List of works - Robert J Gorelick

6th international symposium on retroviral nucleocapsid

scientific article published on 25 February 2008

A Guanosine-Centric Mechanism for RNA Chaperone Function ⬇️

scientific article published on March 7, 2013

A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA.

scientific article published on 24 September 2012

A succession of mechanisms stimulate efficient reconstituted HIV-1 minus strand strong stop DNA transfer

scientific article

Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues

scientific article

Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors

scientific article

Amino-terminal region of the human immunodeficiency virus type 1 nucleocapsid is required for human APOBEC3G packaging

scientific article

An immature retroviral RNA genome resembles a kinetically trapped intermediate state

scientific article

Architecture and secondary structure of an entire HIV-1 RNA genome

scientific article

Aromatic residue mutations reveal direct correlation between HIV-1 nucleocapsid protein's nucleic acid chaperone activity and retroviral replication

scientific article published on 16 July 2012

Blocking premature reverse transcription fails to rescue the HIV-1 nucleocapsid-mutant replication defect ⬇️

scientific article published on June 17, 2011

C-terminal domain modulates the nucleic acid chaperone activity of human T-cell leukemia virus type 1 nucleocapsid protein via an electrostatic mechanism

scientific article

Characterization of human immunodeficiency virus type 1 (HIV-1) containing mutations in the nucleocapsid protein at a putative HIV-1 protease cleavage site

scientific article published on 9 August 2006

Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo

scientific article published on 8 February 2016

Coassembly and complementation of Gag proteins from HIV-1 and HIV-2, two distinct human pathogens.

scientific article published in July 2006

Cofactors for human immunodeficiency virus type 1 cDNA integration in vitro

scientific article

Comparison of SIV and HIV-1 Genomic RNA Structures Reveals Impact of Sequence Evolution on Conserved and Non-Conserved Structural Motifs ⬇️

scientific article published on April 4, 2013

Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides

scientific article

Corrigendum: Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.

scientific article published on 23 March 2016

Definition of a high-affinity Gag recognition structure mediating packaging of a retroviral RNA genome.

scientific article

Differential contribution of basic residues to HIV-1 nucleocapsid protein's nucleic acid chaperone function and retroviral replication

scientific article

Differing roles of the N- and C-terminal zinc fingers in human immunodeficiency virus nucleocapsid protein-enhanced nucleic acid annealing

scientific article published on 3 June 2003

Dimeric RNA recognition regulates HIV-1 genome packaging

scientific article

Discovery of small-molecule human immunodeficiency virus type 1 entry inhibitors that target the gp120-binding domain of CD4.

scientific article

Distinct nucleic acid interaction properties of HIV-1 nucleocapsid protein precursor NCp15 explain reduced viral infectivity

scientific article

Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation ⬇️

scientific article

Efficiency of human immunodeficiency virus type 1 postentry infection processes: evidence against disproportionate numbers of defective virions

scientific article published on 31 January 2007

Elimination of protease activity restores efficient virion production to a human immunodeficiency virus type 1 nucleocapsid deletion mutant

scientific article

Elimination of retroviral infectivity by N-ethylmaleimide with preservation of functional envelope glycoproteins

scientific article

Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions

scientific article

Factors that determine the efficiency of HIV-1 strand transfer initiated at a specific site

scientific article

Features, processing states, and heterologous protein interactions in the modulation of the retroviral nucleocapsid protein function

scientific article

Femtomole SHAPE Reveals Regulatory Structures in the Authentic XMRV RNA Genome ⬇️

scientific article published on November 29, 2011

Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein

scientific article published on 21 January 2009

Frontiers of Retrovirology 2011, Amsterdam, The Netherlands, 3-5 October 2011. Meeting Abstracts

Functional complementation of nucleocapsid and late domain PTAP mutants of human immunodeficiency virus type 1 during replication.

scientific article published on 19 March 2008

Fundamental differences between the nucleic acid chaperone activities of HIV-1 nucleocapsid protein and Gag or Gag-derived proteins: biological implications

scientific article

G-quartets direct assembly of HIV-1 nucleocapsid protein along single-stranded DNA.

scientific article

Gag-dependent enrichment of HIV-1 RNA near the uropod membrane of polarized T cells

scientific article published on 21 August 2013

Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA

scientific article (publication date: 2012)

HIV-1 Nucleocapsid Protein Increases Strand Transfer Recombination by Promoting Dimeric G-quartet Formation ⬇️

scientific article published on July 7, 2011

HIV-1 inactivation by 4-vinylpyridine is enhanced by dissociating Zn(2+) from nucleocapsid protein

scientific article published on 4 March 2008

HIV-1 protease and reverse transcriptase control the architecture of their nucleocapsid partner

scientific article (publication date: 2007)

High recombination potential of subtype A HIV-1.

scientific article published on 8 July 2015

High-throughput SHAPE analysis reveals structures in HIV-1 genomic RNA strongly conserved across distinct biological states

scientific article published on April 2008

Human T-cell lymphotropic virus type 1 nucleocapsid protein-induced structural changes in transactivation response DNA hairpin measured by single-molecule fluorescence resonance energy transfer

scientific article published on October 2008

Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs.

scientific article

Human cellular nucleic acid-binding protein Zn2+ fingers support replication of human immunodeficiency virus type 1 when they are substituted in the nucleocapsid protein

scientific article

Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration

scientific article

Human immunodeficiency virus type 1 nucleocapsid zinc-finger mutations cause defects in reverse transcription and integration

scientific article published on 19 June 2006

Human immunodeficiency virus type 1 nucleocapsid zn(2+) fingers are required for efficient reverse transcription, initial integration processes, and protection of newly synthesized viral DNA.

scientific article

Interactions of murine APOBEC3 and human APOBEC3G with murine leukemia viruses

scientific article published on 30 April 2008

Mechanistic differences between HIV-1 and SIV nucleocapsid proteins and cross-species HIV-1 genomic RNA recognition

scientific article published on 29 December 2016

Mechanistic insights into the kinetics of HIV-1 nucleocapsid protein-facilitated tRNA annealing to the primer binding site

scientific article published on April 2004

Minimal Contribution of APOBEC3-Induced G-to-A Hypermutation to HIV-1 Recombination and Genetic Variation

scientific article

Modulation of the HIV nucleocapsid dynamics finely tunes its RNA-binding properties during virion genesis

article

Molecular determinants of HIV-1 NCp7 chaperone activity in maturation of the HIV-1 dimerization initiation site ⬇️

scientific article published on December 28, 2012

Mutational analysis of the C-terminal gag cleavage sites in human immunodeficiency virus type 1

scientific article

Mutations in human immunodeficiency virus type 1 nucleocapsid protein zinc fingers cause premature reverse transcription

scientific article published on 30 July 2008

Noninfectious papilloma virus-like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27.

scientific article published on 26 October 2006

Nucleic acid binding and chaperone properties of HIV-1 Gag and nucleocapsid proteins

scientific article

Nucleocapsid protein function in early infection processes

scientific article published on 14 February 2008

Nucleotide excision repair and template-independent addition by HIV-1 reverse transcriptase in the presence of nucleocapsid protein

scientific article published on 23 February 2006

Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase 2b Trial

article

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection

article

Rapid kinetics of protein-nucleic acid interaction is a major component of HIV-1 nucleocapsid protein's nucleic acid chaperone function

article

Retroviral nucleocapsid proteins display nonequivalent levels of nucleic acid chaperone activity

scientific article published on 06 August 2008

Retrovirus-specific differences in matrix and nucleocapsid protein-nucleic acid interactions: implications for genomic RNA packaging

scientific article

Role of the Reverse Transcriptase, Nucleocapsid Protein, and Template Structure in the Two-step Transfer Mechanism in Retroviral Recombination

scientific article published on 11 June 2003

Role of the zinc fingers of HIV-1 nucleocapsid protein in maturation of genomic RNA.

scientific article published in November 2003

Secondary structure of the mature ex virio Moloney murine leukemia virus genomic RNA dimerization domain

scientific article

Selection of fully processed HIV-1 nucleocapsid protein is required for optimal nucleic acid chaperone activity in reverse transcription

scientific article

Sequence and structural determinants of human APOBEC3H deaminase and anti-HIV-1 activities

scientific article

Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study

scientific article

Single DNA molecule stretching measures the activity of chemicals that target the HIV-1 nucleocapsid protein.

scientific article

Single aromatic residue location alters nucleic acid binding and chaperone function of FIV nucleocapsid protein

scientific article

Specific interactions between HIV-1 nucleocapsid protein and the TAR element

scientific article published on 7 April 2005

Specific zinc-finger architecture required for HIV-1 nucleocapsid protein's nucleic acid chaperone function

scientific article

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes ⬇️

scientific article published on February 8, 2013

Structural determinants of HIV-1 nucleocapsid protein for cTAR DNA binding and destabilization, and correlation with inhibition of self-primed DNA synthesis

scientific article published on 01 April 2005

Structure-Based Alignment and Consensus Secondary Structures for Three HIV-Related RNA Genomes

scientific article (publication date: May 2015)

Structure/function mapping of amino acids in the N-terminal zinc finger of the human immunodeficiency virus type 1 nucleocapsid protein: residues responsible for nucleic acid helix destabilizing activity

scientific article published on October 2006

Studies on the restriction of murine leukemia viruses by mouse APOBEC3

scientific article (publication date: 2012)

Subtle alterations of the native zinc finger structures have dramatic effects on the nucleic acid chaperone activity of human immunodeficiency virus type 1 nucleocapsid protein

scientific article

TCR triggering transcriptionally downregulates CCR5 expression on rhesus macaque CD4(+) T-cells with no measurable effect on susceptibility to SIV infection

scientific article

Targeted binding of nucleocapsid protein transforms the folding landscape of HIV-1 TAR RNA.

scientific article

The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6.

scientific article published on 26 April 2013

The immunologic effects of mesalamine in treated HIV-infected individuals with incomplete CD4+ T cell recovery: a randomized crossover trial

scientific article

The interaction of APOBEC3G with human immunodeficiency virus type 1 nucleocapsid inhibits tRNA3Lys annealing to viral RNA.

scientific article

The interdomain linker region of HIV-1 capsid protein is a critical determinant of proper core assembly and stability

scientific article published on 26 October 2011

Transmission electron microscopy reveals an optimal HIV-1 nucleocapsid aggregation with single-stranded nucleic acids and the mature HIV-1 nucleocapsid protein

scientific article published on 30 August 2006

Ultrasensitive Immunoassay for Simian Immunodeficiency Virus p27

scholarly article by Adrienne E Swanstrom et al published November 2018 in AIDS Research and Human Retroviruses

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.

scientific article published on 08 April 2015

Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

scientific article published on December 2015

Zinc finger domain of murine leukemia virus nucleocapsid protein enhances the rate of viral DNA synthesis in vivo.

scientific article

Zinc finger function of HIV-1 nucleocapsid protein is required for removal of 5'-terminal genomic RNA fragments: a paradigm for RNA removal reactions in HIV-1 reverse transcription.

scientific article published on 10 November 2012

Zinc finger-dependent HIV-1 nucleocapsid protein-TAR RNA interactions

scientific article

List of works by Robert J Gorelick

6th international symposium on retroviral nucleocapsid

A Guanosine-Centric Mechanism for RNA Chaperone Function ⬇️

A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA.

A succession of mechanisms stimulate efficient reconstituted HIV-1 minus strand strong stop DNA transfer

Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues

Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors

Amino-terminal region of the human immunodeficiency virus type 1 nucleocapsid is required for human APOBEC3G packaging

An immature retroviral RNA genome resembles a kinetically trapped intermediate state

Architecture and secondary structure of an entire HIV-1 RNA genome

Aromatic residue mutations reveal direct correlation between HIV-1 nucleocapsid protein's nucleic acid chaperone activity and retroviral replication

Blocking premature reverse transcription fails to rescue the HIV-1 nucleocapsid-mutant replication defect ⬇️

C-terminal domain modulates the nucleic acid chaperone activity of human T-cell leukemia virus type 1 nucleocapsid protein via an electrostatic mechanism

Characterization of human immunodeficiency virus type 1 (HIV-1) containing mutations in the nucleocapsid protein at a putative HIV-1 protease cleavage site

Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo

Coassembly and complementation of Gag proteins from HIV-1 and HIV-2, two distinct human pathogens.

Cofactors for human immunodeficiency virus type 1 cDNA integration in vitro

Comparison of SIV and HIV-1 Genomic RNA Structures Reveals Impact of Sequence Evolution on Conserved and Non-Conserved Structural Motifs ⬇️

Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides

Corrigendum: Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.

Definition of a high-affinity Gag recognition structure mediating packaging of a retroviral RNA genome.

Differential contribution of basic residues to HIV-1 nucleocapsid protein's nucleic acid chaperone function and retroviral replication

Differing roles of the N- and C-terminal zinc fingers in human immunodeficiency virus nucleocapsid protein-enhanced nucleic acid annealing

Dimeric RNA recognition regulates HIV-1 genome packaging

Discovery of small-molecule human immunodeficiency virus type 1 entry inhibitors that target the gp120-binding domain of CD4.

Distinct nucleic acid interaction properties of HIV-1 nucleocapsid protein precursor NCp15 explain reduced viral infectivity

Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation ⬇️

Efficiency of human immunodeficiency virus type 1 postentry infection processes: evidence against disproportionate numbers of defective virions

Elimination of protease activity restores efficient virion production to a human immunodeficiency virus type 1 nucleocapsid deletion mutant

Elimination of retroviral infectivity by N-ethylmaleimide with preservation of functional envelope glycoproteins

Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions

Factors that determine the efficiency of HIV-1 strand transfer initiated at a specific site

Features, processing states, and heterologous protein interactions in the modulation of the retroviral nucleocapsid protein function

Femtomole SHAPE Reveals Regulatory Structures in the Authentic XMRV RNA Genome ⬇️

Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein

Frontiers of Retrovirology 2011, Amsterdam, The Netherlands, 3-5 October 2011. Meeting Abstracts

Functional complementation of nucleocapsid and late domain PTAP mutants of human immunodeficiency virus type 1 during replication.

Fundamental differences between the nucleic acid chaperone activities of HIV-1 nucleocapsid protein and Gag or Gag-derived proteins: biological implications

G-quartets direct assembly of HIV-1 nucleocapsid protein along single-stranded DNA.

Gag-dependent enrichment of HIV-1 RNA near the uropod membrane of polarized T cells

Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA

HIV-1 Nucleocapsid Protein Increases Strand Transfer Recombination by Promoting Dimeric G-quartet Formation ⬇️

HIV-1 inactivation by 4-vinylpyridine is enhanced by dissociating Zn(2+) from nucleocapsid protein

HIV-1 protease and reverse transcriptase control the architecture of their nucleocapsid partner

High recombination potential of subtype A HIV-1.

High-throughput SHAPE analysis reveals structures in HIV-1 genomic RNA strongly conserved across distinct biological states

Human T-cell lymphotropic virus type 1 nucleocapsid protein-induced structural changes in transactivation response DNA hairpin measured by single-molecule fluorescence resonance energy transfer

Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs.

Human cellular nucleic acid-binding protein Zn2+ fingers support replication of human immunodeficiency virus type 1 when they are substituted in the nucleocapsid protein

Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration

Human immunodeficiency virus type 1 nucleocapsid zinc-finger mutations cause defects in reverse transcription and integration

Human immunodeficiency virus type 1 nucleocapsid zn(2+) fingers are required for efficient reverse transcription, initial integration processes, and protection of newly synthesized viral DNA.

Interactions of murine APOBEC3 and human APOBEC3G with murine leukemia viruses

Mechanistic differences between HIV-1 and SIV nucleocapsid proteins and cross-species HIV-1 genomic RNA recognition

Mechanistic insights into the kinetics of HIV-1 nucleocapsid protein-facilitated tRNA annealing to the primer binding site

Minimal Contribution of APOBEC3-Induced G-to-A Hypermutation to HIV-1 Recombination and Genetic Variation

Modulation of the HIV nucleocapsid dynamics finely tunes its RNA-binding properties during virion genesis

Molecular determinants of HIV-1 NCp7 chaperone activity in maturation of the HIV-1 dimerization initiation site ⬇️

Mutational analysis of the C-terminal gag cleavage sites in human immunodeficiency virus type 1

Mutations in human immunodeficiency virus type 1 nucleocapsid protein zinc fingers cause premature reverse transcription

Noninfectious papilloma virus-like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27.

Nucleic acid binding and chaperone properties of HIV-1 Gag and nucleocapsid proteins

Nucleocapsid protein function in early infection processes

Nucleotide excision repair and template-independent addition by HIV-1 reverse transcriptase in the presence of nucleocapsid protein

Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase 2b Trial

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection

Rapid kinetics of protein-nucleic acid interaction is a major component of HIV-1 nucleocapsid protein's nucleic acid chaperone function

Retroviral nucleocapsid proteins display nonequivalent levels of nucleic acid chaperone activity

Retrovirus-specific differences in matrix and nucleocapsid protein-nucleic acid interactions: implications for genomic RNA packaging

Role of the Reverse Transcriptase, Nucleocapsid Protein, and Template Structure in the Two-step Transfer Mechanism in Retroviral Recombination

Role of the zinc fingers of HIV-1 nucleocapsid protein in maturation of genomic RNA.

Secondary structure of the mature ex virio Moloney murine leukemia virus genomic RNA dimerization domain

Selection of fully processed HIV-1 nucleocapsid protein is required for optimal nucleic acid chaperone activity in reverse transcription

Sequence and structural determinants of human APOBEC3H deaminase and anti-HIV-1 activities

Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study

Single DNA molecule stretching measures the activity of chemicals that target the HIV-1 nucleocapsid protein.

Single aromatic residue location alters nucleic acid binding and chaperone function of FIV nucleocapsid protein

Specific interactions between HIV-1 nucleocapsid protein and the TAR element

Specific zinc-finger architecture required for HIV-1 nucleocapsid protein's nucleic acid chaperone function

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes ⬇️