List of works - Takeshi Nagamatsu

A New Enzyme Immunoassay for the Quantitative Determination of Classical Autotaxins (ATXα, ATXβ, and ATXγ) and Novel Autotaxins (ATXδ and ATXε).

scientific article published on 17 June 2015

A Rho-associated coiled-coil containing kinases (ROCK) inhibitor, Y-27632, enhances adhesion, viability and differentiation of human term placenta-derived trophoblasts in vitro

scientific article

A case of a surviving co-twin diagnosed with porencephaly and renal hypoplasia after a single intrauterine fetal death at 21 weeks of gestation in a monochorionic monoamniotic twin pregnancy

scientific article published on 17 January 2017

A case of pregnancy complicated with dilated cardiomyopathy 1X.

scientific article

A possible coagulation-independent mechanism for pregnancy loss involving β(2) glycoprotein 1-dependent antiphospholipid antibodies and CD1d

scientific article published on 20 June 2011

ASK1 promotes uterine inflammation leading to pathological preterm birth

scientific article published on 05 February 2020

Abdominal compartment syndrome complicated by preeclampsia and partial HELLP syndrome in a 45-year-old woman: A case report

scientific article published on 28 April 2020

Adenomyosis and adverse perinatal outcomes: increased risk of second trimester miscarriage, preeclampsia, and placental malposition

scientific article published on 23 January 2017

Assisted reproductive technology pregnancy complications are significantly associated with endometriosis severity before conception: a retrospective cohort study.

scientific article

Authors' reply re: Peripartum type B aortic dissection in patients with Marfan syndrome who underwent aortic root replacement: a case series study

scientific article published on 10 August 2017

Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways

scientific article

CD1d, a Sentinel Molecule Bridging Innate and Adaptive Immunity, Is Downregulated by the Human Papillomavirus (HPV) E5 Protein: a Possible Mechanism for Immune Evasion by HPV ⬇️

scientific article published on September 1, 2010

Cancer-associated fibroblast suppresses killing activity of natural killer cells through downregulation of poliovirus receptor (PVR/CD155), a ligand of activating NK receptor

scientific article published on 26 July 2016

Cervical Expression of Elafin and SLPI in Pregnancy and Their Association With Preterm Labor.

scientific article published on 5 January 2015

Characterization of gut-derived intraepithelial lymphocyte (IEL) residing in human papillomavirus (HPV)-infected intraepithelial neoplastic lesions

scientific article published on 12 July 2011

Chlamydia trachomatis immune evasion via downregulation of MHC class I surface expression involves direct and indirect mechanisms

scientific article

Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma.

scientific article published on 31 May 2018

Classification of factors involved in nonreportable results of noninvasive prenatal testing (NIPT) and prediction of success rate of second NIPT

scientific article published on 10 January 2019

Congenital extracardiac venous system anomaly in two siblings with normal karyotype and increased nuchal translucency thickness: a case report

scientific article published on 13 June 2020

Current status of non-invasive prenatal testing in Japan.

scientific article published on 06 June 2017

Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication for the placental vascular development and the pathophysiology of preeclampsia

scientific article published on 29 July 2004

Decreased expression of the plasminogen activator inhibitor type 1 is involved in degradation of extracellular matrix surrounding cervical cancer stem cells.

scientific article published on 9 December 2015

Detachment from the primary site and suspension in ascites as the initial step in metabolic reprogramming and metastasis to the omentum in ovarian cancer

scientific article published on 9 November 2017

Differential expression of human papillomavirus 16-, 18-, 52-, and 58-derived transcripts in cervical intraepithelial neoplasia

scientific article published on 06 March 2020

Effect of progesterone on HLA-E gene expression in JEG-3 choriocarcinoma cell line

scientific article

Efficacy and safety of controlled-release dinoprostone vaginal delivery system (PROPESS) in Japanese pregnant women requiring cervical ripening: Results from a multicenter, randomized, double-blind, placebo-controlled phase III study

scientific article published on 22 October 2020

Elevated concentration of secretory leukocyte protease inhibitor in the cervical mucus before delivery.

scientific article published on 14 January 2016

Elevation of maternal serum sFlt-1 in pregnancy with mirror syndrome caused by fetal cardiac failure.

scientific article

Emerging roles for lysophospholipid mediators in pregnancy

scientific article published on April 2014

Enhanced HIF2α expression during human trophoblast differentiation into syncytiotrophoblast suppresses transcription of placental growth factor

scientific article published on 29 September 2017

Establishment and Molecular Phenotyping of Organoids from the Squamocolumnar Junction Region of the Uterine Cervix

scientific article published on 15 March 2020

Expression of CD1d and ligand-induced cytokine production are tissue specific in mucosal epithelia of the human lower reproductive tract

scientific article published on 5 May 2008

Expression of Par3 polarity protein correlates with poor prognosis in ovarian cancer

scientific article

Expression of autotaxin, an ectoenzyme that produces lysophosphatidic acid, in human placenta.

scientific article published in August 2009

Expression of surface CD1d in the extravillous trophoblast cells of early gestational placenta is downregulated in a manner dependent on trophoblast differentiation

scientific article published on 21 April 2008

Expression patterns of lectin-like natural killer receptors, inhibitory CD94/NKG2A, and activating CD94/NKG2C on decidual CD56bright natural killer cells differ from those on peripheral CD56dim natural killer cells

scientific article published on 20 February 2006

Extremely high levels of multiple cytokines in the cord blood of neonates born to mothers with systemic autoimmune diseases

scientific article published on 19 December 2019

Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy.

scientific article published on 26 March 2018

HIF-2α, but not HIF-1α, mediates hypoxia-induced up-regulation of Flt-1 gene expression in placental trophoblasts

scientific article published in Scientific Reports

Human decidual macrophages suppress IFN-γ production by T cells through costimulatory B7-H1:PD-1 signaling in early pregnancy

scientific article published on 22 August 2013

Human decidual stromal cells suppress cytokine secretion by allogenic CD4+ T cells via PD-1 ligand interactions

scientific article published on 03 September 2009

Human leukocyte antigen F protein is expressed in the extra-villous trophoblasts but not on the cell surface of them

scientific article published on September 2006

Hypoxia does not reduce HLA-G expression on extravillous cytotrophoblasts

scientific article published on 01 October 2004

Impact of Th1/Th2 cytokine polarity induced by invariant NKT cells on the incidence of pregnancy loss in mice.

scientific article

Impact of additional risk factors on the incidence of preterm delivery among pregnant women diagnosed with short cervix

scientific article published on 01 March 2020

Increased LIGHT leading to sFlt-1 elevation underlies the pathogenic link between hydatidiform mole and preeclampsia

scientific article published on 12 July 2019

Increased production of inflammatory cytokines and activation of microglia in the fetal brain of preeclamptic mice induced by angiotensin II

scientific article published in 2022

Increased risk of pregnancy-induced hypertension and operative delivery after conception induced by in vitro fertilization/intracytoplasmic sperm injection in women aged 40 years and older

scientific article published on 11 August 2014

Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth

scientific article

Inhibition of endoplasmic reticulum (ER) stress sensors sensitizes cancer stem-like cells to ER stress-mediated apoptosis

scientific article published on 17 June 2016

Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlamydia trachomatis persistence in human epithelial cells

scientific article published on 12 September 2011

Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix

scientific article published on 22 September 2011

Intracellular signaling entropy can be a biomarker for predicting the development of cervical intraepithelial neoplasia

scientific article

Intraperitoneal neutrophils activated by KRAS-induced ovarian cancer exert antitumor effects by modulating adaptive immunity

scientific article published on 26 July 2018

Labor prediction based on the expression patterns of multiple genes related to cervical maturation in human term pregnancy.

scientific article published on 30 May 2017

Low uptake of fluorodeoxyglucose in positron emission tomography/computed tomography in ovarian clear cell carcinoma may reflect glutaminolysis of its cancer stem cell-like properties.

scientific article published on 20 January 2017

Lymphokine-activated killer cells induced from decidual lymphocytes reduce the angiogenic activity of trophoblasts by enhancing the release of soluble fms-like tyrosine kinase-1 from trophoblasts: an implication for the pathophysiology of preeclamps

scientific article published on 17 October 2005

Management of a pregnant woman with hypouricemia: a case report

scientific article published on 31 May 2019

Modification of the Tumor Microenvironment in KRAS or c-MYC-Induced Ovarian Cancer-Associated Peritonitis

scientific article

Multistate Markov Model to Predict the Prognosis of High-Risk Human Papillomavirus-Related Cervical Lesions

scientific article published on 22 January 2020

Omega-3 polyunsaturated Fatty acids suppress the cystic lesion formation of peritoneal endometriosis in transgenic mouse models

scientific article

Placental abnormalities detected by ultrasonography in a case of confined placental mosaicism for trisomy 2 with severe fetal growth restriction.

scientific article published on 5 September 2013

Placental autotaxin expression is diminished in women with pre-eclampsia.

scientific article

Placental expression of lysophosphatidic acid receptors in normal pregnancy and preeclampsia

scientific article published on 16 August 2019

Polyhydramnios is associated with postnatal dysphagia determining short-term prognosis of the newborn with 22q11.2 deletion syndrome - A case series analysis

scientific article published on 01 September 2020

Pravastatin for preeclampsia: From animal to human

scientific article published on 02 June 2020

Prediction model for the incidence of emergent cesarean section during induction of labor specialized in nulliparous low-risk women

scientific article published on 27 July 2011

Prediction of sustained fetal toxicity induced by ketoprofen based on PK/PD analysis using human placental perfusion and rat toxicity data

scientific article

Prevalence of common aneuploidy in twin pregnancies

scientific article published in 2022

Production of an anti-angiogenic factor sFLT1 is suppressed via promoter hypermethylation of FLT1 gene in choriocarcinoma cells

scientific article published on 10 February 2020

Quantitative prediction of fetal plasma concentration of fluvoxamine during dosage-tapering to the mother.

scientific article

Real-time Monitoring of Hypoxic-Ischemic Brain Damage in Neonatal Rats Using Diffuse Light Reflectance Spectroscopy

scientific article published on 01 January 2020

Recent Progress in Therapeutics for Inflammation-Associated Preterm Birth: A Review

scientific article

Reciprocal upregulation of hypoxia-inducible factor-1α and persistently enhanced placental adenosine signaling contribute to the pathogenesis of preeclampsia

scientific article published on 12 January 2020

Recombinant Thrombomodulin Attenuates Preeclamptic Symptoms by Inhibiting High Mobility Group Box 1 in Mice

scientific article published on 06 January 2021

Reconstructed uterine length is critical for the prevention of cervical stenosis following abdominal trachelectomy in cervical cancer patients

scientific article published on 20 January 2020

Regeneration of cervical reserve cell-like cells from human induced pluripotent stem cells (iPSCs): A new approach to finding targets for cervical cancer stem cell treatment.

scientific article published on 3 April 2017

Resveratrol Protects Against Pathological Preterm Birth by Suppression of Macrophage-Mediated Inflammation.

scientific article published on 2 June 2015

STAT3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells.

scientific article published on 06 September 2016

Safety and efficacy of preoperative autologous blood donation for high-risk pregnant women: experience of a large university hospital in Japan

scientific article published on 21 April 2014

Secretory leukocyte protease inhibitor and progranulin as possible regulators of cervical remodeling in pregnancy

scientific article published on 01 November 2020

Spheroid cancer stem cells display reprogrammed metabolism and obtain energy by actively running the tricarboxylic acid (TCA) cycle

scientific article published on 23 April 2016

Successful Pregnancy and Delivery in a Heart Transplantation Recipient

scientific article published on 28 April 2016

Successful right heart remodelling and subsequent pregnancy in a patient with chronic thromboembolic pulmonary hypertension undergoing balloon pulmonary angioplasty: a case report

scientific article published on 01 June 2019

Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes

scientific article published on 12 March 2016

Targeting glutamine metabolism and the focal adhesion kinase additively inhibits the mammalian target of the rapamycin pathway in spheroid cancer stem-like properties of ovarian clear cell carcinoma in vitro.

scientific article published on 23 February 2017

The contribution of macrophages to normal and pathological pregnancies

scientific article published on 16 February 2010

The immunomodulatory roles of macrophages at the maternal-fetal interface

scientific article published on 11 January 2010

The oncogene KRAS promotes cancer cell dissemination by stabilizing spheroid formation via the MEK pathway

The prevalence of cervical regulatory T cells in HPV-related cervical intraepithelial neoplasia (CIN) correlates inversely with spontaneous regression of CIN.

scientific article

Theoretical basis for herbal medicines, Tokishakuyaku-San and Sairei-To, in the treatment of recurrent abortion: enhancing the production of granulocyte-macrophage colony-stimulating factor in decidual stromal cells

scientific article published on 01 April 2007

Therapeutic significance of targeting survivin in cervical cancer and possibility of combination therapy with TRAIL.

scientific article published on 5 February 2018

Tokishakuyakusan, a traditional Japanese medicine (Kampo) mitigates iNKT cell-mediated pregnancy loss in mice

scientific article published on 12 July 2018

Ultrasonographic vascularity assessment for predicting future severe hemorrhage in retained products of conception after second-trimester abortion

scientific article published on 29 April 2019

Use of Cap Analysis Gene Expression to detect human papillomavirus promoter activity patterns at different disease stages

scientific article published on 22 October 2020

List of works by Takeshi Nagamatsu

A New Enzyme Immunoassay for the Quantitative Determination of Classical Autotaxins (ATXα, ATXβ, and ATXγ) and Novel Autotaxins (ATXδ and ATXε).

A Rho-associated coiled-coil containing kinases (ROCK) inhibitor, Y-27632, enhances adhesion, viability and differentiation of human term placenta-derived trophoblasts in vitro

A case of a surviving co-twin diagnosed with porencephaly and renal hypoplasia after a single intrauterine fetal death at 21 weeks of gestation in a monochorionic monoamniotic twin pregnancy

A case of pregnancy complicated with dilated cardiomyopathy 1X.

A possible coagulation-independent mechanism for pregnancy loss involving β(2) glycoprotein 1-dependent antiphospholipid antibodies and CD1d

ASK1 promotes uterine inflammation leading to pathological preterm birth

Abdominal compartment syndrome complicated by preeclampsia and partial HELLP syndrome in a 45-year-old woman: A case report

Adenomyosis and adverse perinatal outcomes: increased risk of second trimester miscarriage, preeclampsia, and placental malposition

Assisted reproductive technology pregnancy complications are significantly associated with endometriosis severity before conception: a retrospective cohort study.

Authors' reply re: Peripartum type B aortic dissection in patients with Marfan syndrome who underwent aortic root replacement: a case series study

Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways

CD1d, a Sentinel Molecule Bridging Innate and Adaptive Immunity, Is Downregulated by the Human Papillomavirus (HPV) E5 Protein: a Possible Mechanism for Immune Evasion by HPV ⬇️

Cancer-associated fibroblast suppresses killing activity of natural killer cells through downregulation of poliovirus receptor (PVR/CD155), a ligand of activating NK receptor

Cervical Expression of Elafin and SLPI in Pregnancy and Their Association With Preterm Labor.

Characterization of gut-derived intraepithelial lymphocyte (IEL) residing in human papillomavirus (HPV)-infected intraepithelial neoplastic lesions

Chlamydia trachomatis immune evasion via downregulation of MHC class I surface expression involves direct and indirect mechanisms

Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma.

Classification of factors involved in nonreportable results of noninvasive prenatal testing (NIPT) and prediction of success rate of second NIPT

Congenital extracardiac venous system anomaly in two siblings with normal karyotype and increased nuchal translucency thickness: a case report

Current status of non-invasive prenatal testing in Japan.

Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication for the placental vascular development and the pathophysiology of preeclampsia

Decreased expression of the plasminogen activator inhibitor type 1 is involved in degradation of extracellular matrix surrounding cervical cancer stem cells.

Detachment from the primary site and suspension in ascites as the initial step in metabolic reprogramming and metastasis to the omentum in ovarian cancer

Differential expression of human papillomavirus 16-, 18-, 52-, and 58-derived transcripts in cervical intraepithelial neoplasia

Effect of progesterone on HLA-E gene expression in JEG-3 choriocarcinoma cell line

Efficacy and safety of controlled-release dinoprostone vaginal delivery system (PROPESS) in Japanese pregnant women requiring cervical ripening: Results from a multicenter, randomized, double-blind, placebo-controlled phase III study

Elevated concentration of secretory leukocyte protease inhibitor in the cervical mucus before delivery.

Elevation of maternal serum sFlt-1 in pregnancy with mirror syndrome caused by fetal cardiac failure.

Emerging roles for lysophospholipid mediators in pregnancy

Enhanced HIF2α expression during human trophoblast differentiation into syncytiotrophoblast suppresses transcription of placental growth factor

Establishment and Molecular Phenotyping of Organoids from the Squamocolumnar Junction Region of the Uterine Cervix

Expression of CD1d and ligand-induced cytokine production are tissue specific in mucosal epithelia of the human lower reproductive tract

Expression of Par3 polarity protein correlates with poor prognosis in ovarian cancer

Expression of autotaxin, an ectoenzyme that produces lysophosphatidic acid, in human placenta.

Expression of surface CD1d in the extravillous trophoblast cells of early gestational placenta is downregulated in a manner dependent on trophoblast differentiation

Expression patterns of lectin-like natural killer receptors, inhibitory CD94/NKG2A, and activating CD94/NKG2C on decidual CD56bright natural killer cells differ from those on peripheral CD56dim natural killer cells

Extremely high levels of multiple cytokines in the cord blood of neonates born to mothers with systemic autoimmune diseases

Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy.

HIF-2α, but not HIF-1α, mediates hypoxia-induced up-regulation of Flt-1 gene expression in placental trophoblasts

Human decidual macrophages suppress IFN-γ production by T cells through costimulatory B7-H1:PD-1 signaling in early pregnancy

Human decidual stromal cells suppress cytokine secretion by allogenic CD4+ T cells via PD-1 ligand interactions

Human leukocyte antigen F protein is expressed in the extra-villous trophoblasts but not on the cell surface of them

Hypoxia does not reduce HLA-G expression on extravillous cytotrophoblasts

Impact of Th1/Th2 cytokine polarity induced by invariant NKT cells on the incidence of pregnancy loss in mice.

Impact of additional risk factors on the incidence of preterm delivery among pregnant women diagnosed with short cervix

Increased LIGHT leading to sFlt-1 elevation underlies the pathogenic link between hydatidiform mole and preeclampsia

Increased production of inflammatory cytokines and activation of microglia in the fetal brain of preeclamptic mice induced by angiotensin II

Increased risk of pregnancy-induced hypertension and operative delivery after conception induced by in vitro fertilization/intracytoplasmic sperm injection in women aged 40 years and older

Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth

Inhibition of endoplasmic reticulum (ER) stress sensors sensitizes cancer stem-like cells to ER stress-mediated apoptosis

Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlamydia trachomatis persistence in human epithelial cells

Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix

Intracellular signaling entropy can be a biomarker for predicting the development of cervical intraepithelial neoplasia

Intraperitoneal neutrophils activated by KRAS-induced ovarian cancer exert antitumor effects by modulating adaptive immunity

Labor prediction based on the expression patterns of multiple genes related to cervical maturation in human term pregnancy.

Low uptake of fluorodeoxyglucose in positron emission tomography/computed tomography in ovarian clear cell carcinoma may reflect glutaminolysis of its cancer stem cell-like properties.

Lymphokine-activated killer cells induced from decidual lymphocytes reduce the angiogenic activity of trophoblasts by enhancing the release of soluble fms-like tyrosine kinase-1 from trophoblasts: an implication for the pathophysiology of preeclamps

Management of a pregnant woman with hypouricemia: a case report

Modification of the Tumor Microenvironment in KRAS or c-MYC-Induced Ovarian Cancer-Associated Peritonitis

Multistate Markov Model to Predict the Prognosis of High-Risk Human Papillomavirus-Related Cervical Lesions

Omega-3 polyunsaturated Fatty acids suppress the cystic lesion formation of peritoneal endometriosis in transgenic mouse models

Placental abnormalities detected by ultrasonography in a case of confined placental mosaicism for trisomy 2 with severe fetal growth restriction.

Placental autotaxin expression is diminished in women with pre-eclampsia.

Placental expression of lysophosphatidic acid receptors in normal pregnancy and preeclampsia

Polyhydramnios is associated with postnatal dysphagia determining short-term prognosis of the newborn with 22q11.2 deletion syndrome - A case series analysis

Pravastatin for preeclampsia: From animal to human

Prediction model for the incidence of emergent cesarean section during induction of labor specialized in nulliparous low-risk women

Prediction of sustained fetal toxicity induced by ketoprofen based on PK/PD analysis using human placental perfusion and rat toxicity data

Prevalence of common aneuploidy in twin pregnancies

Production of an anti-angiogenic factor sFLT1 is suppressed via promoter hypermethylation of FLT1 gene in choriocarcinoma cells

Quantitative prediction of fetal plasma concentration of fluvoxamine during dosage-tapering to the mother.

Real-time Monitoring of Hypoxic-Ischemic Brain Damage in Neonatal Rats Using Diffuse Light Reflectance Spectroscopy

Recent Progress in Therapeutics for Inflammation-Associated Preterm Birth: A Review

Reciprocal upregulation of hypoxia-inducible factor-1α and persistently enhanced placental adenosine signaling contribute to the pathogenesis of preeclampsia

Recombinant Thrombomodulin Attenuates Preeclamptic Symptoms by Inhibiting High Mobility Group Box 1 in Mice

Reconstructed uterine length is critical for the prevention of cervical stenosis following abdominal trachelectomy in cervical cancer patients

Regeneration of cervical reserve cell-like cells from human induced pluripotent stem cells (iPSCs): A new approach to finding targets for cervical cancer stem cell treatment.

Resveratrol Protects Against Pathological Preterm Birth by Suppression of Macrophage-Mediated Inflammation.

STAT3 activity regulates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cervical cancer cells.