List of works - Peter Pickkers

A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1.

scientific article published on 12 December 2011

A worldwide multicentre evaluation of the influence of deterioration or improvement of acute kidney injury on clinical outcome in critically ill patients with and without sepsis at ICU admission: results from The Intensive Care Over Nations audit

scientific article published on 03 August 2018

Acetazolamide-mediated decrease in strong ion difference accounts for the correction of metabolic alkalosis in critically ill patients

scientific article

Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference

scientific article

Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

scientific article published on 10 December 2020

BCG Vaccination Enhances the Immunogenicity of Subsequent Influenza Vaccination in Healthy Volunteers: A Randomized, Placebo-Controlled Pilot Study.

scientific article

Biomarker discovery with SELDI-TOF MS in human urine associated with early renal injury: evaluation with computational analytical tools

scientific article

C1-esterase inhibitor attenuates the inflammatory response during human endotoxemia.

scientific article published in November 2010

COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup

scientific article published on 15 October 2020

COVID-19: 10 things I wished I'd known some months ago

scientific article published on 03 June 2020

Cardiac and Vascular Surgery-Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group.

scientific article

Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury

scientific article published on 6 January 2011

Correction to: What's new in immunostimulating strategies in the ICU

scientific article published on 01 January 2019

Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients

scientific article published on 05 August 2021

Differential antibacterial control by neutrophil subsets

scientific article published on 01 June 2018

Dynamic preload indicators decrease when the abdomen is opened

scientific article

Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans

scientific article

Effects of Vagus Nerve Stimulation and Vagotomy on Systemic and Pulmonary Inflammation in a Two-Hit Model in Rats ⬇️

scientific article published on April 6, 2012

Emphysema and pneumothorax after percutaneous tracheostomy: case reports and an anatomic study

scientific article published on May 2004

F-18-fluorodeoxyglucose positron emission tomography combined with CT in critically ill patients with suspected infection

scientific article

Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia

scientific article published on 16 April 2010

Gamma-irradiated bacille Calmette-Guérin vaccination does not modulate the innate immune response during experimental human endotoxemia in adult males

scientific article

Gender-specific differences in outcome after trauma may be explained by differences in immunity

scientific article

Haloperidol prophylaxis in critically ill patients with a high risk for delirium

scientific article

Homology in systemic neutrophil response induced by human experimental endotoxemia and by trauma

scientific article published on 01 February 2012

Human suppressive neutrophils CD16bright/CD62Ldim exhibit decreased adhesion.

scientific article published on 27 August 2012

IFN-γ-stimulated neutrophils suppress lymphocyte proliferation through expression of PD-L1.

scientific article

Immunotherapy for the Adjunctive Treatment of Sepsis: From Immunosuppression to Immunostimulation. Time for a Paradigm Change? ⬇️

scientific article published on June 15, 2013

Implementation of a delirium assessment tool in the ICU can influence haloperidol use.

scientific article

Infections and use of antibiotics in patients admitted for severe acute pancreatitis: data from the EPIC II study

scientific article

Infections, antibiotic treatment and mortality in patients admitted to ICUs in countries considered to have high levels of antibiotic resistance compared to those with low levels

scientific article

Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps

scientific article

Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients: an observational study ⬇️

scientific article published on January 10, 2011

Inhibition of caspase-1 activation in Gram-negative sepsis and experimental endotoxemia

scientific article published on 18 January 2011

Intensive insulin therapy does not alter the inflammatory response in patients undergoing coronary artery bypass grafting: a randomized controlled trial [ISRCTN95608630].

scientific article

Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series

scientific article

Intestinal fatty acid binding protein as a marker for intra-abdominal pressure-related complications in patients admitted to the intensive care unit; study protocol for a prospective cohort study (I-Fabulous study).

scientific article

Metformin improves survival in intensive care unit patients, but why?

scientific article

Microvascular permeability during experimental human endotoxemia: an open intervention study

scientific article

Modulation of the Innate Immune Response through the Vagus Nerve

scientific article

Monocytic HLA-DR expression kinetics in septic shock patients with different pathogens, sites of infection and adverse outcomes

scientific article published on 20 March 2020

Noise pollution in the ICU: time to look into the mirror

scientific article

Pharmacokinetic Modeling and Dose Selection in a Randomized, Double-Blind, Placebo-Controlled Trial of a Human Recombinant Alkaline Phosphatase in Healthy Volunteers

scientific article

Physicians' and nurses' opinions on selective decontamination of the digestive tract and selective oropharyngeal decontamination: a survey

scientific article

Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients

scientific article

Promotion of vascular integrity in sepsis through modulation of bioactive adrenomedullin and dipeptidyl peptidase 3

scientific article published on 30 December 2020

Publisher Correction: COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup

scientific article published on 02 November 2020

Quality Improvement Goals for Acute Kidney Injury

scientific article published on 17 May 2019

Reduced rate of intensive care unit acquired gram-negative bacilli after removal of sinks and introduction of 'water-free' patient care

scientific article

Renal replacement therapy in acute kidney injury: controversy and consensus

scientific article

Severe vagal response after endotoxin administration in humans

scientific article published on 26 October 2004

Simultaneously Mounted Pro- and Anti-inflammatory Host Response Relates to the Development of Secondary Infections in Patients with Sepsis.

scientific article published on August 2017

Synergistic Signaling of TLR and IFNα/β Facilitates Escape of IL-18 Expression from Endotoxin Tolerance

scientific article published on 01 March 2020

Systemic inflammation decreases pain threshold in humans in vivo

scientific article

Targeting the Heme-Heme Oxygenase System to Prevent Severe Complications Following COVID-19 Infections

scientific article published on 19 June 2020

The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection.

scientific article

The Safety, Tolerability, and Effects on the Systemic Inflammatory Response and Renal Function of the Human Chorionic Gonadotropin Hormone-Derivative EA-230 Following On-Pump Cardiac Surgery (The EASI Study): Protocol for a Randomized, Double-Blind,

scientific article published on 06 February 2019

The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity

scientific article

The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases.

scientific article

The effects of orally administered Beta-glucan on innate immune responses in humans, a randomized open-label intervention pilot-study

scientific article

The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys ⬇️

scientific article published on January 24, 2013

The furosemide stress test to predict renal function after continuous renal replacement therapy

scientific article

The impact of delirium on the prediction of in-hospital mortality in intensive care patients

scientific article

The mechanism of action of the adrenomedullin-binding antibody adrecizumab.

scientific article published on 13 June 2018

The role of outcome expectancies for a training program consisting of meditation, breathing exercises, and cold exposure on the response to endotoxin administration: a proof-of-principle study

scientific article

Towards precision medicine for sepsis patients.

scientific article published on 12 January 2017

Transcriptome kinetics of circulating neutrophils during human experimental endotoxemia

scientific article

Treatment with a polymyxin B filter to capture endotoxin in sepsis patients: is there a signal for therapeutic efficacy?

scientific article published on 03 December 2018

Tubular reabsorption and local production of urine hepcidin-25.

scientific article

Upregulation of renal inducible nitric oxide synthase during human endotoxemia and sepsis is associated with proximal tubule injury.

scientific article

Urinary protein profiling in hyperactive delirium and non-delirium cardiac surgery ICU patients ⬇️

scientific article published on March 22, 2011

Vascular endothelial growth factor in systemic capillary leak syndrome.

scientific article

Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans

scientific article

What's new in immunostimulating strategies in the ICU

scientific article published on 19 November 2018

What's new in the extracorporeal treatment of sepsis?

scientific article published on 17 March 2017

List of works by Peter Pickkers

A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1.

A worldwide multicentre evaluation of the influence of deterioration or improvement of acute kidney injury on clinical outcome in critically ill patients with and without sepsis at ICU admission: results from The Intensive Care Over Nations audit

Acetazolamide-mediated decrease in strong ion difference accounts for the correction of metabolic alkalosis in critically ill patients

Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference

Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

BCG Vaccination Enhances the Immunogenicity of Subsequent Influenza Vaccination in Healthy Volunteers: A Randomized, Placebo-Controlled Pilot Study.

Biomarker discovery with SELDI-TOF MS in human urine associated with early renal injury: evaluation with computational analytical tools

C1-esterase inhibitor attenuates the inflammatory response during human endotoxemia.

COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup

COVID-19: 10 things I wished I'd known some months ago

Cardiac and Vascular Surgery-Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group.

Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury

Correction to: What's new in immunostimulating strategies in the ICU

Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients

Differential antibacterial control by neutrophil subsets

Dynamic preload indicators decrease when the abdomen is opened

Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans

Effects of Vagus Nerve Stimulation and Vagotomy on Systemic and Pulmonary Inflammation in a Two-Hit Model in Rats ⬇️

Emphysema and pneumothorax after percutaneous tracheostomy: case reports and an anatomic study

F-18-fluorodeoxyglucose positron emission tomography combined with CT in critically ill patients with suspected infection

Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia

Gamma-irradiated bacille Calmette-Guérin vaccination does not modulate the innate immune response during experimental human endotoxemia in adult males

Gender-specific differences in outcome after trauma may be explained by differences in immunity

Haloperidol prophylaxis in critically ill patients with a high risk for delirium

Homology in systemic neutrophil response induced by human experimental endotoxemia and by trauma

Human suppressive neutrophils CD16bright/CD62Ldim exhibit decreased adhesion.

IFN-γ-stimulated neutrophils suppress lymphocyte proliferation through expression of PD-L1.

Immunotherapy for the Adjunctive Treatment of Sepsis: From Immunosuppression to Immunostimulation. Time for a Paradigm Change? ⬇️

Implementation of a delirium assessment tool in the ICU can influence haloperidol use.

Infections and use of antibiotics in patients admitted for severe acute pancreatitis: data from the EPIC II study

Infections, antibiotic treatment and mortality in patients admitted to ICUs in countries considered to have high levels of antibiotic resistance compared to those with low levels

Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps

Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients: an observational study ⬇️

Inhibition of caspase-1 activation in Gram-negative sepsis and experimental endotoxemia

Intensive insulin therapy does not alter the inflammatory response in patients undergoing coronary artery bypass grafting: a randomized controlled trial [ISRCTN95608630].

Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series

Intestinal fatty acid binding protein as a marker for intra-abdominal pressure-related complications in patients admitted to the intensive care unit; study protocol for a prospective cohort study (I-Fabulous study).

Metformin improves survival in intensive care unit patients, but why?

Microvascular permeability during experimental human endotoxemia: an open intervention study

Modulation of the Innate Immune Response through the Vagus Nerve

Monocytic HLA-DR expression kinetics in septic shock patients with different pathogens, sites of infection and adverse outcomes

Noise pollution in the ICU: time to look into the mirror

Pharmacokinetic Modeling and Dose Selection in a Randomized, Double-Blind, Placebo-Controlled Trial of a Human Recombinant Alkaline Phosphatase in Healthy Volunteers

Physicians' and nurses' opinions on selective decontamination of the digestive tract and selective oropharyngeal decontamination: a survey

Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients

Promotion of vascular integrity in sepsis through modulation of bioactive adrenomedullin and dipeptidyl peptidase 3

Publisher Correction: COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup

Quality Improvement Goals for Acute Kidney Injury

Reduced rate of intensive care unit acquired gram-negative bacilli after removal of sinks and introduction of 'water-free' patient care

Renal replacement therapy in acute kidney injury: controversy and consensus

Severe vagal response after endotoxin administration in humans

Simultaneously Mounted Pro- and Anti-inflammatory Host Response Relates to the Development of Secondary Infections in Patients with Sepsis.

Synergistic Signaling of TLR and IFNα/β Facilitates Escape of IL-18 Expression from Endotoxin Tolerance

Systemic inflammation decreases pain threshold in humans in vivo

Targeting the Heme-Heme Oxygenase System to Prevent Severe Complications Following COVID-19 Infections

The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection.

The Safety, Tolerability, and Effects on the Systemic Inflammatory Response and Renal Function of the Human Chorionic Gonadotropin Hormone-Derivative EA-230 Following On-Pump Cardiac Surgery (The EASI Study): Protocol for a Randomized, Double-Blind,

The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity

The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases.

The effects of orally administered Beta-glucan on innate immune responses in humans, a randomized open-label intervention pilot-study

The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys ⬇️

The furosemide stress test to predict renal function after continuous renal replacement therapy

The impact of delirium on the prediction of in-hospital mortality in intensive care patients

The mechanism of action of the adrenomedullin-binding antibody adrecizumab.

The role of outcome expectancies for a training program consisting of meditation, breathing exercises, and cold exposure on the response to endotoxin administration: a proof-of-principle study

Towards precision medicine for sepsis patients.

Transcriptome kinetics of circulating neutrophils during human experimental endotoxemia

Treatment with a polymyxin B filter to capture endotoxin in sepsis patients: is there a signal for therapeutic efficacy?

Tubular reabsorption and local production of urine hepcidin-25.

Upregulation of renal inducible nitric oxide synthase during human endotoxemia and sepsis is associated with proximal tubule injury.

Urinary protein profiling in hyperactive delirium and non-delirium cardiac surgery ICU patients ⬇️

Vascular endothelial growth factor in systemic capillary leak syndrome.

Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans

What's new in immunostimulating strategies in the ICU

What's new in the extracorporeal treatment of sepsis?