List of works by Christine Skerka

14th European Meeting on Complement in Human Disease, Jena, Germany, August 17-21, 2013.

scientific article

A genome-wide association study identifies key modulators of complement factor H binding to malondialdehyde-epitopes

scientific article published on 22 April 2020

A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples.

scientific article

Acquisition of human plasminogen facilitates complement evasion by the malaria parasite Plasmodium falciparum

scientific article published on 06 October 2020

Activation of endogenously expressed ion channels by active complement in the retinal pigment epithelium

scientific article

Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator

scientific article

An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)

scientific article

Anaphylatoxins Activate Ca2+, Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium

scientific article

Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome

scientific article

ApoE attenuates unresolvable inflammation by complex formation with activated C1q

scientific article published on 28 January 2019

Aspf2 From Recruits Human Immune Regulators for Immune Evasion and Cell Damage

Atypical aHUS: State of the art.

scientific article

Autoantibodies in haemolytic uraemic syndrome (HUS).

scientific article

Autoimmune forms of thrombotic microangiopathy and membranoproliferative glomerulonephritis: Indications for a disease spectrum and common pathogenic principles

scientific article

BBA70 of Borrelia burgdorferi is a novel plasminogen-binding protein

scientific article published on 16 July 2013

BGA66 and BGA71 facilitate complement resistance of Borrelia bavariensis by inhibiting assembly of the membrane attack complex.

scientific article

Binding of human complement regulators FHL-1 and factor H to CRASP-1 orthologs of Borrelia burgdorferi

scientific article published in November 2006

Binding of human factor H-related protein 1 to serum-resistant Borrelia burgdorferi is mediated by borrelial complement regulator-acquiring surface proteins

scientific article

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components

scientific article published in 2013

C3 deposition glomerulopathy due to a functional factor H defect

scientific article published on 16 July 2008

C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases.

scientific article published on 31 May 2019

CFHR Gene Variations Provide Insights in the Pathogenesis of the Kidney Diseases Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy

scientific article published on 24 January 2020

Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin

scientific article

Chronic course of a hemolytic uremic syndrome caused by a deficiency of factor H-related proteins (CFHR1 and CFHR3).

scientific article

Combined C3b and factor B autoantibodies and MPGN type II

scientific article published on 01 December 2011

Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces

scientific article

Complement Inhibitors in Clinical Trials for Glomerular Diseases

scientific article published on 27 September 2019

Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases

scientific article published on 28 November 2016

Complement Resistance of Borrelia burgdorferi Correlates with the Expression of BbCRASP-1, a Novel Linear Plasmid-encoded Surface Protein That Interacts with Human Factor H and FHL-1 and Is Unrelated to Erp Proteins ⬇️

scientific article published on November 7, 2003

Complement and diseases: defective alternative pathway control results in kidney and eye diseases

scientific article

Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans

scientific article published on 26 June 2013

Complement evasion of pathogens: common strategies are shared by diverse organisms

scientific article published on September 2007

Complement factor H binds malondialdehyde epitopes and protects from oxidative stress

scientific article published on 5 October 2011

Complement factor H related proteins (CFHRs)

scientific article

Complement factor H related proteins in immune diseases

scientific article

Complement factor H-related hybrid protein deregulates complement in dense deposit disease

scientific article published on 16 December 2013

Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi

scientific article

Complement regulation at necrotic cell lesions is impaired by the age-related macular degeneration-associated factor-H His402 risk variant

scientific article published on 19 September 2011

Complement regulator-acquiring surface protein 1 of Borrelia burgdorferi binds to human bone morphogenic protein 2, several extracellular matrix proteins, and plasminogen.

scientific article

Complement regulator-acquiring surface proteins of Borrelia burgdorferi: a new protein family involved in complement resistance

scientific article

Complement regulators and inhibitory proteins

scientific article

Complement, Candida, and cytokines: the role of C5a in host response to fungi

scientific article published on 01 April 2012

Conserved Patterns of Microbial Immune Escape: Pathogenic Microbes of Diverse Origin Target the Human Terminal Complement Inhibitor Vitronectin via a Single Common Motif

scientific article published on 25 January 2016

Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi

scientific article published on 30 January 2012

CspA from Borrelia burgdorferi inhibits the terminal complement pathway

scientific article published on 13 August 2013

Cutting Edge: FHR-1 Binding Impairs Factor H-Mediated Complement Evasion by the Malaria Parasite Plasmodium falciparum

scientific article published on 19 November 2018

DEAP-HUS: deficiency of CFHR plasma proteins and autoantibody-positive form of hemolytic uremic syndrome

scientific article

De novo gene conversion in the RCA gene cluster (1q32) causes mutations in complement factor H associated with atypical hemolytic uremic syndrome

scientific article

Deciphering the ligand-binding sites in the Borrelia burgdorferi complement regulator-acquiring surface protein 2 required for interactions with the human immune regulators factor H and factor H-like protein 1.

scientific article published on 29 September 2008

Defective complement control of factor H (Y402H) and FHL-1 in age-related macular degeneration

scientific article published on 30 March 2007

Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome

scientific article

Dihydrolipoamide dehydrogenase of Pseudomonas aeruginosa is a surface-exposed immune evasion protein that binds three members of the factor H family and plasminogen

scientific journal article

Dual binding specificity of a Borrelia hermsii-associated complement regulator-acquiring surface protein for factor H and plasminogen discloses a putative virulence factor of relapsing fever spirochetes.

scientific article published on June 2007

Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression

scientific article

Early growth response proteins EGR-4 and EGR-3 interact with immune inflammatory mediators NF-kappaB p50 and p65.

scientific article published on July 2005

Enolase From Aspergillus fumigatus Is a Moonlighting Protein That Binds the Human Plasma Complement Proteins Factor H, FHL-1, C4BP, and Plasminogen

scientific article published on 22 November 2019

Evaluation of serum sphingolipids and the influence of genetic risk factors in age-related macular degeneration

scientific article published in PLoS ONE

FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene.

scientific article

FHR3 Blocks C3d-Mediated Coactivation of Human B Cells.

scientific article

Factor H Binds to Extracellular DNA Traps Released from Human Blood Monocytes in Response to Candida albicans

scientific article

Factor H and atypical hemolytic uremic syndrome: mutations in the C-terminus cause structural changes and defective recognition functions

scientific article

Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency

scientific article

Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation

scientific article published on 15 June 2009

Factor H-related protein 1 (FHR-1): A complement regulatory protein and guardian of necrotic type surfaces

scientific article published on 21 October 2020

Factor I and factor H deficiency in renal diseases: similar defects in the fluid phase have a different outcome at the surface of the glomerular basement membrane.

scientific article published on 04 December 2008

Functional characterization of BbCRASP-2, a distinct outer membrane protein of Borrelia burgdorferi that binds host complement regulators factor H and FHL-1

scientific article published on 01 September 2006

Functional characterization of Borrelia spielmanii outer surface proteins that interact with distinct members of the human factor H protein family and with plasminogen

scientific article

Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration

scientific article

Glycerol-3-phosphate dehydrogenase 2 is a novel factor H-, factor H-like protein 1-, and plasminogen-binding surface protein of Candida albicans

scientific article published on 29 November 2012

HED

scholarly article

Hemolytic uremic syndrome: a factor H mutation (E1172Stop) causes defective complement control at the surface of endothelial cells

scientific article

Host-pathogen interactions between the human innate immune system and Candida albicans-understanding and modeling defense and evasion strategies

scientific article

Human factor H-related protein 2 (CFHR2) regulates complement activation

scientific article

Human pathogenic Borrelia spielmanii sp. nov. resists complement-mediated killing by direct binding of immune regulators factor H and factor H-like protein 1

scientific article

Identification and characterization of the factor H and FHL-1 binding complement regulator-acquiring surface protein 1 of the Lyme disease spirochete Borrelia spielmanii sp. nov.

scientific article

Immune escape of the human facultative pathogenic yeast Candida albicans: the many faces of the Candida Pra1 protein

scientific article published on 11 May 2011

Immune evasion of Borrelia burgdorferi: insufficient killing of the pathogens by complement and antibody

scientific article

Immune evasion of Borrelia burgdorferi: mapping of a complement-inhibitor factor H-binding site of BbCRASP-3, a novel member of the Erp protein family

scientific article

Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles

scientific article published on 11 May 2020

Immunological characterization of the complement regulator factor H-binding CRASP and Erp proteins of Borrelia burgdorferi.

scientific article

In situ Visualization of C3/C5 Convertases to Differentiate Complement Activation

scientific article published on 21 April 2020

Inadequate binding of immune regulator factor H is associated with sensitivity of Borrelia lusitaniae to human complement

scientific article published on 7 September 2010

Interaction of Shiga toxin 2 with complement regulators of the factor H protein family

scientific article

Kallikrein Cleaves C3 and Activates Complement.

scientific article published on 14 December 2017

Long-term data on two sisters with C3GN due to an identical, homozygous CFH mutation and autoantibodies

scientific article published on 01 September 2020

Monitoring Surface Reactions by Combined Western Blot-ELISA Analysis

scientific article published on 01 January 2019

Mutations in FN1 cause glomerulopathy with fibronectin deposits.

scholarly article

New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases

scientific article

Novel developments in thrombotic microangiopathies: is there a common link between hemolytic uremic syndrome and thrombotic thrombocytic purpura?

scientific article

Pseudomonas aeruginosa Uses Dihydrolipoamide Dehydrogenase (Lpd) to Bind to the Human Terminal Pathway Regulators Vitronectin and Clusterin to Inhibit Terminal Pathway Complement Attack

scientific article published on 14 September 2015

Publisher Correction: ApoE attenuates unresolvable inflammation by complex formation with activated C1q

scientific article published on 01 March 2019

Recruitment of complement factor H-like protein 1 promotes intracellular invasion by group A streptococci

scientific article

Secreted pH-regulated antigen 1 of Candida albicans blocks activation and conversion of complement C3.

scientific article published on 19 July 2010

Sequence variations and protein expression levels of the two immune evasion proteins Gpm1 and Pra1 influence virulence of clinical Candida albicans isolates

scientific article published on 18 February 2015

Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies

scientific article published on 04 July 2019

Standardisation of the factor H autoantibody assay

scientific article

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b.

scientific article

Staphylococcus aureus: the multi headed hydra resists and controls human complement response in multiple ways

scientific article published on December 2013

Streptococcus pneumoniae From Patients With Hemolytic Uremic Syndrome Binds Human Plasminogen via the Surface Protein PspC and Uses Plasmin to Damage Human Endothelial Cells

scientific article

The MFHR1 Fusion Protein Is a Novel Synthetic Multitarget Complement Inhibitor with Therapeutic Potential

scientific article published on 15 January 2018

The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b

scientific article

The alternative pathway of complement: a pattern recognition system

scientific article published on January 2007

The autoimmune disease DEAP-hemolytic uremic syndrome

scientific article

The complement factor H R1210C mutation is associated with atypical hemolytic uremic syndrome

scientific article

The complement fitness factor H: role in human diseases and for immune escape of pathogens, like pneumococci

scientific article

The host immune regulator factor H interacts via two contact sites with the PspC protein of Streptococcus pneumoniae and mediates adhesion to host epithelial cells

scientific article published on 01 May 2007

The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models

scientific article

The pH-regulated antigen 1 of Candida albicans binds the human complement inhibitor C4b-binding protein and mediates fungal complement evasion

scientific article published on 6 January 2011

The role of complement in AMD.

scientific article

The role of complement in C3 glomerulopathy

scientific article

The role of defective complement control in hemolytic uremic syndrome

scientific article

The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments

scientific article published on 28 August 2017

The yeast Candida albicans evades human complement attack by secretion of aspartic proteases

scientific article published on 31 October 2009

Thrombotic microangiopathies: new insights and new challenges

scientific article

Tuf of Streptococcus pneumoniae is a surface displayed human complement regulator binding protein

scientific article published on 01 November 2014

Versatile roles of CspA orthologs in complement inactivation of serum-resistant Lyme disease spirochetes

scientific article published on 4 November 2013

β₂-glycoprotein I, the major target in antiphospholipid syndrome, is a special human complement regulator

Scientific article published on 14 July 2011

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