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List of works by Yusuf A. Hannun

A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation

scientific article (publication date: May 2011)

A guide to biochemical systems modeling of sphingolipids for the biochemist.

scientific article published in January 2007

A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria.

scientific article

A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing.

scientific article

A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury.

scientific article published on 13 August 2007

A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.

scientific article published on 24 March 2015

A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway

scientific article

A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis

scientific article published on 24 September 2008

A role of sphingosine kinase 1 in head and neck carcinogenesis

scientific article published on 5 January 2011

AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells

scientific article published on 17 April 2018

AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells.

scientific article published on 15 June 2009

ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation

scientific article published on 24 March 2016

Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction.

scientific article

Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid

scientific article

Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production.

scientific article published on 27 June 2006

Acid ceramidase inhibition: a novel target for cancer therapy

scientific article published on January 2008

Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer

scientific article

Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy

scientific article published on December 2009

Acid ceramidase‐mediated production of sphingosine 1‐phosphate promotes prostate cancer invasion through upregulation of cathepsin B ⬇️

scientific article published on March 27, 2012

Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages ⬇️

scientific article published on 06 August 2013

Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis

scientific article published on 07 January 2021

Activation and localization of inositol phosphosphingolipid phospholipase C, Isc1p, to the mitochondria during growth of Saccharomyces cerevisiae

scientific article

Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation

scientific article published on 15 February 2007

Activation of p38 Mitogen-Activated Protein Kinase in Gaucher's Disease

scientific article published on 27 August 2015

Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols.

scientific article published on 18 August 2015

Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins.

scientific article published on 27 August 2002

Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function

scientific article published on 19 March 2016

Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells

scientific article published on 13 October 2017

Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain

scientific article

Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response

scientific article published on March 2016

Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates

scientific article published on 22 January 2018

Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk

scientific article published on September 2006

An Overview of Sphingolipid Metabolism: From Synthesis to Breakdown ⬇️

scientific article published on January 1, 2010

An intrinsic lipid-binding interface controls sphingosine kinase 1 function

scientific article published on 11 January 2018

Analysis and quantitation of ceramide

scientific article published on 01 January 2002

Anterograde and retrograde transport of neutral sphingomyelinase-2 between the Golgi and the plasma membrane

scientific article

Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats

scientific article published on 14 August 2008

Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways

scientific article

Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase

scientific article

BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome

scientific article (publication date: 25 April 2003)

Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes.

scientific article

Bcl-xL interrupts oxidative activation of neutral sphingomyelinase.

scientific article published in October 2002

Bioactive sphingolipid profile in a xenograft mouse model of head and neck squamous cell carcinoma

Bioactive sphingolipids in the modulation of the inflammatory response.

scientific article

Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.

scientific article published on 28 January 2002

Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism

scientific article

Blood sphingolipidomics in healthy humans: impact of sample collection methodology

scientific article

CHK1 regulates NF-κB signaling upon DNA damage in p53- deficient cells and associated tumor-derived microvesicles

scientific article published on 22 February 2016

Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells

scientific article published on 01 June 2006

Ceramidases, roles in sphingolipid metabolism and in health and disease

scientific article

Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2

scientific article (publication date: 19 March 2004)

Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets

scientific article published in March 2017

Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells

scientific article

Ceramide in apoptosis: an overview and current perspectives

scientific article

Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release

scientific article (publication date: 3 October 2003)

Ceramide regulation of apoptosis versus differentiation: a walk on a fine line. Lessons from neurobiology

scientific article

Ceramide synthase 2-C<sub>24:1</sub> -ceramide axis limits the metastatic potential of ovarian cancer cells

scientific article published on 01 February 2021

Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events

scientific article

Ceramide synthases at the centre of sphingolipid metabolism and biology

scientific article

Ceramide-enriched membrane domains in red blood cells and the mechanism of sphingomyelinase-induced hot-cold hemolysis

scientific article published on October 2008

Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis

scientific article

Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation

scientific article published on 19 September 2017

Computational analysis of sphingolipid pathway systems.

scientific article published on January 2010

Confluence induced threonine41/serine45 phospho-beta-catenin dephosphorylation via ceramide-mediated activation of PP1cgamma

scientific article published on 8 November 2007

Coordination of the dynamics of yeast sphingolipid metabolism during the diauxic shift.

scientific article

Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain

scientific article

Correction: PKCα is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation

scientific article published on 01 November 2019

Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization

scientific article

De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation.

scientific article

De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.

scientific article published on 18 January 2002

Decreased ceramide underlies mitochondrial dysfunction in Charcot-Marie-Tooth 2F.

scientific article published on 13 November 2017

Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis

scientific article published on 23 January 2009

Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas

scientific article

Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway

scientific article

Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane

scientific article

Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low‐density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release ⬇️

scientific article published on May 1, 2012

Differentiate and switch, a tale of two heads of a lipid

scientific article published on 23 March 2018

Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts.

scientific article published on 8 November 2005

Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling

scientific article

Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae

scientific article published in February 2006

Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease

scientific article

Distinct signaling roles of ceramide species in yeast revealed through systematic perturbation and systems biology analyses

scientific article published on 29 October 2013

Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.

scientific article published on 26 February 2004

Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation

scientific article published on 02 April 2009

Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases ⬇️

scientific article published on June 1, 2011

Dural MALT Lymphoma with Disseminated Disease ⬇️

scientific article published on January 26, 2010

Dynamic sequestration of the recycling compartment by classical protein kinase C.

scientific article published on 2 June 2006

Dynamics of Positional Enrichment: Theoretical Development and Application to Carbon Labeling in Zymomonas mobilis

scientific article published on May 2008

Effect of sphingosine kinase 1 inhibition on blood pressure ⬇️

scientific article published on October 29, 2012

Effects of sphingosine and other sphingolipids on protein kinase C

scientific article (publication date: 2000)

Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration

scientific journal article

Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis

scientific article

Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation.

scientific article published on 29 April 2013

Evaluating intrinsic and non-intrinsic cancer risk factors

scientific article published in Nature Communications

Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis ⬇️

scientific article published on August 30, 2013

Evolving concepts in cancer therapy through targeting sphingolipid metabolism

scientific article

Functional analysis of ISC1 by site-directed mutagenesis

scientific article

Functions of neutral ceramidase in the Golgi apparatus

scientific article published on 28 August 2018

GPR40/FFA1 and neutral sphingomyelinase are involved in palmitate-boosted inflammatory response of microvascular endothelial cells to LPS.

scientific article

Golgi fragmentation is associated with ceramide-induced cellular effects.

scientific article

Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells

scientific article published on 07 March 2008

Hydroxyurea sensitivity reveals a role for ISC1 in the regulation of G2/M.

scientific article published on 21 January 2009

IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice

scientific article published on 5 June 2015

ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae

scientific article published on 29 January 2009

Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5

scientific journal article

Identification and characterization of protein phosphatase 2C activation by ceramide ⬇️

scientific article published on May 21, 2012

Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans ⬇️

scientific article published on October 1, 2003

Identification of Novel Anionic Phospholipid Binding Domains in Neutral Sphingomyelinase 2 with Selective Binding Preference ⬇️

scientific article published on May 6, 2011

Identification of a novel amidase motif in neutral ceramidase

scientific article

Identification of a novel phosphatidic acid binding domain in protein phosphatase-1.

scientific article

Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5.

scientific article

Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide.

scientific article

Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury

scientific article published on 10 May 2017

Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase

scientific article published in August 2002

Integration of kinetic information on yeast sphingolipid metabolism in dynamical pathway models

scientific article published on February 2004

Integrin-associated Lyn kinase promotes cell survival by suppressing acid sphingomyelinase activity

scientific article published on 05 August 2008

Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion

scientific article

Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation

scientific article

Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells

scientific article

Involvement of sphingolipids in apoptin-induced cell killing

scientific article published on 22 August 2006

Isc1 regulates sphingolipid metabolism in yeast mitochondria.

scientific article

Isoenzyme-specific translocation of protein kinase C (PKC)betaII and not PKCbetaI to a juxtanuclear subset of recycling endosomes: involvement of phospholipase D.

scientific article published on 5 April 2004

Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse.

scientific article

Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration

scientific article published on 13 July 2015

Large-scale purification and characterization of recombinant Pseudomonas ceramidase: regulation by calcium

scientific article

Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment.

scientific article

Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease ⬇️

scientific article published on August 31, 2012

Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death

scientific article

Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis.

scientific article published on 30 December 2005

Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses

scientific article published on 16 June 2010

Many ceramides.

scientific article

Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae

scientific article

Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641.

scientific article published on 15 May 2007

Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine ⬇️

scientific article published on September 20, 2010

Metabolism and Function of Sphingolipids in Saccharomyces Cerevisiae: Relevance to Cancer Research

Mitochondria and ceramide: intertwined roles in regulation of apoptosis

scientific article

Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis.

scientific article

Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism

scientific article

Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators.

scientific article published on 6 January 2003

Molecular targeting of acid ceramidase: implications to cancer therapy.

scientific article published on August 2008

Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis

scientific article published on 20 December 2018

Murine Model for Colitis-Associated Cancer of the Colon

scientific article published on January 2016

Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity

scientific article

Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits

scientific article published on 4 January 2010

Neutral Sphingomyelinase-2 Mediates Growth Arrest by Retinoic Acid through Modulation of Ribosomal S6 Kinase ⬇️

scientific article published on May 2, 2011

Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids

scientific article published on 27 December 2005

Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-α in MCF-7 cells

scientific article published on April 2011

Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization

scientific article

Neutral sphingomyelinases and nSMase2: bridging the gaps

scientific article published on 21 July 2006

New insights on the use of desipramine as an inhibitor for acid ceramidase

scientific article published on 4 August 2006

New role for ceramide in the pheromone response

scientific article published on 29 January 2016

Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents

scientific article published on 24 August 2007

Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids

scientific article

Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA.

scientific article

Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis

scientific article published on April 2017

Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction

scientific article published on 27 March 2012

On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging.

scientific article

Oncogenic K-Ras Regulates Bioactive Sphingolipids in a Sphingosine Kinase 1-dependent Manner ⬇️

scientific article published on July 24, 2012

Overview of Acid and Neutral Sphingomyelinases in Cell Signaling

PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)

scientific article (publication date: 20 September 2002)

PKCα is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation

scientific article published on 16 August 2019

Positively charged ceramide is a potent inducer of mitochondrial permeabilization.

scientific article

Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo.

scientific article published on March 2006

Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases

scientific article published on 26 June 2019

Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry.

scientific article published on 2 April 2018

Prodrug modification increases potassium tricyclo[5.2.1.0(2,6)]-decan-8-yl dithiocarbonate (D609) chemical stability and cytotoxicity against U937 leukemia cells

scientific article published on 11 February 2004

Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1.

scientific article

Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.

scientific article published on 9 October 2006

Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase

scientific article

Purification and characterization of a second type of neutral ceramidase from rat brain: a second more hydrophobic form of rat brain ceramidase.

scientific article

Purification, characterization, and identification of a sphingomyelin synthase from Pseudomonas aeruginosa. PlcH is a multifunctional enzyme

scientific journal article

Quantification of 3-ketodihydrosphingosine using HPLC-ESI-MS/MS to study SPT activity in yeast Saccharomyces cerevisiae

scientific article published in November 2017

RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis

scientific article published on 28 January 2019

Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase

scientific article published on 20 November 2003

Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation.

scientific article

Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase ⬇️

scientific article published on February 18, 2011

Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway

scientific article published on April 2008

Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein

scientific article published in September 2005

Results of a Phase II Trial of Gemcitabine Plus Doxorubicin in Patients with Recurrent Head and Neck Cancers: Serum C18-Ceramide as a Novel Biomarker for Monitoring Response ⬇️

scientific article published on July 26, 2011

Revealing a signaling role of phytosphingosine-1-phosphate in yeast

scientific article published on 16 February 2010

Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells.

scientific article published on 28 June 2011

Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells

scientific article

Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2.

scientific article

Role for sphingosine kinase 1 in colon carcinogenesis.

scientific article published on 29 September 2008

Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy

scientific article published on 10 April 2007

Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas

scientific article published on February 2007

Role of neutral ceramidase in colon cancer

scientific article published on 8 September 2016

Roles and regulation of secretory and lysosomal acid sphingomyelinase

scientific article published on June 2009

Roles for Sphingolipid Biosynthesis in Mediation of Specific Programs of the Heat Stress Response Determined through Gene Expression Profiling

scientific article published in Journal of Biological Chemistry

Safety Study of Adeno-Associated Virus Serotype 2-Mediated Human Acid Sphingomyelinase Expression in the Nonhuman Primate Brain ⬇️

scientific article published on August 1, 2012

Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway

scientific article

Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism

scientific article

Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis

scientific article published on 23 February 2007

Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations

scientific article

Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae

scientific article

Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae

scientific article

Specific saposin C deficiency: CNS impairment and acid beta-glucosidase effects in the mouse

scientific article

Sphingoid Bases and the Serine Catabolic Enzyme CHA1 Define a Novel Feedforward/Feedback Mechanism in the Response to Serine Availability ⬇️

scientific article published on January 25, 2012

Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1.

scientific article published on 12 December 2013

Sphingolipids and mitochondrial function in budding yeast

scientific article published on 25 June 2014

Sphingolipids in colon cancer

scientific article published on 21 September 2013

Sphingolipids in vascular biology.

scientific article

Sphingolipids mediate formation of mRNA processing bodies during the heat-stress response of Saccharomyces cerevisiae

scientific article published on October 2010

Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids

scientific article

Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells

scientific article published in January 2004

Sphingosine 1-phosphate activation of ERM contributes to vascular calcification

scientific article published on 22 November 2017

Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins

scientific article

Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis

scientific article

Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation.

scientific article

Sphingosine kinase 1 is up-regulated in colon carcinogenesis

scientific article published on 30 November 2005

Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor κB activation

scientific article published on 09 August 2013

Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease

scientific article

Sphingosine-1-phosphate receptor 2

scientific article

Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation

scientific article published on 01 December 2020

Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase

scientific article

Structural determinants of sphingolipid recognition by commercially available anti-ceramide antibodies

scientific article published on 01 December 2002

Structural requirements for selective binding of ISC1 to anionic phospholipids

scientific article

Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation

scientific article

Substrate specificity of rat brain ceramidase

scientific article published in January 2002

Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner

scientific article published on 11 October 2013

Sustained activation of protein kinase C induces delayed phosphorylation and regulates the fate of epidermal growth factor receptor

scientific article published on 11 November 2013

Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner

scientific article

Tailoring structure-function and targeting properties of ceramides by site-specific cationization

scientific article

Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice

scientific article published on 01 August 2020

Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides

scientific article published on 04 January 2021

The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind

scientific article (publication date: 19 July 2002)

The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase

scientific article

The Synergy between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation.

scientific article published on 9 April 2018

The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1.

scientific article

The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate

scientific article

The extended family of neutral sphingomyelinases

scientific article

The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy

scientific article

The neutral sphingomyelinase family: Identifying biochemical connections ⬇️

scientific article published on October 28, 2010

The phosphatidylglycerol/cardiolipin biosynthetic pathway is required for the activation of inositol phosphosphingolipid phospholipase C, Isc1p, during growth of Saccharomyces cerevisiae

scientific article published on 15 December 2004

The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans

scientific article published on 10 March 2004

The sphingolipid salvage pathway in ceramide metabolism and signaling

scientific article

The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha

scientific article (publication date: August 2003)

The structural requirements for ceramide activation of serine-threonine protein phosphatases

scientific article (publication date: March 2004)

Thematic review series: sphingolipids. ISC1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases

scientific article published on 27 February 2008

Tight binding inhibition of protein phosphatase-1 by phosphatidic acid. Specificity of inhibition by the phospholipid

scientific article

Transcriptional Regulation of Sphingosine Kinase 1

scientific article published on 08 November 2020

Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells.

scientific article published on 21 March 2017

Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway

scientific article published on 28 August 2018

Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death

scientific article

Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism.

scientific article published on 14 February 2005

Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2.

scientific article

cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes

scientific article published on 3 October 2003

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