Search filters

List of works by Frank J. M. van Kuppeveld

(+)RNA viruses rewire cellular pathways to build replication organelles ⬇️

scientific article published on October 1, 2012

A Novel 9-Arylpurine Acts as a Selective Inhibitor of In Vitro Enterovirus Replication Possibly by Targeting Virus Encapsidation

scientific article published in 2010

A Single Point Mutation Creating a Furin Cleavage Site in the Spike Protein Renders Porcine Epidemic Diarrhea Coronavirus Trypsin Independent for Cell Entry and Fusion.

scientific article published on 13 May 2015

A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies

scientific article

A human monoclonal antibody blocking SARS-CoV-2 infection

scientific article (preprint)

A human monoclonal antibody blocking SARS-CoV-2 infection

scientific article published on 04 May 2020

A new inhibitor of apoptosis from vaccinia virus and eukaryotes

scientific article published in February 2007

A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.

scientific article published on 29 July 2013

A proline-rich region in the coxsackievirus 3A protein is required for the protein to inhibit endoplasmic reticulum-to-golgi transport

scientific article

A viral protein that blocks Arf1-mediated COP-I assembly by inhibiting the guanine nucleotide exchange factor GBF1.

scientific article published on August 2006

ACBD3 Is an Essential Pan-enterovirus Host Factor That Mediates the Interaction between Viral 3A Protein and Cellular Protein PI4KB

scientific article published on 12 February 2019

ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells

scientific article

Adaptation of novel H7N9 influenza A virus to human receptors

scientific article published on 28 October 2013

Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry

scientific article published on 28 March 2017

An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets

scientific article published on 21 December 2016

An alphavirus replicon-based vaccine expressing a stabilized Spike antigen induces protective immunity and prevents transmission of SARS-CoV-2 between cats

scientific article published on 20 October 2021

An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication.

scientific article published on August 2016

Antiapoptotic activity of the cardiovirus leader protein, a viral "security" protein

scientific article

Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.

scientific article

Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases

scientific article published on 4 January 2014

Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity.

scientific article published on March 2017

Binding of glutathione to enterovirus capsids is essential for virion morphogenesis

scientific article (publication date: April 2014)

Biological significance of a human enterovirus B-specific RNA element in the 3' nontranslated region.

scientific article

Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIIIβ) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus, and Human Rhinoviruses

scientific article

Breaking pseudo-twofold symmetry in the poliovirus 3'-UTR Y-stem by restoring Watson-Crick base pairs

scientific article

Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility

scientific article

Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP.

scientific article

Building Viral Replication Organelles: Close Encounters of the Membrane Types

scientific article (publication date: October 2016)

Bypassing pan-enterovirus host factor PLA2G16

scientific article published on 18 July 2019

Ca2+-mobilizing agonists increase mitochondrial ATP production to accelerate cytosolic Ca2+ removal: aberrations in human complex I deficiency.

scientific article

Cellular entry of the porcine epidemic diarrhea virus

scientific article

Characterization of Epitope-Specific Anti-Respiratory Syncytial Virus (Anti-RSV) Antibody Responses after Natural Infection and after Vaccination with Formalin-Inactivated RSV

scientific article published on 20 April 2016

Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication

scientific article published on 12 December 2019

Chimeric coxsackie B3 virus genomes that express hybrid coxsackievirus-poliovirus 2B proteins: functional dissection of structural domains involved in RNA replication ⬇️

scientific article published on August 1, 1997

Cholesterol shuttling is important for RNA replication of coxsackievirus B3 and encephalomyocarditis virus.

scientific article published on 10 March 2015

Cholesterol: fa(s)t-food for enterovirus genome replication.

scientific article published on 6 October 2013

Comment on "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome"

scientific article published in Science

Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins

scientific article published on 18 June 2015

Convergent evolution in the mechanisms of ACBD3 recruitment to picornavirus replication sites

scientific article published on 05 August 2019

Coronavirus cell entry occurs through the endo-/lysosomal pathway in a proteolysis-dependent manner.

scientific article

Coronavirus hemagglutinin-esterase and spike proteins co-evolve for functional balance and optimal virion avidity

scientific article published on 06 April 2020

Coronavirus hemagglutinin-esterase and spike proteins coevolve for functional balance and optimal virion avidity

scientific article published on 29 September 2020

Coronavirus receptor switch explained from the stereochemistry of protein-carbohydrate interactions and a single mutation

scientific article published on 16 May 2016

Coxsackie B virus infection of mice: inoculation by the oral route protects the pancreas from damage, but not from infection.

scientific article published on December 2005

Coxsackie B3 virus protein 2B contains cationic amphipathic helix that is required for viral RNA replication.

scientific article published on June 1996

Coxsackievirus B1-induced murine myositis: no evidence for viral persistence

scientific article published in October 1993

Coxsackievirus cloverleaf RNA containing a 5' triphosphate triggers an antiviral response via RIG-I activation

scientific article

Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication

scientific article

Coxsackievirus protein 2B modifies endoplasmic reticulum membrane and plasma membrane permeability and facilitates virus release.

scientific article

Cross-talk between human dendritic cell subsets influences expression of RNA sensors and inhibits picornavirus infection

scientific article published on 20 March 2010

Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans

scientific article published on 26 March 2020

Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans

scientific article published on 16 September 2020

Cytokine and chemokine production by human pancreatic islets upon enterovirus infection

scientific article

Deletion of Cytoplasmic Double-Stranded RNA Sensors Does Not Uncover Viral Small Interfering RNA Production in Human Cells

scientific article

Demonstration of Mycoplasma Contamination in Cell Cultures by a Mycoplasma Group-Specific Polymerase Chain Reaction

article

Detection of Mycoplasma pulmonis in experimentally infected laboratory rats by 16S rRNA amplification

scientific article published on March 1993

Detection of enterovirus RNA in peripheral blood mononuclear cells of type 1 diabetic patients beyond the stage of acute infection.

scientific article published in February 2010

Detection of mycoplasma contamination in cell cultures by a mycoplasma group-specific PCR

scientific article

Determinants for Membrane Association and Permeabilization of the Coxsackievirus 2B Protein and the Identification of the Golgi Complex as the Target Organelle

scientific article published on 18 September 2002

Development and Validation of a S1 Protein-Based ELISA for the Specific Detection of Antibodies against Equine Coronavirus

scientific article published in 2019

Development of a SARS-CoV-2 Total Antibody Assay and the Dynamics of Antibody Response over Time in Hospitalized and Nonhospitalized Patients with COVID-19

scientific article published on 30 October 2020

Differential IFN-alpha/beta production suppressing capacities of the leader proteins of mengovirus and foot-and-mouth disease virus.

scientific article published on 27 October 2009

Differential effects of the putative GBF1 inhibitors Golgicide A and AG1478 on enterovirus replication

scientific article

Differential membrane association properties and regulation of class I and class II Arfs

scientific article

Differential susceptibility and response of primary human myeloid BDCA1(+) dendritic cells to infection with different Enteroviruses

scientific article

Direct PCR enables detection of Mycoplasma pneumoniae in patients with respiratory tract infections

scientific article published on January 1994

Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression

scientific article published on 15 July 2020

Dissecting virus entry: replication-independent analysis of virus binding, internalization, and penetration using minimal complementation of β-galactosidase

scientific article

Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection

scientific article published on 28 August 2020

Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication

scientific article

Echovirus infection causes rapid loss-of-function and cell death in human dendritic cells

scientific article published on 09 February 2007

Effects of picornavirus 3A Proteins on Protein Transport and GBF1-dependent COP-I recruitment.

scientific article

Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine

scientific article published on 27 May 2021

Enterovirus 2Apro targets MDA5 and MAVS in infected cells

scientific article

Enterovirus D68 receptor requirements unveiled by haploid genetics.

scientific article published on 19 January 2016

Enterovirus protein 2B po(u)res out the calcium: a viral strategy to survive?

scientific article

Enterovirus-infected β-cells induce distinct response patterns in BDCA1+ and BDCA3+ human dendritic cells

scientific article published on 25 March 2015

Erratum for Sooksawasdi Na Ayudhya et al., "Enhanced Enterovirus D68 Replication in Neuroblastoma Cells Is Associated with a Cell Culture-Adaptive Amino Acid Substitution in VP1"

scientific article published on 09 December 2020

Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles.

scientific article

Essential Role of Enterovirus 2A Protease in Counteracting Stress Granule Formation and the Induction of Type I Interferon

scientific article published on 01 May 2019

Evolution of the hemagglutinin protein of the new pandemic H1N1 influenza virus: maintaining optimal receptor binding by compensatory substitutions.

scientific article

FMDV leader protease cleaves G3BP1 and G3BP2 and inhibits stress granule formation

scientific article published on 04 January 2019

Fat(al) attraction: Picornaviruses Usurp Lipid Transfer at Membrane Contact Sites to Create Replication Organelles

scientific article published on 22 March 2016

Feline Calicivirus Infection Disrupts Assembly of Cytoplasmic Stress Granules and Induces G3BP1 Cleavage ⬇️

scientific article published on 4 May 2016

Fitness and virulence of a coxsackievirus mutant that can circumnavigate the need for phosphatidylinositol 4-kinase class III beta

scientific article

Fluoxetine Inhibits Enterovirus Replication by Targeting the Viral 2C Protein in a Stereospecific Manner

scientific article published on 31 July 2019

Front Cover: Bithiazole Inhibitors of Phosphatidylinositol 4‐Kinase (PI4KIIIβ) as Broad‐Spectrum Antivirals Blocking the Replication of SARS‐CoV‐2, Zika Virus, and Human Rhinoviruses (ChemMedChem 23/2021)

scientific article

Functional analysis of picornavirus 2B proteins: effects on calcium homeostasis and intracellular protein trafficking.

scientific article published on 23 January 2008

GBF1, a guanine nucleotide exchange factor for Arf, is crucial for coxsackievirus B3 RNA replication

scientific article published on 09 September 2009

GBF1- and ACBD3-independent recruitment of PI4KIIIβ to replication sites by rhinovirus 3A proteins

scientific article published on 19 November 2014

Genetic analysis of a hydrophobic domain of coxsackie B3 virus protein 2B: a moderate degree of hydrophobicity is required for a cis-acting function in viral RNA synthesis

scientific article published on December 1995

Genetic analysis of mengovirus protein 2A: its function in polyprotein processing and virus reproduction ⬇️

scientific article published on January 1, 1998

Genetic analysis ofStreptococcus agalactiaestrains isolated from neonates and their mothers

scientific article published on 01 May 2003

Genus- and species-specific identification of mycoplasmas by 16S rRNA amplification

scientific article published on 01 February 1993

Genus- and species-specific identification of mycoplasmas by 16S rRNA amplification.

scientific article

Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity

scientific article published on 15 February 2017

Homomultimerization of the coxsackievirus 2B protein in living cells visualized by fluorescence resonance energy transfer microscopy

scientific article

Host factor prioritization for pan-viral genetic perturbation screens using random intercept models and network propagation

scientific article published on 10 February 2020

Human Golgi antiapoptotic protein modulates intracellular calcium fluxes

scientific article

Human coronaviruses OC43 and HKU1 bind to 9--acetylated sialic acids via a conserved receptor-binding site in spike protein domain A

scientific article

Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions

scientific article published on 13 July 2022

Identification and characterization of a proteolytically primed form of the murine coronavirus spike proteins after fusion with the target cell.

scientific article

Identification of Residues That Affect Oligomerization and/or Enzymatic Activity of Influenza Virus H5N1 Neuraminidase Proteins

scientific article published on 10 August 2016

Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication

scientific article

Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells

scientific article published on 18 February 2014

Identification of fukinolic acid from Cimicifuga heracleifolia and its derivatives as novel antiviral compounds against enterovirus A71 infection

scientific article published on 29 July 2018

Identification of potential recombination breakpoints in human parechoviruses

scientific article published on 28 January 2009

Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein.

scientific article published on 18 September 2017

Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus

scientific article published on 13 August 2019

Illuminating the Sites of Enterovirus Replication in Living Cells by Using a Split-GFP-Tagged Viral Protein

scientific article published on 6 July 2016

Immunologic defects in severe mucocutaneous HSV-2 infections: Response to IFN-γ therapy

scientific article published on 7 April 2016

Immunometabolism pathways as the basis for innovative anti-viral strategies (INITIATE): A Marie Sklodowska-Curie innovative training network

scientific article published on 27 July 2020

In silico structure-based design and synthesis of novel anti-RSV compounds

scientific article published on 8 August 2015

Induction and suppression of innate antiviral responses by picornaviruses

scientific article published on 18 July 2014

Inhibition of mRNA export and dimerization of interferon regulatory factor 3 by Theiler's virus leader protein

scientific article published on January 2009

Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association

scientific article published on 20 July 2020

Integrative Genomics-Based Discovery of Novel Regulators of the Innate Antiviral Response

scientific article published on 20 October 2015

Interactions between viral and prokaryotic pathogens in a mixed infection with cardiovirus and mycoplasma

scientific article

Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice

scientific article published on 03 August 2018

Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence

scientific article published on 01 January 2019

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

scientific article published on 20 February 2018

Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein

scientific article

Kinetic analysis of the influenza A virus HA/NA balance reveals contribution of NA to virus-receptor binding and NA-dependent rolling on receptor-containing surfaces

scientific article published on 13 August 2018

Knockout of cGAS and STING Rescues Virus Infection of Plasmid DNA-Transfected Cells

scientific article published on 26 August 2015

Lipid Droplets Grease Enterovirus Replication

scientific article published on 01 August 2019

MDA5 Localizes to Stress Granules, but This Localization Is Not Required for the Induction of Type I Interferon ⬇️

scientific article published on March 27, 2013

MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells.

scientific article

Manipulation of the porcine epidemic diarrhea virus genome using targeted RNA recombination

scientific article

Mengovirus leader is involved in the inhibition of host cell protein synthesis

scientific article published on August 1996

Mengovirus-induced rearrangement of the nuclear pore complex: hijacking cellular phosphorylation machinery

scientific article published on 14 January 2009

Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses

scientific article

Modification of picornavirus genomic RNA using 'click' chemistry shows that unlinking of the VPg peptide is dispensable for translation and replication of the incoming viral RNA.

scientific article

Modulation of proteolytic polyprotein processing by coxsackievirus mutants resistant to inhibitors targeting phosphatidylinositol-4-kinase IIIβ or oxysterol binding protein

scientific article published on 9 October 2017

Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus

scientific article published on 25 September 2015

Molecular basis for the acid-initiated uncoating of human enterovirus D68.

scientific article published on 10 December 2018

Molecular determinants of the interaction between coxsackievirus protein 3A and guanine nucleotide exchange factor GBF1

scientific article published on 28 February 2007

Mouse Hepatitis Coronavirus RNA Replication Depends on GBF1-Mediated ARF1 Activation

scientific article (publication date: 13 June 2008)

Multimerization reactions of coxsackievirus proteins 2B, 2C and 2BC: a mammalian two-hybrid analysis

scientific article published in April 2002

Mutagenesis of the coxsackie B3 virus 2B/2C cleavage site: determinants of processing efficiency and effects on viral replication

scientific article

Mutation of the Second Sialic Acid-Binding Site, Resulting in Reduced Neuraminidase Activity, Preceded the Emergence of H7N9 Influenza A Virus

scientific article

Mutation of the second sialic acid-binding site of influenza A virus neuraminidase drives compensatory mutations in hemagglutinin

scientific article published on 27 August 2020

Mutational analysis of different regions in the coxsackievirus 2B protein: requirements for homo-multimerization, membrane permeabilization, subcellular localization, and virus replication.

scientific article published on 18 February 2004

Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein

scientific article published on 11 May 2016

Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307.

scientific article published on 23 February 2009

Neurotropism of Saffold virus in a mouse model.

scientific article

No evidence for viral small RNA production and antiviral function of Argonaute 2 in human cells

scientific article published on 24 September 2019

Novel 9-Arylpurines, as Selective Inhibitors of In Vitro Enterovirus Replication

scientific article published in 2009

Nucleocytoplasmic traffic disorder induced by cardioviruses.

scientific article

Origins of Enterovirus Replication Organelles Established by Whole-Cell Electron Microscopy

scientific article published on 11 June 2019

PDTC inhibits picornavirus polyprotein processing and RNA replication by transporting zinc ions into cells

scientific article published on April 2007

PLA2G16 represents a switch between entry and clearance of Picornaviridae

scientific journal article

Phagocytosis of enterovirus-infected pancreatic beta-cells triggers innate immune responses in human dendritic cells.

scientific article

Phagocytosis of picornavirus-infected cells induces an RNA-dependent antiviral state in human dendritic cells

scientific article

Picornavirus infection induces temporal release of multiple extracellular vesicle subsets that differ in molecular composition and infectious potential

article

Polyadenylation of genomic RNA and initiation of antigenomic RNA in a positive-strand RNA virus are controlled by the same cis-element

scientific article

Posaconazole inhibits dengue virus replication by targeting oxysterol-binding protein

scientific article published on 03 July 2018

Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort

scientific article

Protein synthesis persists during necrotic cell death

scientific article published on 7 February 2005

Proteolytic activation of the porcine epidemic diarrhea coronavirus spike fusion protein by trypsin in cell culture

scientific article published on 7 May 2014

Publisher Correction: A human monoclonal antibody blocking SARS-CoV-2 infection

scientific article published on 14 May 2020

Publisher Correction: The life cycle of non-polio enteroviruses and how to target it.

scientific article

Random mutagenesis defines a domain of Theiler's virus leader protein that is essential for antagonism of nucleocytoplasmic trafficking and cytokine gene expression

scientific article published on 26 August 2009

Rapid Emergence of Highly Pathogenic Avian Influenza Subtypes from a Subtype H5N1 Hemagglutinin Variant

scientific article published on May 2015

Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C

scientific article published on 06 November 2020

Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics.

scientific article published on 24 June 2015

Recruitment of PI4KIIIβ to coxsackievirus B3 replication organelles is independent of ACBD3, GBF1, and Arf1.

scientific article

Reduction of phospholipase D activity during coxsackievirus infection.

scientific article published on November 2007

Replication and Inhibitors of Enteroviruses and Parechoviruses

scientific article

Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface.

scientific article published on 12 November 2014

Rhinovirus-induced calcium flux triggers NLRP3 and NLRC5 activation in bronchial cells

scientific article published on December 2013

Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus ⬇️

scientific article published on 28 December 2017

SARS-CoV-2 Neutralizing Human Antibodies Protect Against Lower Respiratory Tract Disease in a Hamster Model

scientific article

SARS-CoV-2 mucosal antibody development and persistence and their relation to viral load and COVID-19 symptoms

scientific article published on 23 September 2021

Saffold cardiovirus and multiple sclerosis: no evidence for an association

scientific article published on 23 July 2014

Saffold virus, a human Theiler's-like cardiovirus, is ubiquitous and causes infection early in life

scientific article published in May 2009

Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C

scientific article (publication date: May 2016)

Second sialic acid-binding site of influenza A virus neuraminidase: Binding receptors for efficient release

scientific article published on 14 December 2020

Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enteroviruses B and D by targeting viral protein 2C.

scientific article published on 18 January 2013

Sensing of latent EBV infection through exosomal transfer of 5'pppRNA

scientific article published on 14 January 2016

Seroepidemiology of Saffold cardiovirus type 2.

scientific article published in August 2011

Serologic Screening of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Cats and Dogs during First Coronavirus Disease Wave, the Netherlands

scientific article published on 01 May 2021

Serological Screening for Coronavirus Infections in Cats

scientific article published on 13 August 2019

Serological screening of influenza A virus antibodies in cats and dogs indicates frequent infection with different subtypes

scientific article published on 02 September 2020

Sialic acid-dependent cell entry of human enterovirus D68.

scientific article

Small molecule ISRIB suppresses the integrated stress response within a defined window of activation

article published in the Proceedings of the National Academy of Sciences of the United States of America

Stress granules regulate double-stranded RNA-dependent protein kinase activation through a complex containing G3BP1 and Caprin1.

scientific article published on 17 March 2015

Structural and functional characterization of the coxsackievirus B3 CRE(2C): role of CRE(2C) in negative- and positive-strand RNA synthesis

scientific article published on January 2006

Structural and functional integrity of the coxsackievirus B3 oriR: spacing between coaxial RNA helices

scientific article published on 01 March 2006

Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11

scientific article

Structure and Genome Release Mechanism of the Human Cardiovirus Saffold Virus 3

scientific article published on 08 June 2016

Structure of the pyrimidine-rich internal loop in the poliovirus 3'-UTR: the importance of maintaining pseudo-2-fold symmetry in RNA helices containing two adjacent non-canonical base-pairs

scientific article

Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP)

scientific article published on 26 May 2018

Structure-function analysis of the coxsackievirus protein 3A: identification of residues important for dimerization, viral rna replication, and transport inhibition.

scientific article published on 25 July 2006

Studies towards the potential of poliovirus as a vector for the expression of HPV 16 virus-like-particles.

scientific article

Substrate Binding by the Second Sialic Acid-Binding Site of Influenza A Virus N1 Neuraminidase Contributes to Enzymatic Activity

scholarly article by Wenjuan Du published in October 2018

Synergistic antiviral activity of gemcitabine and ribavirin against enteroviruses

scientific article published on 22 October 2015

Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors

scientific article published on 29 March 2020

Synthesis and biological properties of novel brefeldin A analogues

scientific article published on 8 July 2013

Targeting of the hydrophobic metabolome by pathogens.

scientific article

The 2nd sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance.

scientific article published on 10 June 2019

The Crystal Structure of a Cardiovirus RNA-Dependent RNA Polymerase Reveals an Unusual Conformation of the Polymerase Active Site

scientific article

The Origin, Dynamic Morphology, and PI4P-Independent Formation of Encephalomyocarditis Virus Replication Organelles.

scientific article published on 17 April 2018

The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family

scientific article

The coxsackievirus 2B protein increases efflux of ions from the endoplasmic reticulum and Golgi, thereby inhibiting protein trafficking through the Golgi

scientific article published on 15 March 2006

The coxsackievirus 2B protein suppresses apoptotic host cell responses by manipulating intracellular Ca2+ homeostasis.

scientific article published on 19 February 2004

The life cycle of non-polio enteroviruses and how to target it

scientific article published on 01 June 2018

The mengovirus leader protein blocks interferon-α/β gene transcription and inhibits activation of interferon regulatory factor 3

article

The mengovirus leader protein suppresses alpha/beta interferon production by inhibition of the iron/ferritin-mediated activation of NF-kappa B.

scientific article published on October 2002

The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies

scientific article

The structure-function relationship of the enterovirus 3'-UTR.

scientific article published on 30 August 2008

The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C.

scientific article published on 12 March 2008

The transformation of enterovirus replication structures: a three-dimensional study of single- and double-membrane compartments

scientific article

There is no evidence for persistent enterovirus infections in chronic medical conditions in humans

article

Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein

scientific article published on 01 January 2019

Trans-complementation of a genetic defect in the coxsackie B3 virus 2B protein

scientific article published on February 2002

Translation and Replication Dynamics of Single RNA Viruses

scientific article published on 06 November 2020

Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα.

scientific article published on August 2016

Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307.

scientific article published on 11 January 2017

Unusual loop-sequence flexibility of the proximal RNA replication element in EMCV

scientific article

Viral reorganization of the secretory pathway generates distinct organelles for RNA replication

scientific article

XMRV and CFS--the sad end of a story

scientific article published on 21 June 2011

Paulina is supported by:

About Paulina

Help