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List of works by Peter F Zipfel

14th European Meeting on Complement in Human Disease, Jena, Germany, August 17-21, 2013.

scientific article

A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples.

scientific article

A synthetic protein as efficient multitarget regulator against complement over-activation

scientific article published on 22 February 2022

Activation of endogenously expressed ion channels by active complement in the retinal pigment epithelium

scientific article

An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)

scientific article

An interactive web database of factor H-associated hemolytic uremic syndrome mutations: insights into the structural consequences of disease-associated mutations

scientific article

Anaphylatoxins Activate Ca2+, Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium

scientific article

Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome

scientific article

ApoE attenuates unresolvable inflammation by complex formation with activated C1q

scientific article published on 28 January 2019

Aspf2 From Recruits Human Immune Regulators for Immune Evasion and Cell Damage

Atypical aHUS: State of the art.

scientific article

Author Correction: Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties

scholarly article published in Scientific Reports

Autoantibodies in haemolytic uraemic syndrome (HUS).

scientific article

Autoimmune forms of thrombotic microangiopathy and membranoproliferative glomerulonephritis: Indications for a disease spectrum and common pathogenic principles

scientific article

BBA70 of Borrelia burgdorferi is a novel plasminogen-binding protein

scientific article published on 16 July 2013

BGA66 and BGA71 facilitate complement resistance of Borrelia bavariensis by inhibiting assembly of the membrane attack complex.

scientific article

Bevacizumab-associated glomerular microangiopathy

scientific article published on 14 December 2018

Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding site

scientific article published on October 2005

Binding of human complement regulators FHL-1 and factor H to CRASP-1 orthologs of Borrelia burgdorferi

scientific article published in November 2006

Binding of human factor H-related protein 1 to serum-resistant Borrelia burgdorferi is mediated by borrelial complement regulator-acquiring surface proteins

scientific article

Binding of the Human Complement Regulators CFHR1 and Factor H by Streptococcal Collagen-like Protein 1 (Scl1) via Their Conserved C Termini Allows Control of the Complement Cascade at Multiple Levels ⬇️

scientific article published on September 20, 2010

Binding of vitronectin and Factor H to Hic contributes to immune evasion of Streptococcus pneumoniae serotype 3

scientific article published on 28 August 2014

Borrelia burgdorferi infection-associated surface proteins ErpP, ErpA, and ErpC bind human plasminogen

scientific article published on 10 November 2008

Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity

scientific article

Borrelia valaisiana Resist Complement-Mediated Killing Independently of the Recruitment of Immune Regulators and Inactivation of Complement Components ⬇️

scientific article published on January 8, 2013

C3 deposition glomerulopathy due to a functional factor H defect

scientific article published on 16 July 2008

C3 glomerulopathy - understanding a rare complement-driven renal disease

scientific article published on 01 March 2019

C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases.

scientific article published on 31 May 2019

CFHR Gene Variations Provide Insights in the Pathogenesis of the Kidney Diseases Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy

scientific article published on 24 January 2020

CRASP2 of Candida albicans binds C4b-binding protein and mediates fungal contact with human endothelial cells

scholarly article by Shanshan Luo et al published August 2010 in Molecular Immunology

Candida albicans scavenges host zinc via Pra1 during endothelial invasion ⬇️

scientific article

Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin

scientific article

Chronic course of a hemolytic uremic syndrome caused by a deficiency of factor H-related proteins (CFHR1 and CFHR3).

scientific article

CipA of Acinetobacter baumannii Is a Novel Plasminogen Binding and Complement Inhibitory Protein

scientific article published on 17 December 2015

Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis

scientific article

Combined C3b and Factor B Autoantibodies and MPGN Type II ⬇️

scientific article published on December 15, 2011

Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi

scientific article

Comparison of surface recognition and C3b binding properties of mouse and human complement factor H

scientific journal article

Complement C3b/C3d and cell surface polyanions are recognized by overlapping binding sites on the most carboxyl-terminal domain of complement factor H

scientific article published on 01 December 2002

Complement Factor H as a Marker for Detection of Bladder Cancer

scientific article published on 17 March 2005

Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces

scientific article

Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases

scientific article published on 28 November 2016

Complement Resistance of Borrelia burgdorferi Correlates with the Expression of BbCRASP-1, a Novel Linear Plasmid-encoded Surface Protein That Interacts with Human Factor H and FHL-1 and Is Unrelated to Erp Proteins ⬇️

scientific article published on November 7, 2003

Complement and diseases: defective alternative pathway control results in kidney and eye diseases

scientific article

Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans

scientific article published on 26 June 2013

Complement evasion of pathogens: common strategies are shared by diverse organisms

scientific article published on September 2007

Complement factor H binds malondialdehyde epitopes and protects from oxidative stress

scientific article published on 5 October 2011

Complement factor H-related hybrid protein deregulates complement in dense deposit disease

scientific article published on 16 December 2013

Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi

scientific article

Complement inhibitor eculizumab in atypical hemolytic uremic syndrome

scientific article

Complement regulation at necrotic cell lesions is impaired by the age-related macular degeneration-associated factor-H His402 risk variant

scientific article published on 19 September 2011

Complement regulator Factor H mediates a two-step uptake of Streptococcus pneumoniae by human cells

scientific article

Complement regulator-acquiring surface protein 1 of Borrelia burgdorferi binds to human bone morphogenic protein 2, several extracellular matrix proteins, and plasminogen.

scientific article

Complement regulator-acquiring surface proteins of Borrelia burgdorferi: a new protein family involved in complement resistance

scientific article

Complement, Candida, and cytokines: The role of C5a in host response to fungi ⬇️

scientific article published on 01 April 2012

Conidial Dihydroxynaphthalene Melanin of the Human Pathogenic Fungus Aspergillus fumigatus Interferes with the Host Endocytosis Pathway

scientific article published on 3 May 2011

Conserved Patterns of Microbial Immune Escape: Pathogenic Microbes of Diverse Origin Target the Human Terminal Complement Inhibitor Vitronectin via a Single Common Motif

scientific article published on 25 January 2016

Contribution of the Infection-Associated Complement Regulator-Acquiring Surface Protein 4 (ErpC) to Complement Resistance ofBorrelia burgdorferi ⬇️

scientific article published on January 30, 2012

Correction: Translation Elongation Factor Tuf of Acinetobacter baumannii Is a Plasminogen-Binding Protein

scientific article published on 14 September 2015

CspA from Borrelia burgdorferi inhibits the terminal complement pathway

scientific article published on 13 August 2013

Cutting Edge: FHR-1 Binding Impairs Factor H-Mediated Complement Evasion by the Malaria Parasite Plasmodium falciparum

scientific article published on 19 November 2018

DEAP-HUS: deficiency of CFHR plasma proteins and autoantibody-positive form of hemolytic uremic syndrome

scientific article

De novo gene conversion in the RCA gene cluster (1q32) causes mutations in complement factor H associated with atypical hemolytic uremic syndrome

scientific article

Deciphering the Counterplay of Aspergillus fumigatus Infection and Host Inflammation by Evolutionary Games on Graphs

scientific article published on 13 June 2016

Deciphering the ligand-binding sites in the Borrelia burgdorferi complement regulator-acquiring surface protein 2 required for interactions with the human immune regulators factor H and factor H-like protein 1.

scientific article published on 29 September 2008

Defective Complement Action and Control Defines Disease Pathology for Retinal and Renal Disorders and Provides a Basis for New Therapeutic Approaches ⬇️

scientific article published on January 1, 2013

Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome

scientific article

Different factor H-related protein patterns in siblings with typical hemolytic uremic syndrome

scientific article published on 21 April 2011

Dihydrolipoamide Dehydrogenase of Pseudomonas aeruginosa Is a Surface-Exposed Immune Evasion Protein That Binds Three Members of the Factor H Family and Plasminogen ⬇️

scientific article published on October 15, 2012

Direct Binding of the pH-Regulated Protein 1 (Pra1) from Candida albicans Inhibits Cytokine Secretion by Mouse CD4+ T Cells

scientific article published on 11 May 2017

Dual binding specificity of a Borrelia hermsii-associated complement regulator-acquiring surface protein for factor H and plasminogen discloses a putative virulence factor of relapsing fever spirochetes.

scientific article published on June 2007

Enolase From Aspergillus fumigatus Is a Moonlighting Protein That Binds the Human Plasma Complement Proteins Factor H, FHL-1, C4BP, and Plasminogen

scientific article published on 22 November 2019

FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene.

scientific article

FHR3 Blocks C3d-Mediated Coactivation of Human B Cells.

scientific article

FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces.

scientific article published on 26 February 2018

Factor H Binds to Extracellular DNA Traps Released from Human Blood Monocytes in Response to Candida albicans

scientific article

Factor H and atypical hemolytic uremic syndrome: mutations in the C-terminus cause structural changes and defective recognition functions

scientific article

Factor H and factor H-related protein 1 bind to human neutrophils via complement receptor 3, mediate attachment to Candida albicans, and enhance neutrophil antimicrobial activity.

scientific article published on 11 December 2009

Factor H autoantibodies and deletion of Complement Factor H-Related protein-1 in rheumatic diseases in comparison to atypical hemolytic uremic syndrome

scientific article

Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency

scientific article

Factor H dysfunction contributes to platelet activation in hemolytic uremic syndrome (HUS)

Factor H dysfunction in patients with atypical hemolytic uremic syndrome contributes to complement deposition on platelets and their activation

scientific article

Factor H family proteins and human diseases

scientific article

Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation

scientific article published on 15 June 2009

Factor I and factor H deficiency in renal diseases: similar defects in the fluid phase have a different outcome at the surface of the glomerular basement membrane.

scientific article published on 04 December 2008

Functional analyses indicate a pathogenic role of factor H autoantibodies in atypical haemolytic uraemic syndrome

scientific article

Functional characterization of BbCRASP-2, a distinct outer membrane protein of Borrelia burgdorferi that binds host complement regulators factor H and FHL-1

scientific article published on 01 September 2006

Functional characterization of Borrelia spielmanii outer surface proteins that interact with distinct members of the human factor H protein family and with plasminogen

scientific article

Generation and functional in vivo characterization of a lipid kinase defective phosphatidylinositol 3-kinase Vps34p of Candida albicans.

scientific article

Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive

scientific article published on 14 September 2016

Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration

scientific article

Genetic screening in haemolytic uraemic syndrome ⬇️

scientific article published on November 1, 2003

Glomeruli of Dense Deposit Disease contain components of the alternative and terminal complement pathway

scientific article

Glycerol-3-Phosphate Dehydrogenase 2 Is a Novel Factor H–, Factor H–like Protein 1–, and Plasminogen-Binding Surface Protein of Candida albicans ⬇️

scientific article published on November 29, 2012

Gpm1p is a factor H-, FHL-1-, and plasminogen-binding surface protein of Candida albicans

scientific article published on 24 October 2007

HED

scholarly article

Haemophilus influenzae interacts with the human complement inhibitor factor H

scientific article published on 01 July 2008

Haemophilus influenzae protein E recognizes the C-terminal domain of vitronectin and modulates the membrane attack complex

scientific article (publication date: July 2011)

Haemophilus influenzae uses the surface protein E to acquire human plasminogen and to evade innate immunity.

scientific article

Hemolytic uremic syndrome: a factor H mutation (E1172Stop) causes defective complement control at the surface of endothelial cells

scientific article

Human complement control and complement evasion by pathogenic microbes--tipping the balance

scientific article

Human complement factor H-related protein 4 binds and recruits native pentameric C-reactive protein to necrotic cells

scientific article

Human factor H-related protein 2 (CFHR2) regulates complement activation

scientific article

Human pathogenic Borrelia spielmanii sp. nov. resists complement-mediated killing by direct binding of immune regulators factor H and factor H-like protein 1

scientific article

Identification and characterization of the factor H and FHL-1 binding complement regulator-acquiring surface protein 1 of the Lyme disease spirochete Borrelia spielmanii sp. nov.

scientific article

Identification and functional characterization of complement regulator-acquiring surface protein 1 of the Lyme disease spirochetes Borrelia afzelii and Borrelia garinii

scientific article published on April 2005

Identification of a Haemophilus influenzae factor H-Binding lipoprotein involved in serum resistance

scientific journal article

Immune escape of the human facultative pathogenic yeast Candida albicans: The many faces of the Candida Pra1 protein ⬇️

scientific article published on May 11, 2011

Immune evasion of Borrelia burgdorferi: insufficient killing of the pathogens by complement and antibody

scientific article

Immune evasion of Borrelia burgdorferi: mapping of a complement-inhibitor factor H-binding site of BbCRASP-3, a novel member of the Erp protein family

scientific article

Immune evasion of Moraxella catarrhalis involves ubiquitous surface protein A-dependent C3d binding.

scientific article

Immune evasion of the human pathogen Pseudomonas aeruginosa: elongation factor Tuf is a factor H and plasminogen binding protein

scientific article published on September 2007

Immune evasion of the human pathogenic yeast Candida albicans: Pra1 is a Factor H, FHL-1 and plasminogen binding surface protein

scientific article

Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles

scientific article published on 11 May 2020

Immunological characterization of the complement regulator factor H-binding CRASP and Erp proteins of Borrelia burgdorferi.

scientific article

Inadequate binding of immune regulator factor H is associated with sensitivity of Borrelia lusitaniae to human complement

scientific article published on 7 September 2010

Interaction of Shiga toxin 2 with complement regulators of the factor H protein family

scientific article

Interaction of phagocytes with filamentous fungi

scientific article published on 02 June 2010

Kallikrein Cleaves C3 and Activates Complement.

scientific article published on 14 December 2017

Leptospiral endostatin-like protein A is a bacterial cell surface receptor for human plasminogen

scientific article

LfhA, a novel factor H-binding protein of Leptospira interrogans

scientific article

Membranoproliferative glomerulonephritis type II (dense deposit disease): an update

scientific article

Monomeric C-reactive protein modulates classic complement activation on necrotic cells

scientific article published on 19 August 2011

Moraxella catarrhalis Binds Plasminogen To Evade Host Innate Immunity

scientific article published on 22 June 2015

Mutations in FN1 cause glomerulopathy with fibronectin deposits.

scholarly article

Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome

scientific article

Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome

article by Tamara Manuelian et al published 15 April 2003 in Journal of Clinical Investigation

New approaches to the treatment of dense deposit disease

scientific article published on 5 August 2007

New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases

scientific article

Nontypeable Haemophilus influenzae protein E binds vitronectin and is important for serum resistance.

scientific article

Novel developments in thrombotic microangiopathies: is there a common link between hemolytic uremic syndrome and thrombotic thrombocytic purpura?

scientific article

Onchocerca volvulus microfilariae avoid complement attack by direct binding of factor H

scientific article published on 31 May 2002

Outer membrane protein OlpA contributes to Moraxella catarrhalis serum resistance via interaction with factor H and the alternative pathway

scientific article published on 25 April 2014

Pig complement regulator factor H: molecular cloning and functional characterization.

scientific article published on 27 September 2003

Plasminogen Is a Complement Inhibitor ⬇️

scientific article published on March 27, 2012

Protein load impairs factor H binding promoting complement-dependent dysfunction of proximal tubular cells

scientific article

Pseudomonas aeruginosa Uses Dihydrolipoamide Dehydrogenase (Lpd) to Bind to the Human Terminal Pathway Regulators Vitronectin and Clusterin to Inhibit Terminal Pathway Complement Attack

scientific article published on 14 September 2015

Publisher Correction: ApoE attenuates unresolvable inflammation by complex formation with activated C1q

scientific article published on 01 March 2019

Recombinant Production of MFHR1, A Novel Synthetic Multitarget Complement Inhibitor, in Moss Bioreactors

scientific article published in 2019

Recruitment of complement factor H-like protein 1 promotes intracellular invasion by group A streptococci

scientific article

Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype

scientific article

Reply to Kang and Brooks: Comment on the interpretation of binding of Pra1, the fungal immune evasion protein from Candida albicans to the human C3 and on the conformational changes of C3 upon activation: Kang and Brooks Optimization of biolayer-int

scientific article published on 01 September 2018

Role of pH-regulated antigen 1 of Candida albicans in the fungal recognition and antifungal response of human neutrophils

scientific article published on 4 August 2011

Role of the Vps34p-interacting protein Ade5,7p in hyphal growth and virulence of Candida albicans

scientific article published on 01 July 2007

Secreted Aspergillus fumigatus protease Alp1 degrades human complement proteins C3, C4, and C5.

scientific article

Secreted pH-regulated antigen 1 of Candida albicans blocks activation and conversion of complement C3.

scientific article published on 19 July 2010

Sequence variations and protein expression levels of the two immune evasion proteins Gpm1 and Pra1 influence virulence of clinical Candida albicans isolates

scientific article published on 18 February 2015

Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies

scientific article published on 04 July 2019

Standardisation of the factor H autoantibody assay

scientific article

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b.

scientific article

Staphylococcus aureus: the multi headed hydra resists and controls human complement response in multiple ways

scientific article published on December 2013

Streptococcus pneumoniae From Patients With Hemolytic Uremic Syndrome Binds Human Plasminogen via the Surface Protein PspC and Uses Plasmin to Damage Human Endothelial Cells

scientific article

Streptococcus pneumoniae evades complement attack and opsonophagocytosis by expressing the pspC locus-encoded Hic protein that binds to short consensus repeats 8-11 of factor H.

scientific article published in February 2002

Successful (?) therapy of hemolytic-uremic syndrome with factor H abnormality

scientific article

Successful discontinuation of eculizumab under immunosuppressive therapy in DEAP-HUS.

scientific article published on 20 February 2017

Successful plasma therapy for atypical hemolytic uremic syndrome caused by factor H deficiency owing to a novel mutation in the complement cofactor protein domain 15.

scientific article

Susceptibility to invasive meningococcal disease: polymorphism of complement system genes and Neisseria meningitidis factor H binding protein

scientific article

The C-terminus of complement factor H is essential for host cell protection

scientific article published on 17 January 2007

The Complement Inhibitor Factor H Generates an Anti-Inflammatory and Tolerogenic State in Monocyte-Derived Dendritic Cells

scientific article published on 13 April 2016

The MFHR1 Fusion Protein Is a Novel Synthetic Multitarget Complement Inhibitor with Therapeutic Potential

scientific article published on 15 January 2018

The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b

scientific article

The alternative pathway of complement: a pattern recognition system

scientific article published on January 2007

The autoimmune disease DEAP-hemolytic uremic syndrome

scientific article

The choline-binding protein PspC of Streptococcus pneumoniae interacts with the C-terminal heparin-binding domain of vitronectin

scientific article published on 19 April 2013

The complement factor H R1210C mutation is associated with atypical hemolytic uremic syndrome

scientific article

The complement fitness factor H: role in human diseases and for immune escape of pathogens, like pneumococci

scientific article

The group B streptococcal beta and pneumococcal Hic proteins are structurally related immune evasion molecules that bind the complement inhibitor factor H in an analogous fashion

scientific article published in March 2004

The host immune regulator factor H interacts via two contact sites with the PspC protein of Streptococcus pneumoniae and mediates adhesion to host epithelial cells

scientific article published on 01 May 2007

The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models

scientific article

The molecular basis for hereditary porcine membranoproliferative glomerulonephritis type II: point mutations in the factor H coding sequence block protein secretion

scientific article published on December 2002

The opportunistic human pathogenic fungus Aspergillus fumigatus evades the host complement system

scientific article published on 26 November 2007

The pH-regulated antigen 1 of Candida albicans binds the human complement inhibitor C4b-binding protein and mediates fungal complement evasion

scientific article published on 6 January 2011

The phosphatidylinositol 3-kinase Vps34p of the human pathogenic yeast Candida albicans is a multifunctional protein that interacts with the putative vacuolar H+ -ATPase subunit Vma7p

scientific article published on 01 April 2005

The putative vacuolar ATPase subunit Vma7p of Candida albicans is involved in vacuole acidification, hyphal development and virulence

article

The role of complement in AMD.

scientific article

The role of complement in C3 glomerulopathy

scientific article

The role of defective complement control in hemolytic uremic syndrome

scientific article

The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments

scientific article published on 28 August 2017

The vesicle transport protein Vac1p is required for virulence of Candida albicans

scientific article

The yeast Candida albicans evades human complement attack by secretion of aspartic proteases

scientific article published on 31 October 2009

Thrombotic microangiopathies: new insights and new challenges

scientific article

Translation Elongation Factor Tuf of Acinetobacter baumannii Is a Plasminogen-Binding Protein

scientific article published on 31 July 2015

Tuf of Streptococcus pneumoniae is a surface displayed human complement regulator binding protein

scientific article published on 01 November 2014

Two factor H-related proteins from the mouse: expression analysis and functional characterization

scientific article

Versatile roles of CspA orthologs in complement inactivation of serum-resistant Lyme disease spirochetes

scientific article published on 4 November 2013

Where next with atypical hemolytic uremic syndrome?

scientific article

Yersinia enterocolitica YadA Mediates Complement Evasion by Recruitment and Inactivation of C3 Products ⬇️

scientific article published on October 15, 2012

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