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List of works by H J Wichers

Adaptation of exercise-induced stress in well-trained healthy young men.

scientific article published on 3 November 2016

Agaricus bisporus and Agaricus brasiliensis (1→6)-β-d-glucans show immunostimulatory activity on human THP-1 derived macrophages ⬇️

scientific article published on January 16, 2013

Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

scientific article (publication date: 2017)

Beyond Heat Stress: Intestinal Integrity Disruption and Mechanism-Based Intervention Strategies

scientific article published on 11 March 2020

Binding of CML-Modified as Well as Heat-Glycated β-lactoglobulin to Receptors for AGEs Is Determined by Charge and Hydrophobicity

scientific article published on 26 June 2020

Bioavailability of angiotensin I-converting enzyme (ACE) inhibitory peptides derived from Virgibacillus halodenitrificans SK1-3-7 proteinases hydrolyzed tilapia muscle proteins.

scientific article published on 29 September 2016

Biochemical and functional characterization of recombinant fungal immunomodulatory proteins (rFIPs) ⬇️

scientific article published on November 19, 2012

Characterization of polarized THP-1 macrophages and polarizing ability of LPS and food compounds ⬇️

scientific article published on February 1, 2013

Cloning, expression and characterisation of two tyrosinase cDNAs from Agaricus bisporus ⬇️

scientific article published on February 11, 2003

Consumption of β-glucans to spice up T cell treatment of tumors: a review

scientific article published on 01 October 2018

Crystallization and preliminary X-ray crystallographic analysis of tyrosinase from the mushroom Agaricus bisporus ⬇️

scientific article published on April 27, 2011

Detection of peanut allergen in human blood after consumption of peanuts is skewed by endogenous immunoglobulins.

scientific article published on 11 November 2016

Development and validation of bioengineered intestinal tubules for translational research aimed at safety and efficacy testing of drugs and nutrients

scientific article published on 06 May 2019

Differential Effects of Dry vs. Wet Heating of β-Lactoglobulin on Formation of sRAGE Binding Ligands and sIgE Epitope Recognition

scientific article published on 25 June 2019

Effect of roasting on the allergenicity of major peanut allergens Ara h 1 and Ara h 2/6: the necessity of degranulation assays ⬇️

scientific article published on August 1, 2011

Endurance Exercise Increases Intestinal Uptake of the Peanut Allergen Ara h 6 after Peanut Consumption in Humans

scientific article published on 21 January 2017

Generation of Soluble Advanced Glycation End Products Receptor (sRAGE)-Binding Ligands during Extensive Heat Treatment of Whey Protein/Lactose Mixtures Is Dependent on Glycation and Aggregation

scientific article

High Molecular Weight Glucan of the Culinary Medicinal Mushroom Agaricus bisporus is an α-Glucan that Forms Complexes with Low Molecular Weight Galactan ⬇️

scientific article published on August 25, 2010

Hydrolysates of glycated and heat-treated peanut 7S globulin (Ara h 1) modulate human gut microbial proliferation, survival and adhesion ⬇️

scientific article published on November 8, 2013

Hydrophobicity and aggregation, but not glycation, are key determinants for uptake of thermally processed β-lactoglobulin by THP-1 macrophages

scientific article published on 22 January 2019

Hydrophobicity drives receptor-mediated uptake of heat-processed proteins by THP-1 macrophages and dendritic cells, but not cytokine responses

scientific article published on 14 August 2020

Hypoxia and heat stress affect epithelial integrity in a Caco-2/HT-29 co-culture

scientific article published on 23 June 2021

IgE Cross-Reactivity of Cashew Nut Allergens

scientific article published on 26 October 2018

Immunomodulation by Processed Animal Feed: The Role of Maillard Reaction Products and Advanced Glycation End-Products (AGEs)

scientific article published on 13 September 2018

Immunomodulatory activity of protein hydrolysates derived from Virgibacillus halodenitrificans SK1-3-7 proteinase.

scientific article published on 16 December 2016

In Vitro Studies Towards the use of Chitin as Nutraceutical: Impact on the Intestinal Epithelium, Macrophages and Microbiota

scientific article published on 16 October 2020

Influence of processing and in vitro digestion on the allergic cross-reactivity of three mealworm species

scientific article published on 22 October 2015

Introduction of Heated Cow’s Milk Protein in Challenge-Proven Cow’s Milk Allergic Children: The iAGE Study

scientific article published in 2022

Isolation, Purification, and Cytotoxicity of 5-Methoxypodophyllotoxin, a Lignan from a Root Culture of Linum flavum ⬇️

scientific article published on 01 January 1992

Lactobacillus acidophilus Attenuates Salmonella-Induced Stress of Epithelial Cells by Modulating Tight-Junction Genes and Cytokine Responses

scientific article published on 02 July 2018

Lactobacillus strains differentially modulate cytokine production by hPBMC from pollen-allergic patients ⬇️

scientific article published on October 19, 2010

Large-Scale Recombinant Expression and Purification of Human Tyrosinase Suitable for Structural Studies

scientific article

Long Chain Polyunsaturated Fatty Acids (LCPUFAs) in the Prevention of Food Allergy.

scientific article

Low percentage of clinically relevant pistachio nut and mango co-sensitisation in cashew nut sensitised children.

scientific article published on 20 March 2017

Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy

scientific article published on 15 December 2020

Melanin biosynthesis pathway in Agaricus bisporus mushrooms ⬇️

scientific article published on October 31, 2012

Mitochondrial ATP Depletion Disrupts Caco-2 Monolayer Integrity and Internalizes Claudin 7

scientific article published on 11 October 2017

Multicentre Double-Blind Placebo-Controlled Food Challenge Study in Children Sensitised to Cashew Nut

scientific article

No difference in health-related quality of life, after a food challenge with cashew nut in children participating in a clinical trial.

scientific article

Novel Dietary Proteins Selectively Affect Intestinal Health In Vitro after Clostridium difficile-Secreted Toxin A Exposure

scientific article published on 11 September 2020

Optimized Triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins.

scientific article

Origin and Processing Methods Slightly Affect Allergenic Characteristics of Cashew Nuts (Anacardium occidentale)

scientific article published on 10 March 2018

Peptide Release after Simulated Infant In Vitro Digestion of Dry Heated Cow's Milk Protein and Transport of Potentially Immunoreactive Peptides across the Caco-2 Cell Monolayer

scientific article published on 18 August 2020

Phenylthiourea Binding to Human Tyrosinase-Related Protein 1

scientific article published on 30 January 2020

Polysaccharides from Agaricus bisporus and Agaricus brasiliensis show similarities in their structures and their immunomodulatory effects on human monocytic THP-1 cells ⬇️

scientific article published on July 25, 2011

Prediction of cashew nut allergy in sensitized children.

scientific article

Purification and Characterization of Anacardium occidentale (Cashew) Allergens Ana o 1, Ana o 2, and Ana o 3.

scientific article

Release of Major Peanut Allergens from Their Matrix under Various pH and Simulated Saliva Conditions-Ara h2 and Ara h6 Are Readily Bio-Accessible

scientific article published on 11 September 2018

Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion

scientific article published on 24 July 2019

Sequence and structural features of plant and fungal tyrosinases ⬇️

scientific article published on August 1, 1997

Small percentage of anaphylactic reactions treated with epinephrine during food challenges in Dutch children

scientific article

Structure and Function of Human Tyrosinase and Tyrosinase-Related Proteins

scientific article

Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.

scientific article published on 29 June 2017

Systematic review on cashew nut allergy

scientific article

THP-1 cell line: an in vitro cell model for immune modulation approach

scientific article

The Effect of Tomatine on Gene Expression and Cell Monolayer Integrity in Caco-2.

scientific article published on 13 March 2018

The effect of endurance exercise on intestinal integrity in well-trained healthy men.

scientific article

Transcription profiles of LPS-stimulated THP-1 monocytes and macrophages: a tool to study inflammation modulating effects of food-derived compounds ⬇️

scientific article published on November 1, 2010

Water-Soluble Polysaccharide Extracts from the Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Agaricomycetes) with HMGCR Inhibitory Activity.

scientific article

Wheat-derived arabinoxylans reduced M2-macrophage functional activity, but enhanced monocyte-recruitment capacity

scientific article published on 29 July 2020

sIgE Ana o 1, 2 and 3 accurately distinguish tolerant from allergic children sensitized to cashew nuts.

scientific article published on 11 August 2016

β‐Glucans are involved in immune‐modulation of THP‐1 macrophages ⬇️

scientific article published on May 1, 2012

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