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List of works by Kevan C Herold

A Call for Improved Reporting of Human Islet Characteristics in Research Articles

scientific article published on 14 December 2018

A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice.

scientific article published on 30 December 2015

A call for improved reporting of human islet characteristics in research articles

scientific article published on 14 December 2018

A carbon nanotube-polymer composite for T-cell therapy

scientific article published on 3 August 2014

A humanized mouse model of autoimmune insulitis.

scientific article published on 29 January 2014

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.

scientific article

A new approach for diagnosing type 1 diabetes in autoantibody-positive individuals based on prediction and natural history

scientific article

A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

scientific article

Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes

scientific article published on 20 September 2018

Acceleration of the Loss of the First-Phase Insulin Response During the Progression to Type 1 Diabetes in Diabetes Prevention Trial–Type 1 Participants ⬇️

scientific article published on July 17, 2013

Achieving antigen-specific tolerance in diabetes: regulating specifically

scientific article

Acquisition of regulatory function by human CD8(+) T cells treated with anti-CD3 antibody requires TNF ⬇️

scientific article published on October 1, 2010

Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala).

scientific article

Acute metabolic effects of exenatide in patients with type 1 diabetes with and without residual insulin to oral and intravenous glucose challenges

scientific article published on 12 August 2013

Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation

scientific article

Advances in Type 1 diabetes therapeutics: immunomodulation and beta-cell salvage

scientific article published on June 2009

Alterations in the patterns of insulin secretion before and after diagnosis of IDDM.

scientific article published in April 1995

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

scientific article published on 09 June 2019

Analysis of Human Biologics With a Mouse Skin Transplant Model in Humanized Mice ⬇️

scientific article published on August 17, 2012

Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes

article

Analysis of β-cell death in type 1 diabetes by droplet digital PCR.

scientific article

Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

scientific article

Anti-CD3 clinical trials in type 1 diabetes mellitus ⬇️

scientific article published on May 11, 2013

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

scientific article published on May 2002

Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial ⬇️

scientific article published on June 27, 2011

Associations of HbA1c with the timing of C-peptide responses during the oral glucose tolerance test at the diagnosis of type 1 diabetes

scientific article published on 15 April 2019

Autoimmune Endocrinopathies: An Emerging Complication of Immune Checkpoint Inhibitors

scientific article published on 04 September 2020

Autoimmunity and beta cell regeneration in mouse and human type 1 diabetes: the peace is not enough

scientific article published on 21 March 2007

Beta-cell mass and type 1 diabetes: going, going, gone?

scientific article published on November 2008

Biomarkers in type 1 diabetes: application to the clinical trial setting

scientific article

Blockade of RAGE suppresses alloimmune reactions in vitro and delays allograft rejection in murine heart transplantation

scientific article published on 01 February 2007

Blockade of late stages of autoimmune diabetes by inhibition of the receptor for advanced glycation end products

scientific article published in July 2004

C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001.

scientific article published in January 2004

Challenges in developing endpoints for type 1 diabetes intervention studies

scientific article

Changes in T-cell subsets identify responders to FcR-nonbinding anti-CD3 mAb (teplizumab) in patients with type 1 diabetes

scientific article published on 31 October 2015

Changing the landscape for type 1 diabetes: the first step to prevention

scientific article published on 15 September 2019

Characterization of Diabetogenic CD8+ T Cells: IMMUNE THERAPY WITH METABOLIC BLOCKADE.

scientific article published on 18 March 2016

Characterization of residual β cell function in long-standing type 1 diabetes.

scientific article published in February 2014

Checkpoint inhibitor-induced insulin-dependent diabetes: an emerging syndrome

scientific article published on 15 March 2019

Circulating Unmethylated Insulin DNA As a Biomarker of Human Beta Cell Death: A Multi-laboratory Assay Comparison

scientific article published on 01 March 2020

Clinical and molecular heterogeneity of familial hyperinsulinism

scientific article published on 01 December 1998

Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors

scientific article published on 24 June 2018

Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes

scientific article published on 24 August 2020

Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/gammac-/-, Balb/c-Rag1-/-gammac-/-, and C.B-17-scid/bg immunodeficient mice

scientific article

Continuous glucose monitoring: long live the revolution!

scientific article

Control of TH17 cells occurs in the small intestine.

scientific article

Defining pathways for development of disease-modifying therapies in children with type 1 diabetes: a consensus report

scientific article

Delayed anti-CD3 therapy in a mouse heart transplant model induced tolerance and long-term survival of allograft: achieving tolerance

scientific article published on 01 November 2013

Detection of β cell death in diabetes using differentially methylated circulating DNA.

scientific article published on 9 November 2011

Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity

scientific article published on 21 March 2007

Does tight glucose control enhance brain sensitivity to low glucose?

scientific article published in February 1991

Drug insight: New immunomodulatory therapies in type 1 diabetes

scientific article published on February 2006

Early and late C-peptide responses during oral glucose tolerance testing are oppositely predictive of type 1 diabetes in autoantibody-positive individuals

scientific article published on 31 January 2020

Effect of rituximab on human in vivo antibody immune responses ⬇️

scientific article published on September 9, 2011

Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes

scientific article published on 01 December 2006

Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes

scientific article published on 21 June 2018

Enhanced anti-serpin antibody activity inhibits autoimmune inflammation in type 1 diabetes

scientific article

Exenatide ER in patients with Type 1 diabetes with and without residual insulin production

scientific article published on 23 June 2020

Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells

scientific article published on 02 August 2007

Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite Type 1 Diabetes TrialNet data

scientific article

Familial hyperinsulinism caused by an activating glucokinase mutation

Familial hyperinsulinism with apparent autosomal dominant inheritance: Clinical and genetic differences from the autosomal recessive variant

scientific article published on 01 January 1998

GAD vaccine reduces insulin loss in recently diagnosed type 1 diabetes: findings from a Bayesian meta-analysis

scientific article

Generation and function of human regulatory CD8+ T cells induced by a humanized OKT3 monoclonal antibody hOKT3gamma1 (Ala-Ala).

scientific article published on 24 September 2008

Genetics, pathogenesis and clinical interventions in type 1 diabetes

scientific article

Glucose and inflammation control islet vascular density and beta-cell function in NOD mice: control of islet vasculature and vascular endothelial growth factor by glucose. ⬇️

scientific article

Glucose counterregulation in patients after pancreatectomy. Comparison with other clinical forms of diabetes

scientific article published in November 1984

Glucose excursions between states of glycemia with progression to type 1 diabetes in the diabetes prevention trial-type 1 (DPT-1).

scientific article

Have we pushed the needle for treatment of Type 1 diabetes?

scientific article published on 6 October 2017

Hepatic glucagon clearance during insulin induced hypoglycemia

scientific article published on 01 July 1986

How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited

scientific article published on May 2011

Human regulatory CD8 T cells

scientific article published on 01 December 2008

Humanized mice as a model for aberrant responses in human T cell immunotherapy.

scientific article published on 18 June 2014

Identification and Analysis of Islet Antigen-Specific CD8+ T Cells with T Cell Libraries

scientific article published on 06 August 2018

Immune Therapy and β-Cell Death in Type 1 Diabetes ⬇️

scientific article published on February 19, 2013

Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients

scientific article published on 21 September 2020

Immunologic and metabolic biomarkers of β-cell destruction in the diagnosis of type 1 diabetes

scientific article published on June 2012

Immunomodulatory activity of humanized anti-IL-7R monoclonal antibody RN168 in subjects with type 1 diabetes

scientific article published on 19 December 2019

Immunomodulatory therapy to preserve pancreatic β-cell function in type 1 diabetes.

scientific article published on June 2011

Increased T cell proliferative responses to islet antigens identify clinical responders to anti-CD20 monoclonal antibody (rituximab) therapy in type 1 diabetes

scientific article

Increasing the accuracy of oral glucose tolerance testing and extending its application to individuals with normal glucose tolerance for the prediction of type 1 diabetes: the Diabetes Prevention Trial-Type 1.

scientific article published in January 2007

Inducing and Administering Tregs to Treat Human Disease

scientific article

Insulin secretion in type 1 diabetes

scientific article published in February 2004

Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials ⬇️

scientific article published on 05 April 2013

Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development.

scientific article published on 11 September 2017

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

scientific article published on 21 November 2019

Irish endocrine society

Islet Harvest in Carbon Monoxide-Saturated Medium for Chronic Pancreatitis Patients Undergoing Islet Autotransplantation

scientific article published on 30 December 2019

Life and death of β cells in Type 1 diabetes: A comprehensive review

scientific article published on 23 March 2016

Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA in New-Onset Type 1 Diabetes

article

Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data

scientific article published on 09 April 2019

MAIT Cells: A Link between Gut Integrity and Type 1 Diabetes

scientific article published in December 2017

Methylation of insulin DNA in response to proinflammatory cytokines during the progression of autoimmune diabetes in NOD mice

scientific article published on 24 February 2016

Microbiota control immune regulation in humanized mice

scientific article published on 2 November 2017

Monitoring of antigen-specific CD8 T cells in patients with type 1 diabetes treated with antiCD3 monoclonal antibodies

scientific article

NKG2A is a marker for acquisition of regulatory function by human CD8+ T cells activated with anti‐CD3 antibody ⬇️

scientific article published on June 6, 2011

Natural history of beta-cell function in type 1 diabetes

scientific article

New and future immunomodulatory therapy in type 1 diabetes ⬇️

scientific article published on February 17, 2012

Oral treatment with foralumab, a fully human anti-CD3 monoclonal antibody, prevents skin xenograft rejection in humanized mice

scientific article

Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes

scientific article published on 18 November 2016

Patterns of metabolic progression to type 1 diabetes in the Diabetes Prevention Trial-Type 1.

scientific article published in March 2006

Precipitation of autoimmune diabetes with anti-PD-1 immunotherapy

scientific article published in April 2015

Prevention of type 1 diabetes: the time has come.

scientific article published on 29 April 2008

Progress and challenges for treating Type 1 diabetes

scientific article published on 17 May 2016

Promotion of beta-cell differentiation in pancreatic precursor cells by adult islet cells

scientific article published on 09 October 2008

RAGE Expression in Human T Cells: A Link between Environmental Factors and Adaptive Immune Responses ⬇️

scientific article published on April 11, 2012

RAGE ligation affects T cell activation and controls T cell differentiation

scientific article published on September 2008

RAGE: a journey from the complications of diabetes to disorders of the nervous system - striking a fine balance between injury and repair.

scientific article

RAGE: exacting a toll on the host in response to polymicrobial sepsis and Listeria monocytogenes

scientific article published on January 2007

Receptor for AGE (RAGE): weaving tangled webs within the inflammatory response.

scientific article published on December 2007

Receptor for advanced glycation end products (RAGE) in a dash to the rescue: inflammatory signals gone awry in the primal response to stress

scientific article published on 18 May 2007

Receptor for advanced glycation end products and its ligands: a journey from the complications of diabetes to its pathogenesis

scientific article

Receptor for advanced glycation end products and its ligands: initiators or amplifiers of joint inflammation--a bit of both?

scientific article published on 01 January 2006

Receptor for advanced glycation end products and the cardiovascular complications of diabetes and beyond: lessons from AGEing

scientific article published on September 2006

Receptor for advanced glycation end products expression on T cells contributes to antigen-specific cellular expansion in vivo

scientific article published on 01 December 2007

Receptor for advanced glycation end products: fundamental roles in the inflammatory response: winding the way to the pathogenesis of endothelial dysfunction and atherosclerosis

scientific article published on April 2008

Regulatory T cells and type 1 diabetes

scientific article published on 01 April 2005

Relapsing and remitting severe hypoglycemia due to a monoclonal anti-insulin antibody heralding a case of multiple myeloma

scientific article published on 16 October 2012

Remission of type 1 diabetes after anti-CD3 antibody treatment and transplantation of embryonic pancreatic precursors

scientific article published on 09 July 2009

Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes

scientific article published on 18 August 2017

Reprogramming human T cell function and specificity with non-viral genome targeting

Reprogramming human T cell function and specificity with non-viral genome targeting

scientific article published in Nature

Rituximab Selectively Suppresses Specific Islet Antibodies ⬇️

scientific article published on August 10, 2011

Rituximab does not reset defective early B cell tolerance checkpoints

scientific article

Role of Interleukin 32 in Human Immunodeficiency Virus Reactivation and Its Link to Human Immunodeficiency Virus-Herpes Simplex Virus Coinfection

scientific article published on 22 December 2016

Slowed Metabolic Decline after One Year of Oral Insulin Treatment among Individuals at High Risk for Type 1 Diabetes in the Diabetes Prevention Trial-Type 1 and TrialNet Oral Insulin Prevention Trials

scientific article published on 21 May 2020

Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells.

scientific article

Specific peripheral B cell tolerance defects in patients with multiple sclerosis

scientific article published on 15 May 2013

Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association

scientific article published on October 2015

Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances

scientific article published on 01 July 2019

Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes-The TrialNet Experience

scientific article published on 16 May 2018

Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation

scientific article published on 31 October 2011

Systematic approach to diagnosis and management of biphasic insulin allergy with local anti-inflammatory agents

scientific article published in June 1989

TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs

scientific article published on 15 September 2005

Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders

scientific article published on 08 July 2013

Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial

scientific article

Teplizumab in Relatives at Risk for Type 1 Diabetes. Reply

scientific article published on 01 November 2019

Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients.

scientific article

Teplizumab preserves C-peptide in recent-onset type 1 diabetes: two-year results from the randomized, placebo-controlled Protégé trial

scientific article published on 25 June 2013

Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial ⬇️

scientific article published on October 21, 2012

The Receptor for Advanced Glycation Endproducts Drives T Cell Survival and Inflammation in Type 1 Diabetes Mellitus.

scientific article published on 21 September 2016

The development and utility of a novel scale that quantifies the glycemic progression toward type 1 diabetes over 6 months

scientific article

The ligand/RAGE axis: lighting the fuse and igniting vascular stress

scientific article

The metabolic progression to type 1 diabetes as indicated by serial oral glucose tolerance testing in the Diabetes Prevention Trial-type 1.

scientific article

The receptor for advanced glycation end products (RAGE) affects T cell differentiation in OVA induced asthma

scientific article

The receptor for advanced glycation endproducts (RAGE) modulates T cell signaling

scientific article published on 28 September 2020

The role of AIRE in human autoimmune disease

scientific article

Thinking bedside at the bench: the NOD mouse model of T1DM.

scientific article published on 27 January 2015

Towards a curative therapy in type 1 diabetes: remission of autoimmunity, maintenance and augmentation of beta cell mass

scientific article published in January 2008

Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice

scientific article

Treatment of Type 1 Diabetes With Anti-CD3 Monoclonal Antibody: Induction of Immune Regulation? ⬇️

scientific article published on January 1, 2003

Treatment of new onset type 1 diabetes with teplizumab: successes and pitfalls in development

scientific article published on March 2014

Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years

scientific article published on 14 May 2009

Treatment of type 1 diabetes with anti-CD3 monoclonal antibody

scientific article published on December 1, 2003

Treatment of type 1 diabetes with anti-T-cell agents: from T-cell depletion to T-cell regulation

scientific article published in August 2004

Treatment of type 1 diabetes with teplizumab: clinical and immunological follow-up after 7 years from diagnosis

scientific article published on 19 December 2018

Two- and Four-Hour Tests Differ in Capture of C-Peptide Responses to a Mixed Meal in Type 1 Diabetes

scientific article published on 13 April 2016

Type 1 Diabetes Immunotherapy: Is the Glass Half Empty or Half Full? ⬇️

scientific article published on August 10, 2011

Type 1 diabetes as a relapsing-remitting disease?

scientific article published on December 2007

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

scientific article published on November 2015

Type 1 diabetes: translating mechanistic observations into effective clinical outcomes

scientific article

Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells

scientific article published on 12 December 2013

Unmethylated Insulin as an Adjunctive Marker of Beta Cell Death and Progression to Type 1 Diabetes in Participants at Risk for Diabetes

scientific article published on 08 August 2019

Use of anti-CD3 monoclonal antibody to induce immune regulation in type 1 diabetes

scientific article

Use of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS) for improving the accuracy of the risk classification of type 1 diabetes

scientific article

Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes.

scientific article published on 12 August 2009

Variable deterioration in cortical function during insulin-induced hypoglycemia

scientific article published in July 1985

β Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice

scientific article published on 4 February 2017

β cell death and dysfunction during type 1 diabetes development in at-risk individuals

scientific article

β cell responses to inflammation

scientific article published on 01 September 2019

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