List of works by Jonathan W Yewdell

A Simple Flow-Cytometric Method Measuring B Cell Surface Immunoglobulin Avidity Enables Characterization of Affinity Maturation to Influenza A Virus.

scientific article published on 4 August 2015

All roads lead to "ome": defining the DRiPome

scientific article published on 01 June 2012

Amsterdamming DRiPs

scientific article published on 23 December 2012

Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin

scientific article published on February 2013

Antibodies to PB1-F2 protein are induced in response to influenza A virus infection

scientific article published on 12 August 2009

Antibody pressure by a human monoclonal antibody targeting the 2009 pandemic H1N1 virus hemagglutinin drives the emergence of a virus with increased virulence in mice

scientific article

Antigen processing and recognition

scientific article published on 01 February 2003

Applying the ribopuromycylation method to detect nuclear translation

scientific article

Autoimmune T cell recognition of alternative-reading-frame-encoded peptides

scientific article published on April 2017

Back to the fold: T cell recognition of HFE, a MHC class Ib molecule that regulates iron metabolism

scientific article

Biogenesis of influenza a virus hemagglutinin cross-protective stem epitopes

scientific article (publication date: June 2014)

CD8 alpha alpha-mediated intraepithelial lymphocyte snatching of thymic leukemia MHC class Ib molecules in vitro and in vivo

scientific article published on August 2006

CD8+ T cell cross-priming via transfer of proteasome substrates

scientific article published on May 2004

CXCR3 chemokine receptor enables local CD8(+) T cell migration for the destruction of virus-infected cells

scientific article

Caught in the act: intravital multiphoton microscopy of host-pathogen interactions

scientific article

Characterization of rapidly degraded polypeptides in mammalian cells reveals a novel layer of nascent protein quality control

scientific article published in November 2005

Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells.

scientific article published on 31 October 2011

Comment on "Large-scale sequence analysis of avian influenza isolates".

scientific article published in September 2006

Comparative immunopeptidomics of humans and their pathogens

scholarly article

Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action.

scientific article

Confronting complexity: real-world immunodominance in antiviral CD8+ T cell responses

scientific article published on October 2006

Correction: Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs.

scientific article published on 20 June 2018

Cross-priming of CD8+ T cells by viral and tumor antigens is a robust phenomenon.

scientific article published in January 2004

Cutting edge: MHC class I-Ly49 interaction regulates neuronal function.

scientific article published on May 2008

Cutting edge: Sympathetic nervous system increases proinflammatory cytokines and exacerbates influenza A virus pathogenesis

scientific article

Cysteinyl-tRNA deacylation can be uncoupled from protein synthesis

scientific article

DRiPs solidify: progress in understanding endogenous MHC class I antigen processing

scientific article

Defective ribosomal products are the major source of antigenic peptides endogenously generated from influenza A virus neuraminidase

scientific article

Defining B cell immunodominance to viruses

scientific article published on 13 February 2017

Defining Viral Defective Ribosomal Products: Standard and Alternative Translation Initiation Events Generate a Common Peptide from Influenza A Virus M2 and M1 mRNAs

scientific article published on 25 March 2016

Defining influenza A virus hemagglutinin antigenic drift by sequential monoclonal antibody selection

scientific article published on March 2013

Designing CD8+ T cell vaccines: it's not rocket science (yet).

scientific article published on 04 May 2010

Determining Ribosome Translational Status by Ribo-ELISA.

scientific article published in January 2018

Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes

scientific article published on 13 January 2008

Dissection of the interaction of the human cytomegalovirus-derived US2 protein with major histocompatibility complex class I molecules: prominent role of a single arginine residue in human leukocyte antigen-A2.

scientific article published on February 2006

Distinct pathways generate peptides from defective ribosomal products for CD8+ T cell immunosurveillance

scientific article

Don't mess with ERAAP!

scientific article published on 18 May 2012

Editorial overview: Antigen processing and presentation: Where cellular immunity begins

scientific article published on 8 May 2015

Editorial overview: Viral immunology: Dealing with bad news

scientific article

Editorial: Proteostenosis: cancer's Achilles heel?

scientific article published on November 2012

Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent

scientific article published on 14 September 2009

Emetine optimally facilitates nascent chain puromycylation and potentiates the ribopuromycylation method (RPM) applied to inert cells

scientific article published on 11 December 2012

Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters

scientific article

Enhancing responses to cancer immunotherapy

scientific article

Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia

scientific article

Fitness costs limit influenza A virus hemagglutinin glycosylation as an immune evasion strategy.

scientific article published on 21 November 2011

Flow cytometry reveals that H5N1 vaccination elicits cross-reactive stem-directed antibodies from multiple Ig heavy-chain lineages.

scientific article published on 05 February 2014

Flow-Cytometric Method Measuring B Cell Surface Immunoglobulin Avidity

scientific article published on January 2017

Flu DRiPs in MHC Class I Immunosurveillance

scientific article published on 19 November 2018

From optical bench to cageside: intravital microscopy on the long road to rational vaccine design

scientific article

Fusion proteins with COOH-terminal ubiquitin are stable and maintain dual functionality in vivo

scientific article published on 05 August 2002

Getting to the heart of influenza

scientific article published on June 2013

Glycosylation focuses sequence variation in the influenza A virus H1 hemagglutinin globular domain.

scientific article

Going Pro to enhance T-cell immunogenicity: easy as π?

scientific article published on 24 October 2013

Greasing the SCIDs for universal flu antibodies

scientific article published on July 2013

HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation

scientific article

HLA-A*0201, HLA-A*1101, and HLA-B*0702 transgenic mice recognize numerous poxvirus determinants from a wide variety of viral gene products.

scientific article published in October 2005

Heat-aggregated noninfectious influenza virus induces a more balanced CD8(+)-T-lymphocyte immunodominance hierarchy than infectious virus

scientific article

Hemagglutinin receptor binding avidity drives influenza A virus antigenic drift

scientific article

Heterosubtypic immunity to influenza A virus: where do we stand?

scientific article

Host versus flu: antibodies win a round?

scientific article published on March 2013

How to succeed in science: a concise guide for young biomedical scientists. Part I: taking the plunge

scientific article published on May 2008

How to succeed in science: a concise guide for young biomedical scientists. Part II: making discoveries

scientific article published on 10 April 2008

I've got algorithm: predicting tumor and autoimmune peptide targets for CD8+ T cells

scientific article published on 14 November 2016

Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines

scientific article

Immune recognition of a human renal cancer antigen through post-translational protein splicing.

scientific article published on January 2004

Immunodominance in TCD8+ responses to viruses: cell biology, cellular immunology, and mathematical models

scientific article published on 01 August 2004

Immunology. Hide and seek in the peptidome

scientific article published in September 2003

Immunology: Cross-dressers turn on T cells

scientific article published in March 2011

Immunoproteasomes: regulating the regulator

scientific article

Immunoribosomes: Where's there's fire, there's fire

scientific article published on 17 January 2018

Influenza A Virus Negative Strand RNA Is Translated for CD8 T Cell Immunosurveillance

scholarly article by Heather D Hickman et al published 15 August 2018 in Journal of Immunology

Influenza A virus hemagglutinin antibody escape promotes neuraminidase antigenic variation and drug resistance

scientific article

Influenza A virus hemagglutinin specific antibodies interfere with virion neuraminidase activity via two distinct mechanisms.

scientific article published on 5 November 2016

Influenza A virus hemagglutinin trimerization completes monomer folding and antigenicity

scientific article published on 03 July 2013

Influenza A virus nucleoprotein selectively decreases neuraminidase gene-segment packaging while enhancing viral fitness and transmissibility

scientific article

Influenza virus still surprises.

scientific article

Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens

scientific article published on 15 August 2017

Inhibitory effects of cytomegalovirus proteins US2 and US11 point to contributions from direct priming and cross-priming in induction of vaccinia virus-specific CD8(+) T cells

scientific article published in June 2002

Innate immune and chemically triggered oxidative stress modifies translational fidelity.

scientific article

Inside the professionals

scientific article published in Nature

Intranasal live influenza vaccine priming elicits localized B cell responses in mediastinal lymph nodes

scientific article published on 14 February 2018

Is It Possible to Develop a "Universal" Influenza Virus Vaccine? Outflanking Antibody Immunodominance on the Road to Universal Influenza Vaccination

scientific article published on 29 June 2017

Localization of influenza virus proteins to nuclear dot 10 structures in influenza virus-infected cells

scientific article published in May 2003

Locally Produced IL-10 Limits Cutaneous Vaccinia Virus Spread

scientific article

MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines

scientific article

MHC class I antigen processing distinguishes endogenous antigens based on their translation from cellular vs. viral mRNA.

scientific article

Making sense of mass destruction: quantitating MHC class I antigen presentation

scientific article published on December 2003

Measles immunometrics

scientific article

Mice deficient in perforin, CD4+ T cells, or CD28-mediated signaling maintain the typical immunodominance hierarchies of CD8+ T-cell responses to influenza virus

scientific article

Mild acid treatment induces cross-reactivity of 4H84 monoclonal antibody specific to nonclassical HLA-G antigen with classical HLA class I molecules

scientific article published on 01 February 2003

Mining the plasma immunopeptidome for cancer peptides as biomarkers and beyond ⬇️

scientific article published on October 25, 2010

Mixed proteasomes function to increase viral peptide diversity and broaden antiviral CD8+ T cell responses

scientific article published on 24 May 2013

Monitoring cotranslational protein folding in mammalian cells at codon resolution

scientific article

Monoclonal antibodies specific for discontinuous epitopes direct refolding of influenza A virus hemagglutinin

scientific article published on 4 January 2010

Monocytes, viruses and metaphors: hanging the Trojan horse

scientific article published in May 2012

Most influenza a virions fail to express at least one essential viral protein

scientific article published on 2 January 2013

Murine norovirus infection has no significant effect on adaptive immunity to vaccinia virus or influenza A virus

scientific article published on 29 April 2009

New lane in the information highway: alternative reading frame peptides elicit T cells with potent antiretrovirus activity

scientific article

Nuclear translation for immunosurveillance

scientific article published on 18 October 2013

Nuclear translation visualized by ribosome-bound nascent chain puromycylation.

scientific article

Out with the old, in with the new? Comparing methods for measuring protein degradation

scientific article

Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells

scientific article

Peptide secretion triggers diabetes

scientific article published in Nature

Plumbing the sources of endogenous MHC class I peptide ligands

scientific article published on 30 November 2006

Positional bias of MHC class I restricted T-cell epitopes in viral antigens is likely due to a bias in conservation

scientific article

Poxvirus CD8+ T-cell determinants and cross-reactivity in BALB/c mice

scientific article

Proteasomes get by with lots of help from their friends

scientific article published on April 2004

Protein Translation Activity: A New Measure of Host Immune Cell Activation

scientific article published on 6 July 2016

Quantitating Defective Ribosome Products

scientific article published on 01 January 2005

Quantitating T cell cross-reactivity for unrelated peptide antigens

scientific article (publication date: October 2009)

Quantitating protein synthesis, degradation, and endogenous antigen processing

scientific article published on March 2003

Que sera, sera: evolution of the swine H1N1 influenza A virus

scientific article

RNA Polymerase II Inhibitors Dissociate Antigenic Peptide Generation from Normal Viral Protein Synthesis: A Role for Nuclear Translation in Defective Ribosomal Product Synthesis? ⬇️

scientific article published on November 3, 2010

RNA binding targets aminoacyl-tRNA synthetases to translating ribosomes.

scientific article

Reactivation of stalled polyribosomes in synaptic plasticity

scientific article published on 16 September 2013

Reassortment complements spontaneous mutation in influenza A virus NP and M1 genes to accelerate adaptation to a new host

scientific article published on 30 January 2013

Recycling CD1d1 molecules present endogenous antigens processed in an endocytic compartment to NKT cells.

scientific article

Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities.

scientific article published in March 2005

Reversal in the immunodominance hierarchy in secondary CD8+ T cell responses to influenza A virus: roles for cross-presentation and lysis-independent immunodomination

scientific article

Self-reporting peptides illuminate the MHC groove

scientific article published on 01 April 2007

Structure and accessibility of HA trimers on intact 2009 H1N1 pandemic influenza virus to stem region-specific neutralizing antibodies

scientific article

Sympathetic nervous system control of anti-influenza CD8+ T cell responses

scholarly article

Systematic search fails to detect immunogenic MHC class-I-restricted determinants encoded by influenza A virus noncoding sequences

scientific article published in January 2003

T cells bite the hand that feeds them

scientific article published on 01 June 2003

Terminal deoxynucleotidyl transferase establishes and broadens antiviral CD8+ T cell immunodominance hierarchies

scientific article

The DRiP hypothesis decennial: support, controversy, refinement and extension

scientific article published on 11 July 2006

The RiboPuromycylation Method (RPM): an Immunofluorescence Technique to Map Translation Sites at the Sub-cellular Level.

scientific article

The TL MHC class Ib molecule has only marginal effects on the activation, survival and trafficking of mouse small intestinal intraepithelial lymphocytes

scientific article published on 09 August 2004

The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation

scientific article published on June 2008

The influenza A virus PB1-F2 protein targets the inner mitochondrial membrane via a predicted basic amphipathic helix that disrupts mitochondrial function

scientific article

The latest killer AP

The seven dirty little secrets of major histocompatibility complex class I antigen processing

scientific article

Tight linkage between translation and MHC class I peptide ligand generation implies specialized antigen processing for defective ribosomal products

scientific article published on July 2006

To DRiP or not to DRiP: generating peptide ligands for MHC class I molecules from biosynthesized proteins

scientific article

To dream the impossible dream: universal influenza vaccination

scientific article published on June 2013

Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors.

scientific article published on 14 February 2014

Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands

scientific article published on 17 March 2011

Ubiquitous Autofragmentation of Fluorescent Proteins Creates Abundant Defective Ribosomal Products (DRiPs) for Immunosurveillance

scientific article published on 13 May 2015

Understanding presentation of viral antigens to CD8+ T cells in vivo: the key to rational vaccine design

scientific article

Unexpected role for the immunoproteasome subunit LMP2 in antiviral humoral and innate immune responses

scientific article

Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques

Vaccinia and influenza A viruses select rather than adjust tRNAs to optimize translation.

scientific article published on 18 December 2012

Varied Role of Ubiquitylation in Generating MHC Class I Peptide Ligands.

scientific article published on 31 March 2017

Viral alteration of cellular translational machinery increases defective ribosomal products

scientific article published on 25 April 2007

Viral infection triggers rapid differentiation of human blood monocytes into dendritic cells

scientific article published on 6 February 2012

Viral interference with antigen presentation

scientific article

Virology. Frameshifting to PA-X influenza

scientific article

Viruses in control of the immune system. Workshop on molecular mechanisms of immune modulation: lessons from viruses

scientific article published in October 2002

Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo

scientific article published on 4 February 2002

Viva la revolución: rethinking influenza a virus antigenic drift

scientific article published on September 2011

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

scientific article

Youth has its privileges: maturation inhibits DC cross-priming

scientific article published on 01 February 2006

mTORC1 links protein quality and quantity control by sensing chaperone availability

scientific article

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