List of works by Edmund Capparelli

A chewable pediatric fixed-dose combination tablet of stavudine, lamivudine, and nevirapine: pharmacokinetics and safety compared with the individual liquid formulations in human immunodeficiency virus-infected children in Thailand

scientific article

Adverse events associated with meropenem versus imipenem/cilastatin therapy in a large retrospective cohort of hospitalized infants

scientific article

Antiretroviral concentrations in breast-feeding infants of mothers receiving highly active antiretroviral therapy

scientific article published on 29 December 2008

Antiretroviral concentrations in breast-feeding infants of women in Botswana receiving antiretroviral treatment

scientific article

Assessing the safety and pharmacokinetics of the anti-HIV monoclonal antibody CAP256V2LS alone and in combination with VRC07-523LS and PGT121 in South African women: study protocol for the first-in-human CAPRISA 012B phase I clinical trial

scientific article published on 26 November 2020

Assessment of Nevirapine Prophylactic and Therapeutic Dosing Regimens for Neonates

scientific article published on 9 May 2017

Association of Virologic Failure and Nonnucleoside Reverse Transcriptase Inhibitor Resistance Found in Antiretroviral-Naive Children Infected With Human Immunodeficiency Virus and Given Efavirenz-Based Treatment

scientific article published on 13 June 2019

Atazanavir pharmacokinetics with and without tenofovir during pregnancy

scientific article

Basis and Statistical Design of the Passive HIV-1 Antibody Mediated Prevention (AMP) Test-of-Concept Efficacy Trials

scientific article

Bayesian Estimation of Vancomycin Pharmacokinetics in Obese Children: Matched Case-Control Study

scientific article published on 29 May 2015

CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children.

scientific article published in October 2007

CYP2B6 genotype-directed dosing is required for optimal efavirenz exposure in children 3-36 months with HIV infection.

scientific article

CYP2C19 genetic variants affect nelfinavir pharmacokinetics and virologic response in HIV-1-infected children receiving highly active antiretroviral therapy

scientific article

Cell-Associated HIV-1 DNA and RNA Decay Dynamics During Early Combination Antiretroviral Therapy in HIV-1-Infected Infants.

scientific article

Characterization of the population pharmacokinetics of ampicillin in neonates using an opportunistic study design

scientific article

Concurrent use of efavirenz and oxcarbazepine may not affect efavirenz plasma concentrations

scientific article published in July 2006

Darunavir Pharmacokinetics With an Increased Dose During Pregnancy

scientific article published on 01 April 2020

Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration

scientific article published on 9 November 2012

Determination of Benznidazole in Human Dried Blood Spots by Liquid Chromatography-Mass Spectrometry to Monitor Adherence to Trypanosoma cruzi Infection Treatment in Infants and Children

scientific article published on 01 July 2019

Determining population and developmental pharmacokinetics of metronidazole using plasma and dried blood spot samples from premature infants

scientific article

Development of Tolerance to Chronic Intermittent Furosemide Therapy in Pediatric Patients

scientific article published in November 2017

Developmental pharmacokinetic changes of Lamivudine in infants and children

scientific article

Developmental pharmacokinetics of piperacillin and tazobactam using plasma and dried blood spots from infants

scientific article published on 10 March 2014

Dolutegravir pharmacokinetics in pregnant and postpartum women living with HIV.

scientific article published on 23 January 2018

Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age.

scientific article

Early initiation of lopinavir/ritonavir in infants less than 6 weeks of age: pharmacokinetics and 24-week safety and efficacy

scientific article

Efavirenz concentrations in CSF exceed IC50 for wild-type HIV ⬇️

scientific article published on November 23, 2010

Efavirenz pharmacokinetics during the third trimester of pregnancy and postpartum

scientific article published on March 2012

Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption

scientific article

Electronic Health Records and Pharmacokinetic Modeling to Assess the Relationship between Ampicillin Exposure and Seizure Risk in Neonates

scientific article

Elvitegravir/cobicistat pharmacokinetics in pregnant and postpartum women with HIV

scientific article published on 01 November 2018

Establishing Dosing Recommendations for Efavirenz in HIV/TB-Coinfected Children Younger Than 3 Years

scientific article published on 01 August 2019

Etravirine Pharmacokinetics in HIV-Infected Pregnant Women

scientific article published on 04 August 2016

Etravirine in CSF is highly protein bound

scientific article published on 20 January 2013

Evaluation of Omeprazole Limited Sampling Strategies to Estimate Constitutive Cytochrome P450 2C19 Activity in Healthy Adults

scientific article published on 01 December 2018

Failure of modified directly observed therapy combined with therapeutic drug monitoring to enhance antiretroviral adherence in a patient with major depression

scientific article published in April 2006

Fosamprenavir with Ritonavir Pharmacokinetics during Pregnancy

scientific article published on 24 March 2020

Immune Reconstitution after Receipt of Highly Active Antiretroviral Therapy in Children with Advanced or Progressive HIV Disease and Complete or Partial Viral Load Responsea

article

Immunotherapy in neonatal sepsis: advances in treatment and prophylaxis

scientific article published in April 2009

Impact of body weight and missed doses on lopinavir concentrations with standard and increased lopinavir/ritonavir doses during late pregnancy

scientific article

Impact of pregnancy on abacavir pharmacokinetics

scientific article

Implications of gender and pregnancy for antiretroviral drug dosing

scientific article

Improved vancomycin dosing in children using area under the curve exposure

scientific article published on April 2013

Infliximab Pharmacokinetics are Influenced by Intravenous Immunoglobulin Administration in Patients with Kawasaki Disease.

scientific article published on 5 April 2018

Infliximab treatment of intravenous immunoglobulin-resistant Kawasaki disease

scientific article

Influence of CYP2B6 polymorphisms on the persistence of plasma nevirapine concentrations following a single intra-partum dose for the prevention of mother to child transmission in HIV-infected Thai women

scientific article published on 06 October 2009

Innovative clinical trial design for pediatric therapeutics

scientific article

Instability of lopinavir/ritonavir capsules at ambient temperatures in sub-Saharan Africa: relevance to WHO antiretroviral guidelines

scientific article published on July 2005

Intracellular pharmacokinetics of once versus twice daily zidovudine and lamivudine in adolescents.

scientific article

Intraperitoneal vancomycin for peritoneal dialysis-associated peritonitis in children: Evaluation of loading dose guidelines

scientific article published on 31 August 2020

Long-acting or extended-release antiretroviral products for HIV treatment and prevention in infants, children, adolescents, and pregnant and breastfeeding women: knowledge gaps and research priorities

scientific article published on 12 July 2019

Long-term outcomes for HIV-infected infants less than 6 months of age at initiation of lopinavir/ritonavir combination antiretroviral therapy

scientific article

Lopinavir exposure with an increased dose during pregnancy

scientific article published on December 2008

Lopinavir tablet pharmacokinetics with an increased dose during pregnancy

scientific article published on August 2010

Low atazanavir concentrations in cerebrospinal fluid

scientific article published on January 2009

Low cerebrospinal fluid concentrations of the nucleotide HIV reverse transcriptase inhibitor, tenofovir

scientific article published in April 2012

Maraviroc Pharmacokinetics in HIV-1-Infected Pregnant Women

scientific article

Meeting practical challenges of a trial involving a multitude of treatment regimens: an example of a multi-center randomized controlled clinical trial in neuroAIDS.

scientific article published on 10 January 2007

Meropenem pharmacokinetics during extracorporeal membrane oxygenation and continuous hemodialysis: A case report

scientific article published on 14 May 2020

Meropenem pharmacokinetics, pharmacodynamics, and Monte Carlo simulation in the neonate

scientific article published in September 2008

Midazolam Limited Sampling Strategy With a Population Pharmacokinetic Approach to Simultaneously Estimate Cytochrome P450 (CYP) 3A Constitutive, Inhibition, and Induction/Activation Conditions in Healthy Adults

scientific article published on 03 May 2019

Midazolam Single Time Point Concentrations to Estimate Exposure and Cytochrome P450 (CYP) 3A Constitutive Activity Utilizing Limited Sampling Strategy With a Population Pharmacokinetic Approach.

scientific article published on 17 April 2018

Model Informed Development of VRC01 in Newborn Infants Using a Population Pharmacokinetics Approach

scientific article published on 31 August 2020

Multicenter study to determine antibody concentrations and assess the safety of administration of INH-A21, a donor-selected human Staphylococcal immune globulin, in low-birth-weight infants

scientific article

Nevirapine exposure with WHO pediatric weight band dosing: enhanced therapeutic concentrations predicted based on extensive international pharmacokinetic experience

scientific article

Optimizing pediatric esmolol dosing using computerized practitioner order entry

scientific article

Optimizing pharmacology studies in pregnant and lactating women using lessons from HIV: a consensus statement

scientific article published on 15 September 2020

Penetration and Effectiveness of Antiretroviral Therapy in the Central Nervous System

Persistence of nevirapine exposure during the postpartum period after intrapartum single-dose nevirapine in addition to zidovudine prophylaxis for the prevention of mother-to-child transmission of HIV-1.

scientific article published in March 2005

Pharmacodynamic Characteristics of Nephrotoxicity Associated With Vancomycin Use in Children

scientific article

Pharmacokinetic and tolerability assessment of a pediatric oral formulation of pentoxifylline in kawasaki disease

scientific article

Pharmacokinetics and safety of a new paediatric fixed-dose combination of zidovudine/lamivudine/nevirapine in HIV-infected children

scientific article

Pharmacokinetics and tolerance of zidovudine in preterm infants

scientific article

Pharmacokinetics of Increased Nelfinavir Plasma Concentrations in Women During Pregnancy and Postpartum

scientific article published on 25 October 2018

Pharmacokinetics of Once Versus Twice Daily Darunavir in Pregnant HIV-Infected Women

scientific article

Pharmacokinetics of Rilpivirine in HIV-Infected Pregnant Women

scientific article published on 25 February 2016

Pharmacokinetics of antiretrovirals in pregnant women

scientific article

Pharmacokinetics of didanosine and drug resistance mutations in infants exposed to zidovudine during gestation or postnatally and treated with didanosine or zidovudine in the first three months of life

scientific article

Pharmacokinetics of gatifloxacin in infants and children

scientific article

Pharmacokinetics of high-dose lopinavir-ritonavir with and without saquinavir or nonnucleoside reverse transcriptase inhibitors in human immunodeficiency virus-infected pediatric and adolescent patients previously treated with protease inhibitors

scientific article published on 14 July 2008

Pharmacokinetics of nevirapine in HIV and tuberculosis-coinfected children receiving antiretroviral fixed-dose combination tablets while receiving rifampicin-containing tuberculosis treatment and after rifampicin discontinuation

scientific article published on 01 April 2012

Pharmacokinetics of nevirapine in HIV-infected children receiving an adult fixed-dose combination of stavudine, lamivudine and nevirapine

scientific article published in September 2005

Pharmacokinetics of tenofovir alafenamide with and without cobicistat in pregnant and postpartum women living with HIV: Results from IMPAACT P1026s

scientific article published on 25 November 2020

Pharmacokinetics, Safety and Tolerability of Single Oral or Intravenous Administration of 200 mg Tedizolid Phosphate in Adolescents

scientific article

Pharmacokinetics, safety and efficacy of lopinavir/ritonavir in infants less than 6 months of age: 24 week results

scientific article published in January 2008

Pharmacotherapy of perinatal HIV.

scientific article

Physiologically Based Pharmacokinetic Models to Predict Maternal Pharmacokinetics and Fetal Exposure to Emtricitabine and Acyclovir

scientific article published on 06 September 2019

Planned multiple exposures to autologous virus in HIV type 1-infected pediatric populations increases HIV-specific immunity and reduces HIV viremia

scientific article published in March 2008

Population Pharmacokinetic Assessment and Pharmacodynamic Implications of Pediatric Cefepime Dosing for Susceptible-Dose-Dependent Organisms

scientific article published on 25 January 2016

Population Pharmacokinetics and Exploratory Pharmacodynamics of Lorazepam in Pediatric Status Epilepticus

scientific article published on 9 December 2016

Population Pharmacokinetics of Dexmedetomidine in Infants

scientific article published on 25 April 2017

Population Pharmacokinetics of Fluconazole in Premature Infants with Birth Weights Less than 750 Grams

scientific article published on 11 July 2016

Population Pharmacokinetics of Lopinavir/Ritonavir: Changes Across Formulations and Human Development From Infancy Through Adulthood

scientific article published on 25 September 2018

Population Pharmacokinetics of Praziquantel in Pregnant and Lactating Filipino Women infected with Schistosoma japonicum

scientific article published on 06 July 2020

Population Pharmacokinetics of Tenofovir in Pregnant and Postpartum Women using Tenofovir Disoproxil Fumarate

scientific article published on 14 December 2020

Population pharmacokinetic model for gatifloxacin in pediatric patients

scientific article published on 12 January 2007

Population pharmacokinetics and pharmacodynamics of zidovudine in HIV-infected infants and children

scientific article

Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid

scientific article

Population pharmacokinetics of cefepime in the neonate

scientific article

Population pharmacokinetics of intravenous acyclovir in preterm and term infants

scientific article

Population pharmacokinetics of lamivudine in human immunodeficiency virus-exposed and -infected infants

scientific article

Population pharmacokinetics of meropenem in plasma and cerebrospinal fluid of infants with suspected or complicated intra-abdominal infections

scientific article

Population-Based Pharmacokinetic Modeling of Vancomycin in Children with Renal Insufficiency

scientific article

Predictive performance of a gentamicin population pharmacokinetic model in neonates receiving full-body hypothermia

scientific article

Raltegravir pharmacokinetics during pregnancy.

scientific article

Reduced indinavir exposure during pregnancy

scientific article published on September 2013

Reduced lopinavir exposure during pregnancy

scientific article published in October 2006

Rilpivirine Plasma and Cervicovaginal Concentrations in Women During Pregnancy and Postpartum

scientific article published on 01 July 2018

Safety and Efficacy of Starting Antiretroviral Therapy in the First Week of Life

scientific article published on 12 January 2020

Safety and effectiveness of meropenem in infants with suspected or complicated intra-abdominal infections

scientific article

Safety and pharmacokinetics of broadly neutralising human monoclonal antibody VRC07-523LS in healthy adults: a phase 1 dose-escalation clinical trial

scientific article published on 28 August 2019

Safety and pharmacokinetics of nelfinavir coadministered with zidovudine and lamivudine in infants during the first 6 weeks of life.

scientific article published in June 2005

Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults.

scientific article published on 24 January 2018

Safety, Tolerability, and Pharmacokinetics of the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01 in HIV-Exposed Newborn Infants

scientific article published on 4 November 2019

Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study

article by Martin R Gaudinski et al published 2 March 2019 in The Lancet

Sertraline Pharmacokinetics in HIV-Infected and Uninfected Children, Adolescents, and Young Adults

article

Short-course Benznidazole treatment to reduce Trypanosoma cruzi parasitic load in women of reproductive age (BETTY): a non-inferiority randomized controlled trial study protocol

scientific article published on 24 August 2020

Therapeutic amprenavir concentrations in cerebrospinal fluid

scientific article published on 30 January 2012

Therapeutic levels of lopinavir in late pregnancy and abacavir passage into breast milk in the Mma Bana Study, Botswana

scientific article

Therapeutic ritonavir-boosted atazanavir plasma concentration and concurrent omeprazole use

scientific article published on 01 October 2006

Total raltegravir concentrations in cerebrospinal fluid exceed the 50-percent inhibitory concentration for wild-type HIV-1.

scientific article

Use of Modeling and Simulations to Determine Raltegravir Dosing in Neonates: A Model for Safely and Efficiently Determining Appropriate Neonatal Dosing Regimens: IMPAACT P1110

scientific article published on 01 December 2019

Use of Simulation Strategies to Predict Subtherapeutic Meropenem Exposure Caused by Augmented Renal Clearance in Critically Ill Pediatric Patients With Sepsis

scientific article published on 01 January 2020

Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system

scientific article published on January 2008

Vancomycin monitoring in children using bayesian estimation

scientific article

Variable and suboptimal nevirapine levels in infants given single-dose nevirapine at birth without maternal prophylaxis

scientific article

Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

scientific article published on December 2015

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