell lines

scientific article

Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay

scientific article published on November 2007

Lipid-based oral delivery systems for skin deposition of a potential chemopreventive DIM derivative: characterization and evaluation

scientific article published on 12 July 2016

Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self-renewal of colonic stem and progenitor cells

scientific article published on 10 August 2020

MDM2 regulates estrogen receptor α and estrogen responsiveness in breast cancer cells

scientific article

Mass spectra of fifteen chlorinated aromatic fungicides

scientific article published on January 1, 1971

Mass spectra of some fungicidal organomercury compounds

scientific article published on 01 November 1971

Mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists: Characterization of 6-[125I]methyl-8-iodo-1, 3-dichlorodibenzofuran-Ah receptor complexes ⬇️

scientific article published on January 1, 1991

Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression

scientific article published on November 1, 1992

Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents

scientific article

Mechanism of benzo[a]pyrene-induced Cyp1a-1 gene expression in mouse Hepa 1c1c7 cells: Role of the nuclear 6 s and 4 s proteins ⬇️

scientific article published on January 1, 1992

Mechanism of chlorobiphenyl metabolism ⬇️

scientific article published on 01 September 1975

Mechanism of inhibition of MDA-MB-468 breast cancer cell growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin

scientific article published on May 1997

Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors

scientific article

Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures

scientific article

Metabolism of 4,4'-dihalogenobiphenyls

scientific article published on 01 January 1976

Metabolism of bromobenzenes in the rabbit ⬇️

scientific article published on 01 March 1976

Metabolism of chlorinated naphthalenes

scientific article published on 01 May 1976

Metabolism of chlorobiphenyls in the goat and cow

scientific article published on March 1, 1975

Metabolism of the systemic fungicide 2,5-dimethyl-3-furancarboxylic acid anilide (BAS 3191) by Rhizopus japonicus and related fungi ⬇️

scientific article published on 01 January 1972

Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors

scientific article published on 26 June 2013

Metformin-induced anticancer activities: recent insights

scientific article published on 27 June 2017

Methods for xenoestrogen testing

scientific article published on 01 December 1998

Methyl 2-cyano-3,11-dioxo-18 beta-olean-1,12-dien-30-oate is a peroxisome proliferator-activated receptor-gamma agonist that induces receptor-independent apoptosis in LNCaP prostate cancer cells

scientific article published on 7 November 2007

Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a

scientific article

MiR-150 Inhibits MLL-AF9 Associated Leukemia By Suppressing Leukemic Stem Cells ⬇️

scholarly article

MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation

scientific article

MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 expression.

scientific article

MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells

scientific article

Microbial hydroxylation of the herbicide N-(3,4-dichlorophenyl)methacrylamide (dicryl).

scientific article published in May 1973

Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities

scientific article

Minireview: role of orphan nuclear receptors in cancer and potential as drug targets

scientific article published on 02 December 2013

Mithramycin A inhibits myeloid cell leukemia-1 to induce apoptosis in oral squamous cell carcinomas and tumor xenograft through activation of Bax and oligomerization

scientific article

Modulation of rat hepatic microsomal testosterone hydroxylases by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related toxic isostereomers

scientific article published on 01 December 1985

Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.

scientific article published on 4 May 2006

Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line

scientific article (publication date: 15 May 2011)

Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines

scientific article (publication date: February 2009)

NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration

scientific article published on 29 February 2016

Naringenin: a weakly estrogenic bioflavonoid that exhibits antiestrogenic activity

scientific article published on 01 October 1995

Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease.

scientific article

Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways

scientific article published on 04 September 2008

Non-dioxin-like AhR ligands in a mouse peanut allergy model.

scientific article

Nonadditive interactive effects of polychlorinated biphenyl congeners in rats: role of the 2,3,7,8-tetrachlorodibenzo-p-dioxin receptor

scientific article published on 01 September 1987

Novel diindolylmethane derivatives based NLC formulations to improve the oral bioavailability and anticancer effects in triple negative breast cancer.

scientific article published on 29 August 2016

Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease

scientific article

Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma

scientific article

Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma

scientific article published on 01 November 2021

Nuclear receptor 4A (NR4A) family - orphans no more

scientific article published on 23 April 2015

Nuclear receptor 4A1 (NR4A1) antagonists induce ROS-dependent inhibition of mTOR signaling in endometrial cancer

scientific article published on 30 April 2019

Nuclear receptor 4A1 (NR4A1) as a drug target for treating rhabdomyosarcoma (RMS).

scientific article published on 29 April 2016

Nuclear receptor 4A1 as a drug target for breast cancer chemotherapy

scientific article

Nuclear receptor 4A2 (NR4A2) is a druggable target for glioblastomas

scientific article published on 21 November 2019

Nuclear receptor-mediated transactivation through interaction with Sp proteins

scientific article published on January 2004

Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways

scientific article published on 01 January 2007

Octachloronaphthalene induction of hepatic microsomal aryl hydrocarbon hydroxylase activity in the immature male rat ⬇️

scientific article published on 01 January 1981

Omeprazole Inhibits Glioblastoma Cell Invasion and Tumor Growth

scientific article published on 28 July 2020

Omeprazole Inhibits Pancreatic Cancer Cell Invasion through a Nongenomic Aryl Hydrocarbon Receptor Pathway

scientific article published on 09 April 2015

Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells

scientific article published on October 2009

Organochlorine exposure and risk for breast cancer

scientific article published on January 1997

PAH Particles Perturb Prenatal Processes and Phenotypes: Protection from Deficits in Object Discrimination Afforded by Dampening of Brain Oxidoreductase Following In Utero Exposure to Inhaled Benzo(a)pyrene ⬇️

scientific article published on October 10, 2011

PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1.

scientific article published on 18 November 2016

PCB isomers and congeners: induction of aryl hydrocarbon hydroxylase and ethoxyresorufin O-deethylase enzyme activities in rat hepatoma cells

scientific article published on 01 September 1982

PCBs: structure-function relationships and mechanism of action

scientific article

Partial antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated induction of aryl hydrocarbon hydroxylase by 6-methyl-1,3,8-trichlorodibenzofuran: mechanistic studies

scientific article published on 01 May 1989

Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors

scientific article published on 3 November 2016

Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells.

scientific article

Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins

scientific article

Peroxisome proliferator-activated receptor gamma-dependent activity of indole ring-substituted 1,1-bis(3'-indolyl)-1-(p-biphenyl)methanes in cancer cells

scientific article

Pharmacokinetic evaluation and In Vitro–In Vivo Correlation (IVIVC) of novel methylene-substituted 3,3′ diindolylmethane (DIM) ⬇️

scientific article published on February 8, 2012

Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells

scientific article

Photoaffinity labeling of the nuclear Ah receptor from mouse Hepa 1c1c7 cells using 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin

scientific article (publication date: 5 November 1989)

Photochemical Degradation of Chloro-biphenyls (PCBs).

scientific article

Photochemical degradation of di- and octachlorodibenzofuran

scientific article

Photodecomposition of unsymmetrical polychlorobisphenyls

scientific article published on 01 May 1975

Photodegradation of polybromobiphenyls (PBB)

scientific article published on September 1, 1976

Photodegradation of polychloronaphthalenes in methanol solution ⬇️

scientific article published on September 1, 1975

Piperlongumine Induces Reactive Oxygen Species (ROS)-Dependent Downregulation of Specificity Protein Transcription Factors.

scientific article published on 3 July 2017

Polybrominated dibenzo-p-dioxins and related compounds: quantitative in vivo and in vitro structure-activity relationships

scientific article published on June 1987

Polybrominated dibenzo-p-dioxins, dibenzofurans, and biphenyls: inclusion in the toxicity equivalency factor concept for dioxin-like compounds

scientific article published on 14 March 2013

Polychlorinated Biphenyls: Metabolic Behavior of Pure Isomers in Pigeons, Rats, and Brook Trout ⬇️

scientific article published on October 20, 1972

Polychlorinated Biphenyls: Photolysis of 2,4,6,2′,4′,6′-Hexachlorobiphenyl

scientific article published in Nature

Polychlorinated benzene and phenol congeners as inducers of rat hepatic drug-metabolizing enzymes in immature male Wistar rats

scientific article published on 01 September 1983

Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: structure-activity rules

scientific article published on 01 June 1980

Polychlorinated biphenyls as phenobarbitone-type inducers of microsomal enzymes. Structure-activity relationships for a series of 2,4-dichloro-substituted congeners

scientific article published on 01 October 1983

Polychlorinated biphenyls: synthesis of some individual chlorobiphenyls

scientific article published on 01 May 1971

Polychlorinated dibenzo-p-dioxins and dibenzofurans associated with wood-preserving chemical sites: biomonitoring with pine needles

Polychlorinated dibenzo-p-dioxins: quantitative in vitro and in vivo structure-activity relationships

scientific article published on 01 October 1986

Polychlorinated dibenzofurans (PCDFs): correlation between in vivo and in vitro structure-activity relationships

scientific article published on 01 October 1985

Polychlorinated dibenzofurans (PCDFs): effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity

scientific article published on 01 August 1984

Polychlorinated dibenzofurans as 2,3,7,8-TCDD antagonists: in vitro inhibition of monooxygenase enzyme induction

scientific article published on May 1986

Polychlorinated naphthalenes as hepatic microsomal enzyme inducers in the immature male rat

scientific article published on 01 January 1981

Potency of combined estrogenic pesticides

scientific article published in January 1997

Potent inhibition of breast cancer by bis-indole-derived nuclear receptor 4A1 (NR4A1) antagonists

scientific article published on 22 May 2019

Preparation, gas chromatographic behavior, and spectroscopic properties of hydroxylated chlorobiphenyls.

scientific article

Problems for risk assessment of endocrine-active estrogenic compounds

scientific article

Quantitative structure-activity relationships: analysis of interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2-substituted analogues with rat, mouse, guinea pig, and hamster cytosolic receptor

scientific article published in October 1987

REACTIVE OXYGEN SPECIES AND COLORECTAL CANCER.

scientific article

RNAi and cancer: Implications and applications.

scientific article published on 28 February 2006

Radioligand-dependent differences in the molecular properties of the mouse and rat hepatic aryl hydrocarbon receptor complexes

scientific article published on November 1988

Reactive Oxygen Species (ROS)-Inducing Triterpenoid Inhibits Rhabdomyosarcoma Cell and Tumor Growth through Targeting Sp Transcription Factors

scientific article published on 04 January 2019

Reconstituted halogenated hydrocarbon pesticide and pollutant mixtures found in human tissues: effects on the immature male Wistar rat after short-term exposure

scientific article published on 01 January 1985

Reconstituted human breast milk PCBs as potent inducers of aryl hydrocarbon hydroxylase

scientific article published on 01 September 1980

Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer

scientific journal article

Regulation of KiSS-1 metastasis suppressor gene expression in breast cancer cells by direct interaction of transcription factors activator protein-2alpha and specificity protein-1.

scientific article published on 27 October 2005

Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells

scientific article published on April 2007

Regulation of vascular endothelial growth factor receptor-2 expression in pancreatic cancer cells by Sp proteins

scientific article published on 2 May 2006

Resveratrol and quercetin in combination have anticancer activity in colon cancer cells and repress oncogenic microRNA-27a

scientific article published on January 2013

Retention times and electron-capture detector responses of some individual chlorobiphenyls ⬇️

scientific article published on 01 March 1971

Ring-substituted analogs of 3,3'-diindolylmethane (DIM) induce apoptosis and necrosis in androgen-dependent and -independent prostate cancer cells.

scientific article

Role of SP transcription factors in hormone-dependent modulation of genes in MCF-7 breast cancer cells: microarray and RNA interference studies

scientific article published on 24 October 2008

Role of Sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells

scientific article published on 01 September 2004

Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer.

scientific article published in February 2018

Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia

scientific article

Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells.

scientific article

Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target

scientific article published on 14 June 2013

Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target.

scientific article published on 15 May 2017

Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells

scientific article

Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells

scientific article

Small molecule tolfenamic acid inhibits PC-3 cell proliferation and invasion in vitro, and tumor growth in orthotopic mouse model for prostate cancer.

scientific article

Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development

scientific article published on 15 March 2018

Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells

scientific article published on 05 March 2016

Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC.

scientific article

Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavones.

scientific article published on 23 March 2018

Structure-dependent Ah receptor agonist activities of chlorinated biphenylenes

scientific article published on 3 May 2006

Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3′-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells ⬇️

scientific article published on March 3, 2012

Structure-dependent activation of endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer by 1,1-bis(3'-indoly)-1-(p-substituted phenyl)methanes

scientific article published on October 2008

Structure-dependent activation of gene expression by bis-indole and quinoline-derived activators of nuclear receptor 4A2

scientific article published on 21 July 2019

Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells

scientific article published on May 2007

Structure-dependent induction of aryl hydrocarbon hydroxylase activity in C57BL/6 mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related congeners: mechanistic studies

scientific article published on 01 September 1990

Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor

scientific article

Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives

scientific article published on 14 March 2008

Studies on the relationship between estrogen receptor content, glutathione S-transferase pi expression, and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and drug resistance in human breast cancer cells

scientific article published on 01 December 1997

Substituted polychlorinated dibenzofuran receptor binding affinities and aryl hydrocarbon hydroxylase induction potencies--a QSAR analysis

scientific article published in February 1986

Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors

scientific article published on 16 December 2015

Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric-oxide synthase 2 expression in astrocytes by a novel diindolylmethane analog protects striatal neurons against apoptosis

scientific article published on 07 October 2008

Synergistic interactions of 2,3,7,8-TCDD and 2,2',4,4',5,5'-hexachlorobiphenyl in C57BL/6J and DBA/2J mice: role of the Ah receptor

scientific article published on 01 May 1987

Synthesis and characterization of hydroxylated polychlorinated biphenyls (PCBs) identified in human serum.

scientific article published in August 1995

Synthesis and spectroscopic and gas chromatographic behavior of isomeric chlorinated terphenyls

scientific article published on March 1, 1977

Synthesis of the Octa- and nonachlorobiphenyl isomers and congeners and their quantitation in commercial polychlorinated biphenyls and identification in human breast milk

scientific article published on 01 May 1981

Synthesis, biologic and toxic effects of the major 2,3,7,8-tetrachlorodibenzo-p-dioxin metabolites in the rat.

scientific article published on October 1986

Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells

scientific article published in February 2006

TGFβ-Induced Lung Cancer Cell Migration Is NR4A1-Dependent

scientific article published on 02 August 2018

THE HISTONE METHYLTRANSFERASE GENE G9A IS REGULATED BY NUCLEAR RECEPTOR 4A1 (NR4A1) IN ALVEOLAR RHABDOMYOSARCOMA CELLS

scientific article published on 04 December 2020

Targeting NR4A1 (TR3) in cancer cells and tumors ⬇️

scientific article published on 05 January 2011

Teratogenicity and immunotoxicity of 3,3',4,4',5-pentachlorobiphenyl in C57BL/6 mice

scientific article published on 01 January 1993

The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds

scientific article

The Aryl Hydrocarbon Receptor (AhR) as a Drug Target for Cancer Chemotherapy

scientific article published on 01 February 2017

The Metabolism of 4-Chlorobiphenyl in the Pig ⬇️

scientific article published on June 1, 1975

The Metabolism of 4′-Chloro-4-biphenylol in the Rat ⬇️

scientific article published on 01 April 1975

The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB

scientific article published on 9 April 2015

The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism.

scientific article

The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer

scientific article published on 26 October 2020

The Role of Self-Nanoemulsifying Drug Delivery Systems of CDODA-Me in Sensitizing Erlotinib-Resistant Non-Small Cell Lung Cancer

scientific article published on 15 January 2020

The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy

scientific article published on 15 May 2009

The aryl hydrocarbon receptor is a tumor suppressor-like gene in glioblastoma

scientific article published on 06 June 2019

The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis

scientific article

The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes

scientific article

The bioactive compounds alpha-chaconine and gallic acid in potato extracts decrease survival and induce apoptosis in LNCaP and PC3 prostate cancer cells.

scientific article published on January 2010

The biologic and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in chickens

scientific article published on 01 May 1986

The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells

scientific article

The comparative biologic and toxic potencies of polychlorinated biphenyls and polybrominated biphenyls ⬇️

scientific article published on September 15, 1983

The cytochrome P-450-mediated metabolism of biphenyl and the 4-halobiphenyls

scientific article published on 01 January 1981

The cytosolic receptor binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons

scientific article published on November 1986

The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis.

scientific article published on 8 March 2013

The effects of organochlorine pesticides as inducers of testosterone and benzo[a]pyrene hydroxylases

scientific article published on January 1987

The effects of ortho chloro substituents on the retention of PCB isomers in rat, rabbit, Japanese quail, guinea pig and trout

scientific article published on 01 November 1980

The effects of twenty-two organochlorine pesticides as inducers of the hepatic drug-metabolizing enzymes

scientific article published in January 1983

The in vitro hydroxylation of 4'-chloro-4-biphenylol by a mushroom tyrosinase preparation

scientific article published on January 1, 1976

The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration.

scientific article published on May 2015

The mass spectra of polychlorinated biphenyls

scientific article published on 01 January 1972

The metabolism of chlorinated aromatic pollutants by the frog

scientific article published on 01 November 1976

The nonsteroidal anti-inflammatory drug tolfenamic acid inhibits BT474 and SKBR3 breast cancer cell and tumor growth by repressing erbB2 expression

scientific article

The nuclear orphan receptor NR4A1 regulates β1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists

scientific article published on 18 April 2017

The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53.

scientific article published on 14 November 2011

The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells.

scientific article

The origin, fate, and health effects of combustion by-products: a research framework

scientific article

The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells.

scientific article published on 10 February 2014

The p38 MAPK pathway is critical for 5,5'-dibromodiindolylmethane-induced apoptosis to prevent oral squamous carcinoma cells

scientific article published in March 2010

The peroxisome proliferator-activated receptor-gamma agonist 1,1-bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells

scientific article

The structure-dependent effects of heptachlorodibenzofuran isomers in male C57BL/6 mice: immunotoxicity and monooxygenase enzyme induction

scientific article published on 01 August 1990

The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis

scientific article

The ultraviolet absorption spectra of some chlorinated biphenyls

scientific article published on 01 January 1976

Theranostic tumor homing nanocarriers for the treatment of lung cancer

scientific article

Therapeutic applications of NSAIDS in cancer special emphasis on tolfenamic acid ⬇️

scientific article published on January 1, 2011

Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation

scientific article

Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice

scientific article published on 23 October 2009

Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expression

scientific article published on 3 March 2009

Tolfenamic acid inhibits colon cancer cell and tumor growth and induces degradation of specificity protein (Sp) transcription factors

scientific article published on 14 May 2013

Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met.

scientific article published on 30 April 2009

Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife

scientific article

Toxicology of environmental estrogens

scientific article

Transcription factor Sp1, also known as specificity protein 1 as a therapeutic target

scientific article published on 03 May 2014

Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists

scientific article

Transforming Growth Factor β/NR4A1-Inducible Breast Cancer Cell Migration and Epithelial-to-Mesenchymal Transition Is p38α (Mitogen-Activated Protein Kinase 14) Dependent

scientific article

Ultra-flexible nanocarriers for enhanced topical delivery of a highly lipophilic antioxidative molecule for skin cancer chemoprevention

scientific article published on 15 March 2016

Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs

scientific article

Vascular endothelial growth factor receptor-2 expression is down-regulated by 17beta-estradiol in MCF-7 breast cancer cells by estrogen receptor alpha/Sp proteins

scientific article

Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins.

scientific article

Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins

scientific article

miR-150 blocks MLL-AF9-associated leukemia through oncogene repression.

scientific article published on 19 April 2013

miR-150 regulates obesity-associated insulin resistance by controlling B cell functions

scientific article published on February 2016

p21 expression is induced by activation of nuclear nerve growth factor-induced Balpha (Nur77) in pancreatic cancer cells

scientific article published on 07 July 2009

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