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List of works by Wei Li

1α,20S-Dihydroxyvitamin D3 Interacts with Vitamin D Receptor: Crystal Structure and Route of Chemical Synthesis

scientific article published on 31 August 2017

20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells

scientific article

20-hydroxyvitamin D₃ inhibits proliferation of cancer cells with high efficacy while being non-toxic ⬇️

scientific article published on March 1, 2012

20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits potent antifibrogenic activity in vivo

scientific article published on 7 January 2013

A new steroidal 5,7-diene derivative, 3beta-hydroxyandrosta-5,7-diene-17beta-carboxylic acid, shows potent anti-proliferative activity

scientific article

An Orally Available Tubulin Inhibitor, VERU-111, Suppresses Triple-Negative Breast Cancer Tumor Growth and Metastasis and Bypasses Taxane Resistance

scientific article published on 23 October 2019

An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site ⬇️

scientific article published on July 20, 2012

An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2.

scientific article published on July 2006

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6

scientific article published on 28 December 2019

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4

scientific article published on 31 December 2018

Calcium‐ and Voltage‐Gated Potassium (BK) Channel Activators in the 5β‐Cholanic Acid‐3α‐ol Analogue Series with Modifications in the Lateral Chain ⬇️

scientific article published on September 4, 2012

Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols

scientific article published on 12 September 2017

Characterization of serotonin and N-acetylserotonin systems in the human epidermis and skin cells

scientific article published on 20 December 2019

Chemical Synthesis and Biological Activities of 20S,24S/R-Dihydroxyvitamin D3 Epimers and Their 1α-Hydroxyl Derivatives.

scientific article

Chemical synthesis of 20S-hydroxyvitamin D3, which shows antiproliferative activity.

scientific article published on 11 June 2010

Classical and non-classical metabolic transformation of vitamin D in dermal fibroblasts

scientific article published on 6 October 2015

Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy

scientific article published on 01 May 2019

Correlation between secosteroid-induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength

scientific article published on 21 April 2012

Corrigendum to ‘A new slteroidal 5,7diene derivat ive, 3β-hydroxyandrosta-5,7-diene-17β-carboxylic acid, shows potent anti-proliferative activity’.

scientific article published in September 2010

Current Advances of Tubulin Inhibitors in Nanoparticle Drug Delivery and Vascular Disruption/Angiogenesis

scientific article published on 2 November 2016

Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy

scientific article published on 11 February 2019

Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes ⬇️

scientific article published on August 2, 2012

Design, synthesis, and biological action of 20R-hydroxyvitamin D3.

scientific article published on 20 March 2012

Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland.

scientific article

Drugs Targeting Tubulin Polymerization ⬇️

scientific article published on September 28, 2012

Effects of sidechain length and composition on the kinetic conversion and product distribution of vitamin D analogs determined by real-time NMR.

scientific article

Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ.

scientific article published on 28 September 2016

Enzymatic metabolism of ergosterol by cytochrome p450scc to biologically active 17alpha,24-dihydroxyergosterol

scientific article published on August 2005

Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.

scientific article published on 6 February 2018

Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol.

scientific article published on 21 November 2011

Hydroxylation of CYP11A1-derived products of vitamin D3 metabolism by human and mouse CYP27B1.

scientific article published on March 2013

In vivo evidence for a novel pathway of vitamin D 3 metabolism initiated by P450scc and modified by CYP27B1 ⬇️

scientific article published on June 8, 2012

In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland.

scientific article published on 29 December 2013

Investigation of 20S-hydroxyvitamin D3 analogs and their 1α-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities.

scientific article published on 24 January 2018

Lumisterol is metabolized by CYP11A1: discovery of a new pathway

scientific article

Metabolism of 1alpha-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1alpha,20-dihydroxyvitamin D3.

scientific article published on 21 October 2008

Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1

scientific article

Metabolism of cholesterol, vitamin D3 and 20-hydroxyvitamin D3 incorporated into phospholipid vesicles by human CYP27A1

scientific article published on 24 December 2011

Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells.

scientific article published on 25 April 2013

Metabolism of vitamin d2 to 17,20,24-trihydroxyvitamin d2 by cytochrome p450scc (CYP11A1).

scientific article published on 30 December 2008

N1-Acetyl-5-Methoxykynuramine (AMK) is produced in the human epidermis and shows antiproliferative effects.

scientific article

Nanoparticulate delivery of potent microtubule inhibitor for metastatic melanoma treatment

scientific article published on 19 July 2019

Novel activities of CYP11A1 and their potential physiological significance.

scientific article published on 13 November 2014

Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation.

scientific article

Novel vitamin D photoproducts and their precursors in the skin.

scientific article published on January 2013

Ovarian Primary and Metastatic Tumors Suppressed by Survivin Knockout or a Novel Survivin Inhibitor

scientific article published on 12 September 2019

Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc

scientific article

Production of 22-hydroxy metabolites of vitamin d3 by cytochrome p450scc (CYP11A1) and analysis of their biological activities on skin cells

scientific article

Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity.

scientific article

Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3, producing 1alpha,20,23-trihydroxyvitamin D3, which has altered biological activity

scientific article

RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D.

scientific article

Rat CYP24A1 acts on 20-hydroxyvitamin D(3) producing hydroxylated products with increased biological activity

scientific article published on 5 October 2012

Steroidogenesis in the skin: implications for local immune functions

scientific article

Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities

scientific article published on 30 August 2018

Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties

scientific article published on 07 January 2020

Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin

scientific article published on 12 July 2019

Synthesis and Biological Evaluation of Vitamin D3 Metabolite 20S,23S-Dihydroxyvitamin D3 and Its 23R Epimer.

scientific article published on 12 April 2016

Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors.

scientific article published on 19 February 2018

Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid ⬇️

scientific article published on October 8, 2010

Synthesis and photo-conversion of androsta- and pregna-5,7-dienes to vitamin D3-like derivatives

scientific article published on 04 September 2008

Synthesis and photochemical transformation of 3β,21-dihydroxypregna-5,7-dien-20-one to novel secosteroids that show anti-melanoma activity.

scientific article published on 9 November 2010

The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism.

scientific article published on August 2005

The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions.

scientific article published on 28 October 2013

The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy

scientific article published on 09 May 2019

Total synthesis of biologically active 20S-hydroxyvitamin D3.

scientific article

Vitamin D analogs 17,20S(OH)2pD and 17,20R(OH)2pD are noncalcemic and exhibit antifibrotic activity.

scientific article

X-ray Crystal Structure Guided Discovery and Antitumor Efficacy of Dihydroquinoxalinone as Potent Tubulin Polymerization Inhibitors

scientific article published on 25 November 2019

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