List of works by Douglas F Covey

11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.

scientific article

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

scientific article published on 17 June 2020

3,3-Dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones: a new class of anticonvulsant agents

scientific article published on 01 April 1996

3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists.

scientific article published in May 2002

5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo

scientific article

A Clickable Oxysterol Photolabel Retains NMDA Receptor Activity and Accumulates in Neurons

scientific article published on 06 December 2018

A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition

scientific article

A facile total synthesis of ent-17beta-estradiol and structurally related analogues

scientific article published on 27 December 2006

A neuroactive steroid with a therapeutically interesting constellation of actions at GABAA and NMDA receptors

scientific article published on 23 October 2020

A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis

scientific article

A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain

scientific article published on 09 February 2018

A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol.

scientific article

A novel mechanism of non-feminizing estrogens in neuroprotection

scientific article published on 3 November 2016

A practical and facile route for the preparation of 18-norandrostan-17-ones from androstan-17-ones using SmI(2)-promoted cyclization and dehydroxylation

scientific article published on 01 June 2000

A simple efficient synthesis of [23,24]-(13)C(2)-labeled bile salts as NMR probes of protein-ligand interactions

scientific article published on 01 February 2002

A single hydroxyl group governs ligand site selectivity in human ileal bile acid binding protein.

scientific article

A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors

scientific article

ACCP Template for Evaluating a Clinical Pharmacist

scientific article published on 17 April 2017

Abnormal Beckmann fragmentation/ring closing metathesis route for preparation of 18-nor-Delta-androgens and their 18-nor-13,17-epoxide derivatives

scientific article published on November 2006

Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model

scientific article published in Scientific Reports

Alkyl-substituted gamma-butyrolactones act at a distinct site allosterically linked to the TBPS/picrotoxinin site on the GABAA receptor complex

scientific article published in June 1993

Alkyl-substituted thiolo-, thiono-, and dithio-gamma-butyrolactones: new classes of convulsant and anticonvulsant agents

scientific article

Alkyl-substituted γ-butyrolactones as potential tools in the study and treatment of epilepsy ⬇️

scientific article published on October 15, 1983

Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones

scientific article published on January 1994

Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs

scientific article published on 01 September 1982

Alpha-substituted thiobutyrolactones potentiate GABA currents in voltage-clamped chick spinal cord neurons

scientific article (publication date: 22 April 1988)

An Improved Synthesis of 18-Nor-17-ketosteroids and Application of the Method for the Preparation of (3beta,5beta,13alpha)- and (3beta,5beta,13beta)-3-Hydroxygonan-17-one

scientific article published on 01 October 1996

Analysis of GABAA receptor activation by combinations of agonists acting at the same or distinct binding sites

scientific article published on 18 October 2018

Antagonism of neurosteroid modulation of native gamma-aminobutyric acid receptors by (3alpha,5alpha)-17-phenylandrost-16-en-3-ol

scientific article

Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light.

scientific article published on 25 February 2007

Anticonvulsant medications extend worm life-span

scientific article

Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms

scientific article

Anticonvulsant properties of alpha, gamma, and alpha, gamma-substituted gamma-butyrolactones.

scientific article published in September 1982

Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain?

scientific article

Binding and intracellular transport of 25-hydroxycholesterol by Niemann-Pick C2 protein

scientific article published on 12 September 2019

Binding interactions of convulsant and anticonvulsant gamma-butyrolactones and gamma-thiobutyrolactones with the picrotoxin receptor

scientific article published on August 1990

Blockade of Ba2+ current through human alpha1E channels by two steroid analogs, (+)-ACN and (+)-ECN.

scientific article published on June 1999

Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes

scientific article

Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines

scientific article

Chirality in Membranes: First Evidence that Enantioselective Interactions Between Cholesterol and Cell Membrane Lipids Can Be a Determinant of Membrane Physical Properties

article

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

scientific article published on 01 April 2020

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

scientific article published on 30 October 2019

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.

scientific article published on 05 October 2016

Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects. Studies with cholesterol enantiomers

scientific article

Cholesterol tuning of BK ethanol response is enantioselective, and is a function of accompanying lipids

scientific article

Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins.

scientific article

Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel

scientific article published on 22 November 2018

Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1β2γ2L GABA(A) Receptors.

scientific article published on 14 January 2016

Comparison of effects of U18666A and enantiomeric U18666A on sterol synthesis and induction of apoptosis

scientific article

Comparison of epileptogenic properties of unsubstituted and beta-alkyl-substituted gamma-butyrolactones

scientific article published in September 1982

Comparison of the anticonvulsant activities of ethosuximide, valproate, and a new anticonvulsant, thiobutyrolactone

scientific article (publication date: 1989)

Computer-assisted modeling of the picrotoxinin and gamma-butyrolactone receptor site ⬇️

scientific article published on March 1, 1983

Convulsant and anti-convulsant gammabutyrolactones bind at the picrotoxinin/T-butylbicyclophosphorothionate (TBPS) receptor

scientific article published on 01 December 1985

Convulsant and anticonvulsant cyclopentanones and cyclohexanones

scientific article published on 01 January 1990

Convulsant gamma-butyrolactones block GABA currents in cultured chick spinal cord neurons

scientific article published on 01 April 1989

Correction to Synthesis of a Smoothened Cholesterol: 18,19-Di-nor-cholesterol

scientific article published on 19 May 2015

Cyclodextrins sequester neuroactive steroids and differentiate mechanisms that rate limit steroid actions

scientific article

Development of a bile acid-based newborn screen for Niemann-Pick disease type C

scientific article published on May 2016

Developmental alteration in GABAA receptor structure and physiological properties in cultured cerebellar granule neurons

scientific article published in July 1994

Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.

scientific article

Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats

scientific article

Differential interaction of the two cholesterol-dependent, membrane-damaging toxins, streptolysin O and Vibrio cholerae cytolysin, with enantiomeric cholesterol

scientific article

Dual modulation of the gamma-aminobutyric acid type A receptor/ionophore by alkyl-substituted gamma-butyrolactones ⬇️

scientific article published on June 1, 1995

Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors

scientific article published on 22 March 2006

Effects of a benz[e]indene on gamma-aminobutyric acid-gated chloride currents in cultured postnatal rat hippocampal neurons ⬇️

scientific article published on December 1, 1992

Effects of anticonvulsant and convulsant gamma-butyrolactones and thiobutyrolactones on GABA-mediated chloride uptake

scientific article published on March 1987

Effects of anticonvulsant lactams on in vitro seizures in the hippocampal slice preparation

scientific article

Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains

scientific article published on July 2000

Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains

scientific article published on 01 July 2000

Effects of natural and enantiomeric cholesterol on the thermotropic phase behavior and structure of egg sphingomyelin bilayer membranes

scientific article

Effects of neurosteroid and benz[e]indene enantiomers on GABAA receptors in cultured hippocampal neurons and transfected HEK-293 cells

scientific article

Effects on gamma-aminobutyric acid (GABA)(A) receptors of a neuroactive steroid that negatively modulates glutamate neurotransmission and augments GABA neurotransmission

scientific article published in October 2001

Effects on membrane capacitance of steroids with antagonist properties at GABAA receptors

scientific article published on 13 March 2008

Eliminating the roughness in cholesterol's β-face: does it matter?

scientific article

Enantiomeric deoxycholic acid: total synthesis, characterization, and preliminary toxicity toward colon cancer cell lines

scientific article published on 25 October 2007

Enantiomers of neuroactive steroids support a specific interaction with the GABA-C receptor as the mechanism of steroid action

scientific article published on 9 March 2006

Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activity

scientific article published in November 1998

Enantioselective modulation of GABAergic synaptic transmission by steroids and benz[e]indenes in hippocampal microcultures

scientific article published in June 1998

Enantioselective protein-sterol interactions mediate regulation of both prokaryotic and eukaryotic inward rectifier K+ channels by cholesterol.

scientific article

Enantioselectivity of alpha-benzyl-alpha-methyl-gamma-butyrolactone-mediated modulation of anticonvulsant activity and GABA(A) receptor function

scientific article published on 23 January 2004

Enantioselectivity of pregnanolone-induced gamma-aminobutyric acid(A) receptor modulation and anesthesia

scientific article published in June 2000

Enantioselectivity of steroid-induced gamma-aminobutyric acidA receptor modulation and anesthesia.

scientific article

Enantiospecific interactions between cholesterol and phospholipids

scientific article published on 3 January 2008

Enantiospecificity of cholesterol function in vivo

scientific article

Enantiospecificity of sterol–lipid interactions: first evidence that the absolute configuration of cholesterol affects the physical properties of cholesterol–sphingomyelin membranes

article

Energetics by NMR: site-specific binding in a positively cooperative system

scientific article

Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and a

scientific article published on 23 June 2004

Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats

scientific article published in July 2005

Estrogen receptor-independent neuroprotection via protein phosphatase preservation and attenuation of persistent extracellular signal-regulated kinase 1/2 activation

scientific article

Estrogen-like compounds for ischemic neuroprotection

scientific article

Fatty acid synthesis configures the plasma membrane for inflammation in diabetes

scientific article published on 2 November 2016

First synthesis of enantiopure 1,6-difunctionalized dodecahydrobenz[f]indenes

scientific article

First synthesis of ent-desmosterol and its conversion to ent-deuterocholesterol

scientific article published in February 2003

GABAergic neurosteroids mediate the effects of ethanol on long-term potentiation in rat hippocampal slices

scientific article published on 20 September 2007

Gamma-butyrolactone antagonism of the picrotoxin receptor: comparison of a pure antagonist and a mixed antagonist/inverse agonist

scientific article published on 01 January 1991

Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humans

scientific article published in April 2002

Glucuronidation of the steroid enantiomers ent-17β-estradiol, ent-androsterone and ent-etiocholanolone by the human UDP-glucuronosyltransferases

scientific article published on 27 August 2011

Hydrogen bonding between the 17beta-substituent of a neurosteroid and the GABA(A) receptor is not obligatory for channel potentiation

scientific article published on 20 August 2009

Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis

scientific article

Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone.

scientific article

Inhibition of T-type calcium current in the reticular thalamic nucleus by a novel neuroactive steroid

scientific article

Inhibition of voltage-dependent sodium channels by the anticonvulsant gamma-aminobutyric acid type A receptor modulator, 3-benzyl-3-ethyl-2-piperidinone

scientific article published in June 1998

Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies

scientific article

Kinetic analysis of voltage-dependent potentiation and block of the glycine alpha 3 receptor by a neuroactive steroid analogue

scientific article published on 5 January 2009

Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids.

scientific article

Lack of enantiomeric specificity in the effects of anesthetic steroids on lipid bilayers

scientific article published on 26 July 2006

Lactone Modulation of the γ-Aminobutyric Acid A Receptor: Evidence for a Positive Modulatory Site ⬇️

scientific article published on 01 July 1997

Localization of tolbutamide binding sites on human serum albumin using titration calorimetry and heteronuclear 2-D NMR

scientific article published on 01 July 1995

Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.

scientific article published in March 2017

Mapping Two Neurosteroid Modulatory Sites in the Prototypic Pentameric Ligand Gated Ion Channel GLIC.

scientific article published on 4 January 2018

Mechanism of Action of VP1-001 in cryAB(R120G)-Associated and Age-Related Cataracts

scientific article published on 01 August 2019

Mechanism of okadaic acid-induced neuronal death and the effect of estrogens

scientific article

Mechanisms of neurosteroid interactions with GABA(A) receptors.

scientific article

Membrane dipole potential is sensitive to cholesterol stereospecificity: implications for receptor function

scientific article published on 16 September 2014

Membrane organization and intracellular transport of a fluorescent analogue of 27-hydroxycholesterol

scientific article published on 30 October 2020

Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders

scientific article published on 19 April 2019

Modulation of GABAA receptor function by benz[e]indenes and phenanthrenes

scientific article

Modulation of the human ρ1 GABAA receptor by inhibitory steroids

scientific article

Modulation of the picrotoxin receptor by fluorinated ethyl, methyl-butyrolactones.

scientific article published on October 1990

Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol

scientific article

Multiple functional neurosteroid binding sites on GABAA receptors

scientific article published on 07 March 2019

Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling

scientific article published on 05 June 2019

Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids.

scientific article published on 10 June 2008

NMDA potentiation by visible light in the presence of a fluorescent neurosteroid analogue.

scientific article published on 29 April 2009

Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor

scientific article

Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia

scientific article published on 30 October 2003

Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABAA currents, but are not neurotoxic to the developing rat brain

scientific article published on 06 March 2020

Neuroactive steroids and human recombinant rho1 GABAC receptors

scientific article (publication date: October 2007)

Neuroactive steroids have multiple actions to potentiate GABAA receptors

scientific article published on 14 May 2004

Neuroprotection by the synthetic neurosteroid enantiomers ent-PREGS and ent-DHEAS against Aβ₂₅₋₃₅ peptide-induced toxicity in vitro and in vivo in mice

scientific article

Neuroprotection with non-feminizing estrogen analogues: an overlooked possible therapeutic strategy

scientific article published on 3 April 2012

Neuroprotective agent riluzole potentiates postsynaptic GABA(A) receptor function

scientific article published in February 2002

Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells

scientific article published on 13 April 2006

Neuroprotective effects of a novel non-receptor-binding estrogen analogue: in vitro and in vivo analysis

scientific article published on October 2002

Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo

scientific article

Neurosteroid Analogues. 13. Synthetic methods for the preparation of 2beta-hydroxygonane derivatives as structural mimics of ent-3alpha-hydroxysteroid modulators of GABA(A) receptors

scientific article published on August 2007

Neurosteroid access to the GABAA receptor

scientific article

Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor

scientific article

Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one

scientific article published in April 2005

Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes

scientific article published in July 2006

Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens

scientific article published on 12 March 2007

Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes

scientific article published on 15 February 2008

Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues.

scientific article published on 15 September 2010

Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity

scientific article published on 6 May 2011

Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptors

scientific article published on 18 January 2012

Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone.

scientific article

Neurosteroid analogues. 3. The synthesis and electrophysiological evaluation of benz[e]indene congeners of neuroactive steroids having the 5 beta-configuration.

scientific article published in October 1995

Neurosteroid analogues. 4. The effect of methyl substitution at the C-5 and C-10 positions of neurosteroids on electrophysiological activity at GABAA receptors

scientific article published in October 1996

Neurosteroid analogues. 6. The synthesis and GABAA receptor pharmacology of enantiomers of dehydroepiandrosterone sulfate, pregnenolone sulfate, and (3alpha,5beta)-3-hydroxypregnan-20-one sulfate

scientific article published in July 1998

Neurosteroid analogues. 7. A synthetic route for the conversion of 5 beta-methyl-3-ketosteroids into 7(S)-methyl-substituted analogues of neuroactive benz[e]indenes

scientific article published in April 2000

Neurosteroid analogues. 8. Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3alpha, 5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one

scientific article

Neurosteroid analogues. 9. Conformationally constrained pregnanes: structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one

scientific article published on December 2003

Neurosteroid analogues: structure-activity studies of benz[e]indene modulators of GABAA receptor function. 1. The effect of 6-methyl substitution on the electrophysiological activity of 7-substituted benz[e]indene-3-carbonitriles

scientific article published on 01 November 1993

Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation

scientific article published on 30 August 2007

Neurosteroids and oxysterols as potential therapeutic agents for glaucoma and Alzheimer's disease

scientific article published on 01 January 2018

Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond

scientific article published on 27 September 2019

Neurosteroids enhance spontaneous glutamate release in hippocampal neurons. Possible role of metabotropic sigma1-like receptors.

scientific article published on 31 May 2002

Neurosteroids in Pain Management: A New Perspective on an Old Player

scholarly article by Sonja L Joksimovic et al published 2018 in Frontiers in Pharmacology

Neurosteroids, stress and depression: potential therapeutic opportunities.

scientific article published on 17 October 2012

New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids

scientific article

Novel neuroactive steroid with hypnotic and T-type calcium channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain

scientific article published on 23 January 2020

Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum

scientific article published on 28 February 2019

Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone.

scientific article

Oxysterols are allosteric activators of the oncoprotein Smoothened

scientific article published on 8 January 2012

Oxysterols as non-genomic regulators of cholesterol homeostasis

scientific article published on 11 January 2012

Palladium-catalyzed potassium enoxyborate alkylation of enantiopure Hajos-Parrish indenone to construct rearranged steroid ring systems

scientific article published on 27 May 2007

Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain

scientific article published on 03 June 2022

Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain.

scientific article

Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1.

scientific article

Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors

scientific article published on 13 July 2009

Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog

scientific article published in November 2004

Physiological comparison of alpha-ethyl-alpha-methyl-gamma-thiobutyrolactone with benzodiazepine and barbiturate modulators of GABAA receptors

scientific article published in February 1996

Physiological modulation of the GABA receptor by convulsant and anticonvulsant barbiturates in cultured rat hippocampal neurons

scientific article published in May 1990

Physiological regulation of the picrotoxin receptor by gamma-butyrolactones and gamma-thiobutyrolactones in cultured hippocampal neurons.

scientific article published in June 1990

Potential clinical uses of neuroactive steroids

scientific article

Potential clinical uses of neuroactive steroids

scientific article published on 01 September 2000

Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels

scientific article published on 12 December 2020

Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease

scientific article

Pregnenolone sulfate and dehydroepiandrosterone sulfate inhibit GABA-gated chloride currents in Xenopus oocytes expressing picrotoxin-insensitive GABA(A) receptors

scientific article published in February 1999

Pregnenolone sulfate and its enantiomer: differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient mice

scientific article

Pregnenolone sulfate modulates inhibitory synaptic transmission by enhancing GABA(A) receptor desensitization

scientific article published on 01 May 2000

Quantitative imaging of membrane contact sites for sterol transfer between endo-lysosomes and mitochondria in living cells

scientific article

Racemic progesterone: predicted in silico and produced in the solid state

scientific article published on 16 October 2006

Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters.

scientific article published on 26 August 2006

Recent developments in structure–activity relationships for steroid modulators of GABAA receptors

article

Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIalpha at the trans-Golgi network

scientific article published on 13 April 2010

Relative anticonvulsant effects of GABAmimetic and GABA modulatory agents

scientific article published on November 1, 1992

Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels

scientific article

Role of nonfeminizing estrogen analogues in neuroprotection of rat retinal ganglion cells against glutamate-induced cytotoxicity

scientific article

Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice

scientific article

Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors

scientific article

Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions

scientific article published on 6 November 2008

Side-chain oxysterols modulate cholesterol accessibility through membrane remodeling

scientific article

Site-specific effects of neurosteroids on GABAA receptor activation and desensitization

scientific article published on 21 September 2020

Slow actions of neuroactive steroids at GABAA receptors.

scientific article

Slow death of postnatal hippocampal neurons by GABA(A) receptor overactivation

scientific article published on 01 May 2000

Stereospecific requirement of cholesterol in the function of the serotonin1A receptor

scientific article published on 2 September 2013

Steroid Ring Hydroxylation Patterns Govern Cooperativity in Human Bile Acid Binding Protein ⬇️

scientific article published on October 14, 2003

Steroid inhibition of rat neuronal nicotinic alpha4beta2 receptors expressed in HEK 293 cells.

scientific article published in August 2000

Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats.

scientific article published in December 2001

Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands.

scientific article published on 20 July 2006

Structural basis of Smoothened regulation by its extracellular domains

scientific article

Structural design of intrinsically fluorescent oxysterols

scientific article published on 26 December 2017

Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR

scientific article

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

scientific article

Structure-activity relationships of alkyl-substituted gamma-butyrolactones and succinimides.

scientific article

Structure-activity studies of fluoroalkyl-substituted gamma-butyrolactone and gamma-thiobutyrolactone modulators of GABA(A) receptor function

scientific article

Structure-activity studies of non-steroid analogues structurally-related to neuroprotective estrogens

scientific article published on 26 September 2016

Subunit-specific action of an anticonvulsant thiobutyrolactone on recombinant glycine receptors involves a residue in the M2 membrane-spanning region.

scientific article published in July 2000

Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis

scientific article published on 04 February 2020

Synthesis and anticonvulsant activities of 3,3-dialkyl- and 3-alkyl-3-benzyl-2-piperidinones (delta-valerolactams) and hexahydro-2H-azepin-2-ones (epsilon-caprolactams)

scientific article published on 01 January 1997

Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking

scientific article published on 07 January 2019

Synthesis and structure-activity studies of alkyl-substituted .gamma.-butyrolactones and .gamma.-thiobutyrolactones: ligands for the picrotoxin receptor ⬇️

scientific article published on April 1, 1991

Synthesis of (17R)- and (17S)-17-hydroxy-14, 15-secoandrost-4-en-15-yn-3-one and the X-ray crystal structure of the (17S)-diastereomer

scientific article published on 01 June 1995

Synthesis of (17R)- and (17S)-17-hydroxy-14, 15-secoandrost-4-en-15-yn-3-one and the X-ray crystal structure of the (17S)-diastereomer

scientific article published on 01 March 1995

Synthesis of (5alpha)-17-azaandrostan-3-ols and (5alpha)-17-aza-D-homoandrostan-3-ols and their N-acylated derivatives

scientific article published on 01 August 2001

Synthesis of 19-Trideuterated ent-Testosterone and the GABA(A) Receptor Potentiators ent-Androsterone and ent-Etiocholanolone

scientific article published on November 2008

Synthesis of [3,4-(13)c(2)]-enriched bile salts as NMR probes of protein-ligand interactions

scientific article published in September 2002

Synthesis of a smoothened cholesterol: 18,19-di-nor-cholesterol

scientific article

Synthesis of ent-25-hydroxycholesterol

scientific article published on 6 March 2006

Synthesis of side-chain oxysterols and their enantiomers through cross-metathesis reactions of Δ22 steroids

scientific article published on 11 March 2017

Synthesis of the enantiomer of the oxysterol-antagonist LY295427.

scientific article published on 4 April 2011

Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids

scientific article published on 27 October 2007

T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor.

scientific article published on 12 June 2010

TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model

scientific article

The Efficient and Enantiospecific Total Synthesis of Cyclopenta[b]phenanthrenes Structurally-related to Neurosteroids

scientific article published on October 2010

The T-type calcium channel isoform Cav3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile

scientific article published on 25 August 2020

The anesthetic steroid (+)-3alpha-hydroxy-5alpha-androstane-17beta-carbonitrile blocks N-, Q-, and R-type, but not L- and P-type, high voltage-activated Ca2+ current in hippocampal and dorsal root ganglion neurons of the rat.

scientific article published in September 1998

The assessment of non-feminizing estrogens for use in neuroprotection ⬇️

scientific article published on November 25, 2010

The enantiomer of cholesterol

scientific article

The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21.

scientific article published in January 2003

The enantiomer of progesterone acts as a molecular neuroprotectant after traumatic brain injury

scientific article published on 22 August 2006

The estrogen receptor is not essential for all estrogen neuroprotection: new evidence from a new analog

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The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction

scientific article published on 24 June 2009

The influence of the membrane on neurosteroid actions at GABA(A) receptors.

scientific article published on December 2009

The molecular determinants of neurosteroid binding in the GABA(A) receptor

scientific article published on 28 May 2019

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism

scientific article published on 23 September 2019

The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABAA receptors in rat glaucoma models

scientific article published on 27 February 2020

The neurosteroids dehydroepiandrosterone sulfate and pregnenolone sulfate inhibit the UNC-49 GABA receptor through a common set of residues

scientific article published on 22 August 2007

The nonfeminizing enantiomer of 17beta-estradiol exerts protective effects in neuronal cultures and a rat model of cerebral ischemia

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The sticky issue of neurosteroids and GABA(A) receptors

scientific article

The structural basis of cholesterol accessibility in membranes

scientific article published on October 2013

The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: distinct mechanisms?

scientific article

The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response

scientific article published on 27 December 2012

The use of symmetry in enantioselective synthesis: four pairs of chrysene enantiomers prepared from 19-nortestosterone

scientific article published on 3 May 2011

Total synthesis of ent-cholesterol via a steroid C,D-ring side-chain synthon

scientific article published in July 2002

Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi

scientific article

Visualizing pregnenolone sulfate-like modulators of NMDA receptor function reveals intracellular and plasma-membrane localization

scholarly article by Mariangela Chisari et al published January 2019 in Neuropharmacology

Voltage-dependent calcium channels as targets for convulsant and anticonvulsant alkyl-substituted thiobutyrolactones

scientific article published on 01 February 1997

ent-Steroids: novel tools for studies of signaling pathways

scientific article published on 03 December 2008

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