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List of works by Michael Robert Savona

A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia.

scientific article

A Phase Ib/II Study of Oprozomib in Patients with Advanced Multiple Myeloma and Waldenström Macroglobulinemia

scientific article published on 29 May 2019

A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia.

scientific article published on 23 March 2017

A phase 2 study of simtuzumab in patients with primary, post-polycythaemia vera or post-essential thrombocythaemia myelofibrosis

scientific article published on 21 February 2017

Acceleration of spleen segmentation with end-to-end deep learning method and automated pipeline

scientific article published on 05 February 2019

An International MDS/MPN Working Group's perspective and recommendations on molecular pathogenesis, diagnosis and clinical characterization of myelodysplastic/myeloproliferative neoplasms.

scientific article published on September 2015

An international consortium proposal of uniform response criteria for myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in adults

scientific article published on 26 January 2015

An oral fixed-dose combination of decitabine and cedazuridine in myelodysplastic syndromes: a multicentre, open-label, dose-escalation, phase 1 study

scientific article published on 01 April 2019

Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase

scientific article published on 02 December 2021

Are we altering the natural history of primary myelofibrosis?

scientific article

BET inhibition enhances the antileukemic activity of low-dose Venetoclax in acute myeloid leukemia

scientific article published on 04 November 2020

BET inhibitors reduce cell size and induce reversible cell cycle arrest in AML

scientific article published on 11 November 2018

CD9 phones home with a TEM of its own

scientific article published on 01 February 2011

Challenges in Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN)

scientific article published on 23 November 2018

Chronic myeloid leukemia: changing the treatment paradigms.

scientific article published on June 2006

Comparison of a semipermeable dressing bonded to an absorbent pad and a semipermeable dressing over a separate gauze pad for containment of vaccinia virus at the vaccination site

scientific article published on 19 October 2007

Connect MDS/AML: design of the myelodysplastic syndromes and acute myeloid leukemia disease registry, a prospective observational cohort study

scientific article

Considerations for Successful Treatment-free Remission in Chronic Myeloid Leukemia

scientific article published on 29 November 2017

Correction to: Evaluation of the bioequivalence and food effect on the bioavailability of CC-486 (oral azacitidine) tablets in adult patients with cancer

scientific article published on 25 March 2020

Dasatinib vs. imatinib in patients with chronic myeloid leukemia in chronic phase (CML-CP) who have not achieved an optimal response to 3 months of imatinib therapy: the DASCERN randomized study

scientific article published on 07 April 2020

Detection of vaccinia DNA in the blood following smallpox vaccination

scientific article

Determining the recommended dose of pacritinib: results from the PAC203 dose-finding trial in advanced myelofibrosis

scientific article published on 01 November 2020

Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors

scientific article published on 23 November 2016

Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer

scientific article published on 16 April 2019

Erythropoietin-stimulating agents in oncology

scientific article published on March 2008

Establishing specific response criteria for MDS/MPN - Getting closer to reality?

scientific article published on 07 May 2020

Evaluation of the bioequivalence and food effect on the bioavailability of CC-486 (oral azacitidine) tablets in adult patients with cancer

scientific article published on 08 February 2020

Evidence of vaccinia dissemination despite lack of major reaction following smallpox vaccination

scientific article published on 31 December 2019

Extended dosing with CC-486 (oral azacitidine) in patients with myeloid malignancies

scientific article published on 03 September 2018

Genotypic and clinical heterogeneity within NCCN favorable-risk acute myeloid leukemia

scientific article published on 2 January 2018

Getting to the stem of chronic myeloid leukaemia

scientific article published on May 2008

Guadecitabine (SGI-110) in patients with intermediate or high-risk myelodysplastic syndromes: phase 2 results from a multicentre, open-label, randomised, phase 1/2 trial

scientific article published on 03 May 2019

Guadecitabine (SGI-110) in treatment-naive patients with acute myeloid leukaemia: phase 2 results from a multicentre, randomised, phase 1/2 trial

scientific article published on 24 August 2017

HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs.

scientific article

HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells

scientific article

High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML.

scientific article published on 03 August 2016

Human and rhesus macaque hematopoietic stem cells cannot be purified based only on SLAM family markers

scientific article published on 16 December 2010

Identifying the time to change BCR-ABL inhibitor therapy in patients with chronic myeloid leukemia.

scientific article published on 15 August 2013

Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

scientific article published on 03 August 2020

Improving Splenomegaly Segmentation by Learning from Heterogeneous Multi-Source Labels

scientific article published on 01 February 2019

Incorporating Precision BH3 Warheads Into the Offensive Against Acute Myeloid Leukemia

scientific article published on 21 May 2019

Increased Ripk1-mediated bone marrow necroptosis leads to myelodysplasia and bone marrow failure in mice

scientific article published on 09 November 2018

Ironing out the details of iron overload in myelofibrosis: Lessons from myelodysplastic syndromes

scientific article published on 19 April 2016

Ivosidenib or enasidenib combined with intensive chemotherapy in patients with newly diagnosed AML: a phase 1 study

scientific article published on 05 September 2020

Learning from dispersed manual annotations with an optimized data weighting policy

scientific article published on 30 July 2020

Leveraging JAK-STAT regulation in myelofibrosis to improve outcomes with allogeneic hematopoietic stem-cell transplant

scientific article published on 16 July 2018

Low Clinical Trial Accrual of Patients With Myelodysplastic Syndromes: Causes and Potential Solutions

scientific article published on 05 October 2018

Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes

scientific article published on 01 January 2020

Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade

scientific article published on 01 July 2019

Molecular Testing in Patients with Suspected Myelodysplastic Syndromes

scientific article

Molecular monitoring and minimal residual disease in the management of chronic myelogenous leukemia.

scientific article

Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia

scientific article published on 23 January 2020

Mutational landscape of myelodysplastic/myeloproliferative neoplasm-unclassifiable

scientific article published on 21 September 2018

Myelodysplastic Syndrome Revealed by Systems Immunology in a Melanoma Patient Undergoing Anti-PD-1 Therapy

scientific article published on 10 March 2016

Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia

scientific article published on 15 May 2020

Oral Azacitidine and Cedazuridine Approximate Parenteral Azacitidine Efficacy in Murine Model

scientific article published on 28 March 2020

Oral cedazuridine/decitabine: a phase 2, pharmacokinetic/pharmacodynamic, randomized, crossover study in MDS and CMML

scientific article published on 13 April 2020

Overcoming resistance in chronic myelogenous leukemia

scientific article

Pevonedistat, a first-in-class NEDD8-activating enzyme (NAE) inhibitor, combined with azacitidine, in patients with AML.

scientific article published on 18 January 2018

Pharmacokinetics of different formulations of oral azacitidine (CC-486) and the effect of food and modified gastric pH on pharmacokinetics in subjects with hematologic malignancies

scientific article published on 18 January 2014

Phase Ib Study of Glasdegib, A Hedgehog Pathway Inhibitor, in Combination With Standard Chemotherapy in Patients With AML or High-Risk MDS.

scientific article published on 20 February 2018

Primary analysis of a phase II open-label trial of INCB039110, a selective JAK1 inhibitor, in patients with myelofibrosis

scientific article

Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions

scientific article published on 02 May 2019

Prospective Study of Cardiac Events During Proteasome Inhibitor Therapy for Relapsed Multiple Myeloma

scientific article published on 12 June 2019

Real-world diagnostic testing patterns for assessment of ring sideroblasts and SF3B1 mutations in patients with newly diagnosed lower-risk myelodysplastic syndromes

scientific article published on 21 November 2020

SF3B1-mutant myelodysplastic syndrome as a distinct disease subtype - A Proposal of the International Working Group for the Prognosis of Myelodysplastic Syndromes (IWG-PM)

scientific article published on 29 April 2020

Safety and efficacy of selinexor in relapsed or refractory multiple myeloma and Waldenstrom's macroglobulinemia

scientific article published on 4 December 2017

Selective inhibition of nuclear export with selinexor in patients with non-Hodgkin lymphoma.

scientific article

Sotatercept with long-term extension for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes: a phase 2, dose-ranging trial

scientific article published on 10 January 2018

Special Considerations in the Management of Patients with Myelodysplastic Syndrome / Myeloproliferative Neoplasm Overlap Syndromes During the SARS-CoV-2 Pandemic

scientific article published on 30 April 2020

Special considerations in the management of adult patients with acute leukaemias and myeloid neoplasms in the COVID-19 era: recommendations from a panel of international experts

scientific article published on 18 June 2020

Splenomegaly Segmentation on Multi-Modal MRI Using Deep Convolutional Networks

scientific article published on 13 November 2018

Symptom Burden and Blood Counts in Patients With Polycythemia Vera in the United States: An Analysis From the REVEAL Study

scientific article published on 13 June 2019

SynSeg-Net: Synthetic Segmentation Without Target Modality Ground Truth

scientific article published on 17 October 2018

TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups

scientific article published on 11 January 2019

The CDK7 inhibitor THZ1 alters RNA polymerase dynamics at the 5' and 3' ends of genes

article

The Challenge of Treating Myelodysplastic Syndromes/Myeloproliferative Neoplasms

scientific article published in July 2017

The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia

scientific article published on 03 May 2018

The delta isoform of phosphatidylinositol-3-kinase predominates in chronic myelomonocytic leukemia and can be targeted effectively with umbralisib and ruxolitinib

scientific article published on 19 February 2021

The evolving role of next generation sequencing in myelodysplastic syndromes

scientific article published on 01 October 2019

The failure of years of experience with electrocardiographic transmission from paramedics to the hospital emergency department to reduce the delay from door to primary coronary intervention below the 90-minute threshold during acute myocardial infar

scientific article

The use of higher dose clofarabine in adults with relapsed acute lymphoblastic leukemia

scientific article published on April 2009

The use of venetoclax-based salvage therapy for post-hematopoietic cell transplantation relapse of acute myeloid leukemia

scientific article published on 10 May 2020

Therapeutic approaches in myelofibrosis and myelodysplastic/myeloproliferative overlap syndromes

scientific article

Therapy for Chronic Myelomonocytic Leukemia in a New Era.

scientific article published on 6 October 2017

Treatment Patterns and Blood Counts in Patients With Polycythemia Vera Treated With Hydroxyurea in the United States: An Analysis From the REVEAL Study

scientific article published on 30 September 2019

Umbralisib, a novel PI3Kδ and casein kinase-1ε inhibitor, in relapsed or refractory chronic lymphocytic leukaemia and lymphoma: an open-label, phase 1, dose-escalation, first-in-human study

scientific article published on 20 February 2018

Unfavorable-risk acute myeloid leukemia dissected

scientific article published on 25 January 2016

Venetoclax Combined With Low-Dose Cytarabine for Previously Untreated Patients With Acute Myeloid Leukemia: Results From a Phase Ib/II Study

scientific article published on 20 March 2019

Venetoclax response is enhanced by selective inhibitor of nuclear export compounds in hematologic malignancies

scientific article published on 01 February 2020

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