List of works - Jian Li

A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1

scientific article published on 11 December 2020

Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in <i>Caenorhabditis elegans</i> via inhibiting OSM-9

scientific article published on 05 May 2022

Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease.

scientific article

Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents

scientific article published on 22 January 2020

Development of the First Generation of Disulfide-Based Subtype-Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors.

scientific article

Discovery of Potent Benzocycloalkane Derived Diapophytoene Desaturase (CrtN) Inhibitors with Enhanced Safety Profile for the Treatment of MRSA, VISA and LRSA Infection.

scientific article published on 29 January 2018

Discovery of Potent, Selective Stem Cell Factor Receptor/Platelet Derived Growth Factor Receptor Alpha (c-KIT/PDGFRα) Dual Inhibitor for the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors (GISTs).

scientific article

Drug Repurposing of Haloperidol: Discovery of New Benzocyclane Derivatives as Potent Antifungal Agents against Cryptococcosis and Candidiasis

scientific article published on 08 October 2019

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.

scientific article published on 20 February 2017

Extra Sugar on Vancomycin: New Analogues for Combating Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci.

scientific article

Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway

scientific article published on 07 April 2021

Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant and Vancomycin-Intermediate Staphylococcus aureus Infections in vivo

scientific article published on 7 September 2017

Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5).

scientific article published on 4 April 2018

Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity.

scientific article

Novel Vilazodone-Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation

scientific article published on 5 September 2017

Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents

scientific article published on 29 August 2018

Ruthenium(II)-Catalyzed Redox-Neutral [3+2] Annulation of Indoles with Internal Alkynes via C-H Bond Activation: Accessing a Pyrroloindolone Scaffold.

scientific article

Spiropyran in Situ Switching: A Real-Time Fluorescence Strategy for Tracking DNA G-Quadruplexes in Live Cells

scientific article published on 29 March 2019

Structural Biology-Inspired Discovery of Novel KRAS-PDEδ Inhibitors

scientific article published on 20 September 2017

Synthesis of 3-substituted 1,5-aldehyde estersvia an organocatalytic highly enantioselective conjugate addition of new carbonylmethyl 2-pyridinylsulfone to enals ⬇️

scientific article published on 07 November 2011

Targeting virulence factors as an antimicrobial approach: Pigment inhibitors

scientific article published on 02 July 2019

The Effect of First-in-Class Small Molecule RhoA Inhibitor, HL07, on the Phenylephrine-induced Artery Contraction ⬇️

scientific article published on 01 January 2012

‘One-pot’ Synthesis of Dihydrobenzo[4,5][1,3]oxazino[2,3-a] isoquinolines via a Silver(I)-Catalyzed Cascade Approach ⬇️

scientific article published on January 11, 2013

List of works by Jian Li

A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1

Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in <i>Caenorhabditis elegans</i> via inhibiting OSM-9

Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease.

Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents

Development of the First Generation of Disulfide-Based Subtype-Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors.

Discovery of Potent Benzocycloalkane Derived Diapophytoene Desaturase (CrtN) Inhibitors with Enhanced Safety Profile for the Treatment of MRSA, VISA and LRSA Infection.

Discovery of Potent, Selective Stem Cell Factor Receptor/Platelet Derived Growth Factor Receptor Alpha (c-KIT/PDGFRα) Dual Inhibitor for the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors (GISTs).

Drug Repurposing of Haloperidol: Discovery of New Benzocyclane Derivatives as Potent Antifungal Agents against Cryptococcosis and Candidiasis

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.

Extra Sugar on Vancomycin: New Analogues for Combating Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci.

Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway

Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant and Vancomycin-Intermediate Staphylococcus aureus Infections in vivo

Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5).

Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity.

Novel Vilazodone-Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation

Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents

Ruthenium(II)-Catalyzed Redox-Neutral [3+2] Annulation of Indoles with Internal Alkynes via C-H Bond Activation: Accessing a Pyrroloindolone Scaffold.

Spiropyran in Situ Switching: A Real-Time Fluorescence Strategy for Tracking DNA G-Quadruplexes in Live Cells

Structural Biology-Inspired Discovery of Novel KRAS-PDEδ Inhibitors

Synthesis of 3-substituted 1,5-aldehyde estersvia an organocatalytic highly enantioselective conjugate addition of new carbonylmethyl 2-pyridinylsulfone to enals ⬇️

Targeting virulence factors as an antimicrobial approach: Pigment inhibitors

The Effect of First-in-Class Small Molecule RhoA Inhibitor, HL07, on the Phenylephrine-induced Artery Contraction ⬇️

‘One-pot’ Synthesis of Dihydrobenzo[4,5][1,3]oxazino[2,3-a] isoquinolines via a Silver(I)-Catalyzed Cascade Approach ⬇️