List of works - Jian Jin

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function

scientific article published on 15 October 2019

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

scientific article published in Nature Communications

A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

scientific article published in 2021

AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B

scientific article published on 01 December 2021

Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity

scientific article published on 12 July 2019

Correction to Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)

scientific article published on 27 June 2018

D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine

scientific article published on 18 April 2019

Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D1 Receptor Agonists

scientific article published on 27 March 2019

Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

scientific article published on 06 July 2020

Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68)

scientific article published on 01 August 2019

Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity

scientific article published on 20 August 2019

Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase

scientific article

Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT).

scientific article published on 10 January 2018

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3).

scientific article

Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders

scientific article published on 14 January 2020

Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.

scientific article

Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader

scientific article published on 27 November 2019

Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor

scientific article published on 05 May 2020

Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1)

scientific article published on 24 July 2019

Discovery of a first-in-class EZH2 selective degrader

scientific article published on 09 December 2019

Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders

scientific article published on 01 March 2021

Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery

scientific article published on 11 November 2019

Epigenetics 2.0: Special Issue on Epigenetics-Call for Papers

scientific article published on 22 October 2020

Gain-of-function genetic alterations of G9a drive oncogenesis

scientific article published on 08 April 2020

Histone Lysine Methylation Dynamics Control EGFR DNA Copy-Number Amplification

scientific article published on 27 November 2019

Identification of an Epi-metabolic dependency on EHMT2/G9a in T-cell acute lymphoblastic leukemia

scientific article published in 2022

Inhibitors of Protein Methyltransferases and Demethylases.

scientific article published on 24 March 2017

Light-induced control of protein destruction by opto-PROTAC

scientific article published on 21 February 2020

Membrane-Permeant, Environment-Sensitive Dyes Generate Biosensors within Living Cells

scientific article published on 23 April 2019

PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation

scientific article published on 05 August 2019

Potent and Selective Mitogen-Activated Protein Kinase Kinase 1/2 (MEK1/2) Heterobifunctional Small-molecule Degraders

scientific article published on 07 December 2020

ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation

scientific article published in 2022

Report and Application of a Tool Compound Data Set.

scientific article published on 16 October 2017

Structural determinants of 5-HT2B receptor activation and biased agonism

article

Structure, function and pharmacology of human itch GPCRs

scientific article published on 17 November 2021

Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs.

scientific article

TF-PROTACs Enable Targeted Degradation of Transcription Factors

scientific article published on 08 June 2021

Targeted Gene Repression Using Novel Bifunctional Molecules to Harness Endogenous Histone Deacetylation Activity.

scientific article

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

scientific article published on 29 March 2019

The dynamic conformational landscape of the protein methyltransferase SETD8.

scientific article published on 13 May 2019

ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism

scientific article published on 16 February 2021

c-Rel Is a Myeloid Checkpoint for Cancer Immunotherapy

scientific article published on 18 May 2020

List of works by Jian Jin

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma

AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B

Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity

Correction to Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)

D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine

Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D1 Receptor Agonists

Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68)

Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity

Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase

Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT).

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3).

Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders

Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.

Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader

Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor

Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1)

Discovery of a first-in-class EZH2 selective degrader

Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders

Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery

Epigenetics 2.0: Special Issue on Epigenetics-Call for Papers

Gain-of-function genetic alterations of G9a drive oncogenesis

Histone Lysine Methylation Dynamics Control EGFR DNA Copy-Number Amplification

Identification of an Epi-metabolic dependency on EHMT2/G9a in T-cell acute lymphoblastic leukemia

Inhibitors of Protein Methyltransferases and Demethylases.

Light-induced control of protein destruction by opto-PROTAC

Membrane-Permeant, Environment-Sensitive Dyes Generate Biosensors within Living Cells

PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation

Potent and Selective Mitogen-Activated Protein Kinase Kinase 1/2 (MEK1/2) Heterobifunctional Small-molecule Degraders

ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation

Report and Application of a Tool Compound Data Set.

Structural determinants of 5-HT2B receptor activation and biased agonism

Structure, function and pharmacology of human itch GPCRs

Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs.

TF-PROTACs Enable Targeted Degradation of Transcription Factors

Targeted Gene Repression Using Novel Bifunctional Molecules to Harness Endogenous Histone Deacetylation Activity.

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

The dynamic conformational landscape of the protein methyltransferase SETD8.

ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism

c-Rel Is a Myeloid Checkpoint for Cancer Immunotherapy