List of works by Christina S Leslie

A Novel Mutation In Bruton Tyrosine Kinase Confers Acquired Resistance To Ibrutinib (PCI-32765) In CLL ⬇️

scholarly article

A Novel iPSC Model Reveals a Role for RUNX1 in the Maintenance of AML Leukemia Stem Cells ⬇️

scholarly article

A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner

scientific article

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).

scientific article

A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance

scientific article published on 25 November 2015

A unified atlas of CD8 T cell dysfunctional states in cancer and infection

scientific article published on 22 April 2021

ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer

scientific article published on 13 January 2020

Abstract 3370: Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers

scholarly article

Abstract 3384: Genome-wide epigenetic and transcriptional comparison of CD8 T cell functional states between mouse models of cancer and chronic viral infection

scholarly article

Abstract 4346: PI3K pathway mediated splicing defects in ER+ breast cancers

scholarly article

Abstract 949: ARID1A is a critical regulator of luminal identity and therapeutic response in estrogen receptor-positive breast cancer

scholarly article

Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells

scientific article published on 01 June 2020

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

scientific article

Affinity regression predicts the recognition code of nucleic acid–binding proteins

scientific article

An allelic series of miR-17 ∼ 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron

scientific article

An atlas of the Epstein-Barr virus transcriptome and epigenome reveals host-virus regulatory interactions

scientific article

An integrated model for detecting significant chromatin interactions from high-resolution Hi-C data.

scientific article

Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

scientific article

Author Correction: FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes

scientific article published on 08 September 2020

BCL6 positively regulates AID and germinal center gene expression via repression of miR-155.

scientific article

Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants

scientific article published in 2022

BindSpace decodes transcription factor binding signals by large-scale sequence embedding

scientific article published on 12 August 2019

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

scientific article

Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells.

scientific article published on 19 January 2016

Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia

scientific article

Characterizing Transcriptional and Epigenetic Signatures Induced By FLT3-ITD Activation ⬇️

scholarly article

Chromatin states define tumour-specific T cell dysfunction and reprogramming.

scientific article

Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers

scientific article published on 25 September 2019

Combining classifiers for improved classification of proteins from sequence or structure

scientific article

Combining integrated genomics and functional genomics to dissect the biology of a cancer-associated, aberrant transcription factor, the ASPSCR1-TFE3 fusion oncoprotein

scientific article

Computational and experimental identification of mirtrons in Drosophila melanogaster and Caenorhabditis elegans

scientific article

Computational searches for splicing signals.

scientific article

Cooperative control of tumor suppressor genes by a network of oncogenic microRNAs

scientific article published on September 2011

Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.

scientific article published on 17 November 2015

Determining frequent patterns of copy number alterations in cancer

scientific article

Dichotomous splicing signals in exon flanks

scientific article published on June 2005

Direct RNA Target Analysis Identifies Signatures That Define Msi2's Role in Sustaining HSC Cell Fate. ⬇️

scholarly article

Early enhancer establishment and regulatory locus complexity shape transcriptional programs in hematopoietic differentiation

scientific article

Epigenetic control of innate and adaptive immune memory

scientific article published on 06 August 2018

Ets transcription factor GABP controls T cell homeostasis and immunity

scientific article published on 20 October 2017

FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes

scientific article published on 26 June 2019

FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation

scientific article published on 01 July 2019

FXR mediates T cell-intrinsic responses to reduced feeding during infection

scientific article published on 14 December 2020

Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

scientific article

Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells

scientific article

Global 3' UTR Sequencing in Multiple Myeloma (MM) ⬇️

scholarly article

Global profiling of stimulus-induced polyadenylation in cells using a poly(A) trap

scientific article published on September 2013

Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

scientific article published on 01 May 2021

GuideScan software for improved single and paired CRISPR guide RNA design

scientific article

Heme controls the regulation of protein tyrosine kinases Jak2 and Src

scientific article

High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down

scientific article published on 29 May 2020

HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells

scientific article published on 24 April 2020

IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation

scientific article published on 21 November 2018

IKZF2 Drives Self-Renewal and Blocks Myeloid Differentiation Programs in Myeloid Leukemic Stem Cells ⬇️

scholarly article

IKZF2, a Novel Target of MSI2 RNA-Binding Protein Plays an Oncogenic Role in Myeloid Leukemia ⬇️

scholarly article

ILC1 Confer Early Host Protection at Initial Sites of Viral Infection

scientific article

Ibrutinib resistance in chronic lymphocytic leukemia

scientific article published on 28 May 2014

Identifying remote protein homologs by network propagation

scientific article

In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA.

scientific article

Induction of specific microRNAs inhibits cutaneous wound healing

scientific journal article

Inferring transcriptional and microRNA-mediated regulatory programs in glioblastoma

scientific article

Integrated genomic profiling identifies microRNA-92a regulation of IQGAP2 in locally advanced rectal cancer

scientific article published on April 2016

KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix

scientific article published on 15 June 2021

Learning to Predict miRNA-mRNA Interactions from AGO CLIP Sequencing and CLASH Data

scientific article

Linking signaling pathways to transcriptional programs in breast cancer.

scientific article

MSI2 is required for maintaining activated myelodysplastic syndrome stem cells

scientific article published on 22 February 2016

Memory of Inflammation in Regulatory T Cells

scientific article published on 3 August 2016

MiR-28 Silencing In Germinal Center-Derived Lymphomas ⬇️

scholarly article

MicroRNA 28 controls cell proliferation and is down-regulated in B-cell lymphomas.

scientific article

Microrna Mediated Regulation of Hematopoietic Stem Cell Aging ⬇️

scholarly article

Mismatch string kernels for discriminative protein classification

scientific article published on 22 January 2004

Motif-based protein ranking by network propagation

scientific article published on 2 August 2005

Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12

scientific article published on 01 July 2019

Msi2 Maintains the MLL Leukemia Stem Cell Regulatory Program ⬇️

scholarly article

Multitask learning improves prediction of cancer drug sensitivity

scientific article published on 23 August 2016

NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A

scientific article published on 29 September 2008

Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8 T Cells

scientific article published on 23 April 2019

Non-redundant ISGF3 Components Promote NK Cell Survival in an Auto-regulatory Manner during Viral Infection

scientific article published on 01 August 2018

PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression

article

PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D.

scientific article

Pancancer modelling predicts the context-specific impact of somatic mutations on transcriptional programs.

scientific article published on 31 January 2017

Pancreatic cancer prognosis is predicted by an ATAC-array technology for assessing chromatin accessibility

scientific article published on 24 May 2021

Prediction of potent shRNAs with a sequential classification algorithm

scientific article

Profile-based string kernels for remote homology detection and motif extraction

scientific article

Profile-based string kernels for remote homology detection and motif extraction

scientific article published on 01 January 2004

Programme of self-reactive innate-like T cell-mediated cancer immunity

scientific article published in May 2022

Protein backbone angle prediction with machine learning approaches.

scientific article

Protein ranking by semi-supervised network propagation

scientific article

Protein ranking: from local to global structure in the protein similarity network

scientific article

RNA Binding Protein Syncrip Regulates the Leukemia Stem Cell Program ⬇️

scholarly article

Randomised double-blind, placebo-controlled trial of coenzyme Q, therapy in class II and III systolic heart failure

scientific article published on January 2003

SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes

scientific article published in 2022

SeqGL Identifies Context-Dependent Binding Signals in Genome-Wide Regulatory Element Maps

scientific article published on 27 May 2015

Sequence information for the splicing of human pre-mRNA identified by support vector machine classification

scientific article

Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets

scientific article published on 10 February 2021

Single-Cell Transcriptional Profiling Reveals Signatures of Helper, Effector, and Regulatory MAIT Cells during Homeostasis and Activation

scientific article published on 11 February 2022

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.

scientific article

Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia

scientific article published on 13 February 2017

Target mRNA abundance dilutes microRNA and siRNA activity

scientific article (publication date: 20 April 2010)

The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma

scientific article

The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries

scientific article published on 06 November 2020

The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types

scientific article published on 17 September 2018

Therapeutic Transgene Expression From Genomic Safe Harbors In Patient-Specific Induced Pluripotent Stem Cells ⬇️

scholarly article

Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function

scientific article published on 14 January 2019

Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity

scientific article published on 24 October 2019

Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting

scientific article

Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs

scientific article (publication date: June 2009)

Ubiquitously transcribed genes use alternative polyadenylation to achieve tissue-specific expression

scientific article published on 21 October 2013

Widespread intronic polyadenylation diversifies immune cell transcriptomes.

scientific article published on 30 April 2018

Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia.

scientific article published on 27 August 2018

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